DK2342233T3 - Anti-CXCR4-antistoffer og anvendelse deraf i behandling af cancer - Google Patents

Anti-CXCR4-antistoffer og anvendelse deraf i behandling af cancer

Info

Publication number
DK2342233T3
DK2342233T3 DK09744645.4T DK09744645T DK2342233T3 DK 2342233 T3 DK2342233 T3 DK 2342233T3 DK 09744645 T DK09744645 T DK 09744645T DK 2342233 T3 DK2342233 T3 DK 2342233T3
Authority
DK
Denmark
Prior art keywords
cancer
treatment
cxcr4 antibodies
cxcr4
antibodies
Prior art date
Application number
DK09744645.4T
Other languages
English (en)
Inventor
Christine Klinguer-Hamour
Véronique Grenir-Caussanel
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of DK2342233T3 publication Critical patent/DK2342233T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
DK09744645.4T 2008-10-01 2009-10-01 Anti-CXCR4-antistoffer og anvendelse deraf i behandling af cancer DK2342233T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13677208P 2008-10-01 2008-10-01
EP08305631A EP2172485A1 (en) 2008-10-01 2008-10-01 Novel anti CXCR4 antibodies and their use for the treatment of cancer
US17374309P 2009-04-29 2009-04-29
PCT/EP2009/062787 WO2010037831A1 (en) 2008-10-01 2009-10-01 Anti cxcr4 antibodies and their use for the treatment of cancer

Publications (1)

Publication Number Publication Date
DK2342233T3 true DK2342233T3 (da) 2014-09-29

Family

ID=40361774

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09744645.4T DK2342233T3 (da) 2008-10-01 2009-10-01 Anti-CXCR4-antistoffer og anvendelse deraf i behandling af cancer

Country Status (29)

Country Link
US (4) US8557964B2 (da)
EP (2) EP2172485A1 (da)
JP (1) JP5723279B2 (da)
KR (1) KR101671039B1 (da)
CN (1) CN102209730B (da)
AR (1) AR073748A1 (da)
AU (1) AU2009299787B2 (da)
BR (1) BRPI0920531A2 (da)
CA (1) CA2738782C (da)
CL (1) CL2011000730A1 (da)
CY (1) CY1115572T1 (da)
DK (1) DK2342233T3 (da)
ES (1) ES2503732T3 (da)
GE (1) GEP20146084B (da)
HK (1) HK1163119A1 (da)
HR (1) HRP20140899T1 (da)
IL (1) IL212066A (da)
MA (1) MA32928B1 (da)
MX (1) MX2011003509A (da)
NZ (1) NZ592363A (da)
PL (1) PL2342233T3 (da)
PT (1) PT2342233E (da)
RS (1) RS53578B1 (da)
RU (1) RU2573897C2 (da)
SI (1) SI2342233T1 (da)
TW (1) TWI469792B (da)
UA (1) UA102867C2 (da)
WO (1) WO2010037831A1 (da)
ZA (1) ZA201102969B (da)

