DK3781561T3 - Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf - Google Patents

Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf Download PDF

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Publication number
DK3781561T3
DK3781561T3 DK19722363.9T DK19722363T DK3781561T3 DK 3781561 T3 DK3781561 T3 DK 3781561T3 DK 19722363 T DK19722363 T DK 19722363T DK 3781561 T3 DK3781561 T3 DK 3781561T3
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Prior art keywords
modulators
compositions
methyl
modifying enzymes
enzymes
Prior art date
Application number
DK19722363.9T
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English (en)
Inventor
Victor S Gehling
Avinash Khanna
Ludivine Moine
Jacob I Stuckey
Alexandre Côté
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Constellation Pharmaceuticals Inc
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Publication of DK3781561T3 publication Critical patent/DK3781561T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK19722363.9T 2018-04-18 2019-04-17 Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf DK3781561T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862659408P 2018-04-18 2018-04-18
PCT/US2019/027932 WO2019204490A1 (en) 2018-04-18 2019-04-17 Modulators of methyl modifying enzymes, compositions and uses thereof

Publications (1)

Publication Number Publication Date
DK3781561T3 true DK3781561T3 (da) 2024-06-17

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DK19722363.9T DK3781561T3 (da) 2018-04-18 2019-04-17 Modulatorer af methylmodificerende enzymer, sammensætninger og anvendelser deraf

Country Status (26)

Country Link
US (3) US10689371B2 (da)
EP (1) EP3781561B1 (da)
JP (2) JP7256823B2 (da)
KR (1) KR20210003160A (da)
CN (1) CN111989325A (da)
AR (1) AR114793A1 (da)
AU (1) AU2019255310B2 (da)
BR (1) BR112020021194A2 (da)
CA (1) CA3098428A1 (da)
CL (1) CL2020002698A1 (da)
CO (1) CO2020014217A2 (da)
CR (1) CR20200553A (da)
DK (1) DK3781561T3 (da)
EA (1) EA202092490A1 (da)
FI (1) FI3781561T3 (da)
IL (1) IL278013B2 (da)
LT (1) LT3781561T (da)
MA (1) MA52288A (da)
MX (1) MX2020010999A (da)
PE (1) PE20201448A1 (da)
PH (1) PH12020551578A1 (da)
PT (1) PT3781561T (da)
SG (1) SG11202009438UA (da)
TW (1) TWI828677B (da)
UA (1) UA127357C2 (da)
WO (1) WO2019204490A1 (da)

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EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US20220251073A1 (en) * 2019-07-24 2022-08-11 Constellation Pharmaceuticals, Inc. Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide
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CN115175905A (zh) * 2020-03-13 2022-10-11 四川海思科制药有限公司 Zeste增强子同源物2抑制剂及其用途
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CA3199421A1 (en) * 2020-11-18 2022-05-27 William D. Bradley Ezh2 inhibition therapies for the treatment of androgen receptor mutated prostate cancers
KR20220101295A (ko) 2021-01-11 2022-07-19 주식회사 엘지에너지솔루션 전극 슬러리의 유량 제어가 가능한 전극 슬러리 코팅 시스템 및 이를 이용한 전극 슬러리 코팅 방법
WO2023135564A1 (ko) * 2022-01-14 2023-07-20 동화약품주식회사 1,3-벤조다이옥솔 유도체 화합물 및 이를 포함하는 약학적 조성물
CN116496263A (zh) * 2022-01-27 2023-07-28 江苏天士力帝益药业有限公司 Ezh1/2抑制剂及其制备和抗肿瘤治疗中的应用
WO2023217018A1 (zh) * 2022-05-07 2023-11-16 贝达药业股份有限公司 Ezh2抑制剂及其在医药上的应用
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