LT3043803T - Nukleotidų ir nukleozidų kompozicijos ir jų panaudojimas - Google Patents

Nukleotidų ir nukleozidų kompozicijos ir jų panaudojimas

Info

Publication number
LT3043803T
LT3043803T LTEPPCT/US2014/054930T LT14054930T LT3043803T LT 3043803 T LT3043803 T LT 3043803T LT 14054930 T LT14054930 T LT 14054930T LT 3043803 T LT3043803 T LT 3043803T
Authority
LT
Lithuania
Prior art keywords
nucleotide
nucleoside compositions
nucleoside
compositions
Prior art date
Application number
LTEPPCT/US2014/054930T
Other languages
English (en)
Inventor
Dennis Liotta
George Painter
Gregory BLUEMLING
Abel De La Rosa
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of LT3043803T publication Critical patent/LT3043803T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/10Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LTEPPCT/US2014/054930T 2013-09-11 2014-09-10 Nukleotidų ir nukleozidų kompozicijos ir jų panaudojimas LT3043803T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361876473P 2013-09-11 2013-09-11
US201461923317P 2014-01-03 2014-01-03
US201461986577P 2014-04-30 2014-04-30
PCT/US2014/054930 WO2015038596A1 (en) 2013-09-11 2014-09-10 Nucleotide and nucleoside compositions and uses related thereto

Publications (1)

Publication Number Publication Date
LT3043803T true LT3043803T (lt) 2022-08-10

Family

ID=52666219

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2014/054930T LT3043803T (lt) 2013-09-11 2014-09-10 Nukleotidų ir nukleozidų kompozicijos ir jų panaudojimas

Country Status (12)

