EA200301040A1 - Способ производства фармацевтической композиции низкой дозы - Google Patents
Способ производства фармацевтической композиции низкой дозыInfo
- Publication number
- EA200301040A1 EA200301040A1 EA200301040A EA200301040A EA200301040A1 EA 200301040 A1 EA200301040 A1 EA 200301040A1 EA 200301040 A EA200301040 A EA 200301040A EA 200301040 A EA200301040 A EA 200301040A EA 200301040 A1 EA200301040 A1 EA 200301040A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- manufacture
- low dose
- manufacturing
- effectiveness
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000009513 drug distribution Methods 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 239000007916 tablet composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Описан способ производства фармацевтической композиции, имеющей равномерные распределение лекарства и эффективность, в котором используют диоксид кремния для уменьшения потерь активного ингредиента в ходе процесса производства. Способ особенно полезен для производства таблеточных композиций низкой дозировки.Отчет о международном поиске был опубликован 2003.02.13.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28784101P | 2001-05-01 | 2001-05-01 | |
| PCT/IB2002/000766 WO2002087546A2 (en) | 2001-05-01 | 2002-03-13 | Method for manufacturing a low dose pharmaceutical composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200301040A1 true EA200301040A1 (ru) | 2004-04-29 |
| EA005949B1 EA005949B1 (ru) | 2005-08-25 |
Family
ID=23104578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200301040A EA005949B1 (ru) | 2001-05-01 | 2002-03-13 | Способ производства фармацевтической композиции низкой дозы |
Country Status (44)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0500025A3 (en) | 2002-03-28 | 2005-10-28 | Pfizer Prod Inc | Purified lasofoxifene and a method for purification of racemic lasofoxifene by recrystallization |
| PA8576201A1 (es) * | 2002-07-10 | 2004-05-26 | Pfizer Prod Inc | Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco |
| US7444197B2 (en) | 2004-05-06 | 2008-10-28 | Smp Logic Systems Llc | Methods, systems, and software program for validation and monitoring of pharmaceutical manufacturing processes |
| US7799273B2 (en) | 2004-05-06 | 2010-09-21 | Smp Logic Systems Llc | Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes |
| EP2023745A1 (en) * | 2006-05-17 | 2009-02-18 | WM. Wrigley Jr., Company | Method of preparing a food product |
| FI20070521L (fi) | 2006-11-10 | 2008-05-11 | Atacama Labs Oy | Rakeita, tabletteja ja rakeistusmenetelmä |
| FI20080351A0 (fi) * | 2008-05-09 | 2008-05-09 | Atacama Labs Oy | Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi |
| US8951562B2 (en) * | 2006-11-10 | 2015-02-10 | Atacama Labs Oy | Method and apparatus or dry granulation |
| CA2671727C (en) * | 2006-12-20 | 2016-02-16 | Genpharm Ulc | A composition containing a bisphosphonic acid in combination with vitamin d |
| US20080181972A1 (en) * | 2007-01-29 | 2008-07-31 | Valentina Amico | Compositions and Methods for Maintaining, Strengthening, Improving, or Promoting Eye Health |
| PT2487166T (pt) | 2007-02-23 | 2016-10-17 | Gilead Sciences Inc | Moduladores de propriedades farmacocinéticas de agentes terapêuticos |
| SI2296633T1 (sl) | 2008-05-02 | 2015-11-30 | Gilead Sciences, Inc. | Uporaba trdnih nosilnih delcev za izboljšanje predelovalnih sposobnosti farmacevtskega sredstva |
| EP2291233B1 (en) * | 2008-05-09 | 2019-09-04 | Atacama Labs Oy | Method for dry granulation |
| KR20170020557A (ko) | 2008-06-06 | 2017-02-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 인돌리논 유도체의 현탁 제형을 포함하는 캡슐 약제학적 투여 형태 |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| ES2520990T3 (es) * | 2009-01-29 | 2014-11-12 | Ucb Pharma, S.A. | Composiciones farmacéuticas que comprenden derivados de 2-oxo-1-pirrolidina |
| PT2391349E (pt) * | 2009-01-29 | 2014-10-27 | Ucb Pharma Sa | Composições farmacêuticas compreendendo derivados de 2- oxo-1-pirrolidina |
| US20140350945A1 (en) * | 2013-05-22 | 2014-11-27 | Professional Compounding Centers Of America | System and Method for Validation of Pharmaceutical Composition Formulations |
| CN103830196A (zh) * | 2014-03-14 | 2014-06-04 | *** | 一种酒石酸拉索昔芬分散片及其制备方法 |
| CN106176649B (zh) * | 2016-08-31 | 2020-04-17 | 北京斯利安药业有限公司 | 叶酸vb12片及其制备方法 |
| JP2020510636A (ja) * | 2017-02-17 | 2020-04-09 | マサチューセッツ インスティテュート オブ テクノロジー | 医薬錠剤を含む錠剤の製作のためのシステムおよび方法 |
| CZ309820B6 (cs) * | 2021-04-23 | 2023-11-08 | Pro.Med.Cs Praha A.S. | Způsob přípravy pevné lékové formy obsahující kompozici s nízkým obsahem účinné látky |
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| US3725555A (en) * | 1967-08-01 | 1973-04-03 | Ciba Geigy Corp | Bactericidal compositions and method of killing bacteria using bis-(phenoxyphenyl) carbonates |
| US3725556A (en) | 1970-11-12 | 1973-04-03 | D Hanssen | Method of manufacturing rapidly disintegrating pharmaceutical tablets |
