DK3456721T3 - Fremgangsmåde til at fremstille forbindelser som har hiv-integrase-inhiberende aktivitet. - Google Patents
Fremgangsmåde til at fremstille forbindelser som har hiv-integrase-inhiberende aktivitet. Download PDFInfo
- Publication number
- DK3456721T3 DK3456721T3 DK18203589.9T DK18203589T DK3456721T3 DK 3456721 T3 DK3456721 T3 DK 3456721T3 DK 18203589 T DK18203589 T DK 18203589T DK 3456721 T3 DK3456721 T3 DK 3456721T3
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- preparing compounds
- inhibiting activity
- hiv integrase
- integrase inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010175899 | 2010-08-05 | ||
JP2010277713 | 2010-12-14 | ||
EP16190894.2A EP3127908B1 (en) | 2010-08-05 | 2011-08-04 | Process for preparing compound having hiv integrase inhibitory activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3456721T3 true DK3456721T3 (da) | 2021-04-26 |
Family
ID=45559561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18203589.9T DK3456721T3 (da) | 2010-08-05 | 2011-08-04 | Fremgangsmåde til at fremstille forbindelser som har hiv-integrase-inhiberende aktivitet. |
Country Status (18)
Country | Link |
---|---|
US (8) | US20140011995A1 (da) |
EP (3) | EP2602260B1 (da) |
JP (1) | JP5636054B2 (da) |
CN (3) | CN103154004B (da) |
BR (1) | BR112013002461A2 (da) |
CY (1) | CY1124582T1 (da) |
DK (1) | DK3456721T3 (da) |
ES (3) | ES2870006T3 (da) |
HR (1) | HRP20210748T1 (da) |
HU (1) | HUE054473T2 (da) |
LT (1) | LT3456721T (da) |
PL (1) | PL3456721T3 (da) |
PT (3) | PT2602260T (da) |
RS (1) | RS61796B1 (da) |
SG (1) | SG187683A1 (da) |
SI (1) | SI3456721T1 (da) |
TW (1) | TWI510451B (da) |
WO (1) | WO2012018065A1 (da) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101772610B1 (ko) | 2008-07-25 | 2017-09-12 | 비이브 헬쓰케어 컴퍼니 | 화합물 |
WO2010068253A1 (en) | 2008-12-11 | 2010-06-17 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
JP5572168B2 (ja) | 2008-12-11 | 2014-08-13 | ビーブ・ヘルスケア・カンパニー | カルバモイルピリドンhivインテグラーゼ阻害剤の製造方法および中間体 |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
PT2602260T (pt) * | 2010-08-05 | 2016-12-27 | Shionogi & Co | Processo para preparar composto possuindo atividade inibidora de integrase do vih |
PT3608325T (pt) | 2012-12-21 | 2022-10-17 | Gilead Sciences Inc | Compostos carbamoílpiridona policíclicos e sua utilização farmacêutica |
NO2865735T3 (da) | 2013-07-12 | 2018-07-21 | ||
PT3019503T (pt) | 2013-07-12 | 2017-11-27 | Gilead Sciences Inc | Compostos carbamoílpiridona- policíclicos e seu uso para o tratamento de infecções por hiv |
WO2015110897A2 (en) | 2014-01-21 | 2015-07-30 | Laurus Labs Private Limited | Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof |
CN105121409B (zh) * | 2014-03-19 | 2017-05-24 | 杭州普晒医药科技有限公司 | 德罗格韦钠盐的晶型及其制备方法 |
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
NO2717902T3 (da) | 2014-06-20 | 2018-06-23 | ||
EP3229804B1 (en) | 2014-12-09 | 2020-05-06 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
