DK3043803T3 - Nukleotid- og nucleosidsammensætninger og deres anvendelse - Google Patents

Nukleotid- og nucleosidsammensætninger og deres anvendelse Download PDF

Info

Publication number
DK3043803T3
DK3043803T3 DK14844012.6T DK14844012T DK3043803T3 DK 3043803 T3 DK3043803 T3 DK 3043803T3 DK 14844012 T DK14844012 T DK 14844012T DK 3043803 T3 DK3043803 T3 DK 3043803T3
Authority
DK
Denmark
Prior art keywords
nucleotide
applications
nucleoside compounds
nucleoside
compounds
Prior art date
Application number
DK14844012.6T
Other languages
English (en)
Inventor
Dennis C Liotta
Gregory R Bluemling
La Rosa Abel De
George R Painter
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Application granted granted Critical
Publication of DK3043803T3 publication Critical patent/DK3043803T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DK14844012.6T 2013-09-11 2014-09-10 Nukleotid- og nucleosidsammensætninger og deres anvendelse DK3043803T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361876473P 2013-09-11 2013-09-11
US201461923317P 2014-01-03 2014-01-03
US201461986577P 2014-04-30 2014-04-30
PCT/US2014/054930 WO2015038596A1 (en) 2013-09-11 2014-09-10 Nucleotide and nucleoside compositions and uses related thereto

Publications (1)

Publication Number Publication Date
DK3043803T3 true DK3043803T3 (da) 2022-08-01

Family

ID=52666219

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14844012.6T DK3043803T3 (da) 2013-09-11 2014-09-10 Nukleotid- og nucleosidsammensætninger og deres anvendelse

Country Status (12)

