DK2665486T3 - Sammensætninger til modulering af gamma-c-cytokin-aktivitet - Google Patents
Sammensætninger til modulering af gamma-c-cytokin-aktivitet Download PDFInfo
- Publication number
- DK2665486T3 DK2665486T3 DK12736203.6T DK12736203T DK2665486T3 DK 2665486 T3 DK2665486 T3 DK 2665486T3 DK 12736203 T DK12736203 T DK 12736203T DK 2665486 T3 DK2665486 T3 DK 2665486T3
- Authority
- DK
- Denmark
- Prior art keywords
- cytokin
- compositions
- activity
- modulating gamma
- modulating
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A61K38/10—Peptides having 12 to 20 amino acids
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161433890P | 2011-01-18 | 2011-01-18 | |
US201161527049P | 2011-08-24 | 2011-08-24 | |
PCT/US2012/021566 WO2012099886A1 (en) | 2011-01-18 | 2012-01-17 | Compositions and mehthods for modulating gamma-c-cytokine activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2665486T3 true DK2665486T3 (da) | 2020-03-09 |
Family
ID=46516044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12736203.6T DK2665486T3 (da) | 2011-01-18 | 2012-01-17 | Sammensætninger til modulering af gamma-c-cytokin-aktivitet |
Country Status (17)
Country | Link |
---|---|
US (10) | US9133244B2 (da) |
EP (2) | EP2665486B1 (da) |
JP (4) | JP6395379B2 (da) |
CN (2) | CN103501805B (da) |
AU (3) | AU2012207456C1 (da) |
BR (1) | BR112013018046B1 (da) |
CA (1) | CA2824515C (da) |
CY (1) | CY1122846T1 (da) |
DK (1) | DK2665486T3 (da) |
ES (1) | ES2778053T3 (da) |
HR (1) | HRP20200470T1 (da) |
LT (1) | LT2665486T (da) |
PL (1) | PL2665486T3 (da) |
PT (1) | PT2665486T (da) |
RS (1) | RS60050B1 (da) |
SI (1) | SI2665486T1 (da) |
WO (1) | WO2012099886A1 (da) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2665486B1 (en) | 2011-01-18 | 2019-12-25 | Bioniz, LLC | Compositions for modulating gamma-c-cytokine activity |
WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
CN104789527B (zh) * | 2015-05-15 | 2018-05-29 | 江苏杰晟生物科技有限公司 | 一种自体自然杀伤细胞鸡尾酒式培养的制备方法及其试剂盒产品 |
US11400134B2 (en) * | 2015-10-09 | 2022-08-02 | Bioniz, Llc | Modulating gamma-c-cytokine activity |
EP3453401A4 (en) * | 2016-05-06 | 2020-01-29 | Wang, Mulin | INTERLEUKIN COMBINATION AND THEIR USE |
JP2020513020A (ja) * | 2017-04-07 | 2020-04-30 | バイオニズ リミテッド ライアビリティー カンパニー | γcサイトカイン活性の安定な調節剤 |
CA3112511A1 (en) * | 2018-07-19 | 2020-01-23 | The University Of Tokyo | Therapeutic or prophylactic agent for htlv-1-associated myelopathy (ham), and method for treating ham |
KR20210055070A (ko) | 2018-08-06 | 2021-05-14 | 메디카인 인코포레이티드 | Il-2 수용체 결합 화합물 |
CN113874075A (zh) * | 2019-05-03 | 2021-12-31 | 比奥尼斯有限责任公司 | 调节γC-细胞因子信号传导对于治疗脱发和脱发相关病症的影响 |
KR20220020879A (ko) | 2019-06-12 | 2022-02-21 | 에스크진 파마, 아이엔씨. | 새로운 il-15 프로드럭 및 이를 사용하는 방법 |
KR102265435B1 (ko) * | 2019-08-20 | 2021-06-15 | 주식회사 케어젠 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
AU2020380296A1 (en) | 2019-11-05 | 2022-06-16 | Medikine Inc. | IL-2RβγC binding compounds |
BR112022008750A2 (pt) | 2019-11-05 | 2022-07-19 | Medikine Inc | Composto de ligação de receptor duplo, composição farmacêutica, método para tratar uma doença em um paciente, método para expandir células imunes, método para reforçar uma vacina, método para modificar a resposta imune e ácido nucleico |
EP4100046A4 (en) | 2020-02-03 | 2024-03-06 | Medikine, Inc. | IL-7R-ALPHA BINDING COMPOUNDS |
US11746139B2 (en) | 2020-02-03 | 2023-09-05 | Medikine, Inc. | IL-7Rαγc binding compounds |
CN115667523A (zh) | 2020-04-10 | 2023-01-31 | 西托姆克斯治疗公司 | 可活化细胞因子构建体和相关组合物以及方法 |
AU2021297801A1 (en) * | 2020-06-24 | 2023-02-02 | Bioniz Therapeutics, Inc. | Antagonistic peptide targeting IL-2, IL-9, and IL-15 signaling for the treatment of cytokine-release syndrome and cytokine storm associated disorders |
EP4212163A1 (en) | 2020-09-08 | 2023-07-19 | Dexon Pharmaceuticals Inc. | Cytokine storm inhibitor, method for using cytokine storm inhibitor, and method for screening for cytokine inhibitor |
TW202304958A (zh) | 2021-03-16 | 2023-02-01 | 美商Cytomx生物製藥公司 | 經遮蔽之可活化之細胞介素構築體及相關之組成物及方法 |
JP6974892B1 (ja) | 2021-05-27 | 2021-12-01 | デクソンファーマシューティカルズ株式会社 | 癌悪液質の改善剤および癌悪液質の改善方法 |
US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
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IL130238A0 (en) | 1999-06-01 | 2000-06-01 | Peptor Ltd | Conformationally constrained backbone cyclized interleukin-6 antagonists |
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