DK3083947T3 - Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf - Google Patents

Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf Download PDF

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Publication number
DK3083947T3
DK3083947T3 DK14827219.8T DK14827219T DK3083947T3 DK 3083947 T3 DK3083947 T3 DK 3083947T3 DK 14827219 T DK14827219 T DK 14827219T DK 3083947 T3 DK3083947 T3 DK 3083947T3
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Prior art keywords
prrs virus
cdna clone
european
variation
european prrs
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DK14827219.8T
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English (en)
Inventor
Andreas Gallei
Christoph Keller
Erik Schacht
Marieke Herrel
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Boehringer Ingelheim Vetmedica Gmbh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10021Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10041Use of virus, viral particle or viral elements as a vector
    • C12N2770/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK14827219.8T 2013-12-20 2014-12-19 Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf DK3083947T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13199177 2013-12-20
EP14175691 2014-07-03
PCT/EP2014/078929 WO2015092058A1 (en) 2013-12-20 2014-12-19 Prrs virus variant, european prrs virus cdna clone, and uses thereof

Publications (1)

Publication Number Publication Date
DK3083947T3 true DK3083947T3 (da) 2019-07-08

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ID=52347295

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19165389.8T DK3591042T3 (da) 2013-12-20 2014-12-19 PRRS-virusvariant, cDNA-klon af europæisk PRRS-virus samt anvendelser deraf
DK14827219.8T DK3083947T3 (da) 2013-12-20 2014-12-19 Prrs-virusvariant, cdna-klon af europæisk prrs-virus, samt anvendelser deraf

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DK19165389.8T DK3591042T3 (da) 2013-12-20 2014-12-19 PRRS-virusvariant, cDNA-klon af europæisk PRRS-virus samt anvendelser deraf

Country Status (13)

Country Link
US (2) US10010601B2 (da)
EP (2) EP3591042B1 (da)
JP (3) JP6886291B2 (da)
KR (2) KR102446025B1 (da)
CN (1) CN105829528B (da)
AU (2) AU2014369774B2 (da)
CA (1) CA2930042C (da)
DK (2) DK3591042T3 (da)
EA (1) EA039060B1 (da)
ES (2) ES2940691T3 (da)
HU (1) HUE061768T2 (da)
MX (2) MX2016007737A (da)
WO (1) WO2015092058A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2675476T3 (da) 2011-02-17 2015-12-14 Boehringer Ingelheim Vetmed Fremgangsmåde til fremstilling af PRRSV i kommerciel skala
ME02271B (me) 2011-02-17 2016-02-20 Boehringer Ingelheim Vetmedica Gmbh Novi evropski prrsv soj
HUE061768T2 (hu) 2013-12-20 2023-08-28 Boehringer Ingelheim Vetmedica Gmbh PRRS virus variáns, európai PRRS virus cDNS klón, és alkalmazásuk
MX2019001395A (es) 2016-08-05 2019-06-17 Hipra Scient S L U Clon de adnc del virus del sindrome reproductivo y respiratorio porcino y usos del mismo.
WO2020138761A1 (ko) * 2018-12-27 2020-07-02 주식회사 바이오포아 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신
KR102335864B1 (ko) * 2018-12-27 2021-12-06 주식회사 바이오포아 돼지 생식기 및 호흡기 증후군 바이러스의 키메라 바이러스 및 이를 이용한 백신
AU2019463018A1 (en) * 2019-08-29 2022-02-03 Elanco Uk Ah Limited Porcine reproductive and respiratory syndrome vaccine virus
CN110894243B (zh) * 2019-12-16 2021-07-13 中国农业大学 一种猪蓝耳病毒嵌合抗原以及检测猪蓝耳病毒抗体的胶体金免疫层析试纸条
AU2020417800A1 (en) 2019-12-31 2022-07-14 Elixirgen Therapeutics, Inc. Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
JP2021153692A (ja) * 2020-03-25 2021-10-07 株式会社三共 遊技機
KR102319508B1 (ko) * 2020-07-27 2021-10-28 연세대학교 산학협력단 인체 감염형 낙타 유래 메르스코로나바이러스 검출용 바이오마커 및 이의 용도
CN113969267B (zh) * 2021-11-15 2024-02-27 中国农业大学 一种猪繁殖与呼吸综合征突变病毒及其构建方法与应用
WO2024077281A2 (en) * 2022-10-06 2024-04-11 Cornell University Genotyping and sequencing assays for prrsv