Country Link
US (4) US10149859B2 (da)
EP (2) EP3043803B1 (da)
JP (3) JP6762873B2 (da)
DK (1) DK3043803T3 (da)
ES (1) ES2927955T3 (da)
HR (1) HRP20220911T1 (da)
LT (1) LT3043803T (da)
PL (1) PL3043803T3 (da)
SI (1) SI3043803T1 (da)
TW (1) TW201542581A (da)
UY (1) UY35732A (da)
WO (1) WO2015038596A1 (da)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2861611T3 (pl) 2012-05-25 2017-08-31 Janssen Sciences Ireland Uc Nukleozydy uracylowe spirooksetanu
NZ708177A (en) 2012-11-16 2017-08-25 Univ College Cardiff Consultants Ltd Process for preparing nucleoside prodrugs
EP3043803B1 (en) 2013-09-11 2022-04-27 Emory University Nucleotide and nucleoside compositions and their uses
EP3160475B1 (en) 2014-06-24 2024-01-03 Janssen Pharmaceuticals, Inc. Substituted nucleosides and nucleotides to treat filoviridae infections
JP6728075B2 (ja) 2014-06-24 2020-07-22 ヤンセン バイオファーマ インク． 置換ヌクレオシド、ヌクレオチドおよびその類似体
SG11201608808TA (en) 2014-06-25 2016-11-29 Nucana Biomed Ltd Gemcitabine prodrugs
IL291927A (en) * 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
CN107428792B (zh) * 2014-12-15 2023-01-24 埃默里大学 用于治疗乙型肝炎病毒的磷酰胺
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
IL295418B2 (en) 2015-03-06 2023-10-01 Atea Pharmaceuticals Inc Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus
WO2017040766A1 (en) 2015-09-02 2017-03-09 Abbvie Inc. Anti-viral tetrahydrofurane derivatives
CN106674297A (zh) * 2015-11-11 2017-05-17 中国科学院生态环境研究中心 具有抗癌活性的新型krn7000类似物及合成方法
US20190085013A1 (en) * 2016-03-07 2019-03-21 Emory University Nucleotide and nucleoside therapeutic compositions and uses related thereto
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
EP3508205B1 (en) 2016-08-31 2022-05-18 FUJIFILM Corporation Anti-tumor agent, anti-tumor effect enhancer, and anti-tumor kit
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
JP7016170B2 (ja) * 2016-12-16 2022-02-04 国立大学法人東海国立大学機構 ヌクレオシド誘導体及びその利用
KR102335193B1 (ko) 2017-02-01 2021-12-03 아테아 파마슈티컬즈, 인크. C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
US10688112B2 (en) 2017-07-13 2020-06-23 Emory University Lipid disulfide prodrugs and uses related thereto
JP7173467B2 (ja) 2017-10-31 2022-11-16 ヤマサ醤油株式会社 ヌクレオシド誘導体及びその利用
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
KR102248165B1 (ko) 2017-12-07 2021-05-06 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
US20210060051A1 (en) * 2017-12-27 2021-03-04 Raymond F. Schinazi Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
JP7266896B2 (ja) * 2018-03-09 2023-05-01 国立研究開発法人科学技術振興機構 β修飾リン酸化合物前駆体、β修飾リン酸化合物、反応阻害剤及びこれを含む医薬並びに反応阻害方法
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
CN110655546B (zh) * 2018-12-18 2023-05-16 安徽贝克制药股份有限公司 索非布韦衍生物及其制备方法和应用
CN109503688A (zh) * 2018-12-21 2019-03-22 佛山科学技术学院 具有抑制病毒复制活性的核苷磷酸长链酯类似物、制备方法及其药物用途
CN113710680A (zh) * 2019-04-05 2021-11-26 株式会社日本触媒 交联型人工核苷的制备
CN110204584B (zh) * 2019-06-17 2022-09-09 大连大学 一种4-s-2’,3’,5’-o-三乙酰基尿苷合成方法
CN110105416B (zh) * 2019-06-17 2022-07-12 大连大学 一种4-S-5-Br-2’，3’,5’-O-三乙酰基尿苷合成方法
AU2020397059A1 (en) 2019-12-06 2022-07-21 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
TW202322824A (zh) 2020-02-18 2023-06-16 美商基利科學股份有限公司 抗病毒化合物
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
KR102145197B1 (ko) * 2020-03-10 2020-08-18 부광약품 주식회사 코로나바이러스를 치료하기 위한 l-뉴클레오사이드의 용도
JP2023518433A (ja) 2020-03-20 2023-05-01 ギリアード サイエンシーズ， インコーポレイテッド ４’－ｃ－置換－２－ハロ－２’－デオキシアデノシンヌクレオシドのプロドラッグ並びにその製造法及び使用法
WO2022081823A1 (en) * 2020-10-14 2022-04-21 Temple University -Of The Commonwealth System Of Higher Education Pharmacologic approach for suppression of coronaviruses
CN112778356B (zh) * 2020-12-26 2022-07-01 山东日兴新材料股份有限公司 一种三(三溴新戊基)磷酸酯阻燃剂的一锅法合成工艺
CN112661802B (zh) * 2021-01-25 2022-05-13 阿里生物新材料（常州）有限公司 一种3′-甲氧基鸟苷的合成方法
TW202241454A (zh) 2021-02-01 2022-11-01 日商第一三共股份有限公司 抗體－免疫賦活化劑共軛物之新穎製造方法
WO2022221514A1 (en) 2021-04-16 2022-10-20 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
CN112979733B (zh) * 2021-04-25 2021-09-10 南京颐媛生物医学研究院有限公司 抗乙肝病毒的化合物及其制备方法和应用
EP4333859A1 (en) * 2021-05-05 2024-03-13 Emory University Nucleotide and nucleoside therapeutic compositions, combinations and uses related thereto
IL308953A (en) 2021-06-04 2024-01-01 Vertex Pharma N-Hydroalkyl(Hetero)Aryl)Tetrahydrofuran Carboxamides as Natrene Channel Modulators
CN113278041B (zh) * 2021-07-16 2021-10-19 南京颐媛生物医学研究院有限公司 一种核苷磷酸酯及其合成方法与抗肝炎病毒的制药应用
CN113501853B (zh) * 2021-09-13 2021-12-07 南京颐媛生物医学研究院有限公司 4-硫代尿嘧啶脱氧核苷磷酸酯及其抗病毒药物用途
CN113735927B (zh) * 2021-10-18 2024-06-28 厦门蔚扬药业有限公司 一种核苷酸类似物及其制备方法和用途
WO2023086557A1 (en) * 2021-11-11 2023-05-19 Emory University Nucleosides for the treatment of dna virus infections
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN116554249A (zh) * 2022-01-28 2023-08-08 北京恩泰伟医药科技有限公司 抗病毒化合物及其用途
WO2023178228A1 (en) * 2022-03-16 2023-09-21 Pharmalectin, Inc. Lectin-binding carbohydrates for treating viral infections
EP4248949A1 (en) 2022-03-21 2023-09-27 R.G.C.C. Holdings AG Liposomal compositions