WO2016092527A1 (en) * | 2014-12-12 | 2016-06-16 | Sun Pharmaceutical Industries Limited | A process for the preparation of dolutegravir |
TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
CN104557686A (zh) * | 2014-12-29 | 2015-04-29 | 徐俊烨 | 一种吡啶酮类化合物的合成方法 |
EP3045461A1 (en) * | 2015-01-16 | 2016-07-20 | LEK Pharmaceuticals d.d. | Processes for preparing dolutegravir and analogues thereof |
PL3277691T3 (pl) | 2015-04-02 | 2019-07-31 | Gilead Sciences, Inc. | Policykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne |
WO2017109649A1 (en) * | 2015-12-21 | 2017-06-29 | Lupin Limited | Process for the preparation of hiv integrase inhibitors |
US11117904B2 (en) | 2016-06-23 | 2021-09-14 | Viiv Healthcare Company | Compositions and methods for the delivery of therapeutics |
JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
ZA201803942B (en) * | 2017-06-13 | 2021-05-26 | Cipla Ltd | Novel processes for preparation of integrase inhibitor |
EP3693373A4 (en) * | 2017-10-06 | 2021-11-03 | Shionogi & Co., Ltd. | PROCESS FOR THE STEREOSELECTIVE PRODUCTION OF SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES |
CN108101838B (zh) * | 2017-12-18 | 2020-10-20 | 安徽唯诗杨信息科技有限公司 | 一种度鲁特韦中间体的合成方法及其有关物质检测方法 |
US11634431B2 (en) | 2018-07-12 | 2023-04-25 | Laurus Labs Limited | Process for purification of protected polycyclic carbamoylpyridone derivatives |
WO2020086555A1 (en) | 2018-10-22 | 2020-04-30 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and nanoformulations thereof |
LT3938047T (lt) | 2019-03-22 | 2022-10-10 | Gilead Sciences, Inc. | Tilteliniai tricikliniai karbamoilpiridono junginiai ir jų naudojimas farmacijoje |
CN110128448A (zh) * | 2019-05-22 | 2019-08-16 | 博诺康源(北京)药业科技有限公司 | 一种度鲁特韦原料及中间体中非对映异构体杂质的合成方法 |
CN110396099A (zh) * | 2019-05-22 | 2019-11-01 | 博诺康源(北京)药业科技有限公司 | 一种度鲁特韦原料中非对映异构体杂质的合成方法 |
US20200398978A1 (en) | 2019-06-20 | 2020-12-24 | Bell Helicopter Textron Inc. | Low-drag rotor blade extension |
US11248005B2 (en) | 2019-07-08 | 2022-02-15 | Lupin Limited | Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor |
CN110698473B (zh) * | 2019-10-08 | 2020-12-18 | 浙江大学 | 哌嗪酮并羟基吡啶酮-5-羧基类化合物及制备和应用 |
JP7453399B2 (ja) | 2020-02-24 | 2024-03-19 | ギリアード サイエンシーズ, インコーポレイテッド | Hiv感染症を治療するための四環式化合物及びその使用 |
CN111620891B (zh) * | 2020-05-27 | 2023-07-14 | 上海启讯医药科技有限公司 | 一种多替拉韦关键中间体溶剂化物多晶型物及其制备方法和用途 |
JPWO2022107755A1 (da) | 2020-11-17 | 2022-05-27 | ||
CN112480007B (zh) * | 2020-12-08 | 2022-11-18 | 宿迁市科莱博生物化学有限公司 | 一种1,3-二甲基-1h-吡唑-4-羧酸的合成方法 |
KR20230134529A (ko) | 2021-01-19 | 2023-09-21 | 길리애드 사이언시즈, 인코포레이티드 | 치환된 피리도트리아진 화합물 및 이의 용도 |
CN115572257B (zh) * | 2021-06-21 | 2024-07-09 | 江西帝劢药业有限公司 | 一种吡啶酮类化合物的合成方法 |
WO2023175386A2 (en) * | 2021-10-08 | 2023-09-21 | Laurus Labs Limited | Processes for preparation of cabotegravir or its pharmaceutically acceptable salts thereof |
TW202400172A (zh) | 2022-04-06 | 2024-01-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769380A (en) | 1983-04-29 | 1988-09-06 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates |
JP4436229B2 (ja) | 2004-10-20 | 2010-03-24 | 株式会社沖データ | 電子装置 |
