DK3847175T3 - Krystallinske former af en phosphoinositid-3-kinase- (pi3k) inhibitor - Google Patents

Krystallinske former af en phosphoinositid-3-kinase- (pi3k) inhibitor Download PDF

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Publication number
DK3847175T3
DK3847175T3 DK19858443.5T DK19858443T DK3847175T3 DK 3847175 T3 DK3847175 T3 DK 3847175T3 DK 19858443 T DK19858443 T DK 19858443T DK 3847175 T3 DK3847175 T3 DK 3847175T3
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DK
Denmark
Prior art keywords
phosphoinositide
pi3k
kinase
inhibitor
crystalline forms
Prior art date
Application number
DK19858443.5T
Other languages
English (en)
Inventor
Daniel Levy
Eddy W Yue
Brent Douty
David M Burns
Andrew P Combs
Zhongjiang Jia
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
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Publication of DK3847175T3 publication Critical patent/DK3847175T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
DK19858443.5T 2018-09-05 2019-09-04 Krystallinske former af en phosphoinositid-3-kinase- (pi3k) inhibitor DK3847175T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862727339P 2018-09-05 2018-09-05
US201862727321P 2018-09-05 2018-09-05
US201862727328P 2018-09-05 2018-09-05
US201862746928P 2018-10-17 2018-10-17
PCT/US2019/049419 WO2020051169A1 (en) 2018-09-05 2019-09-04 Crystalline forms of a phosphoinositide 3-kinase (pi3k) inhibitor

Publications (1)

Publication Number Publication Date
DK3847175T3 true DK3847175T3 (da) 2024-03-18

Family

ID=69642051

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19858443.5T DK3847175T3 (da) 2018-09-05 2019-09-04 Krystallinske former af en phosphoinositid-3-kinase- (pi3k) inhibitor

Country Status (22)

Country Link
US (2) US11186580B2 (da)
EP (2) EP4338801A2 (da)
JP (1) JP2021535182A (da)
KR (1) KR20210091121A (da)
CN (1) CN113677683A (da)
AU (1) AU2019336675A1 (da)
BR (1) BR112021004094A2 (da)
CA (1) CA3111629A1 (da)
CL (1) CL2021000539A1 (da)
CO (1) CO2021004061A2 (da)
CR (1) CR20210165A (da)
DK (1) DK3847175T3 (da)
EC (1) ECSP21022719A (da)
FI (1) FI3847175T3 (da)
IL (2) IL309869A (da)
LT (1) LT3847175T (da)
MA (1) MA53561A (da)
MX (1) MX2021002551A (da)
PE (1) PE20211815A1 (da)
PH (1) PH12021550472A1 (da)
SG (1) SG11202102224UA (da)
WO (1) WO2020051169A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3697789T (lt) * 2017-10-18 2021-12-10 Incyte Corporation Kondensuoti imidazolo dariniai, pakeisti tretinėmis hidroksigrupėmis, kaip pi3k-gama inhibitoriai

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Also Published As

Publication number Publication date
EP3847175B1 (en) 2024-02-07
CL2021000539A1 (es) 2021-08-20
ECSP21022719A (es) 2021-06-30
US20200071335A1 (en) 2020-03-05
EP4338801A2 (en) 2024-03-20
FI3847175T3 (fi) 2024-03-22
SG11202102224UA (en) 2021-04-29
WO2020051169A1 (en) 2020-03-12
CN113677683A (zh) 2021-11-19
PE20211815A1 (es) 2021-09-14
EP3847175A4 (en) 2022-05-11
AU2019336675A1 (en) 2021-03-25
TW202024088A (zh) 2020-07-01
JP2021535182A (ja) 2021-12-16
IL281262A (en) 2021-04-29
PH12021550472A1 (en) 2021-11-22
US11186580B2 (en) 2021-11-30
CO2021004061A2 (es) 2021-06-10
MA53561A (fr) 2022-05-11
EP3847175A1 (en) 2021-07-14
CR20210165A (es) 2021-10-01
CA3111629A1 (en) 2020-03-12
IL309869A (en) 2024-02-01
MX2021002551A (es) 2021-07-15
US20220112198A1 (en) 2022-04-14
BR112021004094A2 (pt) 2021-05-25
LT3847175T (lt) 2024-03-25
KR20210091121A (ko) 2021-07-21

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