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404144A (en) * 1965-12-23 1968-10-01 Research Corp 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds
DE2041735A1 (de) * 1970-08-22 1972-02-24 Merck Patent Gmbh Thio-pyrimidin-derivate
US3975374A (en) * 1970-12-21 1976-08-17 The Upjohn Company Process for preparing 2-thiouracil nucleosides
JPS4947379A (da) * 1972-09-12 1974-05-08
PL107865B1 (pl) 1977-04-27 1980-03-31 Polska Akademia Nauk Instytut Method of obtaining styrene oxide sposob otrzymywania tlenku styrenu
US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69636734T2 (de) 1995-06-07 2007-10-18 Emory University Nucleoside mit anti-hepatitis b virus wirksamkeit
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
JPH107694A (ja) * 1996-06-21 1998-01-13 Toagosei Co Ltd ３’−アミノ−２−チオピリミジンヌクレオシド
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6610835B1 (en) 1998-02-12 2003-08-26 Emory University Sphingolipid derivatives and their methods of use
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6461422B1 (en) * 2000-01-27 2002-10-08 Chartpak, Inc. Pressure sensitive ink jet media for digital printing
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20030036189A (ko) * 2000-05-26 2003-05-09 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
CA2437209A1 (en) 2000-12-26 2002-07-04 Mitsubishi Pharma Corporation Remedies for hepatitis c
WO2003026589A2 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
PL197669B1 (pl) * 2002-02-28 2008-04-30 Pan Inst Biochemii I Biofizyki Nowe analogi 2',3'-dideoksy-3'-fluorotymidyny o aktywności przeciwko wirusom (54) ludzkiego niedoboru immunologicznego HIV-1 i HIV-2, sposób ich wytwarzania oraz zawierające je środki farmaceutyczne
KR20050006221A (ko) 2002-05-06 2005-01-15 제네랩스 테크놀로지스, 인코포레이티드 Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
DE14169110T1 (de) 2002-06-28 2022-05-12 Centre National De La Recherche Scientifique -Cnrs- Modifizierte 2'- und 3'-Nukleosid-Prodrugs zur Behandlung von Flaviridae-Infektionen
US20040035547A1 (en) * 2002-08-20 2004-02-26 3M Innovative Properties Company Metal matrix composites, and methods for making the same
US7902203B2 (en) 2002-11-01 2011-03-08 Abbott Laboratories, Inc. Anti-infective agents
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
WO2006121820A1 (en) * 2005-05-05 2006-11-16 Valeant Research & Development Phosphoramidate prodrugs for treatment of viral infection
WO2007076034A2 (en) 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
HUP0600042A3 (en) * 2006-01-19 2012-12-28 Debreceni Egyetem New medical use of thiolated pyrimidine-mononucleotides and -nucleosides
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8178548B2 (en) 2007-09-17 2012-05-15 Abbott Laboratories Anti-infective agents and uses thereof
CN101801935B (zh) 2007-09-17 2014-12-03 艾伯维巴哈马有限公司 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8541424B2 (en) 2008-12-23 2013-09-24 Abbott Laboratories Anti-viral compounds
CN102448952B (zh) 2009-03-25 2014-10-29 Abbvie公司 抗病毒化合物和其用途
CA2986195A1 (en) 2009-03-25 2010-09-30 Abbvie Inc. Substituted aryl antivrial compounds and uses thereof
RU2541571C2 (ru) 2009-04-15 2015-02-20 Эббви Инк. Противовирусные соединения
SG171708A1 (en) 2009-06-11 2011-07-28 Abbott Lab Anti-viral compounds to treat hcv infection
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
KR101579079B1 (ko) 2010-03-10 2015-12-21 애브비 바하마스 리미티드 고체 조성물
US8691775B2 (en) * 2010-04-19 2014-04-08 Back Bay Scientific, Llc Use of drugs that activate P2Y receptors to enhance synaptogenesis
JP2013528217A (ja) 2010-06-07 2013-07-08 アッヴィ・インコーポレイテッド 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
EP2593439B1 (en) 2010-07-16 2016-08-17 AbbVie Bahamas Ltd. Process for preparing antiviral compounds
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
TWI451439B (zh) 2010-12-10 2014-09-01 Phison Electronics Corp 記憶體儲存裝置、其記憶體控制器與資料寫入方法
MX2013006828A (es) 2010-12-16 2014-10-14 Abbvie Inc Compuestos antivirales.
EP2651885A1 (en) 2010-12-16 2013-10-23 Abbvie Inc. Anti-viral compounds
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
KR20140003521A (ko) 2010-12-30 2014-01-09 이난타 파마슈티칼스, 인코포레이티드 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
EP3384938A1 (en) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3043803B1 (en) * 2013-09-11 2022-04-27 Emory University Nucleotide and nucleoside compositions and their uses
CN107428792B (zh) * 2014-12-15 2023-01-24 埃默里大学 用于治疗乙型肝炎病毒的磷酰胺