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4015100A (en) 1974-01-07 1977-03-29 Avco Everett Research Laboratory, Inc. Surface modification
EP0000062A1 (en) 1977-06-07 1978-12-20 Joseph George Spitzer Vapor tap valve for aerosol containers used with inflammable propellants, and container provided therewith
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
EP0208672B1 (en) 1985-07-08 1993-02-17 REGION WALLONNE représentée par le Ministre des Technologies pour la Région wallonne dans ses attributions Vaccines and diagnostics derived from bovine diarrhea virus
NZ222465A (en) 1986-11-07 1992-11-25 Pasteur Institut Nanb (non a, non b hepatitis viral) antigen
CA2103460C (en) 1991-06-06 2000-09-26 Gert Wensvoort Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
WO1993007898A1 (en) 1991-10-14 1993-04-29 Akzo Nobel N.V. Porcine reproductive respiratory syndrome vaccine and diagnostic
FR2686097B1 (fr) 1992-01-14 1994-12-30 Rhone Merieux Preparation d'antigenes et de vaccins de virus de la mystery disease, antigenes et vaccins obtenus pour la prevention de cette maladie.
US5695766A (en) 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
ES2074950B1 (es) 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.
DE69522984T2 (de) 1994-04-11 2002-04-25 Akzo Nobel Nv Europäische Vakzinstämme des Fortplanzungs-Atmungs-Syndromsvirus des Schweins
GB2289279B (en) 1994-05-13 1998-09-16 Iberica Cyanamid Diagnostic kits and vaccines containing recombinant PRRSV proteins
ES2223058T3 (es) 1995-03-14 2005-02-16 Akzo Nobel N.V. Expresion en la misma celula de polipeptidos del virus del sindrome reproductivo y respiratorio porcino.
ES2102971B1 (es) 1996-01-25 1998-03-01 Hipra Lab Sa Nueva cepa atenuada del virus causante del sindrome respiratorio y reproductivo porcino (prrs), las vacunas y medios de diagnostico obtenibles con la misma y los procedimientos para su obtencion.
US5866401A (en) 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
DK0835930T3 (da) 1996-10-09 2001-06-18 Akzo Nobel Nv Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV)
US20040224327A1 (en) 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
DE69837992T2 (de) 1997-05-06 2008-03-20 Boehringer Ingelheim Vetmedica Gmbh Prrsv-antigene, die auf peptidsequenzen des prrs-virus basieren, für die verwendung als impfstoff und für diagnostische tests
NZ513289A (en) 1998-12-22 2003-04-29 Pfizer Prod Inc Infectious cDNA clone of north american procine reproductive and respiratory syndrome (PRRS) virus and uses thereof
JP3961222B2 (ja) 1999-03-08 2007-08-22 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Prrsvワクチン
CA2370372C (en) 1999-04-22 2009-02-24 United States Department Of Agriculture Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142
WO2002095040A1 (en) 2001-05-21 2002-11-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Delections in arterivirus replicons
ATE333500T1 (de) 2000-02-08 2006-08-15 Univ Minnesota Virus des porzinen reproduktiven und respiratorischen syndroms und dessen verwendung
EP1156111A1 (en) 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
ATE557082T1 (de) 2002-04-05 2012-05-15 Boehringer Ingelheim Vetmed Sequenz positionen zur anpassung bei prrsv
US7722878B2 (en) 2004-06-17 2010-05-25 Boehringer Ingelheim Vetmedica, Inc. PRRSV subunit vaccines
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
RU2007130801A (ru) 2005-01-13 2009-02-20 Берингер Ингельхайм Ветмедика Гмбх (De) Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs)
WO2008121958A1 (en) 2007-04-02 2008-10-09 Boehringer Ingelheim Vetmedica, Inc. Use of prrsv vaccines to reduce pcv2 viremia
MX2010000235A (es) * 2007-06-25 2010-08-02 Univ South Dakota Virus del sindrome respiratorio y reproductivo porcino tipo 1 norteamericano recombinante y metodos de uso.
MX2011002046A (es) 2008-08-25 2011-04-21 Boehringer Ingelheim Vetmed Vacuna contra sindrome disgenesico y respiratorio porcino altamente patogeno (hp prrs).
WO2010084648A1 (ja) 2009-01-20 2010-07-29 シャープ株式会社 照明装置、表示装置、及びテレビ受信装置
EP2558118B1 (en) 2010-04-16 2019-06-05 Universiteit Gent Cross-protecting vaccine for porcine reproductive and respiratory syndrome virus
DK2675476T3 (da) 2011-02-17 2015-12-14 Boehringer Ingelheim Vetmed Fremgangsmåde til fremstilling af PRRSV i kommerciel skala
ME02271B (me) 2011-02-17 2016-02-20 Boehringer Ingelheim Vetmedica Gmbh Novi evropski prrsv soj
WO2013017568A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
MX360415B (es) * 2012-02-14 2018-10-31 Merial Inc Vectores poxvirales recombinantes que expresan proteinas tanto de rabia como de ox40, y vacunas hechas a partir de los mismos.
KR102012109B1 (ko) * 2012-05-17 2019-08-19 조에티스 엘엘씨 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종
EP2968513A2 (en) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
CN105829906B (zh) * 2013-12-19 2020-11-03 皇家飞利浦有限公司 具有水/脂肪分离的相位敏感的反转恢复mri
HUE061768T2 (hu) * 2013-12-20 2023-08-28 Boehringer Ingelheim Vetmedica Gmbh PRRS virus variáns, európai PRRS virus cDNS klón, és alkalmazásuk