Country Link
US (4) US10149859B2 (lt)
EP (2) EP3043803B1 (lt)
JP (3) JP6762873B2 (lt)
DK (1) DK3043803T3 (lt)
ES (1) ES2927955T3 (lt)
HR (1) HRP20220911T1 (lt)
LT (1) LT3043803T (lt)
PL (1) PL3043803T3 (lt)
SI (1) SI3043803T1 (lt)
TW (1) TW201542581A (lt)
UY (1) UY35732A (lt)
WO (1) WO2015038596A1 (lt)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9422323B2 (en) 2012-05-25 2016-08-23 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
IN2015DN04090A (lt) 2012-11-16 2015-10-09 Univ Cardiff
ES2927955T3 (es) * 2013-09-11 2022-11-14 Univ Emory Composiciones de nucleótidos y nucleósidos y sus usos
DK3160476T3 (da) 2014-06-24 2020-12-21 Janssen Biopharma Inc Substituerede nukleosider, nukleotider og analoger dertil til anvendelse til behandling af virusinfektioner
US9603863B2 (en) * 2014-06-24 2017-03-28 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
KR102407935B1 (ko) 2014-06-25 2022-06-10 뉴카나 피엘씨 젬시타빈 전구 약물
RS59264B1 (sr) * 2014-11-28 2019-10-31 NuCana plc Novi 2’ i/ili 5’ derivati 3’-deoksi adenozina supstituisani aminokiselinskim estrom fosforamidata, kao antikancerska jedinjenja
EP3233878A4 (en) 2014-12-15 2019-02-20 Emory University PHOSPHORAMIDATE FOR THE TREATMENT OF HEPATITIS C VIRUS
KR20230130175A (ko) 2014-12-26 2023-09-11 에모리 유니버시티 N4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도
GEP20237502B (en) 2015-03-06 2023-04-25 Atea Pharmaceuticals Inc B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
CN108350016B (zh) 2015-09-02 2021-07-27 艾伯维公司 抗病毒四氢呋喃衍生物
CN106674297A (zh) * 2015-11-11 2017-05-17 中国科学院生态环境研究中心 具有抗癌活性的新型krn7000类似物及合成方法
US20190085013A1 (en) * 2016-03-07 2019-03-21 Emory University Nucleotide and nucleoside therapeutic compositions and uses related thereto
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
MX2019002430A (es) 2016-08-31 2019-07-04 Fujifilm Corp Agente antitumoral, mejorador del efecto antitumoral, y kit antitumoral.
CN116036114A (zh) 2016-09-07 2023-05-02 阿堤亚制药公司 用于rna病毒治疗的2’-取代的-n6-取代的嘌呤核苷酸
WO2018110678A1 (ja) * 2016-12-16 2018-06-21 国立大学法人岐阜大学 ヌクレオシド誘導体及びその利用
CN115477679A (zh) 2017-02-01 2022-12-16 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
US10688112B2 (en) 2017-07-13 2020-06-23 Emory University Lipid disulfide prodrugs and uses related thereto
US11780874B2 (en) 2017-10-31 2023-10-10 Yamasa Corporation Nucleoside derivative and use thereof
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
BR122022008466B1 (pt) 2017-12-07 2023-12-05 Emory University Uso de um composto
EP3732180A4 (en) * 2017-12-27 2022-05-11 Emory University COMBINED MODALITIES FOR NUCLEOSIDES AND/OR NADPH OXIDASE (NOX) INHIBITORS AS MYELOID CELL SPECIFIC ANTIVIRAL AGENTS
JP7266896B2 (ja) * 2018-03-09 2023-05-01 国立研究開発法人科学技術振興機構 β修飾リン酸化合物前駆体、β修飾リン酸化合物、反応阻害剤及びこれを含む医薬並びに反応阻害方法
KR20200140865A (ko) 2018-04-10 2020-12-16 아테아 파마슈티컬즈, 인크. 간경변증을 갖는 hcv 감염 환자의 치료
CN110655546B (zh) * 2018-12-18 2023-05-16 安徽贝克制药股份有限公司 索非布韦衍生物及其制备方法和应用
CN109503688A (zh) * 2018-12-21 2019-03-22 佛山科学技术学院 具有抑制病毒复制活性的核苷磷酸长链酯类似物、制备方法及其药物用途
JP7233660B2 (ja) * 2019-04-05 2023-03-07 株式会社日本触媒 架橋型人工ヌクレオシドの製造
CN110105416B (zh) * 2019-06-17 2022-07-12 大连大学 一种4-S-5-Br-2’,3’,5’-O-三乙酰基尿苷合成方法
CN110204584B (zh) * 2019-06-17 2022-09-09 大连大学 一种4-s-2’,3’,5’-o-三乙酰基尿苷合成方法
JOP20220130A1 (ar) 2019-12-06 2023-01-30 Vertex Pharma مجموعات تترا هيدروفيوران بها استبدال في صورة عوامل تعديل لقنوات الصوديوم
US12030903B2 (en) 2020-02-18 2024-07-09 Gilead Sciences, Inc. Antiviral compounds
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
KR102145197B1 (ko) * 2020-03-10 2020-08-18 부광약품 주식회사 코로나바이러스를 치료하기 위한 l-뉴클레오사이드의 용도
EP4121437A1 (en) 2020-03-20 2023-01-25 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
WO2022081823A1 (en) * 2020-10-14 2022-04-21 Temple University -Of The Commonwealth System Of Higher Education Pharmacologic approach for suppression of coronaviruses
CN112778356B (zh) * 2020-12-26 2022-07-01 山东日兴新材料股份有限公司 一种三(三溴新戊基)磷酸酯阻燃剂的一锅法合成工艺
CN112661802B (zh) * 2021-01-25 2022-05-13 阿里生物新材料(常州)有限公司 一种3′-甲氧基鸟苷的合成方法
TW202241454A (zh) 2021-02-01 2022-11-01 日商第一三共股份有限公司 抗體-免疫賦活化劑共軛物之新穎製造方法
JP2024512771A (ja) 2021-04-16 2024-03-19 ギリアード サイエンシーズ, インコーポレイテッド アミドを使用してカルバヌクレオシドを調製する方法
CN112979733B (zh) * 2021-04-25 2021-09-10 南京颐媛生物医学研究院有限公司 抗乙肝病毒的化合物及其制备方法和应用
EP4333859A1 (en) * 2021-05-05 2024-03-13 Emory University Nucleotide and nucleoside therapeutic compositions, combinations and uses related thereto
IL308953A (en) 2021-06-04 2024-01-01 Vertex Pharma N-Hydroalkyl(Hetero)Aryl)Tetrahydrofuran Carboxamides as Natrene Channel Modulators
CN113278041B (zh) * 2021-07-16 2021-10-19 南京颐媛生物医学研究院有限公司 一种核苷磷酸酯及其合成方法与抗肝炎病毒的制药应用
CN113501853B (zh) * 2021-09-13 2021-12-07 南京颐媛生物医学研究院有限公司 4-硫代尿嘧啶脱氧核苷磷酸酯及其抗病毒药物用途
CN113735927B (zh) * 2021-10-18 2024-06-28 厦门蔚扬药业有限公司 一种核苷酸类似物及其制备方法和用途
WO2023086557A1 (en) * 2021-11-11 2023-05-19 Emory University Nucleosides for the treatment of dna virus infections
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN116554249A (zh) * 2022-01-28 2023-08-08 北京恩泰伟医药科技有限公司 抗病毒化合物及其用途
WO2023178228A1 (en) * 2022-03-16 2023-09-21 Pharmalectin, Inc. Lectin-binding carbohydrates for treating viral infections
EP4248949A1 (en) 2022-03-21 2023-09-27 R.G.C.C. Holdings AG Liposomal compositions
WO2024137577A1 (en) * 2022-12-19 2024-06-27 Ohio State Innovation Foundation Multiparametric integrated molecular detection of viral antigens and viral nucleic acids

