DK2874656T3 - Svækkede svineinfluenzavacciner og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents
Svækkede svineinfluenzavacciner og fremgangsmåder til fremstilling og anvendelse deraf Download PDFInfo
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- DK2874656T3 DK2874656T3 DK13740452.1T DK13740452T DK2874656T3 DK 2874656 T3 DK2874656 T3 DK 2874656T3 DK 13740452 T DK13740452 T DK 13740452T DK 2874656 T3 DK2874656 T3 DK 2874656T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Claims (8)
1. Svækket svineinfluenzastamme der er i stand til at tilvejebringe et sikkert og effektivt immunrespons i svin mod influenza eller sygdomme forårsaget af influenza, der koder for et HA-gen med mindst 4 yderligere glycosyleringssteder i forhold til virulent parental stamme, hvor glycosyleringsstederne er valgt fra S71N, K90N, L173T, P287T og K294T, og hvor lokationen af aminosyreæn-dring(erne) er baseret på HA-genet kodet af den virulente parentale stamme med sekvensen beskrevet i SEQ ID NO: 18.
2. Stammen ifølge krav 1, hvor HA-proteinet har sekvensen beskrevet i SEQ ID NO: 22.
3. Stammen ifølge krav 1, hvor HA-proteinet har sekvensen beskrevet i SEQ ID NO:24.
4. Immunologisk sammensætning omfattende den svækkede stamme ifølge et hvilket som helst af kravene 1 til 3.
5. Sammensætningen ifølge krav 4 yderligere omfattende et farmaceutisk eller veterinært acceptabelt vehikel, fortyndingsmiddel eller excipiens, og som tilvejebringer et beskyttende immunrespons hos svin mod virulent svineinfluenza-challenge.
6. Sammensætningen ifølge krav 5 yderligere omfattende mindst et yderligere antigen associeret med eller afledt af et svinepatogen andet end svineinfluenza; og hvor det mindst ene eller flere yderligere antigen(er) er i stand til at fremkalde immunrespons i et svin mod M. hyo, svinecircovirus 2 (PCV2), svinereproduktions- og respiratorisk syndromvirus (PRRSV), svineinfluenzavirus (SIV) eller andet patogen der er i stand til at inficere og forårsage sygdom eller modtagelighed for sygdom hos et svin.
7. Sammensætningen ifølge et hvilket som helst af kravene 4-6 til anvendelse i vaccination af et svin hvor svinet fortrinsvist er en so på fra ca. 3 uger til ca. 6 uger før faring.
8. Sammensætning omfattende en flerhed af vektorer til fremstilling af svækket svineinfluenza herunder en vektor omfattende en promoter operabelt bundet til et influenzavirus HA cDNA, hvor HA cDNA-et koder for yderligere glycosyleringssteder i forhold til HA kodet afen virulent parental svineinfluenzastamme, hvor de yderligere glycosyleringssteder er valgt fra S71N, K90N, L173T, P287T og K294T, og hvor nummereringen af aminosyreændringerne er baseret på HA-genet kodet af den virulente parentale stamme med sekvensen som vist i SEQ ID NO: 18; og fortrinsvis hvor HA cDNA'et til fremstilling af svækkede influenza koder for proteinet beskrevet i SEQ ID NO: 22 eller 24.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261672398P | 2012-07-17 | 2012-07-17 | |
PCT/US2013/050000 WO2014014726A1 (en) | 2012-07-17 | 2013-07-11 | Attenuated swine influenza vaccines and methods of making and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2874656T3 true DK2874656T3 (da) | 2018-01-15 |
Family
ID=48874529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13740452.1T DK2874656T3 (da) | 2012-07-17 | 2013-07-11 | Svækkede svineinfluenzavacciner og fremgangsmåder til fremstilling og anvendelse deraf |
Country Status (20)
Country | Link |
---|---|
US (2) | US9216211B2 (da) |
EP (1) | EP2874656B1 (da) |
JP (1) | JP6467672B2 (da) |
KR (1) | KR102027758B1 (da) |
CN (1) | CN104582725B (da) |
AU (2) | AU2013290597B2 (da) |
BR (1) | BR112015001020B1 (da) |
CA (1) | CA2879228C (da) |
DK (1) | DK2874656T3 (da) |
EA (1) | EA033027B1 (da) |
ES (1) | ES2662022T3 (da) |
HK (1) | HK1209325A1 (da) |
HU (1) | HUE036110T2 (da) |
MX (1) | MX365880B (da) |
MY (1) | MY166879A (da) |
NZ (2) | NZ704188A (da) |
PH (1) | PH12015500095B1 (da) |
PL (1) | PL2874656T3 (da) |
PT (1) | PT2874656T (da) |
WO (1) | WO2014014726A1 (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ704188A (en) * | 2012-07-17 | 2016-04-29 | Merial Inc | Attenuated swine influenza vaccines and methods of making and use thereof |
MX2018007950A (es) * | 2015-12-28 | 2018-09-21 | Merial Inc | Vacuna multivalente m hyo y usos de la misma. |
EA201991319A1 (ru) | 2016-11-30 | 2019-11-29 | Вакцины аттенуированного свиного гриппа и способы их изготовления и применения | |
CN106939355A (zh) * | 2017-03-01 | 2017-07-11 | 苏州***医学研究所 | 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法 |
CN107064499B (zh) * | 2017-03-15 | 2019-06-18 | 青岛蔚蓝生物制品有限公司 | 禽流感病毒np蛋白抗原表位多肽及其胶体金试纸盒 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
US5585250A (en) | 1993-08-20 | 1996-12-17 | The United States Of America As Represented By The Department Of Health & Human Services | Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies |
ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
KR20060026854A (ko) | 2003-05-28 | 2006-03-24 | 위스콘신 얼럼나이 리서어치 화운데이션 | PolⅡ 프로모터 및 리보자임을 갖는 재조합 인플루엔자벡터 |
US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
JP5666905B2 (ja) * | 2007-06-18 | 2015-02-12 | メディミューン,エルエルシー | ヘマグルチニンポリペプチド中に変化を有するインフルエンザbウイルス |
CN102014953A (zh) | 2008-02-21 | 2011-04-13 | 生物模仿公司 | 流感免疫原组合物 |
CN102985107A (zh) * | 2010-01-24 | 2013-03-20 | 生物模仿公司 | 免疫性流感成分 |
NZ704188A (en) * | 2012-07-17 | 2016-04-29 | Merial Inc | Attenuated swine influenza vaccines and methods of making and use thereof |
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2013
- 2013-07-11 NZ NZ704188A patent/NZ704188A/en unknown
- 2013-07-11 CN CN201380043383.4A patent/CN104582725B/zh active Active
- 2013-07-11 CA CA2879228A patent/CA2879228C/en active Active
- 2013-07-11 EP EP13740452.1A patent/EP2874656B1/en active Active
- 2013-07-11 MY MYPI2015000100A patent/MY166879A/en unknown
- 2013-07-11 ES ES13740452.1T patent/ES2662022T3/es active Active
- 2013-07-11 MX MX2015000713A patent/MX365880B/es active IP Right Grant
- 2013-07-11 HU HUE13740452A patent/HUE036110T2/hu unknown
- 2013-07-11 PT PT137404521T patent/PT2874656T/pt unknown
- 2013-07-11 US US13/939,321 patent/US9216211B2/en active Active
- 2013-07-11 EA EA201500140A patent/EA033027B1/ru not_active IP Right Cessation
- 2013-07-11 DK DK13740452.1T patent/DK2874656T3/da active
- 2013-07-11 NZ NZ712713A patent/NZ712713A/en unknown
- 2013-07-11 JP JP2015523130A patent/JP6467672B2/ja active Active
- 2013-07-11 AU AU2013290597A patent/AU2013290597B2/en active Active
- 2013-07-11 BR BR112015001020-2A patent/BR112015001020B1/pt active IP Right Grant
- 2013-07-11 KR KR1020157004138A patent/KR102027758B1/ko active IP Right Grant
- 2013-07-11 PL PL13740452T patent/PL2874656T3/pl unknown
- 2013-07-11 WO PCT/US2013/050000 patent/WO2014014726A1/en active Application Filing
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2015
- 2015-01-14 PH PH12015500095A patent/PH12015500095B1/en unknown
- 2015-10-14 HK HK15110019.9A patent/HK1209325A1/xx unknown
- 2015-12-21 US US14/977,485 patent/US9623105B2/en active Active
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2016
- 2016-04-27 AU AU2016202693A patent/AU2016202693B2/en active Active
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