DK2445912T3 - Ny forbindelse anvendelig til behandlingen af degenerative og inflammatoriske sygdomme - Google Patents

Ny forbindelse anvendelig til behandlingen af degenerative og inflammatoriske sygdomme

Info

Publication number: DK2445912T3
Authority: DK; Denmark
Prior art keywords: degenerative; treatment; inflammatory diseases; compound useful; new compound
Prior art date: 2009-06-26

Application number

DK10728648.6T

Other languages

English (en)

Inventor

Christel Jeanne Marie Menet

Javier Blanc

Original Assignee

Galapagos Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-26

Filing date

2010-06-25

Publication date

2014-11-10

2010-06-25 Application filed by Galapagos Nv filed Critical Galapagos Nv

2014-11-10 Application granted granted Critical

2014-11-10 Publication of DK2445912T3 publication Critical patent/DK2445912T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

DK10728648.6T 2009-06-26 2010-06-25 Ny forbindelse anvendelig til behandlingen af degenerative og inflammatoriske sygdomme DK2445912T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22068509P	2009-06-26	2009-06-26
US29818810P	2010-01-25	2010-01-25
PCT/EP2010/059067 WO2010149771A1 (en)	2009-06-26	2010-06-25	Novel compound useful for the treatment of degenerative and inflammatory diseases

Publications (1)

Publication Number	Publication Date
DK2445912T3 true DK2445912T3 (da)	2014-11-10

Family

ID=42340530

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK14175887.0T DK2792677T3 (da)	2009-06-26	2010-06-25	Hidtil ukendt forbindelse til behandling af degenerative og inflammatoriske sygdomme.
DK10728648.6T DK2445912T3 (da)	2009-06-26	2010-06-25	Ny forbindelse anvendelig til behandlingen af degenerative og inflammatoriske sygdomme

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK14175887.0T DK2792677T3 (da)	2009-06-26	2010-06-25	Hidtil ukendt forbindelse til behandling af degenerative og inflammatoriske sygdomme.

Country Status (38)

Country	Link
US (2)	US8796457B2 (da)
EP (2)	EP2792677B1 (da)
JP (1)	JP5486084B2 (da)
KR (1)	KR101712561B1 (da)
CN (1)	CN102459261B (da)
AR (1)	AR077221A1 (da)
AU (1)	AU2010264635B2 (da)
BR (1)	BRPI1014759A2 (da)
CA (1)	CA2765988C (da)
CL (1)	CL2011003276A1 (da)
CO (1)	CO6491039A2 (da)
CR (1)	CR20110673A (da)
CY (1)	CY1119711T1 (da)
DK (2)	DK2792677T3 (da)
DO (1)	DOP2011000378A (da)
EA (1)	EA020111B1 (da)
ES (2)	ES2519170T3 (da)
HK (2)	HK1168098A1 (da)
HR (2)	HRP20141057T1 (da)
HU (1)	HUE034205T2 (da)
IL (1)	IL216618A (da)
JO (1)	JO3030B1 (da)
LT (1)	LT2792677T (da)
MA (1)	MA33447B1 (da)
ME (1)	ME01916B (da)
MX (1)	MX2011013451A (da)
NZ (1)	NZ596836A (da)
PE (1)	PE20120494A1 (da)
PL (2)	PL2792677T3 (da)
PT (2)	PT2792677T (da)
RS (1)	RS53617B1 (da)
SG (1)	SG177359A1 (da)
SI (2)	SI2792677T1 (da)
SM (1)	SMT201400169B (da)
TW (1)	TWI469981B (da)
UY (1)	UY32741A (da)
WO (1)	WO2010149771A1 (da)
ZA (1)	ZA201109502B (da)