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404144A (en) * 1965-12-23 1968-10-01 Research Corp 1-beta-d-arabinofuranosyl-5-fluorocytosine compounds
DE2041735A1 (de) * 1970-08-22 1972-02-24 Merck Patent Gmbh Thio-pyrimidin-derivate
US3975374A (en) * 1970-12-21 1976-08-17 The Upjohn Company Process for preparing 2-thiouracil nucleosides
JPS4947379A (lt) * 1972-09-12 1974-05-08
PL107865B1 (pl) 1977-04-27 1980-03-31 Polska Akademia Nauk Instytut Method of obtaining styrene oxide sposob otrzymywania tlenku styrenu
US6448392B1 (en) 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US4954485A (en) * 1987-10-20 1990-09-04 Sanyo-Kokusaku Pulp Co., Ltd. 2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
ES2276404T3 (es) 1995-06-07 2007-06-16 Emory University Nucleosidos con actividad antivirus de la hepatitis-b.
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
JPH107694A (ja) * 1996-06-21 1998-01-13 Toagosei Co Ltd 3’−アミノ−2−チオピリミジンヌクレオシド
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
WO1999041266A1 (en) 1998-02-12 1999-08-19 Emory University Sphingolipid derivatives and their methods of use
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6461422B1 (en) * 2000-01-27 2002-10-08 Chartpak, Inc. Pressure sensitive ink jet media for digital printing
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CN101099745A (zh) * 2000-05-26 2008-01-09 艾登尼科斯(开曼)有限公司 处理黄病毒和瘟病毒的方法和组合物
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
CN1482914A (zh) 2000-12-26 2004-03-17 三菱制药株式会社 丙型肝炎治疗剂
JP2005504087A (ja) * 2001-09-28 2005-02-10 イデニクス(ケイマン)リミテツド 4’が修飾されたヌクレオシドを使用するc型肝炎ウイルス治療のための方法および組成物
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス(ケイマン)リミテツド 4’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
PL197669B1 (pl) * 2002-02-28 2008-04-30 Pan Inst Biochemii I Biofizyki Nowe analogi 2',3'-dideoksy-3'-fluorotymidyny o aktywności przeciwko wirusom (54) ludzkiego niedoboru immunologicznego HIV-1 i HIV-2, sposób ich wytwarzania oraz zawierające je środki farmaceutyczne
RU2004135392A (ru) 2002-05-06 2005-06-27 Дженелэбс Текнолоджиз, Инк. (Us) Производные нуклеозидов для лечения инфекции, вызываемой вирусом гепатита с
TW200500375A (en) 2002-06-28 2005-01-01 Idenix Cayman Ltd Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae
US20040035547A1 (en) 2002-08-20 2004-02-26 3M Innovative Properties Company Metal matrix composites, and methods for making the same
US7902203B2 (en) 2002-11-01 2011-03-08 Abbott Laboratories, Inc. Anti-infective agents
WO2005020885A2 (en) 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
WO2006121820A1 (en) * 2005-05-05 2006-11-16 Valeant Research & Development Phosphoramidate prodrugs for treatment of viral infection
JP2009521479A (ja) 2005-12-21 2009-06-04 アボット・ラボラトリーズ 抗ウイルス化合物
HUP0600042A3 (en) * 2006-01-19 2012-12-28 Debreceni Egyetem New medical use of thiolated pyrimidine-mononucleotides and -nucleosides
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
ES2453591T3 (es) 2007-09-17 2014-04-08 Abbvie Bahamas Ltd. Derivado de uracilo o timina para el tratamiento de la hepatitis C
MX2010002904A (es) 2007-09-17 2010-06-02 Abbott Lab N-fenil-dioxo-hidropirimidinas utiles como inhibidores de virus de hepatitis c (hcv).
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
CN102264737A (zh) 2008-12-23 2011-11-30 雅培制药有限公司 抗病毒化合物
WO2010111437A1 (en) 2009-03-25 2010-09-30 Abbott Laboratories Antiviral compounds and uses thereof
SG10201400957UA (en) 2009-03-25 2014-09-26 Abbott Lab Antiviral Compounds And Uses Thereof
JP5734956B2 (ja) 2009-04-15 2015-06-17 アッヴィ・インコーポレイテッド 抗ウィルス化合物
UY32699A (es) 2009-06-11 2010-12-31 Abbott Lab Compuestos antivirales eficaces para inhibir la replicación del virus de la hepatitis c ("hcv"), procesos, composiciones, y métodos relacionados
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
PE20130198A1 (es) 2010-03-10 2013-03-24 Abbvie Bahamas Ltd Composiciones solidas
US8691775B2 (en) * 2010-04-19 2014-04-08 Back Bay Scientific, Llc Use of drugs that activate P2Y receptors to enhance synaptogenesis
US8748374B2 (en) 2010-06-07 2014-06-10 Abbvie, Inc. Macrocyclic hepatitis C serine protease inhibitors
CA2805748A1 (en) 2010-07-16 2012-01-19 Shashank Shekhar Process for preparing n-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
US8871737B2 (en) 2010-09-22 2014-10-28 Alios Biopharma, Inc. Substituted nucleotide analogs
TWI451439B (zh) 2010-12-10 2014-09-01 Phison Electronics Corp 記憶體儲存裝置、其記憶體控制器與資料寫入方法
MX2013006828A (es) 2010-12-16 2014-10-14 Abbvie Inc Compuestos antivirales.
CN103354808B (zh) 2010-12-16 2016-08-10 Abbvie公司 抗病毒化合物
CA2822357A1 (en) 2010-12-22 2012-06-28 Abbvie Inc. Hepatitis c inhibitors and uses thereof
PE20140039A1 (es) 2010-12-30 2014-03-01 Enanta Pharm Inc Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina
EP3384938A1 (en) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES2927955T3 (es) * 2013-09-11 2022-11-14 Univ Emory Composiciones de nucleótidos y nucleósidos y sus usos
EP3233878A4 (en) * 2014-12-15 2019-02-20 Emory University PHOSPHORAMIDATE FOR THE TREATMENT OF HEPATITIS C VIRUS