JP5317257B2 (ja) | 2005-02-21 | 2013-10-16 | 塩野義製薬株式会社 | Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体 |
LT3284520T (lt) * | 2005-04-28 | 2019-09-25 | Viiv Healthcare Company | Policiklinis karbamoilpiridono darinys, turintis živ integrazę slopinantį poveikį |
UA96568C2 (en) * | 2005-04-28 | 2011-11-25 | Глаксосмиткляйн Ллк | Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor |
JP5297105B2 (ja) | 2008-07-04 | 2013-09-25 | 株式会社クボタ | 乗用型田植機 |
JP4975690B2 (ja) | 2008-07-07 | 2012-07-11 | アルファフーズ株式会社 | レトルト食品の製造方法 |
WO2010011819A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
SI2320908T1 (sl) * | 2008-07-25 | 2014-05-30 | Viiv Healthcare Company | Predzdravila dolutegravirja |
JP2010068253A (ja) | 2008-09-10 | 2010-03-25 | Sony Corp | 暗号処理装置 |
JP2010068262A (ja) | 2008-09-11 | 2010-03-25 | New Japan Radio Co Ltd | 電子ボリウム |
JP2010067176A (ja) | 2008-09-12 | 2010-03-25 | Nec Corp | 情報処理装置 |
WO2010068253A1 (en) | 2008-12-11 | 2010-06-17 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
JP5572168B2 (ja) * | 2008-12-11 | 2014-08-13 | ビーブ・ヘルスケア・カンパニー | カルバモイルピリドンhivインテグラーゼ阻害剤の製造方法および中間体 |
KR101663222B1 (ko) | 2008-12-11 | 2016-10-06 | 시오노기세야쿠 가부시키가이샤 | 말톨 에테르 방법 및 중간체 |
TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
TWI582097B (zh) * | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
PT2602260T (pt) * | 2010-08-05 | 2016-12-27 | Shionogi & Co | Processo para preparar composto possuindo atividade inibidora de integrase do vih |
-
2011
- 2011-08-04 PT PT118146901T patent/PT2602260T/pt unknown
- 2011-08-04 JP JP2012527760A patent/JP5636054B2/ja active Active
- 2011-08-04 PL PL18203589T patent/PL3456721T3/pl unknown
- 2011-08-04 ES ES18203589T patent/ES2870006T3/es active Active
- 2011-08-04 CN CN201180048343.XA patent/CN103154004B/zh active Active
- 2011-08-04 SI SI201131966T patent/SI3456721T1/sl unknown
- 2011-08-04 SG SG2013008057A patent/SG187683A1/en unknown
- 2011-08-04 EP EP11814690.1A patent/EP2602260B1/en active Active
- 2011-08-04 ES ES16190894T patent/ES2710609T3/es active Active
- 2011-08-04 CN CN201610447110.1A patent/CN106046022B/zh active Active
- 2011-08-04 US US13/814,333 patent/US20140011995A1/en not_active Abandoned
- 2011-08-04 EP EP16190894.2A patent/EP3127908B1/en active Active
- 2011-08-04 HU HUE18203589A patent/HUE054473T2/hu unknown
- 2011-08-04 EP EP18203589.9A patent/EP3456721B1/en active Active
- 2011-08-04 LT LTEP18203589.9T patent/LT3456721T/lt unknown
- 2011-08-04 BR BR112013002461A patent/BR112013002461A2/pt not_active Application Discontinuation
- 2011-08-04 DK DK18203589.9T patent/DK3456721T3/da active
- 2011-08-04 PT PT182035899T patent/PT3456721T/pt unknown
- 2011-08-04 PT PT16190894T patent/PT3127908T/pt unknown
- 2011-08-04 RS RS20210566A patent/RS61796B1/sr unknown
- 2011-08-04 CN CN201610447148.9A patent/CN106083891B/zh active Active
- 2011-08-04 WO PCT/JP2011/067832 patent/WO2012018065A1/ja active Application Filing
- 2011-08-04 ES ES11814690.1T patent/ES2608377T3/es active Active
- 2011-08-05 TW TW100127858A patent/TWI510451B/zh active
-
2014
- 2014-10-20 US US14/518,209 patent/US9321789B2/en active Active
-
2016
- 2016-03-17 US US15/072,388 patent/US9650394B2/en active Active
-
2017
- 2017-03-28 US US15/471,133 patent/US9802959B2/en active Active
- 2017-09-20 US US15/709,701 patent/US10000508B2/en active Active
- 2017-09-20 US US15/709,728 patent/US10125147B2/en active Active
- 2017-09-20 US US15/709,716 patent/US10125146B2/en active Active
- 2017-09-20 US US15/709,742 patent/US9969750B2/en active Active
-
2021
- 2021-05-12 HR HRP20210748TT patent/HRP20210748T1/hr unknown
- 2021-05-17 CY CY20211100423T patent/CY1124582T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3456721T3 (da) | Fremgangsmåde til at fremstille forbindelser som har hiv-integrase-inhiberende aktivitet. | |
DK2752006T3 (da) | Fremgangsmåde til at konstruere fletningsliste | |
CL2014002700A1 (es) | Composición herbicida que comprende como ingrediente activo, un compuesto de uracilo | |
EA201491386A1 (ru) | Соединения, ингибирующие металлоферменты | |
BR112014002499A2 (pt) | compostos, processos para a preparação de compostos de fórmula i, composições agroquímicas e usos de compostos de fórmula i ou viii | |
BR112013024491A2 (pt) | neuroestimulador. | |
AU2012258032A1 (en) | Two-dimensionally periodic, colour-filtering grating | |
DK2665486T3 (da) | Sammensætninger til modulering af gamma-c-cytokin-aktivitet | |
DK2596099T3 (da) | Fremgangsmåde til høst af ekspressionsprodukter | |
BR112014026149A2 (pt) | método para a preparação de 2,4-ácido dihidroxibutírico (2,4-dhb) e microrganismo. | |
CL2014000815A1 (es) | Compuestos derivados de 2-metoxibenzamidas insecticidas; composiciones insecticidas. | |
BR112015014579A2 (pt) | compostos da fórmula i, uso de um composto da fórmula i, método para combater fungos nocivos e sementes. | |
DK2895209T3 (da) | Forbedrede sårhelingspræparater, som omfatter mikrosfærer | |
ITTO20121129A1 (it) | Procedimento per la protezione di mais. | |
DK2748147T3 (da) | Substitueret 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinolin-4-carboxamider til antimalaria-terapier | |
IL227587B (en) | An active compound for a spectrally emitting decoy when the active compound is ignited, containing a catalyst for a water-gas reaction | |
ITTO20121127A1 (it) | Procedimento per la protezione di mais. | |
ITMI20120169A1 (it) | Apparecchiatura sfogliatrice per impiallacciatura. | |
ZA201306133B (en) | Active composition for a decoy which radiates spectrally on burnup of the active composition | |
BR112015009581A2 (pt) | espaçador para afastamento de uma ferramenta de um suporte de ferramenta. | |
ES1076043Y (es) | Jamonero desmontable de ajuste multiple. | |
IT1400666B1 (it) | Procedimento per la sintesi di 5-amino, 1-fenil, 3-ciano, 4-trifluorometil sulfinil pirazoli. | |
ITMC20120011A1 (it) | Attrezzatura per la coltivazione di piante. | |
IT1402456B1 (it) | Macchina per realizzare gabbie metalliche. | |
IT1398536B1 (it) | Coperchio per pentola. |