DK171061B1 - Hexahydro-1H-indeno(2,1-c)pyridinforbindelser, farmaceutiske midler indeholdende disse samt anvendelsen heraf til fremstilling af lægemidler til behandling af hypertension, ængstelse eller depression - Google Patents
Hexahydro-1H-indeno(2,1-c)pyridinforbindelser, farmaceutiske midler indeholdende disse samt anvendelsen heraf til fremstilling af lægemidler til behandling af hypertension, ængstelse eller depression Download PDFInfo
- Publication number
- DK171061B1 DK171061B1 DK194490A DK194490A DK171061B1 DK 171061 B1 DK171061 B1 DK 171061B1 DK 194490 A DK194490 A DK 194490A DK 194490 A DK194490 A DK 194490A DK 171061 B1 DK171061 B1 DK 171061B1
- Authority
- DK
- Denmark
- Prior art keywords
- hexahydro
- indeno
- pyridine
- methoxy
- trans
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Fats And Perfumes (AREA)
- Pyridine Compounds (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Networks Using Active Elements (AREA)
- Amplifiers (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28513488A | 1988-12-15 | 1988-12-15 | |
US28513488 | 1988-12-15 | ||
US8905512 | 1989-12-07 | ||
PCT/US1989/005512 WO1990006927A1 (en) | 1988-12-15 | 1989-12-07 | 5-ht selective agents |
Publications (3)
Publication Number | Publication Date |
---|---|
DK194490D0 DK194490D0 (da) | 1990-08-15 |
DK194490A DK194490A (da) | 1990-10-12 |
DK171061B1 true DK171061B1 (da) | 1996-05-13 |
Family
ID=23092880
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK194490A DK171061B1 (da) | 1988-12-15 | 1990-08-15 | Hexahydro-1H-indeno(2,1-c)pyridinforbindelser, farmaceutiske midler indeholdende disse samt anvendelsen heraf til fremstilling af lægemidler til behandling af hypertension, ængstelse eller depression |
DK024595A DK24595A (da) | 1988-12-15 | 1995-03-10 | 8-alkoxy-1,2,3,3a,8,8a-hexahydro-indeno[1,2-a]-pyrrol- og 9-alkoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e]isoindolforbindelser, farmaceutiske midler indeholdende disse samt anvendelsen heraf til fremstilling af lægemidler til behandling af hypertension |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK024595A DK24595A (da) | 1988-12-15 | 1995-03-10 | 8-alkoxy-1,2,3,3a,8,8a-hexahydro-indeno[1,2-a]-pyrrol- og 9-alkoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e]isoindolforbindelser, farmaceutiske midler indeholdende disse samt anvendelsen heraf til fremstilling af lægemidler til behandling af hypertension |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0422134B1 (es) |
JP (1) | JPH03502701A (es) |
KR (1) | KR910700251A (es) |
AT (1) | ATE139230T1 (es) |
AU (1) | AU626621B2 (es) |
CA (1) | CA2005441A1 (es) |
DE (1) | DE68926673T2 (es) |
DK (2) | DK171061B1 (es) |
ES (1) | ES2090119T3 (es) |
WO (1) | WO1990006927A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9014061D0 (en) * | 1990-06-25 | 1990-08-15 | Merck Sharp & Dohme | Therapeutic agents |
AU2559392A (en) * | 1991-10-24 | 1993-05-21 | Upjohn Company, The | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
US5512566A (en) * | 1993-10-25 | 1996-04-30 | Ortho Pharmaceutical Corporation | Tricyclic compounds having affinity for the 5-HT1A receptor |
KR950014099A (ko) * | 1993-11-10 | 1995-06-15 | 장기하 | N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법 |
FR2722194B1 (fr) * | 1994-07-06 | 1996-08-23 | Adir | Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent |
AU2002230411A1 (en) | 2000-11-29 | 2002-06-11 | Eli Lilly And Company | 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence |