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Publication number Priority date Publication date Assignee Title
EP2246364A1 (en) * 2009-04-29 2010-11-03 Pierre Fabre Médicament Anti CXCR4 antibodies for the treatment of HIV
EP2371863A1 (en) * 2010-03-30 2011-10-05 Pierre Fabre Médicament Humanized anti CXCR4 antibodies for the treatment of cancer
CN103180342A (zh) * 2010-10-27 2013-06-26 皮埃尔法布雷医药公司 用于治疗hiv的抗体
US20140120555A1 (en) * 2011-06-20 2014-05-01 Pierre Fabre Medicament Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer
WO2012178137A1 (en) 2011-06-24 2012-12-27 Gillies Stephen D Light chain immunoglobulin fusion proteins and methods of use thereof
AR087364A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
NL2010658C2 (en) * 2013-04-18 2014-10-21 Bosch Gmbh Robert Thermostat for a hvac.
CN106211774B (zh) * 2013-08-02 2020-11-06 辉瑞公司 抗cxcr4抗体及抗体-药物缀合物
US10584354B2 (en) * 2013-09-23 2020-03-10 Wilson Wolf Manufacturing Methods of genetically modifying animal cells
AR104413A1 (es) * 2015-04-27 2017-07-19 Pf Medicament Anticuerpo de igf-1r y su utilización para diagnosticar cáncer
WO2016201425A1 (en) 2015-06-12 2016-12-15 Bristol-Myers Squibb Company Treatment of cancer by combined blockade of the pd-1 and cxcr4 signaling pathways
WO2017079835A1 (en) 2015-11-09 2017-05-18 The University Of British Columbia Amyloid beta epitopes and antibodies thereto
US10774120B2 (en) 2015-11-09 2020-09-15 The University Of British Columbia Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide
US10973852B2 (en) 2016-01-25 2021-04-13 Nantcell, Inc. NK cells with altered CXCL12/CXCR4 signaling
US10514670B2 (en) * 2016-05-25 2019-12-24 Kabushiki Kaisha Toshiba Energy management apparatus, management system, power consumption monitoring method and program
JP7461741B2 (ja) 2016-06-20 2024-04-04 カイマブ・リミテッド 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
JP2020508697A (ja) * 2017-01-31 2020-03-26 エム・エス・エム・プロテイン・テクノロジーズ・インコーポレイテッド 抗ｃｘｃｒ４抗体
CN112513079A (zh) 2018-03-13 2021-03-16 拉巴斯大学医院生物医学研究基金会 用于癌症免疫疗法的联合激活和扩增的自然杀伤细胞的抗cxcr4抗体
CN110804100A (zh) * 2019-11-01 2020-02-18 中国人民解放军陆军特色医学中心 融合多肽及其在增强干细胞归巢能力和抗凋亡能力中的应用和药物组合物
US11883432B2 (en) 2020-12-18 2024-01-30 Century Therapeutics, Inc. Chimeric antigen receptor system with adaptable receptor specificity
CN112521500B (zh) * 2020-12-25 2022-06-24 暨南大学 与cxcr4结合的亲和力成熟结合蛋白及应用
CN112661845B (zh) * 2020-12-25 2022-06-21 暨南大学 与cxcr4结合的亲和力成熟结合蛋白及其应用
CN117003876A (zh) * 2023-08-31 2023-11-07 恺佧生物科技(上海)有限公司 一种Anti-CXCR4膜蛋白抗体及其制备方法和应用

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Also Published As

Publication number Publication date
JP5723279B2 (ja) 2015-05-27
AU2009299787A2 (en) 2011-06-02
US9388248B2 (en) 2016-07-12
TW201018483A (en) 2010-05-16
CY1115572T1 (el) 2017-01-04
CL2011000730A1 (es) 2012-02-03
EP2172485A1 (en) 2010-04-07
US20140050661A1 (en) 2014-02-20
SI2342233T1 (sl) 2014-10-30
RS53578B1 (en) 2015-02-27
US20110020218A1 (en) 2011-01-27
CN102209730B (zh) 2014-11-05
CA2738782C (en) 2017-11-28
AU2009299787A1 (en) 2010-04-08
GEP20146084B (en) 2014-05-13
EP2342233B1 (en) 2014-06-25
MA32928B1 (fr) 2012-01-02
US8557964B2 (en) 2013-10-15
BRPI0920531A2 (pt) 2021-02-23
HK1163119A1 (en) 2012-09-07
US20110294156A1 (en) 2011-12-01
NZ592363A (en) 2012-08-31
PT2342233E (pt) 2014-10-03
US20110287451A1 (en) 2011-11-24
IL212066A (en) 2015-05-31
KR101671039B1 (ko) 2016-11-01
ES2503732T3 (es) 2014-10-07
ZA201102969B (en) 2011-12-28
HRP20140899T1 (hr) 2014-11-07
AR073748A1 (es) 2010-12-01
EP2342233A1 (en) 2011-07-13
RU2011115559A (ru) 2012-11-10
TWI469792B (zh) 2015-01-21
WO2010037831A1 (en) 2010-04-08
PL2342233T3 (pl) 2014-11-28
CA2738782A1 (en) 2010-04-08
JP2012504401A (ja) 2012-02-23
MX2011003509A (es) 2011-05-02
IL212066A0 (en) 2011-06-30
UA102867C2 (uk) 2013-08-27
CN102209730A (zh) 2011-10-05
RU2573897C2 (ru) 2016-01-27
AU2009299787B2 (en) 2015-06-18
KR20110081229A (ko) 2011-07-13

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