DK2178888T3 - Proteasomhæmmere - Google Patents
ProteasomhæmmereInfo
- Publication number
- DK2178888T3 DK2178888T3 DK07811087.1T DK07811087T DK2178888T3 DK 2178888 T3 DK2178888 T3 DK 2178888T3 DK 07811087 T DK07811087 T DK 07811087T DK 2178888 T3 DK2178888 T3 DK 2178888T3
- Authority
- DK
- Denmark
- Prior art keywords
- proteasome inhibitors
- proteasome
- inhibitors
- Prior art date
Links
- 229940079156 Proteasome inhibitor Drugs 0.000 title 1
- 239000003207 proteasome inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2007/017440 WO2009020448A1 (en) | 2007-08-06 | 2007-08-06 | Proteasome inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2178888T3 true DK2178888T3 (da) | 2012-10-01 |
Family
ID=38691782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07811087.1T DK2178888T3 (da) | 2007-08-06 | 2007-08-06 | Proteasomhæmmere |
Country Status (33)
Country | Link |
---|---|
EP (3) | EP2527347A1 (da) |
JP (1) | JP5261488B2 (da) |
KR (6) | KR20140042933A (da) |
CN (1) | CN101772507B (da) |
AU (1) | AU2007357338B2 (da) |
BR (1) | BRPI0721905B8 (da) |
CA (1) | CA2695082C (da) |
CY (2) | CY1113386T1 (da) |
DK (1) | DK2178888T3 (da) |
EA (1) | EA028622B1 (da) |
EC (1) | ECSP10010015A (da) |
ES (1) | ES2390606T3 (da) |
FR (1) | FR17C1011I2 (da) |
GE (1) | GEP20125599B (da) |
HK (2) | HK1143595A1 (da) |
HR (1) | HRP20120745T1 (da) |
HU (1) | HUS1700018I1 (da) |
IL (4) | IL203641A (da) |
LT (1) | LTC2178888I2 (da) |
LU (1) | LUC00013I2 (da) |
MY (1) | MY161991A (da) |
NL (1) | NL300871I2 (da) |
NZ (1) | NZ582693A (da) |
PH (1) | PH12014500053A1 (da) |
PL (1) | PL2178888T3 (da) |
PT (1) | PT2178888E (da) |
RS (1) | RS52435B (da) |
SG (1) | SG10201508712QA (da) |
SI (1) | SI2178888T1 (da) |
TN (1) | TN2010000060A1 (da) |
UA (1) | UA97536C2 (da) |
WO (1) | WO2009020448A1 (da) |
ZA (1) | ZA201000348B (da) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7576206B2 (en) † | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
NZ595196A (en) | 2005-11-09 | 2013-03-28 | Proteolix Inc | Peptide-based compounds for enzyme inhibition |
US7691852B2 (en) | 2006-06-19 | 2010-04-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
US7442830B1 (en) | 2007-08-06 | 2008-10-28 | Millenium Pharmaceuticals, Inc. | Proteasome inhibitors |
SG10201902704TA (en) | 2007-10-04 | 2019-04-29 | Onyx Therapeutics Inc | Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
EA030685B1 (ru) | 2008-06-17 | 2018-09-28 | Милленниум Фармасьютикалз, Инк. | Способ получения соединения боронатного эфира |
AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
EP3090737A1 (en) | 2008-10-21 | 2016-11-09 | Onyx Therapeutics, Inc. | Combination therapy with peptide epoxyketones |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
JP5919196B2 (ja) | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | 転移抑制のためのペプチドエポキシケトンの使用 |
NZ600786A (en) | 2009-12-22 | 2013-12-20 | Cephalon Inc | Proteasome inhibitors and processes for their preparation, purification and use |
SG183843A1 (en) | 2010-03-01 | 2012-10-30 | Onyx Therapeutics Inc | Compounds for immunoproteasome inhibition |
UA110612C2 (uk) | 2010-03-31 | 2016-01-25 | Мілленніум Фармасьютікалз, Інк. | Похідні 1-аміно-2-циклопропілетилборонової кислоти |
JP5944986B2 (ja) * | 2011-06-22 | 2016-07-05 | セファロン、インク. | プロテアソーム阻害剤、ならびにそれらの調製、精製、および使用のためのプロセス |
PT2753334T (pt) * | 2011-08-30 | 2022-11-03 | Tufts College | Inibidores de proteassoma ativados por fap utilizados para o tratamento de tumores sólidos |
WO2013092979A1 (en) * | 2011-12-22 | 2013-06-27 | Ares Trading S.A. | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
