DK2346864T3 - Nye forbindelser anvendelige for behandling af degenerative og inflammatoriske sygdomme - Google Patents

Nye forbindelser anvendelige for behandling af degenerative og inflammatoriske sygdomme

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Publication number
DK2346864T3
DK2346864T3 DK09781073.3T DK09781073T DK2346864T3 DK 2346864 T3 DK2346864 T3 DK 2346864T3 DK 09781073 T DK09781073 T DK 09781073T DK 2346864 T3 DK2346864 T3 DK 2346864T3
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Prior art keywords
inflammatory diseases
relationships used
new relationships
treat degenerative
degenerative
Prior art date
Application number
DK09781073.3T
Other languages
English (en)
Inventor
Christel Jeanne Marie Menet
Javier Blanc
Original Assignee
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv filed Critical Galapagos Nv
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Publication of DK2346864T3 publication Critical patent/DK2346864T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
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  • Surgery (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK09781073.3T 2008-07-25 2009-07-24 Nye forbindelser anvendelige for behandling af degenerative og inflammatoriske sygdomme DK2346864T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13592008P 2008-07-25 2008-07-25
US22068509P 2009-06-26 2009-06-26
PCT/EP2009/059605 WO2010010191A1 (en) 2008-07-25 2009-07-24 Novel compounds useful for the treatment of degenerative and inflammatory diseases.

Publications (1)

Publication Number Publication Date
DK2346864T3 true DK2346864T3 (da) 2013-05-13

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK09781073.3T DK2346864T3 (da) 2008-07-25 2009-07-24 Nye forbindelser anvendelige for behandling af degenerative og inflammatoriske sygdomme
DK09781072.5T DK2361251T3 (da) 2008-07-25 2009-07-24 Hidtil ukendte forbindelser, der er anvendelige til behandling af degenerative og inflammatoriske sygdomme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK09781072.5T DK2361251T3 (da) 2008-07-25 2009-07-24 Hidtil ukendte forbindelser, der er anvendelige til behandling af degenerative og inflammatoriske sygdomme

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US (5) US8242274B2 (da)
EP (2) EP2346864B1 (da)
JP (2) JP5559168B2 (da)
KR (2) KR101676391B1 (da)
CN (2) CN102105472B (da)
AR (1) AR072875A1 (da)
AU (2) AU2009273143B2 (da)
BR (2) BRPI0916862B8 (da)
CA (2) CA2730757A1 (da)
CL (1) CL2009001637A1 (da)
CO (1) CO6361925A2 (da)
CR (1) CR20110092A (da)
CY (2) CY1113945T1 (da)
DK (2) DK2346864T3 (da)
DO (1) DOP2011000022A (da)
EA (2) EA018080B1 (da)
ES (2) ES2406691T3 (da)
HK (2) HK1158634A1 (da)
HR (2) HRP20130357T1 (da)
IL (2) IL210261A (da)
JO (1) JO3041B1 (da)
MA (1) MA32551B1 (da)
ME (1) ME02046B (da)
MX (2) MX2011000758A (da)
MY (1) MY157615A (da)
NZ (1) NZ590646A (da)
PE (1) PE20100152A1 (da)
PL (2) PL2346864T3 (da)
PT (2) PT2346864E (da)
RS (2) RS52823B (da)
SI (2) SI2346864T1 (da)
SM (2) SMT201300051B (da)
TW (1) TWI447118B (da)
UY (1) UY32006A (da)
WO (2) WO2010010190A1 (da)
ZA (2) ZA201100396B (da)

Families Citing this family (73)

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Publication number Priority date Publication date Assignee Title
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI500614B (zh) 2009-06-05 2015-09-21 Cephalon Inc １，２，４－***並〔１，５ａ〕吡啶衍生物之製備和用途
TWI462920B (zh) * 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
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