Also Published As

Publication number Publication date
US20190151432A1 (en) 2019-05-23
EP3083947A1 (en) 2016-10-26
CN105829528B (zh) 2019-10-22
US10010601B2 (en) 2018-07-03
JP2021104028A (ja) 2021-07-26
EP3591042A1 (en) 2020-01-08
MX2020010248A (es) 2020-10-16
JP2017502662A (ja) 2017-01-26
JP6886291B2 (ja) 2021-06-16
KR20160099099A (ko) 2016-08-19
AU2014369774B2 (en) 2020-11-26
US10639364B2 (en) 2020-05-05
AU2021201224B2 (en) 2023-06-15
CN105829528A (zh) 2016-08-03
EA039060B1 (ru) 2021-11-29
JP2020054380A (ja) 2020-04-09
ES2940691T3 (es) 2023-05-10
JP7158523B2 (ja) 2022-10-21
MX2016007737A (es) 2016-09-07
AU2021201224A1 (en) 2021-03-11
AU2014369774A1 (en) 2016-04-21
KR102446025B1 (ko) 2022-09-22
WO2015092058A1 (en) 2015-06-25
EA201600476A1 (ru) 2016-11-30
EP3083947B1 (en) 2019-04-03
EP3591042B1 (en) 2023-01-25
CA2930042C (en) 2022-06-21
KR20210080606A (ko) 2021-06-30
CA2930042A1 (en) 2015-06-25
US20160317642A1 (en) 2016-11-03
HUE061768T2 (hu) 2023-08-28
KR102270344B1 (ko) 2021-07-01
DK3591042T3 (da) 2023-04-17
ES2729838T3 (es) 2019-11-06

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