EA199800350A1 - Биоадгезивная твердая дозированная лекарственная форма - Google Patents

Биоадгезивная твердая дозированная лекарственная форма

Info

Publication number
EA199800350A1
EA199800350A1 EA199800350A EA199800350A EA199800350A1 EA 199800350 A1 EA199800350 A1 EA 199800350A1 EA 199800350 A EA199800350 A EA 199800350A EA 199800350 A EA199800350 A EA 199800350A EA 199800350 A1 EA199800350 A1 EA 199800350A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bioadgeval
dosage forms
solid dosage
medical form
solid dosed
Prior art date
Application number
EA199800350A
Other languages
English (en)
Other versions
EA000818B1 (ru
Inventor
Поль Мари Виктор Жили
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of EA199800350A1 publication Critical patent/EA199800350A1/ru
Publication of EA000818B1 publication Critical patent/EA000818B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Данное изобретение относится к биоадгезивным фармацевтическим композициям, содержащим фармакологически эффективное количество активного ингредиента, от 80 до 98,8 вес.% предварительного превращенного в гель крахмала и от 1 до 10 вес.% гидрофильного образующего матрицу полимера и дополнительно включающим от 0,2 до 5 вес.% Cалкилфумарата щелочного металла в качестве смазывающего вещества; к твердым дозированным формам, таким как таблетки, которые пригодны для перорального, интраназального, ректального и вагинального введения; к способам получения композиций и твердых дозированных форм.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800350A 1995-12-27 1996-12-20 Биоадгезивная твердая дозированная лекарственная форма EA000818B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95203649 1995-12-27
PCT/EP1996/005884 WO1997024109A1 (en) 1995-12-27 1996-12-20 Bioadhesive solid dosage form

Publications (2)

Publication Number Publication Date
EA199800350A1 true EA199800350A1 (ru) 1998-10-29
EA000818B1 EA000818B1 (ru) 2000-04-24

Family

ID=8221021

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800350A EA000818B1 (ru) 1995-12-27 1996-12-20 Биоадгезивная твердая дозированная лекарственная форма

Country Status (27)

Country Link
US (1) US6303147B1 (ru)
EP (1) EP0869772B1 (ru)
JP (1) JP4317264B2 (ru)
KR (1) KR100459029B1 (ru)
CN (1) CN1146401C (ru)
AT (1) ATE206304T1 (ru)
AU (1) AU713849B2 (ru)
BR (1) BR9612291A (ru)
CA (1) CA2232152C (ru)
CY (1) CY2269B1 (ru)
CZ (1) CZ298690B6 (ru)
DE (1) DE69615704T2 (ru)
DK (1) DK0869772T3 (ru)
EA (1) EA000818B1 (ru)
ES (1) ES2164940T3 (ru)
HK (1) HK1015680A1 (ru)
HU (1) HU228350B1 (ru)
IL (1) IL123636A (ru)
NO (1) NO320015B1 (ru)
NZ (1) NZ325844A (ru)
PL (1) PL186278B1 (ru)
PT (1) PT869772E (ru)
SI (1) SI0869772T1 (ru)
SK (1) SK283370B6 (ru)
TR (1) TR199800894T2 (ru)
WO (1) WO1997024109A1 (ru)
ZA (1) ZA9610886B (ru)

