DK1572994T3 - Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer - Google Patents
Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorerInfo
- Publication number
- DK1572994T3 DK1572994T3 DK03782989T DK03782989T DK1572994T3 DK 1572994 T3 DK1572994 T3 DK 1572994T3 DK 03782989 T DK03782989 T DK 03782989T DK 03782989 T DK03782989 T DK 03782989T DK 1572994 T3 DK1572994 T3 DK 1572994T3
- Authority
- DK
- Denmark
- Prior art keywords
- chromatin
- openers
- methods
- nucleic acid
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
- C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02080479 | 2002-12-20 | ||
EP03075089 | 2003-01-13 | ||
PCT/NL2003/000909 WO2004056986A2 (en) | 2002-12-20 | 2003-12-19 | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1572994T3 true DK1572994T3 (da) | 2007-05-29 |
Family
ID=32683814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03782989T DK1572994T3 (da) | 2002-12-20 | 2003-12-19 | Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer |
Country Status (7)
Country | Link |
---|---|
US (1) | US8263393B2 (da) |
EP (1) | EP1572994B1 (da) |
AT (1) | ATE354645T1 (da) |
AU (1) | AU2003290453A1 (da) |
DE (1) | DE60312039T2 (da) |
DK (1) | DK1572994T3 (da) |
WO (1) | WO2004056986A2 (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1600510B1 (en) | 2001-07-04 | 2007-03-28 | Chromagenics B.V. | DNA sequences having anti-repressor activity |
DK1513937T3 (da) | 2002-06-14 | 2011-05-16 | Chromagenics Bv | Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved |
AU2003243059A1 (en) | 2002-06-14 | 2003-12-31 | Chromagenics B.V. | Use of repression blocking sequences in methods for enhancing gene expression |
ES2373549T3 (es) | 2002-12-18 | 2012-02-06 | Chromagenics B.V. | Método para mejorar la producción de proteínas. |
AU2003290453A1 (en) | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
NZ551510A (en) * | 2004-07-08 | 2009-10-30 | Chromagenics Bv | Anti-repressor sequences for improving expression of nucleic acid |
SI1809750T1 (sl) | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
MX2007004595A (es) * | 2004-11-08 | 2007-08-15 | Chromagenics Bv | Seleccion de celulas hospederas que expresan proteinas en altas concentraciones. |
US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
ES2687447T3 (es) * | 2008-11-28 | 2018-10-25 | Anton Bauer | Vector cromosómico artificial |
US8476019B2 (en) | 2009-10-30 | 2013-07-02 | Synaptic Research, Llc | Enhanced gene expression in algae |
CN105658792B (zh) * | 2012-02-28 | 2020-11-10 | 西格马-奥尔德里奇有限责任公司 | 靶向组蛋白乙酰化 |
CA2944813A1 (en) | 2014-05-19 | 2015-11-26 | F. Hoffmann-La Roche Ag | Method for selection of a long-term producing cell using histone acetylation and cmv promoter methylation as markers |
WO2021167994A1 (en) * | 2020-02-17 | 2021-08-26 | The Regents Of The University Of California | Light-inducible gene activation systems and methods for making and using them |
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FR2569723B1 (fr) * | 1984-08-31 | 1986-09-19 | Centre Nat Rech Scient | Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique |
CA2063799A1 (en) | 1989-07-24 | 1991-01-25 | Frank S. Genbauffe | Prevention of internal initiation |
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US6319707B1 (en) * | 1991-08-12 | 2001-11-20 | Fred Hutchinson Cancer Research Center Board Regents Of The University Of Washington | Cap-independent multicistronic retroviral vectors |
JP2686025B2 (ja) * | 1992-08-25 | 1997-12-08 | 理化学研究所 | ブラストサイジンsデアミナーゼ遺伝子 |
DE4228458A1 (de) * | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
DE669986T1 (de) | 1992-11-13 | 1996-10-10 | Idec Pharma Corp | Völlig unfunktionelle konsensus-kozak-sequenzen zur säugetier-exprimierung. |
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US5610053A (en) | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
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AU2003243059A1 (en) * | 2002-06-14 | 2003-12-31 | Chromagenics B.V. | Use of repression blocking sequences in methods for enhancing gene expression |
DK1513937T3 (da) | 2002-06-14 | 2011-05-16 | Chromagenics Bv | Fremgangsmåde til den samtidige produktion af multiple proteiner; vektorer og celler til anvendelse derved |
AU2003263161A1 (en) | 2002-09-20 | 2004-04-08 | Novo Nordisk A/S | Method for making recombinant proteins |
ES2373549T3 (es) * | 2002-12-18 | 2012-02-06 | Chromagenics B.V. | Método para mejorar la producción de proteínas. |
AU2003290453A1 (en) | 2002-12-20 | 2004-07-14 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
CN1846000B (zh) * | 2003-09-05 | 2012-10-03 | 金克克国际有限公司 | Hpv cd8+t细胞表位 |
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NZ551510A (en) * | 2004-07-08 | 2009-10-30 | Chromagenics Bv | Anti-repressor sequences for improving expression of nucleic acid |
US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
SI1809750T1 (sl) * | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
US8039230B2 (en) * | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
MX2007004595A (es) * | 2004-11-08 | 2007-08-15 | Chromagenics Bv | Seleccion de celulas hospederas que expresan proteinas en altas concentraciones. |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
SI1987150T1 (sl) | 2006-02-21 | 2011-09-30 | Chromagenics Bv | Selekcija gostiteljskih celic, ki eksprimirajo protein pri visokih nivojih |
US7968700B2 (en) * | 2006-03-20 | 2011-06-28 | Chromagenics B.V. | Expression augmenting DNA fragments, use thereof, and methods for finding thereof |
-
2003
- 2003-12-19 AU AU2003290453A patent/AU2003290453A1/en not_active Abandoned
- 2003-12-19 EP EP03782989A patent/EP1572994B1/en not_active Expired - Lifetime
- 2003-12-19 WO PCT/NL2003/000909 patent/WO2004056986A2/en active IP Right Grant
- 2003-12-19 AT AT03782989T patent/ATE354645T1/de not_active IP Right Cessation
- 2003-12-19 DE DE60312039T patent/DE60312039T2/de not_active Expired - Lifetime
- 2003-12-19 DK DK03782989T patent/DK1572994T3/da active
-
2005
- 2005-06-20 US US11/156,910 patent/US8263393B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2003290453A8 (en) | 2004-07-14 |
WO2004056986A2 (en) | 2004-07-08 |
AU2003290453A1 (en) | 2004-07-14 |
US8263393B2 (en) | 2012-09-11 |
EP1572994B1 (en) | 2007-02-21 |
DE60312039T2 (de) | 2007-11-08 |
ATE354645T1 (de) | 2007-03-15 |
DE60312039D1 (de) | 2007-04-05 |
US20060003416A1 (en) | 2006-01-05 |
EP1572994A2 (en) | 2005-09-14 |
WO2004056986A3 (en) | 2004-08-19 |
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