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JO3041B1 (ar)	2008-07-25	2016-09-05	Galapagos Nv	مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI462920B (zh)	2009-06-26	2014-12-01	葛萊伯格有限公司	用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar)	2009-06-26	2016-09-05	Galapagos Nv	مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
JO3417B1 (ar)	2010-01-08	2019-10-20	Regeneron Pharma	الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
JP6129155B2 (ja)	2011-04-12	2017-05-17	ライジェルファーマシューティカルズ，インコーポレイテッド	同種移植片拒絶反応を抑制する方法
KR20200039028A (ko) *	2011-10-11	2020-04-14	사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에	류마티스 관절염 치료를 위한 조성물 및 이의 이용방법
TWI589299B (zh) *	2011-10-11	2017-07-01	再生元醫藥公司	用於治療類風濕性關節炎之組成物及其使用方法
PL2863950T3 (pl) *	2012-06-22	2019-02-28	Galapagos Nv	Aminotriazolopirydyna do zastosowania w leczeniu zapalenia i jej kompozycje farmaceutyczne
CN105745209B (zh)	2013-09-05	2018-10-23	豪夫迈·罗氏有限公司	***并吡啶化合物、组合物及其使用方法
GB201402071D0 (en)	2014-02-07	2014-03-26	Galapagos Nv	Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402070D0 (en)	2014-02-07	2014-03-26	Galapagos Nv	Pharmaceutical compositions for the treatment of inflammatory disorders
WO2016165952A1 (en) *	2015-04-13	2016-10-20	Galapagos Nv	Methods for the treatment of cardiovascular disorders
WO2018019222A1 (zh)	2016-07-26	2018-02-01	张文燕	作为jak抑制剂杂环化合物，该化合物的盐类及其治疗用途
WO2019149244A1 (zh) *	2018-01-31	2019-08-08	南京明德新药研发股份有限公司	Jak抑制剂及其应用
MA53481A (fr)	2018-08-29	2021-07-07	Regeneron Pharma	Méthodes et compositions pour le traitement de sujets ayant une polyarthrite rhumatoïde
JP2022519828A (ja)	2019-01-31	2022-03-25	サノフィ・バイオテクノロジー	若年性特発性関節炎を治療するための抗ｉｌ－６受容体抗体
CN111072655B (zh) *	2019-12-30	2021-12-10	深圳市坤健创新药物研究院	一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用
US20230219889A1 (en)	2020-05-19	2023-07-13	Cybin Irl Limited	Deuterated tryptamine derivatives and methods of use
US11596612B1 (en)	2022-03-08	2023-03-07	PTC Innovations, LLC	Topical anesthetics

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US6500854B1 (en)	1999-01-29	2002-12-31	Chugai Sei Yaku Kabushiki Kaisha	Chondrongenesis promotors and indolin-2-one derivatives
JPWO2002087620A1 (ja)	2001-04-27	2004-08-12	中外製薬株式会社	軟骨形成促進剤
US6514989B1 (en) *	2001-07-20	2003-02-04	Hoffmann-La Roche Inc.	Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
MXPA04011956A (es) *	2002-05-30	2005-03-31	Vertex Pharma	Inhibidores de proteinas cinasas jak y cdk2.
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ES2427046T3 (es)	2004-06-21	2013-10-28	Galapagos N.V.	Métodos y medios para el tratamiento de la osteoartritis
WO2006018735A2 (en)	2004-08-18	2006-02-23	Pharmacia & Upjohn Company Llc	Triazolopyridine compounds
US7524860B2 (en)	2004-10-07	2009-04-28	Pfizer Inc.	Antibacterial agents
GB0515026D0 (en)	2005-07-21	2005-08-31	Novartis Ag	Organic compounds
SG174086A1 (en) *	2006-08-30	2011-09-29	Cellzome Ltd	Triazole derivatives as kinase inhibitors
AR066845A1 (es)	2007-06-05	2009-09-16	Takeda Pharmaceutical	Derivados de triazolopiridina e imidazopiridina una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento del cancer
KR20100049073A (ko)	2007-07-18	2010-05-11	노파르티스 아게	비시클릭 헤테로아릴 화합물 및 키나제 억제제로서의 그의 용도
WO2009017954A1 (en) *	2007-08-01	2009-02-05	Phenomix Corporation	Inhibitors of jak2 kinase
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WO2010010184A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	[1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors
WO2010010188A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases.
WO2010010186A1 (en) *	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases
WO2010010189A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases
JO3041B1 (ar) *	2008-07-25	2016-09-05	Galapagos Nv	مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
WO2010010187A1 (en)	2008-07-25	2010-01-28	Galapagos Nv	Novel compounds useful for the treatment of degenerative and inflammatory diseases
EP2438066A2 (en)	2009-06-05	2012-04-11	Cephalon, Inc.	PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES
TWI462920B (zh)	2009-06-26	2014-12-01	葛萊伯格有限公司	用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar)	2009-06-26	2016-09-05	Galapagos Nv	مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات

2010
- 2010-05-31 JO JOP/2010/0179A patent/JO3030B1/ar active
- 2010-06-23 TW TW99120587A patent/TWI469981B/zh not_active IP Right Cessation
- 2010-06-24 AR ARP100102236A patent/AR077221A1/es active IP Right Grant
- 2010-06-25 RS RS20140614A patent/RS53617B1/en unknown
- 2010-06-25 UY UY0001032741A patent/UY32741A/es not_active Application Discontinuation
- 2010-06-25 BR BRPI1014759A patent/BRPI1014759A2/pt active Search and Examination
- 2010-06-25 SI SI201031494T patent/SI2792677T1/sl unknown
- 2010-06-25 PL PL14175887T patent/PL2792677T3/pl unknown
- 2010-06-25 MX MX2011013451A patent/MX2011013451A/es active IP Right Grant
- 2010-06-25 DK DK14175887.0T patent/DK2792677T3/da active
- 2010-06-25 JP JP2012516762A patent/JP5486084B2/ja active Active
- 2010-06-25 PT PT141758870T patent/PT2792677T/pt unknown
- 2010-06-25 EA EA201270076A patent/EA020111B1/ru not_active IP Right Cessation
- 2010-06-25 WO PCT/EP2010/059067 patent/WO2010149771A1/en active Application Filing
- 2010-06-25 CN CN201080028413.0A patent/CN102459261B/zh active Active
- 2010-06-25 LT LTEP14175887.0T patent/LT2792677T/lt unknown
- 2010-06-25 EP EP14175887.0A patent/EP2792677B1/en active Active
- 2010-06-25 HU HUE14175887A patent/HUE034205T2/en unknown
- 2010-06-25 ME MEP-2014-132A patent/ME01916B/me unknown
- 2010-06-25 KR KR1020127002060A patent/KR101712561B1/ko active IP Right Grant
- 2010-06-25 PT PT107286486T patent/PT2445912E/pt unknown
- 2010-06-25 ES ES10728648.6T patent/ES2519170T3/es active Active
- 2010-06-25 DK DK10728648.6T patent/DK2445912T3/da active
- 2010-06-25 NZ NZ596836A patent/NZ596836A/xx not_active IP Right Cessation
- 2010-06-25 SG SG2011096179A patent/SG177359A1/en unknown
- 2010-06-25 SI SI201030775T patent/SI2445912T1/sl unknown
- 2010-06-25 ES ES14175887.0T patent/ES2634325T3/es active Active
- 2010-06-25 MA MA34555A patent/MA33447B1/fr unknown
- 2010-06-25 US US12/823,682 patent/US8796457B2/en active Active
- 2010-06-25 PL PL10728648T patent/PL2445912T3/pl unknown
- 2010-06-25 EP EP10728648.6A patent/EP2445912B1/en active Active
- 2010-06-25 PE PE2011002144A patent/PE20120494A1/es active IP Right Grant
- 2010-06-25 CA CA2765988A patent/CA2765988C/en not_active Expired - Fee Related
- 2010-06-25 AU AU2010264635A patent/AU2010264635B2/en not_active Ceased
2011
- 2011-11-27 IL IL216618A patent/IL216618A/en not_active IP Right Cessation
- 2011-12-06 DO DO2011000378A patent/DOP2011000378A/es unknown
- 2011-12-14 CR CR20110673A patent/CR20110673A/es unknown
- 2011-12-22 ZA ZA2011/09502A patent/ZA201109502B/en unknown
- 2011-12-22 CL CL2011003276A patent/CL2011003276A1/es unknown
2012
- 2012-01-16 CO CO12005375A patent/CO6491039A2/es active IP Right Grant
- 2012-09-11 HK HK12108855.3A patent/HK1168098A1/xx not_active IP Right Cessation
- 2012-09-11 HK HK15103046.1A patent/HK1202537A1/xx not_active IP Right Cessation
2014
- 2014-08-04 US US14/451,127 patent/US9505754B2/en active Active
- 2014-11-03 HR HRP20141057AT patent/HRP20141057T1/hr unknown
- 2014-11-10 SM SM201400169T patent/SMT201400169B/xx unknown
2017
- 2017-07-04 HR HRP20171024TT patent/HRP20171024T1/hr unknown
- 2017-07-24 CY CY20171100784T patent/CY1119711T1/el unknown

