DK2121989T4 - K-ras-mutationer og anti-EGFR-antistofbehandling - Google Patents

K-ras-mutationer og anti-EGFR-antistofbehandling Download PDF

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Publication number
DK2121989T4
DK2121989T4 DK08742061.8T DK08742061T DK2121989T4 DK 2121989 T4 DK2121989 T4 DK 2121989T4 DK 08742061 T DK08742061 T DK 08742061T DK 2121989 T4 DK2121989 T4 DK 2121989T4
Authority
DK
Denmark
Prior art keywords
egfr antibody
antibody therapy
ras mutations
ras
mutations
Prior art date
Application number
DK08742061.8T
Other languages
English (en)
Other versions
DK2121989T3 (da
Inventor
Daniel Freeman
Todd Juan
Robert Radinsky
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39689242&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2121989(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of DK2121989T3 publication Critical patent/DK2121989T3/da
Application granted granted Critical
Publication of DK2121989T4 publication Critical patent/DK2121989T4/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
DK08742061.8T 2007-03-13 2008-03-11 K-ras-mutationer og anti-EGFR-antistofbehandling DK2121989T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90694307P 2007-03-13 2007-03-13
PCT/US2008/003312 WO2008112269A2 (en) 2007-03-13 2008-03-11 K-ras mutations and anti-egfr antibody therapy

Publications (2)

Publication Number Publication Date
DK2121989T3 DK2121989T3 (da) 2014-04-28
DK2121989T4 true DK2121989T4 (da) 2022-06-20

Family

ID=39689242

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12154109.8T DK2465950T3 (da) 2007-03-13 2008-03-11 K-ras-mutationer og anti-egfr-antistofbehandling
DK08742061.8T DK2121989T4 (da) 2007-03-13 2008-03-11 K-ras-mutationer og anti-EGFR-antistofbehandling

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK12154109.8T DK2465950T3 (da) 2007-03-13 2008-03-11 K-ras-mutationer og anti-egfr-antistofbehandling

Country Status (21)

Country Link
US (3) US20080293055A1 (da)
EP (2) EP2465950B1 (da)
JP (1) JP2010521153A (da)
AR (1) AR065687A1 (da)
AU (1) AU2008226803A1 (da)
CA (1) CA2680326A1 (da)
CL (1) CL2008000717A1 (da)
CY (2) CY1115333T1 (da)
DK (2) DK2465950T3 (da)
ES (2) ES2458626T5 (da)
HR (2) HRP20140360T4 (da)
HU (1) HUE033695T2 (da)
LT (1) LT2465950T (da)
MX (1) MX2009009787A (da)
PE (1) PE20081880A1 (da)
PL (2) PL2465950T3 (da)
PT (2) PT2465950T (da)
RS (2) RS56422B1 (da)
SI (2) SI2121989T2 (da)
TW (1) TW200902553A (da)
WO (1) WO2008112269A2 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129114B2 (en) * 2005-08-24 2012-03-06 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
WO2007137187A2 (en) 2006-05-18 2007-11-29 Molecular Profiling Institute, Inc. System and method for determining individualized medical intervention for a disease state
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
ES2426814T3 (es) * 2007-03-13 2013-10-25 Amgen Inc. Mutaciones de K-ras y B-raf y terapia con anticuerpos anti-EGFr
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
GB2463401B (en) 2008-11-12 2014-01-29 Caris Life Sciences Luxembourg Holdings S A R L Characterizing prostate disorders by analysis of microvesicles
US8502015B1 (en) 2009-07-06 2013-08-06 Transgenex Nanobiotech, Inc. Method of inducing cancer
CN102115782B (zh) * 2009-12-30 2014-06-18 北京雅康博生物科技有限公司 用于定量检测K-ras突变的试剂盒
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
AU2011237669B2 (en) 2010-04-06 2016-09-08 Caris Life Sciences Switzerland Holdings Gmbh Circulating biomarkers for disease
EP2558595A2 (en) * 2010-04-12 2013-02-20 Response Genetics, Inc Kras primers and probes
US9309556B2 (en) 2010-09-24 2016-04-12 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
US8628773B2 (en) 2011-04-07 2014-01-14 Amgen Inc. Antigen binding proteins
EP2776043B1 (en) * 2011-11-11 2018-02-21 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
IL269097B2 (en) 2012-09-04 2024-01-01 Guardant Health Inc Systems and methods for detecting rare mutations and changes in number of copies
US20140199405A1 (en) * 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on mutation status of k-ras
EP2977464A4 (en) * 2013-03-19 2016-10-19 Toppan Printing Co Ltd PROCEDURE FOR PREDICTING SENSITIVITY TO EGFR HEMMER
CA2934822A1 (en) 2013-12-28 2015-07-02 Guardant Health, Inc. Methods and systems for detecting genetic variants
WO2015175705A1 (en) 2014-05-13 2015-11-19 Board Of Regents, The University Of Texas System Gene mutations and copy number alterations of egfr, kras and met
SG11201805119QA (en) 2015-12-17 2018-07-30 Guardant Health Inc Methods to determine tumor gene copy number by analysis of cell-free dna
CN110357965A (zh) * 2019-06-24 2019-10-22 浙江大学 一种突变型kras特异性抗体及其制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin Elmer Corp Proben zusammensetzung und verfahren
US5470705A (en) 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
EP1500329B1 (en) 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
WO2000055368A2 (en) 1999-03-15 2000-09-21 Pe Corporation (Ny) Probe/mobility modifier complexes for multiplex nucleic acid detection
AU2001265121A1 (en) 2000-05-30 2001-12-11 Applera Corporation Methods for detecting target nucleic acids using coupled ligation and amplification
US6503914B1 (en) * 2000-10-23 2003-01-07 Board Of Regents, The University Of Texas System Thienopyrimidine-based inhibitors of the Src family
JP2006508899A (ja) 2002-05-20 2006-03-16 アブジエニツクス・インコーポレイテツド ＥＧＦｒに対する抗体を使用する腎癌の治療方法
WO2004111273A2 (en) 2003-05-30 2004-12-23 Genomic Health, Inc. Gene expression markers for response to egfr inhibitor drugs
CN104480200B (zh) 2004-03-31 2017-12-29 综合医院公司 测定癌症对表皮生长因子受体靶向性治疗反应性的方法
EP1766068A4 (en) 2004-06-04 2010-03-03 Genentech Inc EGFR Mutations
US20060141497A1 (en) * 2004-10-22 2006-06-29 Finkelstein Sydney D Molecular analysis of cellular fluid and liquid cytology specimens for clinical diagnosis, characterization, and integration with microscopic pathology evaluation
BRPI0609615A2 (pt) 2005-04-01 2010-04-27 Amgen Inc métodos de predição da eficácia de tratamento de agente de ligação especìfica a egfr em tratamento de cáncer relacionado com egfr num sujeito, de tratamento do mesmo e de determinação da eficácia de tratamento em paciente
KR20080003422A (ko) * 2005-04-14 2008-01-07 메르크 파텐트 게엠베하 종양 조직 내의 ｅｇｆｒ 유전자의 증가된 복제수에 기초한항-ｅｇｆｒ 항체 치료
JP2008546421A (ja) † 2005-06-28 2008-12-25 ジェネンテック・インコーポレーテッド Ｅｇｆｒおよびｋｒａｓ変異
WO2007011702A2 (en) * 2005-07-15 2007-01-25 The University Of North Carolina At Chapel Hill Use of egfr inhibitors to prevent or treat obesity
US8129114B2 (en) * 2005-08-24 2012-03-06 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
WO2007109571A2 (en) * 2006-03-17 2007-09-27 Prometheus Laboratories, Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
WO2008033442A2 (en) * 2006-09-12 2008-03-20 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for performing low background multiplex nucleic acid amplification reactions
ES2426814T3 (es) * 2007-03-13 2013-10-25 Amgen Inc. Mutaciones de K-ras y B-raf y terapia con anticuerpos anti-EGFr

Also Published As

Publication number Publication date
PL2121989T3 (pl) 2014-07-31
US11155876B2 (en) 2021-10-26
LT2465950T (lt) 2017-10-10
SI2121989T2 (sl) 2022-05-31
EP2121989A2 (en) 2009-11-25
WO2008112269A3 (en) 2008-11-20
AR065687A1 (es) 2009-06-24
JP2010521153A (ja) 2010-06-24
SI2121989T1 (sl) 2014-06-30
PT2121989E (pt) 2014-04-30
CL2008000717A1 (es) 2008-09-22
RS56422B1 (sr) 2018-01-31
PL2121989T5 (pl) 2023-03-06
CA2680326A1 (en) 2008-09-18
SI2465950T1 (sl) 2017-11-30
ES2458626T3 (es) 2014-05-06
HRP20140360T4 (hr) 2022-06-10
US20120264129A1 (en) 2012-10-18
PL2465950T3 (pl) 2017-12-29
US10030270B2 (en) 2018-07-24
DK2121989T3 (da) 2014-04-28
CY1119112T1 (el) 2018-02-14
HRP20171509T1 (hr) 2017-11-17
RS53265B2 (sr) 2022-06-30
AU2008226803A1 (en) 2008-09-18
EP2465950A3 (en) 2013-03-13
MX2009009787A (es) 2009-09-22
EP2121989B2 (en) 2022-03-09
RS53265B (en) 2014-08-29
TW200902553A (en) 2009-01-16
US20190048423A1 (en) 2019-02-14
ES2458626T5 (es) 2022-04-29
EP2465950B1 (en) 2017-07-12
PE20081880A1 (es) 2008-12-31
EP2465950A2 (en) 2012-06-20
HUE033695T2 (en) 2017-12-28
CY1115333T1 (el) 2017-01-04
DK2465950T3 (da) 2017-10-09
EP2121989B1 (en) 2014-01-22
PT2465950T (pt) 2017-10-17
HRP20140360T1 (en) 2014-05-23
US20080293055A1 (en) 2008-11-27
ES2635051T3 (es) 2017-10-02
WO2008112269A2 (en) 2008-09-18

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