Also Published As

Publication number Publication date
US11166973B2 (en) 2021-11-09
US20160220595A1 (en) 2016-08-04
JP2020143073A (ja) 2020-09-10
JP2022081641A (ja) 2022-05-31
EP3043803A4 (en) 2017-03-29
EP3043803B1 (en) 2022-04-27
PL3043803T3 (pl) 2022-11-07
EP3043803A1 (en) 2016-07-20
WO2015038596A1 (en) 2015-03-19
TW201542581A (zh) 2015-11-16
US20220296626A1 (en) 2022-09-22
SI3043803T1 (sl) 2022-09-30
LT3043803T (lt) 2022-08-10
ES2927955T3 (es) 2022-11-14
JP7508501B2 (ja) 2024-07-01
UY35732A (es) 2015-06-30
US10149859B2 (en) 2018-12-11
JP6762873B2 (ja) 2020-09-30
HRP20220911T1 (hr) 2022-10-28
EP4094767A1 (en) 2022-11-30
JP7045411B2 (ja) 2022-03-31
US20240173345A1 (en) 2024-05-30
JP2016530313A (ja) 2016-09-29
US20190298750A1 (en) 2019-10-03
US11857560B2 (en) 2024-01-02

Similar Documents

Publication Publication Date Title
DK3043803T3 (da) Nukleotid- og nucleosidsammensætninger og deres anvendelse
HK1220463A1 (zh) 修飾的核苷或核苷酸
DK3043784T3 (da) Arylethere og anvendelser deraf
DK3052485T3 (da) Heterocykliske forbindelser og anvendelser deraf
DK2968443T3 (da) Hepcidinanaloger og anvendelser deraf
BR302013003979S1 (pt) Configuração aplicada em impressora
DK2978844T3 (da) Modificerede tgf-beta2-oligonukleotider
DK3063144T3 (da) Antiparasitære og pesticid-isoxazolinforbindelser
DK2962100T3 (da) Tuberkulosebiomarkører og anvendelser deraf
DK3030549T3 (da) Pyridazinonforbindelser og anvendelser deraf
BR302013003976S1 (pt) Configuração aplicada em impressora
DK3062824T3 (da) Telomerase-kodende dna-vaccine
BR302014000010S1 (pt) Configuração aplicada em impressora
DK2978775T3 (da) Termisk modificeret stivelse
BR112016011692A2 (pt) amplificação de ácido nucléico
DK3077510T3 (da) Antisense-forbindelser og anvendelser deraf
DK3478843T3 (da) Oligonukleotider omfattende modificerede nukleosider
BR302013004898S1 (pt) Configuração aplicada em impressora
ES1151934Y (es) Almohada multifuncional
BR302013005927S1 (pt) Configuração aplicada em puxador
BR302013005929S1 (pt) Configuração aplicada em puxador
BR302013005928S1 (pt) Configuração aplicada em puxador
BR302013005930S1 (pt) Configuração aplicada em puxador
FI10346U1 (fi) Muurauskappale
UA26839S (uk) Цегла облицювальна