US20060025601A1 (en) * | 2004-07-29 | 2006-02-02 | Athersys, Inc. | Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators |
TW200924752A (en) * | 2007-09-17 | 2009-06-16 | Organon Nv | Tricyclic heterocyclic derivatives |
TW201041851A (en) | 2009-03-10 | 2010-12-01 | Organon Nv | Tricyclic heterocyclic derivatives |
US8546377B2 (en) | 2009-04-23 | 2013-10-01 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
US8518933B2 (en) | 2009-04-23 | 2013-08-27 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
AU2010249472B2 (en) | 2009-05-22 | 2015-09-10 | AbbVie Deutschland GmbH & Co. KG | Modulators of 5-HT receptors and methods of use thereof |
CN103002735B (zh) | 2010-05-21 | 2015-05-20 | Abbvie公司 | 5-ht受体的调节剂和其使用方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE792374A (fr) * | 1971-12-08 | 1973-06-06 | Allen & Hanburys Ltd | Nouveaux derives d'isoindoline |
US4341786A (en) * | 1981-03-02 | 1982-07-27 | Smithkline Corporation | Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds |
US4438346A (en) * | 1981-10-15 | 1984-03-20 | Advanced Micro Devices, Inc. | Regulated substrate bias generator for random access memory |
AU560459B2 (en) * | 1982-06-01 | 1987-04-09 | Abbott Laboratories | Tetrahydro-benzo(e) isoindolines |
US4618683A (en) * | 1982-06-01 | 1986-10-21 | Abbott Laboratories | Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives |
SE8302361D0 (sv) * | 1983-04-27 | 1983-04-27 | Astra Laekemedel Ab | New tricyclic amines |
DE3401931C2 (de) * | 1984-01-20 | 1986-06-12 | Continental Gummi-Werke Ag, 3000 Hannover | Biegsamer Schlauch |
DE3576334D1 (de) * | 1984-07-25 | 1990-04-12 | Abbott Lab | 1,2,3,3a,8,8a-hexahydro-indeno-(1,2-c)pyrrde. |
DE3522959A1 (de) * | 1985-06-27 | 1987-01-08 | Merck Patent Gmbh | Indolderivate |
US4842852A (en) * | 1988-03-10 | 1989-06-27 | National Starch And Chemical Corporation | Hydrocarbon tolerant hair fixing compositions |
-
1989
- 1989-12-07 AT AT90900592T patent/ATE139230T1/de not_active IP Right Cessation
- 1989-12-07 KR KR1019900701796A patent/KR910700251A/ko not_active Application Discontinuation
- 1989-12-07 JP JP2500906A patent/JPH03502701A/ja active Pending
- 1989-12-07 EP EP90900592A patent/EP0422134B1/en not_active Expired - Lifetime
- 1989-12-07 WO PCT/US1989/005512 patent/WO1990006927A1/en active IP Right Grant
- 1989-12-07 AU AU47460/90A patent/AU626621B2/en not_active Ceased
- 1989-12-07 ES ES90900592T patent/ES2090119T3/es not_active Expired - Lifetime
- 1989-12-07 DE DE68926673T patent/DE68926673T2/de not_active Expired - Fee Related
- 1989-12-13 CA CA002005441A patent/CA2005441A1/en not_active Abandoned
-
1990
- 1990-08-15 DK DK194490A patent/DK171061B1/da not_active IP Right Cessation
-
1995
- 1995-03-10 DK DK024595A patent/DK24595A/da unknown
Also Published As
Publication number | Publication date |
---|---|
DE68926673T2 (de) | 1997-01-16 |
AU626621B2 (en) | 1992-08-06 |
AU4746090A (en) | 1990-07-10 |
EP0422134A1 (en) | 1991-04-17 |
DK194490A (da) | 1990-10-12 |
WO1990006927A1 (en) | 1990-06-28 |
EP0422134B1 (en) | 1996-06-12 |
DE68926673D1 (de) | 1996-07-18 |
KR910700251A (ko) | 1991-03-14 |
ATE139230T1 (de) | 1996-06-15 |
DK194490D0 (da) | 1990-08-15 |
DK24595A (da) | 1995-03-10 |
JPH03502701A (ja) | 1991-06-20 |
EP0422134A4 (en) | 1992-05-06 |
ES2090119T3 (es) | 1996-10-16 |
CA2005441A1 (en) | 1990-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |