ES2090119T3 - Agentes selectivos de 5-ht. - Google Patents

Agentes selectivos de 5-ht.

Info

Publication number
ES2090119T3
ES2090119T3 ES90900592T ES90900592T ES2090119T3 ES 2090119 T3 ES2090119 T3 ES 2090119T3 ES 90900592 T ES90900592 T ES 90900592T ES 90900592 T ES90900592 T ES 90900592T ES 2090119 T3 ES2090119 T3 ES 2090119T3
Authority
ES
Spain
Prior art keywords
alkoxy
selective agents
hexahydro
selective
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90900592T
Other languages
English (en)
Inventor
John F Debernardis
Michael D Meyer
Kevin B Sippy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2090119T3 publication Critical patent/ES2090119T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Networks Using Active Elements (AREA)
  • Amplifiers (AREA)

Abstract

PIRROLES [1,2-C]HEXAHIDROINDENOL-1,2,3,3A,8,8A-ALCOXI-8 SUSTITUIDO; PIRROLIDINES[1,2-C]INDENO-1H-HEXAHIDRO-2,3,4,4A,9,9A-ALCOXI-5; E ISOINDOLES[E]BENZ-1H-HEXAHIDRO-2,3,3A,4,5,9A-ALCOXI-9, SON AGENTES RECEPTORES 5-HT SELECTIVOS Y SON ASI UTILES EN EL TRATAMIENTO DE ANSIEDAD, DEPRESION E HIPERTENSION.
ES90900592T 1988-12-15 1989-12-07 Agentes selectivos de 5-ht. Expired - Lifetime ES2090119T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28513488A 1988-12-15 1988-12-15

Publications (1)

Publication Number Publication Date
ES2090119T3 true ES2090119T3 (es) 1996-10-16

Family

ID=23092880

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90900592T Expired - Lifetime ES2090119T3 (es) 1988-12-15 1989-12-07 Agentes selectivos de 5-ht.

Country Status (10)

Country Link
EP (1) EP0422134B1 (es)
JP (1) JPH03502701A (es)
KR (1) KR910700251A (es)
AT (1) ATE139230T1 (es)
AU (1) AU626621B2 (es)
CA (1) CA2005441A1 (es)
DE (1) DE68926673T2 (es)
DK (2) DK171061B1 (es)
ES (1) ES2090119T3 (es)
WO (1) WO1990006927A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9014061D0 (en) * 1990-06-25 1990-08-15 Merck Sharp & Dohme Therapeutic agents
EP0539209A1 (en) * 1991-10-24 1993-04-28 The Upjohn Company Benzo-isoquinoline derivatives and analogs and their use in therapeutics
JPH07500333A (ja) * 1991-10-24 1995-01-12 ジ・アップジョン・カンパニー ベンゾ−イソキノリン誘導体
US5512566A (en) * 1993-10-25 1996-04-30 Ortho Pharmaceutical Corporation Tricyclic compounds having affinity for the 5-HT1A receptor
KR950014099A (ko) * 1993-11-10 1995-06-15 장기하 N-(2-피리미딜)피페라지닐 부틸아미드의 제조방법
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
WO2002044159A2 (en) 2000-11-29 2002-06-06 Eli Lilly And Company 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine and pharmaceutically acceptable salts and solvates thereof and their use in the treatment of incontinence
KR101257233B1 (ko) 2004-07-29 2013-04-29 아더시스 인코포레이티드 세로토닌 수용체 조절제로서의 트리사이클릭 인데노-피롤유도체
TW200924752A (en) * 2007-09-17 2009-06-16 Organon Nv Tricyclic heterocyclic derivatives
TW201041851A (en) 2009-03-10 2010-12-01 Organon Nv Tricyclic heterocyclic derivatives
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
SG10201706590VA (en) 2009-05-22 2017-09-28 Abbvie Inc Modulators of 5-ht receptors and methods of use thereof
KR101770979B1 (ko) 2010-05-21 2017-08-24 애브비 인코포레이티드 5­ｈｔ 수용체의 조절제 및 이의 사용방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792374A (fr) * 1971-12-08 1973-06-06 Allen & Hanburys Ltd Nouveaux derives d'isoindoline
US4341786A (en) * 1981-03-02 1982-07-27 Smithkline Corporation Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds
US4438346A (en) * 1981-10-15 1984-03-20 Advanced Micro Devices, Inc. Regulated substrate bias generator for random access memory
AU560459B2 (en) * 1982-06-01 1987-04-09 Abbott Laboratories Tetrahydro-benzo(e) isoindolines
US4618683A (en) * 1982-06-01 1986-10-21 Abbott Laboratories Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives
SE8302361D0 (sv) * 1983-04-27 1983-04-27 Astra Laekemedel Ab New tricyclic amines
DE3401931C2 (de) * 1984-01-20 1986-06-12 Continental Gummi-Werke Ag, 3000 Hannover Biegsamer Schlauch
DE3576334D1 (de) * 1984-07-25 1990-04-12 Abbott Lab 1,2,3,3a,8,8a-hexahydro-indeno-(1,2-c)pyrrde.
DE3522959A1 (de) * 1985-06-27 1987-01-08 Merck Patent Gmbh Indolderivate
US4842852A (en) * 1988-03-10 1989-06-27 National Starch And Chemical Corporation Hydrocarbon tolerant hair fixing compositions

Also Published As

Publication number Publication date
WO1990006927A1 (en) 1990-06-28
DK194490A (da) 1990-10-12
AU4746090A (en) 1990-07-10
DE68926673T2 (de) 1997-01-16
DK24595A (da) 1995-03-10
EP0422134A1 (en) 1991-04-17
DK171061B1 (da) 1996-05-13
DE68926673D1 (de) 1996-07-18
EP0422134A4 (en) 1992-05-06
AU626621B2 (en) 1992-08-06
KR910700251A (ko) 1991-03-14
EP0422134B1 (en) 1996-06-12
DK194490D0 (da) 1990-08-15
ATE139230T1 (de) 1996-06-15
CA2005441A1 (en) 1990-06-15
JPH03502701A (ja) 1991-06-20

Similar Documents

Publication Publication Date Title
ES2090119T3 (es) Agentes selectivos de 5-ht.
DK0992510T3 (da) N6-heterocyklisk substituerede adenosinderivater
MY131298A (en) 5-heteroyl indole derivatives
ES2146627T3 (es) Metalocenos de bis-fluorenilo y su uso.
DE69611315T2 (de) 5-Substituierte-3-(1,2,3,6-Tetrahydropyridin-4-yl) und 3-(Piperidin-4-yl)-1H-indole: 5-HT1F Agonisten
FI962350A0 (fi) BPM-12, BMP-13 sekä niiden jännettä indusoivat koostumukset
CY1111863T1 (el) Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων
FI970310A (fi) 4-indolijohdannaiset serotoniinin vaikuttaja- ja vastavaikuttaja-aineina
ATE82574T1 (de) Bis-aza-bicyclische anxiolytica und antidepressiva.
BR9606743A (pt) Derivados indol úteis no tratamento de osteoporose
DE69023792D1 (de) Ultraschallgenerator und akustisches Mikroskop mit Ultraschall.
EE03682B1 (et) Asendatud bensimidasooli derivaadid, protsessid nende valmistamiseks ning nende kasutamine
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
NO963331D0 (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
DE69610793D1 (de) 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
ID23156A (id) Turunan-turunan amidina, proses pembuatan komposisi dan penggunaannya
ES2061024T3 (es) Uso terapeutico de antagonistas de receptores de 5-ht3.
GR890100826A (en) Method of preparation of s-ht selective agents
IT8920015A0 (it) Copolimeri transesterificati dell'anidride maleica, particolarmente utili nel campo della detergenza.
DE59001699D1 (de) Vorrichtung zum querschneiden und querschweissen von bahnen.
FI971854A (fi) Substituoituja tetrasyklisiä atsepiinijohdannaisia, joilla on 5-HT2-reseptoriaffiniteetti
SE8502865D0 (sv) Naphtoxazine, ihre herstellung und verwendung
DE68918639D1 (de) Färbehilfsmittelzusammensetzung und Färbeverfahren.
FR2735776B1 (fr) Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
DE58907569D1 (de) Isomere Trimethylbicyclo[4.3.0]nonan-Derivate.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 422134

Country of ref document: ES

FG2A Definitive protection

Ref document number: 422134

Country of ref document: ES