EA200301068A1 - Получение и выделение гликозидов индолокарбазола - Google Patents

Получение и выделение гликозидов индолокарбазола

Info

Publication number
EA200301068A1
EA200301068A1 EA200301068A EA200301068A EA200301068A1 EA 200301068 A1 EA200301068 A1 EA 200301068A1 EA 200301068 A EA200301068 A EA 200301068A EA 200301068 A EA200301068 A EA 200301068A EA 200301068 A1 EA200301068 A1 EA 200301068A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glycosides
obtaining
indocharbasol
isolation
inhibit
Prior art date
Application number
EA200301068A
Other languages
English (en)
Other versions
EA005126B1 (ru
Inventor
Стивен Вайссман
Дэвид Чаен
Такехико Ийда
Масаси Кавасаки
Соуйти Хирага
Асаюки Каматани
Original Assignee
Мерк Энд Ко. , Инк.
Баниу Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко. , Инк., Баниу Фармасьютикал Ко., Лтд. filed Critical Мерк Энд Ко. , Инк.
Publication of EA200301068A1 publication Critical patent/EA200301068A1/ru
Publication of EA005126B1 publication Critical patent/EA005126B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Данное изобретение относится к новому способу получения гликозидов индолокарбазола высокой степени чистоты, которые ингибируют рост опухолевых клеток и вследствие чего применимы в лечении рака млекопитающих и подобных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200301068A 2001-03-29 2002-03-25 Получение и выделение гликозидов индолокарбазола EA005126B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27962901P 2001-03-29 2001-03-29
PCT/US2002/009152 WO2002079214A1 (en) 2001-03-29 2002-03-25 Preparation and isolation of indolocarbazole glycosides

Publications (2)

Publication Number Publication Date
EA200301068A1 true EA200301068A1 (ru) 2004-02-26
EA005126B1 EA005126B1 (ru) 2004-12-30

Family

ID=23069774

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200301068A EA005126B1 (ru) 2001-03-29 2002-03-25 Получение и выделение гликозидов индолокарбазола

Country Status (22)

Country Link
US (2) US6559299B2 (ru)
EP (1) EP1390376A1 (ru)
JP (1) JP3439470B1 (ru)
KR (1) KR20040028732A (ru)
CN (1) CN1268633C (ru)
AR (1) AR035449A1 (ru)
AU (1) AU2002306863B2 (ru)
BR (1) BR0208470A (ru)
CA (1) CA2441214A1 (ru)
CZ (1) CZ20032638A3 (ru)
EA (1) EA005126B1 (ru)
HR (1) HRP20030777A2 (ru)
HU (1) HUP0303640A2 (ru)
IL (1) IL157823A0 (ru)
MX (1) MXPA03008805A (ru)
NZ (1) NZ529168A (ru)
PL (1) PL363865A1 (ru)
SK (1) SK11972003A3 (ru)
TW (1) TWI245045B (ru)
UA (1) UA74249C2 (ru)
WO (1) WO2002079214A1 (ru)
YU (1) YU72603A (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559299B2 (en) * 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
WO2005010018A1 (ja) * 2003-07-24 2005-02-03 Banyu Pharmaceutical Co., Ltd. 結晶形態の６−ｎ−ピリジルメチルアミノインドロカルバゾール化合物
US20060227241A1 (en) * 2005-04-06 2006-10-12 Dyke Phil V Apparatus and method for adjusting colors of an image

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
AU1911095A (en) * 1994-02-18 1995-09-04 Cephalon, Inc. Aqueous indolocarbazole solutions
US5922860A (en) 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US6559299B2 (en) * 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides

Also Published As

Publication number Publication date
NZ529168A (en) 2005-03-24
IL157823A0 (en) 2004-03-28
AU2002306863B2 (en) 2007-08-09
BR0208470A (pt) 2004-03-02
AR035449A1 (es) 2004-05-26
JP3439470B1 (ja) 2003-08-25
MXPA03008805A (es) 2004-10-15
SK11972003A3 (sk) 2004-01-08
HRP20030777A2 (en) 2005-08-31
JP2004519518A (ja) 2004-07-02
CN1268633C (zh) 2006-08-09
US20020193324A1 (en) 2002-12-19
PL363865A1 (en) 2004-11-29
EP1390376A1 (en) 2004-02-25
CZ20032638A3 (cs) 2004-02-18
WO2002079214A1 (en) 2002-10-10
EA005126B1 (ru) 2004-12-30
CN1578784A (zh) 2005-02-09
TWI245045B (en) 2005-12-11
CA2441214A1 (en) 2002-10-10
US6559299B2 (en) 2003-05-06
UA74249C2 (ru) 2005-11-15
YU72603A (sh) 2006-05-25
KR20040028732A (ko) 2004-04-03
HUP0303640A2 (hu) 2004-03-01
US20040116688A1 (en) 2004-06-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU