EA201500140A1 - Ослабленные вакцины от свиного гриппа и способы их получения и применения - Google Patents

Ослабленные вакцины от свиного гриппа и способы их получения и применения

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Publication number
EA201500140A1
EA201500140A1 EA201500140A EA201500140A EA201500140A1 EA 201500140 A1 EA201500140 A1 EA 201500140A1 EA 201500140 A EA201500140 A EA 201500140A EA 201500140 A EA201500140 A EA 201500140A EA 201500140 A1 EA201500140 A1 EA 201500140A1
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EA
Eurasian Patent Office
Prior art keywords
methods
vaccines
faced
receiving
application
Prior art date
Application number
EA201500140A
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English (en)
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EA033027B1 (ru
Inventor
Бенджамин М. Хаус
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Мериал Лимитед
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Publication date
Application filed by Мериал Лимитед filed Critical Мериал Лимитед
Publication of EA201500140A1 publication Critical patent/EA201500140A1/ru
Publication of EA033027B1 publication Critical patent/EA033027B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Представлены ослабленные штаммы вируса свиного гриппа, в частности те, что получены методами обратной генетики, содержащие их композиции и способы их получения и применения. Ослабленные штаммы подвергались инженерии с тем, чтобы они кодировали белки НА, содержащие дополнительные сайты гликозилирования по сравнению с белками НА, кодируемыми соответствующими исходными вирулентными вирусами. Предпочтительно ослабленные штаммы вируса гриппа вводятся свиньям для выработки у них эффективного иммунитета против гриппа или заболеваний, вызванных вирусом гриппа.
EA201500140A 2012-07-17 2013-07-11 Ослабленные вакцины от свиного гриппа и способы их получения и применения EA033027B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672398P 2012-07-17 2012-07-17
PCT/US2013/050000 WO2014014726A1 (en) 2012-07-17 2013-07-11 Attenuated swine influenza vaccines and methods of making and use thereof

Publications (2)

Publication Number Publication Date
EA201500140A1 true EA201500140A1 (ru) 2016-02-29
EA033027B1 EA033027B1 (ru) 2019-08-30

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EA201500140A EA033027B1 (ru) 2012-07-17 2013-07-11 Ослабленные вакцины от свиного гриппа и способы их получения и применения

Country Status (20)

Country Link
US (2) US9216211B2 (ru)
EP (1) EP2874656B1 (ru)
JP (1) JP6467672B2 (ru)
KR (1) KR102027758B1 (ru)
CN (1) CN104582725B (ru)
AU (2) AU2013290597B2 (ru)
BR (1) BR112015001020B1 (ru)
CA (1) CA2879228C (ru)
DK (1) DK2874656T3 (ru)
EA (1) EA033027B1 (ru)
ES (1) ES2662022T3 (ru)
HK (1) HK1209325A1 (ru)
HU (1) HUE036110T2 (ru)
MX (1) MX365880B (ru)
MY (1) MY166879A (ru)
NZ (2) NZ704188A (ru)
PH (1) PH12015500095B1 (ru)
PL (1) PL2874656T3 (ru)
PT (1) PT2874656T (ru)
WO (1) WO2014014726A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ704188A (en) 2012-07-17 2016-04-29 Merial Inc Attenuated swine influenza vaccines and methods of making and use thereof
MX2018007950A (es) * 2015-12-28 2018-09-21 Merial Inc Vacuna multivalente m hyo y usos de la misma.
CA3045315A1 (en) * 2016-11-30 2018-06-07 Boehringer Ingelheim Animal Health USA Inc. Attenuated swine influenza vaccines and methods of making and use thereof
CN106939355A (zh) * 2017-03-01 2017-07-11 苏州***医学研究所 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法
CN107064499B (zh) * 2017-03-15 2019-06-18 青岛蔚蓝生物制品有限公司 禽流感病毒np蛋白抗原表位多肽及其胶体金试纸盒

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5585250A (en) 1993-08-20 1996-12-17 The United States Of America As Represented By The Department Of Health & Human Services Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies
EP1537877A3 (en) 1996-10-11 2005-08-03 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
CN1829799A (zh) 2003-05-28 2006-09-06 威斯康星旧生研究基金会 含polii启动子和核酶的重组流感载体
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
CA2690196A1 (en) * 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
CN102014953A (zh) 2008-02-21 2011-04-13 生物模仿公司 流感免疫原组合物
WO2011091376A2 (en) * 2010-01-24 2011-07-28 Biological Mimetics, Inc. Immunogenic influenza composition
NZ704188A (en) * 2012-07-17 2016-04-29 Merial Inc Attenuated swine influenza vaccines and methods of making and use thereof

Also Published As

Publication number Publication date
CA2879228A1 (en) 2014-01-23
US20160120973A1 (en) 2016-05-05
MY166879A (en) 2018-07-24
EA033027B1 (ru) 2019-08-30
MX2015000713A (es) 2015-10-12
JP2015524266A (ja) 2015-08-24
CN104582725A (zh) 2015-04-29
PH12015500095A1 (en) 2015-03-02
NZ704188A (en) 2016-04-29
US9216211B2 (en) 2015-12-22
KR102027758B1 (ko) 2019-10-02
AU2013290597A1 (en) 2015-02-19
PH12015500095B1 (en) 2015-03-02
AU2016202693B2 (en) 2017-11-16
AU2016202693A1 (en) 2016-05-19
WO2014014726A1 (en) 2014-01-23
US9623105B2 (en) 2017-04-18
AU2013290597B2 (en) 2016-02-04
EP2874656B1 (en) 2017-12-06
CN104582725B (zh) 2017-06-23
US20140023681A1 (en) 2014-01-23
BR112015001020A2 (ru) 2017-08-15
CA2879228C (en) 2021-07-13
HK1209325A1 (en) 2016-04-01
ES2662022T3 (es) 2018-04-05
JP6467672B2 (ja) 2019-02-13
PL2874656T3 (pl) 2018-04-30
DK2874656T3 (en) 2018-01-15
HUE036110T2 (hu) 2018-06-28
PT2874656T (pt) 2018-03-09
KR20150036685A (ko) 2015-04-07
NZ712713A (en) 2017-05-26
BR112015001020B1 (pt) 2022-04-19
EP2874656A1 (en) 2015-05-27
MX365880B (es) 2019-06-18

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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