EP2812338A4 (en) * | 2012-01-24 | 2015-09-23 | Millennium Pharm Inc | METHOD FOR THE TREATMENT OF NASOPHARYNGEAL CANCER |
US20160008382A1 (en) * | 2012-01-24 | 2016-01-14 | Millennium Pharmaceuticals, Inc. | Methods of treatment of cancer |
JP2015524394A (ja) | 2012-07-09 | 2015-08-24 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ |
CN103570806B (zh) * | 2012-07-26 | 2020-04-07 | 圣特莱国际公司 | 多肽环氧酮化合物 |
JP2013006855A (ja) * | 2012-09-03 | 2013-01-10 | Millennium Pharmaceuticals Inc | プロテアソーム阻害剤 |
CN104822689B (zh) * | 2012-12-03 | 2016-11-02 | 弗·哈夫曼-拉罗切有限公司 | 取代的***硼酸化合物 |
KR20160058886A (ko) * | 2013-10-03 | 2016-05-25 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 전신 홍반성 낭창 및/또는 낭창성 신염의 예방 또는 치료 방법 |
JP2017524652A (ja) | 2014-05-20 | 2017-08-31 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤 |
US10301273B2 (en) | 2014-08-07 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
MA41555A (fr) * | 2015-02-17 | 2017-12-26 | Millennium Pharm Inc | Polythérapie pour le traitement du cancer |
US10144761B2 (en) | 2015-06-19 | 2018-12-04 | Hanlin Scientific Inc. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
CN106608883A (zh) * | 2015-10-21 | 2017-05-03 | 北京大学 | 蛋白酶体抑制剂mln9708的合成方法 |
CN107400142B (zh) * | 2016-05-19 | 2019-11-19 | 成都奥璟生物科技有限公司 | 一种硼酸和硼酸酯类化合物及其应用 |
CN106008572B (zh) * | 2016-05-23 | 2018-08-17 | 成都千禧莱医药科技有限公司 | 一类二肽硼酸化合物及制备方法和用途 |
EP3472151A4 (en) | 2016-06-21 | 2020-03-04 | Orion Ophthalmology LLC | CARBOCYCLIC PROLINAMIDE DERIVATIVES |
BR112018076614A2 (pt) | 2016-06-21 | 2019-04-02 | Orion Ophthalmology LLC | derivados heterocíclicos de prolinamida |
WO2018019196A1 (zh) * | 2016-07-25 | 2018-02-01 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的硼酸化合物及包含该化合物的药物组合物及其用途 |
CN108440583B (zh) * | 2017-01-23 | 2020-12-04 | 成都奥璟生物科技有限公司 | 一种新的硼酸衍生物及其药物组合物 |
CA3054572A1 (en) | 2017-02-28 | 2018-09-07 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
CN108794516A (zh) * | 2017-04-26 | 2018-11-13 | 上海时莱生物技术有限公司 | 硼酸和硼酸酯类化合物及其制备方法和用途 |
CN109305980B (zh) * | 2017-07-28 | 2022-10-11 | 成都奥璟生物科技有限公司 | 一种硼酸酯化合物、其合成方法及其用途 |
EP3672978B1 (en) | 2017-08-25 | 2021-10-06 | Synthon B.V. | Process for making ixazomib and its intermediates |
JP2018024694A (ja) * | 2017-10-03 | 2018-02-15 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | プロテアソーム阻害剤 |
US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
CN110903310B (zh) * | 2018-09-14 | 2022-11-22 | 成都奥璟生物科技有限公司 | 一种硼酸酯类药物及其用途 |
CN110357787A (zh) * | 2019-08-02 | 2019-10-22 | 苏州艾和医药科技有限公司 | 依沙佐米合成工艺研究 |
WO2021071932A1 (en) * | 2019-10-07 | 2021-04-15 | Cornell University | Antimicrobial and antiviral effects of c2-c7alkyl boronic acids |
CN110950897B (zh) * | 2019-12-12 | 2021-05-28 | 山东大学 | 一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US5242904A (en) | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
US5106948A (en) | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
PT3078667T (pt) * | 2001-01-25 | 2018-12-28 | The United States Of America Represented By The Sec Dep Of Health And Human Services | Formulação de compostos de ácido borónico |
BR0210112A (pt) | 2001-05-30 | 2004-06-08 | Novartis Ag | Derivados do ácido 2-{[n-(2-amino-3-(heteroarila ou arila)propionil)-aminoacil]-amino}-alquilborÈnico |
US7576206B2 (en) * | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
MY162518A (en) * | 2003-08-14 | 2017-06-15 | Cephalon Inc | Proteasome inhibitors and methods of using the same |
HRP20240307T3 (hr) * | 2004-03-30 | 2024-05-10 | Millennium Pharmaceuticals, Inc. | Sinteza spojeva estera borne kiseline i kiseline |