Also Published As

Publication number	Publication date
KR101712561B1 (ko)	2017-03-06
ME01916B (me)	2015-05-20
MA33447B1 (fr)	2012-07-03
ES2634325T3 (es)	2017-09-27
CA2765988C (en)	2017-08-29
IL216618A0 (en)	2012-02-29
WO2010149771A1 (en)	2010-12-29
HRP20141057T1 (en)	2015-03-13
SI2792677T1 (sl)	2017-08-31
HRP20171024T1 (hr)	2017-10-06
CA2765988A1 (en)	2010-12-29
ZA201109502B (en)	2012-09-26
ES2519170T3 (es)	2014-11-06
RS53617B1 (en)	2015-04-30
JP2012530767A (ja)	2012-12-06
CR20110673A (es)	2012-02-09
PT2445912E (pt)	2014-11-07
AU2010264635A1 (en)	2011-12-22
EA020111B1 (ru)	2014-08-29
TWI469981B (zh)	2015-01-21
US9505754B2 (en)	2016-11-29
PL2445912T3 (pl)	2015-02-27
EA201270076A1 (ru)	2012-08-30
DK2792677T3 (da)	2017-07-10
JO3030B1 (ar)	2016-09-05
EP2792677B1 (en)	2017-04-26
PL2792677T3 (pl)	2017-09-29
PT2792677T (pt)	2017-07-06
SMT201400169B (it)	2015-01-15
CN102459261A (zh)	2012-05-16
JP5486084B2 (ja)	2014-05-07
CY1119711T1 (el)	2018-06-27
PE20120494A1 (es)	2012-05-17
SI2445912T1 (sl)	2014-12-31
US20100331359A1 (en)	2010-12-30
SG177359A1 (en)	2012-02-28
LT2792677T (lt)	2017-07-25
CN102459261B (zh)	2014-11-05
KR20120059487A (ko)	2012-06-08
TW201103937A (en)	2011-02-01
AR077221A1 (es)	2011-08-10
MX2011013451A (es)	2012-04-30
HK1202537A1 (en)	2015-10-02
US8796457B2 (en)	2014-08-05
HUE034205T2 (en)	2018-01-29
US20150031671A1 (en)	2015-01-29
AU2010264635B2 (en)	2015-05-07
CO6491039A2 (es)	2012-07-31
DOP2011000378A (es)	2012-02-15
EP2792677A1 (en)	2014-10-22
EP2445912A1 (en)	2012-05-02
UY32741A (es)	2011-01-31
HK1168098A1 (en)	2012-12-21
NZ596836A (en)	2013-02-22
EP2445912B1 (en)	2014-08-13
CL2011003276A1 (es)	2012-08-31
IL216618A (en)	2014-09-30
BRPI1014759A2 (pt)	2016-04-19

Publication	Publication Date	Title
DK2445912T3 (da)	2014-11-10	Ny forbindelse anvendelig til behandlingen af degenerative og inflammatoriske sygdomme
DK1874781T3 (da)	2009-11-02	Dihydrothienopyrimidiner til behandling af inflammatoriske sygdomme
BRPI1015569A2 (pt)	2016-08-16	compostos úteis para o tratamento de doenças degenerativas e inflamatórias.
BRPI0916862A2 (pt)	2016-02-10	compostos úteis para o tratamento de doenças degenerativas e inflamatórias
DK2419114T4 (da)	2019-05-27	Bakteriesammensætninger til profylakse og behandling af degenerative sygdomme
DK2796469T3 (da)	2019-08-12	Hidtil ukendte sammensætninger og fremgangsmåder til behandling af IgE-medierede forstyrrelser
DK2183753T3 (da)	2012-08-20	Fremgangsmåder til køling
DK2504005T3 (da)	2014-01-13	Anvendelse af 1,3-diphenylprop-2-en-1-on-derivater til behandling af lever-sygdomme
DK2853265T3 (da)	2017-11-06	Fremgangsmåder til at øge stabiliseringen af hypoxi-inducerbar faktor-1-alpha
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