Also Published As

Publication number Publication date
EP3043803B1 (en) 2022-04-27
DK3043803T3 (da) 2022-08-01
JP2022081641A (ja) 2022-05-31
US11857560B2 (en) 2024-01-02
US20160220595A1 (en) 2016-08-04
JP7508501B2 (ja) 2024-07-01
SI3043803T1 (sl) 2022-09-30
JP6762873B2 (ja) 2020-09-30
JP2020143073A (ja) 2020-09-10
HRP20220911T1 (hr) 2022-10-28
EP4094767A1 (en) 2022-11-30
US20190298750A1 (en) 2019-10-03
UY35732A (es) 2015-06-30
US11166973B2 (en) 2021-11-09
PL3043803T3 (pl) 2022-11-07
JP7045411B2 (ja) 2022-03-31
ES2927955T3 (es) 2022-11-14
JP2016530313A (ja) 2016-09-29
EP3043803A1 (en) 2016-07-20
EP3043803A4 (en) 2017-03-29
US10149859B2 (en) 2018-12-11
US20220296626A1 (en) 2022-09-22
WO2015038596A1 (en) 2015-03-19
US20240173345A1 (en) 2024-05-30
TW201542581A (zh) 2015-11-16

Similar Documents

Publication Publication Date Title
IL269461B (en) Cytidine-5-carboxamide modified nucleotide preparations and related methods
SI3043803T1 (sl) Nukleotidne in nukleozidne sestave in njihova uporaba
HK1220463A1 (zh) 修飾的核苷或核苷酸
HK1224229A1 (zh) 取代的核苷,核苷酸及其類似物
HK1222178A1 (zh) 取代的核苷、核苷酸及其類似物
IL245014B (en) Nucleosides, modified nucleotides and their analogs
HK1215595A1 (zh) 白細胞介素- 藥物組合物和使用方法
HK1210619A1 (en) Novel nucleoside phosphoramidate compound and use thereof
GB201313235D0 (en) Antiviral Compositions Methods and Animals
EP2953474A4 (en) COMPOSITIONS AND METHODS
GB201313423D0 (en) Compositions and methods
GB201308072D0 (en) Compositions and methods
EP2957567A4 (en) NUCLEOSIDE AND NUCLEOTIDE WITH AN NITROGENIC HETEROCYCLIC STRUCTURE
EP2928876A4 (en) NUCLEOSID KINASEBYPASS COMPOSITIONS AND METHOD
HK1220388A1 (zh) 尿苷核苷衍生物、組合物及使用方法
GB201321693D0 (en) Composition and uses thereof
IL276126B (en) Preparations containing l-4-chloroquinonerine and their uses
GB201305813D0 (en) Compositions and methods
EP2964610A4 (en) VINYL SULFON-BASED 18F LABELING COMPOSITIONS AND METHOD AND USES THEREOF
IL233475A0 (en) Carbocyclic nucleosides, preparations containing them and their uses
ZA201500493B (en) Glycoconjugation processes and compositions
GB201308242D0 (en) Compositions and uses thereof
GB201312393D0 (en) Compositions and Methods
GB201301022D0 (en) Composition and uses thereof