| US4013785A (en) | 1975-03-21 | 1977-03-22 | Bristol-Myers Company | Apap tablet containing fumed silica and process for manufacturing same |
| GB1570993A (en) * | 1976-05-21 | 1980-07-09 | Fisons Ltd | Pharmaceutical tablet formulation |
| DE2845326C2 (de) | 1978-10-18 | 1985-05-23 | Beiersdorf Ag, 2000 Hamburg | Verwendung einer spezifischen mikrodispersen, amorphen, porösen Kieselsäure zur Herstellung von Digoxin enthaltenden Tabletten mit stark beschleunigter Wirkstoff-Freisetzung |
| US4489026A (en) | 1982-09-07 | 1984-12-18 | The Upjohn Company | Process for preparing solid unit dosage forms of ultra-low dose drugs |
| US5004613A (en) | 1987-07-27 | 1991-04-02 | Mcneil-Ppc, Inc. | Oral sustained release pharmaceutical formulation and process |
| US5047246A (en) | 1988-09-09 | 1991-09-10 | Bristol-Myers Company | Direct compression cyclophosphamide tablet |
| US5107331A (en) * | 1989-03-07 | 1992-04-21 | The Color Group | Method and apparatus for producing half-tone separations at the same screen angle |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| IE67345B1 (en) * | 1991-03-12 | 1996-03-20 | Akzo Nv | Low dose dry pharmaceutical preparations |
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| US5976570A (en) | 1993-12-21 | 1999-11-02 | Applied Analytical Industries, Inc. | Method for preparing low dose pharmaceutical products |
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| US5478572A (en) * | 1994-09-06 | 1995-12-26 | Bristol-Myers Squibb Co. | Gepirone dosage form |
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| AR029538A1 (es) * | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
-
2002
- 2002-03-13 KR KR1020037014223A patent/KR100568380B1/ko not_active IP Right Cessation
- 2002-03-13 OA OA1200300274A patent/OA12596A/en unknown
- 2002-03-13 PL PL02366453A patent/PL366453A1/xx not_active Application Discontinuation
- 2002-03-13 PT PT02702671T patent/PT1383482E/pt unknown
- 2002-03-13 EP EP02702671A patent/EP1383482B1/en not_active Expired - Lifetime
- 2002-03-13 GE GE5339A patent/GEP20053654B/en unknown
- 2002-03-13 HU HU0401391A patent/HUP0401391A3/hu unknown
- 2002-03-13 CA CA002445519A patent/CA2445519C/en not_active Expired - Fee Related
- 2002-03-13 CN CNB028092554A patent/CN1240375C/zh not_active Expired - Fee Related
- 2002-03-13 BR BR0209283-2A patent/BR0209283A/pt not_active IP Right Cessation
- 2002-03-13 YU YUP-815/03A patent/YU81503A/sh unknown
- 2002-03-13 AT AT02702671T patent/ATE367152T1/de not_active IP Right Cessation
- 2002-03-13 JP JP2002584892A patent/JP2004531537A/ja not_active Ceased
- 2002-03-13 ES ES02702671T patent/ES2286226T3/es not_active Expired - Lifetime
- 2002-03-13 CZ CZ20032959A patent/CZ20032959A3/cs unknown
- 2002-03-13 AP APAP/P/2003/002900A patent/AP2003002900A0/en unknown
- 2002-03-13 WO PCT/IB2002/000766 patent/WO2002087546A2/en active Application Filing
- 2002-03-13 DK DK02702671T patent/DK1383482T3/da active
- 2002-03-13 UA UA2003109816A patent/UA75135C2/uk unknown
- 2002-03-13 SK SK1355-2003A patent/SK286536B6/sk not_active IP Right Cessation
- 2002-03-13 NZ NZ528886A patent/NZ528886A/en unknown
- 2002-03-13 DE DE60221238T patent/DE60221238T2/de not_active Expired - Fee Related
- 2002-03-13 AU AU2002236166A patent/AU2002236166B2/en not_active Ceased
- 2002-03-13 EA EA200301040A patent/EA005949B1/ru not_active IP Right Cessation
- 2002-03-13 MX MXPA03009391A patent/MXPA03009391A/es active IP Right Grant
- 2002-03-13 IL IL15839002A patent/IL158390A0/xx unknown
- 2002-03-13 EE EEP200300537A patent/EE200300537A/xx unknown
- 2002-04-23 US US10/131,556 patent/US7037530B2/en not_active Expired - Fee Related
- 2002-04-25 TW TW091108572A patent/TWI264311B/zh not_active IP Right Cessation
- 2002-04-26 DO DO2002000389A patent/DOP2002000389A/es unknown
- 2002-04-29 PA PA20028544401A patent/PA8544401A1/es unknown
- 2002-04-29 GT GT200200078A patent/GT200200078A/es unknown
- 2002-04-29 AR ARP020101574A patent/AR033288A1/es unknown
- 2002-04-30 PE PE2002000368A patent/PE20021137A1/es not_active Application Discontinuation
- 2002-04-30 UY UY27277A patent/UY27277A1/es not_active Application Discontinuation
-
2003
- 2003-07-08 TN TNPCT/IB2002/000766A patent/TNSN03106A1/fr unknown
- 2003-10-07 ZA ZA200307819A patent/ZA200307819B/en unknown
- 2003-10-09 IS IS6985A patent/IS6985A/is unknown
- 2003-10-21 NO NO20034709A patent/NO20034709L/no not_active Application Discontinuation
- 2003-10-21 HR HR20030858A patent/HRP20030858A2/xx not_active Application Discontinuation
- 2003-10-28 BG BG108297A patent/BG108297A/bg unknown
- 2003-10-28 MA MA27375A patent/MA27017A1/fr unknown
- 2003-10-31 EC EC2003004826A patent/ECSP034826A/es unknown
-
2004
- 2004-10-30 HK HK04108533A patent/HK1065705A1/xx not_active IP Right Cessation
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2005
- 2005-12-13 US US11/302,894 patent/US7176221B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |