DOP2015000256A - Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas - Google Patents

Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas

Info

Publication number
DOP2015000256A
DOP2015000256A DO2015000256A DO2015000256A DOP2015000256A DO P2015000256 A DOP2015000256 A DO P2015000256A DO 2015000256 A DO2015000256 A DO 2015000256A DO 2015000256 A DO2015000256 A DO 2015000256A DO P2015000256 A DOP2015000256 A DO P2015000256A
Authority
DO
Dominican Republic
Prior art keywords
compound
dihydroimidazo
compound described
combination
active agents
Prior art date
Application number
DO2015000256A
Other languages
English (en)
Inventor
Ningshu Liu
Antje Margret Wengner
Katja Haike
Juliane Paul
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of DOP2015000256A publication Critical patent/DOP2015000256A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

- El uso de un compuesto del tipo de las 2,3-dihidroimidazo[1,2-c]quinazolinas, o de una composición farmacéutica que lo contiene, o de una combinación de (a) el compuesto que se ha descripto o una composición farmacéutica que lo contiene y (b) uno o más agentes activos adicionales en la elaboración de un medicamento útil para tratar o prevenir un linfoma no Hodgkin (NHL). - Combinación que comprende (a) el compuesto que se ha descripto y (b) uno o más agentes activos adicionales. - Composición farmacéutica que comprende el compuesto que se ha descripto. - Composición farmacéutica que está compuesta por una combinación que comprende (a) el compuesto que se ha descripto y (b) uno o más agentes activos adicionales. - El uso de indicadores biológicos para predecir la sensibilidad y/o la resistencia de un paciente que padece un cáncer al compuesto que se ha descripto.
DO2015000256A 2013-04-08 2015-10-08 Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas DOP2015000256A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13162710 2013-04-08
EP13184240 2013-09-13

Publications (1)

Publication Number Publication Date
DOP2015000256A true DOP2015000256A (es) 2015-12-31

Family

ID=50439383

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2015000256A DOP2015000256A (es) 2013-04-08 2015-10-08 Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas

Country Status (28)

Country Link
US (2) US9999623B2 (es)
EP (1) EP2983669B1 (es)
JP (1) JP6368353B2 (es)
KR (1) KR102304108B1 (es)
CN (1) CN105263497B (es)
AP (1) AP2015008750A0 (es)
AU (1) AU2014253348B2 (es)
BR (1) BR112015025304B1 (es)
CA (1) CA2908776C (es)
CL (1) CL2015002978A1 (es)
CR (1) CR20150523A (es)
CU (1) CU24400B1 (es)
DO (1) DOP2015000256A (es)
EA (2) EA037577B1 (es)
ES (1) ES2708350T3 (es)
HK (1) HK1220121A1 (es)
IL (1) IL241543B (es)
JO (1) JOP20140141B1 (es)
MX (1) MX2015014171A (es)
MY (1) MY192626A (es)
NI (1) NI201500148A (es)
PE (1) PE20151780A1 (es)
PH (1) PH12015502317A1 (es)
SG (2) SG11201507265XA (es)
TN (1) TN2015000452A1 (es)
TW (2) TWI689307B (es)
UA (2) UA122822C2 (es)
WO (1) WO2014166820A1 (es)

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Also Published As

Publication number Publication date
PE20151780A1 (es) 2015-12-20
IL241543B (en) 2019-08-29
CR20150523A (es) 2016-01-29
KR20150138858A (ko) 2015-12-10
EA201792650A1 (ru) 2018-04-30
AP2015008750A0 (en) 2015-09-30
EP2983669B1 (en) 2018-10-24
US20160058770A1 (en) 2016-03-03
UA122822C2 (uk) 2021-01-06
BR112015025304B1 (pt) 2022-09-27
CN105263497B (zh) 2019-04-30
TW201517909A (zh) 2015-05-16
UA119537C2 (uk) 2019-07-10
TW201924690A (zh) 2019-07-01
JP6368353B2 (ja) 2018-08-01
EA201591932A1 (ru) 2016-04-29
CA2908776A1 (en) 2014-10-16
EP2983669A1 (en) 2016-02-17
AU2014253348A1 (en) 2015-10-08
SG10201710539QA (en) 2018-01-30
CN105263497A (zh) 2016-01-20
US20180193349A1 (en) 2018-07-12
US9999623B2 (en) 2018-06-19
NI201500148A (es) 2015-11-30
PH12015502317A1 (en) 2016-02-10
HK1220121A1 (zh) 2017-04-28
CU20150140A7 (es) 2016-10-28
JOP20140141B1 (ar) 2021-08-17
BR112015025304A2 (pt) 2017-07-18
EA037577B1 (ru) 2021-04-16
KR102304108B1 (ko) 2021-09-23
US10226469B2 (en) 2019-03-12
JP2016515601A (ja) 2016-05-30
TWI675663B (zh) 2019-11-01
TN2015000452A1 (en) 2017-04-06
CU24400B1 (es) 2019-04-04
MY192626A (en) 2022-08-29
NZ712033A (en) 2021-03-26
SG11201507265XA (en) 2015-10-29
ES2708350T3 (es) 2019-04-09
EA031493B1 (ru) 2019-01-31
CL2015002978A1 (es) 2016-04-15
CA2908776C (en) 2021-08-10
TWI689307B (zh) 2020-04-01
AU2014253348B2 (en) 2019-05-23
MX2015014171A (es) 2015-12-16
EA031493B9 (ru) 2019-12-18
WO2014166820A1 (en) 2014-10-16

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