DK511381A - Mucopolysaccaharider som har biologiske egenskaber deres fremstilling og deres anvendelse som laegemidler - Google Patents

Mucopolysaccaharider som har biologiske egenskaber deres fremstilling og deres anvendelse som laegemidler

Info

Publication number
DK511381A
DK511381A DK511381A DK511381A DK511381A DK 511381 A DK511381 A DK 511381A DK 511381 A DK511381 A DK 511381A DK 511381 A DK511381 A DK 511381A DK 511381 A DK511381 A DK 511381A
Authority
DK
Denmark
Prior art keywords
mucopolysaccaharides
preparation
biological properties
medicinal products
medicinal
Prior art date
Application number
DK511381A
Other languages
English (en)
Other versions
DK172877B1 (da
Inventor
J C Lormeau
M Petitou
J Choay
Original Assignee
Choay Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9239907&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK511381(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Choay Sa filed Critical Choay Sa
Publication of DK511381A publication Critical patent/DK511381A/da
Application granted granted Critical
Publication of DK172877B1 publication Critical patent/DK172877B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK198105113A 1980-03-20 1981-11-18 Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber DK172877B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8006282 1980-03-20
FR8006282A FR2478646A2 (fr) 1980-03-20 1980-03-20 Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
PCT/FR1981/000041 WO1981002737A1 (fr) 1980-03-20 1981-03-20 Mucopolysaccharides possedant des proprietes biologiques, leur preparation et leur application en tant que medicaments
FR8100041 1981-03-20

Publications (2)

Publication Number Publication Date
DK511381A true DK511381A (da) 1981-11-18
DK172877B1 DK172877B1 (da) 1999-09-06

Family

ID=9239907

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198105113A DK172877B1 (da) 1980-03-20 1981-11-18 Analogifremgangsmåde til fremstilling af fra heparin afledede mucopolysaccharider med biologiske egenskaber

Country Status (20)

Country Link
US (1) US4686288A (da)
EP (1) EP0037319B2 (da)
JP (1) JPH0231081B2 (da)
AR (1) AR227417A1 (da)
AT (1) ATE26450T1 (da)
CA (1) CA1207759A (da)
CS (1) CS222245B2 (da)
DD (1) DD157561A5 (da)
DE (1) DE3176086D1 (da)
DK (1) DK172877B1 (da)
ES (1) ES501130A0 (da)
FR (1) FR2478646A2 (da)
HU (1) HU188657B (da)
IE (1) IE52951B1 (da)
IL (1) IL62424A (da)
PL (1) PL135948B1 (da)
SU (1) SU1658820A3 (da)
UA (1) UA5934A1 (da)
WO (1) WO1981002737A1 (da)
YU (1) YU43008B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2553287B1 (fr) * 1983-10-18 1986-09-12 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
CA1260461A (fr) * 1984-10-18 1989-09-26 Jean-Claude Lormeau Procede de preparation de compositions de mucopolysaccharides dotes d'une activite antithrombotique elevee
FR2572080B1 (fr) * 1984-10-18 1987-06-26 Dropic Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4879282A (en) * 1987-03-17 1989-11-07 Saliba Jr Michael J Medical application for heparin and related molecules
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
JP2871822B2 (ja) * 1989-08-29 1999-03-17 玉造株式会社 末端に２，５―アンヒドロマンニトール基または２，５―アンヒドロマンノース基を有するキチン・キトサンオリゴマーおよびその製造方法
AU7681091A (en) * 1990-04-05 1991-10-30 John R Hoidal Method and medicament for prevention or medication of human leucocyte elastase-mediated pulmonary diseases
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
FR2691066B1 (fr) * 1992-05-15 1995-06-09 Sanofi Elf Utilisation de glycosaminoglycanes exogenes, de leurs analogues ainsi que de leurs fragments, fractions et derives, pour la preparation de medicaments destines au traitement de thrombopenies.
DE4217917A1 (de) * 1992-05-30 1993-12-02 Job Prof Dr Med Harenberg Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer
JP3390477B2 (ja) * 1993-01-25 2003-03-24 生化学工業株式会社 薬剤組成物及びその製造法
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
US5646130A (en) * 1995-06-30 1997-07-08 Ocean University Of Oingdao Low molecular weight sulfated polysaccharides and uses thereof
AP1390A (en) * 1996-11-27 2005-04-15 Aventis Pharmaceuticals Products Inc Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound.
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
DE29900874U1 (de) 1999-01-20 1999-07-22 Knoll AG, 67061 Ludwigshafen Organprotektive Lösungen
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
SG191613A1 (en) 2008-05-30 2013-07-31 Momenta Pharmaceuticals Inc Saccharide structures and methods of making and using such structures
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A1 (en) 2020-07-14 2023-05-24 Optimvia, LLC Methods for synthesizing non-anticoagulant heparan sulfate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
US4175182A (en) * 1978-07-03 1979-11-20 Research Corporation Separation of high-activity heparin by affinity chromatography on supported protamine
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
GB2071127B (en) * 1980-02-29 1984-07-25 Italfarmaco Spa Process for the purification of glucosaninoglucans
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity

Also Published As

Publication number Publication date
JPH0231081B2 (da) 1990-07-11
JPS57500335A (da) 1982-02-25
CS222245B2 (en) 1983-05-27
IL62424A (en) 1984-12-31
CA1207759A (en) 1986-07-15
WO1981002737A1 (fr) 1981-10-01
YU43008B (en) 1989-02-28
ES8201596A1 (es) 1982-01-16
PL230237A1 (en) 1981-11-13
EP0037319A1 (fr) 1981-10-07
HU188657B (en) 1986-05-28
DK172877B1 (da) 1999-09-06
YU73681A (en) 1983-10-31
EP0037319B2 (fr) 1995-06-28
ES501130A0 (es) 1982-01-16
DD157561A5 (de) 1982-11-17
IE52951B1 (en) 1988-04-27
IL62424A0 (en) 1981-05-20
FR2478646A2 (fr) 1981-09-25
EP0037319B1 (fr) 1987-04-08
SU1658820A3 (ru) 1991-06-23
AR227417A1 (es) 1982-10-29
DE3176086D1 (en) 1987-05-14
US4686288A (en) 1987-08-11
IE810632L (en) 1981-09-20
FR2478646B2 (da) 1983-06-24
ATE26450T1 (de) 1987-04-15
PL135948B1 (en) 1986-01-31
UA5934A1 (uk) 1994-12-29

Similar Documents

Publication Publication Date Title
DK511381A (da) Mucopolysaccaharider som har biologiske egenskaber deres fremstilling og deres anvendelse som laegemidler
DK247981A (da) Oligosaccharidfraktioner og oligosaccharider der har biologiske egenskaber fremgangsmaader til deres fremstilling og deres anvendelse som laegemidler
DK211981A (da) Hidtil ukendte sulfaterede polysaccharider fremgangsmaader til deres fremstilling og deres anvendelse som medikamenter
DK143588A (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK189581A (da) Hidtil ukendte heparinestere der er anvendelige til fremstilling af laegemidler og fremgangsmaader til deres frmstilling
DK658688A (da) 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler
DK118791D0 (da) 1-benzopyran-4-oner og 2-amino-1,3-benzoxazin-4-oner, deres fremstilling og anvendelse som eller til fremstilling af laegemidler
DK379481A (da) Phosphotsyremonoestersalte deres fremstilling og anvendelse som fungicider
DK308481A (da) Alfa-substituerede o-methylbenzensulfonamider fremgangmaade til fremstilling heraf samt deres anvendelse som herbicider
DK156579A (da) Oximino-triazolyl-ethaner deres fremstilling og anvendelse som fungicider
DK161010C (da) Vandfrit cremeprodukt til avendelse som antitranspirant og/eller deodorant og fremgangsmaade til fremstilling deraf
DK216280A (da) Geometriske isomere af 4,4-dimethyl-1-phenyl-2-(1,2,4-triazol-yl)-1-pentan-3-oler og fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK154382A (da) Hidtil ukendte derivater af 2-piperazinopyrimidin,fremgangsmaader til deres fremstilling og deres anvendelse som laegemidlereller mellemprodukter til fremstilling af laegemidler
DK656588A (da) Substituerede hydroxylaminer, deres fremstilling og anvendelse som laegemidler, samt ved fremstillingen anvendelige mellemprodukter og fremstilling deraf
DK366888A (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
IT8148952A0 (it) Amminoglucosidi ammidinati procedimento per loro preparazione e loro impiego come medicamenti
DK326980A (da) 25-halogen-cholest-5-en-3beta,22-dioler og estere deraf deres fremstilling og anvendelse
DK453184D0 (da) 1-azolyl-substituerede oximethere, fremgangsmaade til fremstilling deraf og deres anvendelse som fungicider
DK243480A (da) N-oximinoalkylanilider og fremgangsmaade til deres fremstilling samt deres anvendelse som fungicider
DK394085A (da) Substituerede arylsulfonylguanidiner eller additionsprodukter deraf,deres fremstilling og anvendelse som herbicider
DK410185A (da) 7-oxo-4-thia-1-azabicyclo(3,2,0)hept-2-en-derivater, deres fremstilling og anvendelse som laegemiddel, samt ved fremstillingen anvendelige mellemprodukter
NO803522L (no) Azolyl-silyl-glykoletere og fremstilling derav og anvendelse derav som fungicid
DK88680A (da) Omega-halogen-acetophenon-oximethere fremgangsmaade til deres fremstilling samt deres anvendelse som mellemprodukter til fremstilling af omega-azolyl-acetophenon-oximethere
DK212680A (da) Fluro-substituerede oxyalkenyl-cyclopropancarboxylsyreestere deres fremstilling og anvendelse som insecticider og acaricider samt fremstillingen anvendte mellemprodukter og disses fremstilling
DK164881A (da) Terpenderivater deres fremstilling og anvendelse som insekticider