WO2006008660A2 (en) | 2004-07-20 | 2006-01-26 | Affinium Pharmaceuticals, Inc. | Streptococcus pneumoniae enoyl- (acyl-carrier-protein) reductase (fabk) |
TW200618820A (en) * | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
GB0513349D0 (en) | 2005-06-29 | 2005-08-03 | Torres Manel | Non-woven fabric |
CN101247799B (zh) | 2005-07-05 | 2013-03-27 | 塔夫茨大学信托人 | 成纤维细胞活化蛋白α的抑制剂 |
-
2007
- 2007-08-06 PL PL07811087T patent/PL2178888T3/pl unknown
- 2007-08-06 KR KR1020147007078A patent/KR20140042933A/ko active IP Right Grant
- 2007-08-06 EA EA201070247A patent/EA028622B1/ru not_active IP Right Cessation
- 2007-08-06 KR KR1020157000064A patent/KR20150010802A/ko not_active Application Discontinuation
- 2007-08-06 EP EP12171220A patent/EP2527347A1/en not_active Withdrawn
- 2007-08-06 UA UAA201002409A patent/UA97536C2/ru unknown
- 2007-08-06 KR KR1020147007077A patent/KR20140042932A/ko not_active Application Discontinuation
- 2007-08-06 JP JP2010519898A patent/JP5261488B2/ja active Active
- 2007-08-06 DK DK07811087.1T patent/DK2178888T3/da active
- 2007-08-06 KR KR1020107003809A patent/KR101474831B1/ko active IP Right Grant
- 2007-08-06 KR KR1020167008358A patent/KR20160040735A/ko not_active Application Discontinuation
- 2007-08-06 NZ NZ582693A patent/NZ582693A/en unknown
- 2007-08-06 CA CA2695082A patent/CA2695082C/en active Active
- 2007-08-06 EP EP07811087A patent/EP2178888B1/en active Active
- 2007-08-06 PT PT07811087T patent/PT2178888E/pt unknown
- 2007-08-06 WO PCT/US2007/017440 patent/WO2009020448A1/en active Application Filing
- 2007-08-06 MY MYPI2010000270A patent/MY161991A/en unknown
- 2007-08-06 SG SG10201508712QA patent/SG10201508712QA/en unknown
- 2007-08-06 RS RS20120405A patent/RS52435B/en unknown
- 2007-08-06 SI SI200731030T patent/SI2178888T1/sl unknown
- 2007-08-06 BR BRPI0721905A patent/BRPI0721905B8/pt active IP Right Grant
- 2007-08-06 EP EP16201780.0A patent/EP3210987A1/en active Pending
- 2007-08-06 GE GEAP200711714A patent/GEP20125599B/en unknown
- 2007-08-06 AU AU2007357338A patent/AU2007357338B2/en active Active
- 2007-08-06 ES ES07811087T patent/ES2390606T3/es active Active
- 2007-08-06 CN CN2007801001423A patent/CN101772507B/zh active Active
- 2007-08-06 KR KR1020167036758A patent/KR101831674B1/ko active IP Right Grant
-
2010
- 2010-01-18 ZA ZA2010/00348A patent/ZA201000348B/en unknown
- 2010-02-01 IL IL203641A patent/IL203641A/en active Protection Beyond IP Right Term
- 2010-02-05 TN TNP2010000060A patent/TN2010000060A1/fr unknown
- 2010-03-04 EC EC2010010015A patent/ECSP10010015A/es unknown
- 2010-10-28 HK HK10110167.4A patent/HK1143595A1/xx unknown
-
2012
- 2012-09-17 CY CY20121100845T patent/CY1113386T1/el unknown
- 2012-09-19 HR HRP20120745TT patent/HRP20120745T1/hr unknown
-
2013
- 2013-09-02 HK HK13110199.3A patent/HK1182924A1/zh unknown
-
2014
- 2014-01-06 PH PH12014500053A patent/PH12014500053A1/en unknown
-
2015
- 2015-10-26 IL IL242291A patent/IL242291A/en active IP Right Grant
- 2015-10-26 IL IL242290A patent/IL242290A/en active IP Right Grant
- 2015-10-26 IL IL242292A patent/IL242292A/en active IP Right Grant
-
2017
- 2017-04-05 LU LU00013C patent/LUC00013I2/fr unknown
- 2017-04-06 LT LTPA2017010C patent/LTC2178888I2/lt unknown
- 2017-04-14 FR FR17C1011C patent/FR17C1011I2/fr active Active
- 2017-04-26 CY CY2017016C patent/CY2017016I2/el unknown
- 2017-05-03 HU HUS1700018C patent/HUS1700018I1/hu unknown
- 2017-05-05 NL NL300871C patent/NL300871I2/nl unknown
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