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US20040013613A1 (en) * 2001-05-18 2004-01-22 Jain Rajeev A Rapidly disintegrating solid oral dosage form
US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6428814B1 (en) * 1999-10-08 2002-08-06 Elan Pharma International Ltd. Bioadhesive nanoparticulate compositions having cationic surface stabilizers
CA2371940C (en) 1999-03-31 2008-07-15 Janssen Pharmaceutica N.V. Pregelatinized starch in a controlled release formulation
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US20040156872A1 (en) * 2000-05-18 2004-08-12 Elan Pharma International Ltd. Novel nimesulide compositions
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EP1236466B1 (en) * 2001-02-28 2011-09-21 Axiomedic Ltd. Solid self-adhesive compositions for topical treatment of oral mucosal disorders
US8980334B2 (en) * 2001-02-28 2015-03-17 Axiomedic Ltd. Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders
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US20030124196A1 (en) 2001-08-22 2003-07-03 Susan Weinbach Pulsatile release compositions and methods for enhanced intestinal drug absorption
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
US7709026B2 (en) * 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
US7846478B2 (en) * 2002-01-31 2010-12-07 Henkel Ag & Co. Kgaa Bioadhesive composition
ATE464880T1 (de) 2002-02-04 2010-05-15 Elan Pharma Int Ltd Arzneistoffnanopartikel mit lysozym- oberflächenstabilisator
US20040258757A1 (en) * 2002-07-16 2004-12-23 Elan Pharma International, Ltd. Liquid dosage compositions of stable nanoparticulate active agents
PA8578501A1 (es) 2002-07-25 2005-02-04 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
EP1667681A4 (en) 2003-10-03 2009-09-30 Astron Res Pvt Ltd NEW TRANSMUCOSAL ADMINISTRATION SYSTEM
EA011862B1 (ru) * 2004-03-24 2009-06-30 Актавис Груп Хф. Композиции рамиприла
EP2468266A3 (en) * 2004-04-22 2012-10-24 AcuCort AB Pharmaceutical compositions for acute glucocorticoid therapy
TWI338583B (en) * 2004-05-20 2011-03-11 Otsuka Pharma Co Ltd Solid pharmaceutical formulation
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US20070048369A1 (en) * 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
GB0518129D0 (en) * 2005-09-06 2005-10-12 Arrow Int Ltd Ramipril formulation
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
US8349120B2 (en) * 2006-03-07 2013-01-08 Ora Health Corporation Multi-layer patch made on a sheet and enclosed in a blister
EP1837020A1 (en) 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
US20070248655A1 (en) * 2006-04-21 2007-10-25 Haley Jeffrey T Lenticular shaped protective mouth sore discs
US20070293587A1 (en) * 2006-05-23 2007-12-20 Haley Jeffrey T Combating sinus, throat, and blood infections with xylitol delivered in the mouth
JP5410964B2 (ja) * 2006-05-23 2014-02-05 オラヘルス コーポレーション 付着性アカシアゴムを含む二層構造の口腔内付着錠
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US20080160065A1 (en) * 2006-07-12 2008-07-03 Janet Anne Halliday Drug delivery polymer with hydrochloride salt of clindamycin
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
EP3620153A1 (en) 2007-07-06 2020-03-11 Lupin Limited Pharmaceutical compositions for gastrointestinal drug delivery
US20120027855A1 (en) 2007-07-06 2012-02-02 Lupin Limited Pharmaceutical compositions for gastrointestinal drug delivery
WO2009008006A2 (en) * 2007-07-06 2009-01-15 Lupin Limited Pharmaceutical compositions for gastrointestinal drug delivery
EP2163240A1 (en) * 2008-09-12 2010-03-17 Universita' Degli Studi Di Genova A method for the production of bioadhesive compact matrices
US8652455B2 (en) 2010-12-20 2014-02-18 E I Du Pont De Nemours And Company Targeted perhydrolases
AU2014224238B2 (en) * 2013-03-06 2016-07-14 Novartis Ag Formulations of organic compounds
CN105193768A (zh) * 2015-08-27 2015-12-30 武汉武药科技有限公司 一种曲安奈德口腔粘贴片及其制备工艺
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Also Published As

Publication number Publication date
ZA9610886B (en) 1998-06-23
HK1015680A1 (en) 1999-10-22
DK0869772T3 (da) 2002-01-21
ATE206304T1 (de) 2001-10-15
TR199800894T2 (xx) 1998-08-21
DE69615704D1 (de) 2001-11-08
IL123636A0 (en) 1998-10-30
JP4317264B2 (ja) 2009-08-19
AU713849B2 (en) 1999-12-09
HU228350B1 (hu) 2013-03-28
HUP9802913A2 (hu) 1999-06-28
PT869772E (pt) 2002-03-28
CY2269B1 (en) 2003-07-04
IL123636A (en) 2001-04-30
KR100459029B1 (ko) 2006-03-27
PL326196A1 (en) 1998-08-31
CA2232152C (en) 2007-02-06
NO981027D0 (no) 1998-03-09
JP2000502691A (ja) 2000-03-07
SI0869772T1 (en) 2002-04-30
BR9612291A (pt) 1999-07-13
WO1997024109A1 (en) 1997-07-10
ES2164940T3 (es) 2002-03-01
CN1146401C (zh) 2004-04-21
PL186278B1 (pl) 2003-12-31
SK283370B6 (sk) 2003-06-03
NZ325844A (en) 1999-06-29
HUP9802913A3 (en) 2000-06-28
AU1308597A (en) 1997-07-28
SK88798A3 (en) 1998-11-04
NO981027L (no) 1998-06-15
CN1200667A (zh) 1998-12-02
EP0869772B1 (en) 2001-10-04
US6303147B1 (en) 2001-10-16
CZ298690B6 (cs) 2007-12-27
CZ199298A3 (cs) 1998-09-16
NO320015B1 (no) 2005-10-10
EA000818B1 (ru) 2000-04-24
CA2232152A1 (en) 1997-07-10
EP0869772A1 (en) 1998-10-14
DE69615704T2 (de) 2002-07-11
KR19990067112A (ko) 1999-08-16

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU