ATE354645T1 - Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können - Google Patents
Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen könnenInfo
- Publication number
- ATE354645T1 ATE354645T1 AT03782989T AT03782989T ATE354645T1 AT E354645 T1 ATE354645 T1 AT E354645T1 AT 03782989 T AT03782989 T AT 03782989T AT 03782989 T AT03782989 T AT 03782989T AT E354645 T1 ATE354645 T1 AT E354645T1
- Authority
- AT
- Austria
- Prior art keywords
- chromatin
- openers
- accessible
- methods
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
- C12N2840/206—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02080479 | 2002-12-20 | ||
EP03075089 | 2003-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE354645T1 true ATE354645T1 (de) | 2007-03-15 |
Family
ID=32683814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03782989T ATE354645T1 (de) | 2002-12-20 | 2003-12-19 | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
Country Status (7)
Country | Link |
---|---|
US (1) | US8263393B2 (de) |
EP (1) | EP1572994B1 (de) |
AT (1) | ATE354645T1 (de) |
AU (1) | AU2003290453A1 (de) |
DE (1) | DE60312039T2 (de) |
DK (1) | DK1572994T3 (de) |
WO (1) | WO2004056986A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60236331D1 (de) | 2001-07-04 | 2010-06-17 | Chromagenics Bv | DNS-Sequenzen mit Anti-Repressor-Aktivität |
WO2003106674A2 (en) | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
ATE524559T1 (de) | 2002-12-18 | 2011-09-15 | Chromagenics Bv | Methode zur verbesserung der proteinproduktion |
DE60312039T2 (de) | 2002-12-20 | 2007-11-08 | Chromagenics B.V. | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
JP4805262B2 (ja) * | 2004-07-08 | 2011-11-02 | クロマジェニックス ベー ヴェー | 核酸の発現を改善するための新規配列 |
US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
EA010863B1 (ru) * | 2004-11-08 | 2008-12-30 | Хромагеникс Б.В. | Отбор клеток-хозяев, экспрессирующих белок на высоких уровнях |
ES2384391T3 (es) | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
DK2356241T3 (en) * | 2008-11-28 | 2018-09-17 | Anton Bauer | ARTIFICIAL CHROMOSOM VECTOR |
KR20120092647A (ko) | 2009-10-30 | 2012-08-21 | 시냅틱 리서치, 엘엘씨 | 조류에서 향상된 유전자 발현 |
JP6309461B2 (ja) * | 2012-02-28 | 2018-04-11 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co., LLC | ヒストンアセチル化の標的化 |
BR112016025972B1 (pt) * | 2014-05-19 | 2022-04-19 | F. Hoffmann-La Roche Ag | Métodos para selecionar um clone celular/linhagem celular e método para a produção de um polipeptídeo |
WO2021167994A1 (en) * | 2020-02-17 | 2021-08-26 | The Regents Of The University Of California | Light-inducible gene activation systems and methods for making and using them |
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FR2569723B1 (fr) * | 1984-08-31 | 1986-09-19 | Centre Nat Rech Scient | Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique |
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JP2686025B2 (ja) * | 1992-08-25 | 1997-12-08 | 理化学研究所 | ブラストサイジンsデアミナーゼ遺伝子 |
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CN100365127C (zh) * | 1998-07-21 | 2008-01-30 | 密理博公司 | 具有遍在染色质开放表达元件(ucoe)的聚核苷酸 |
ATE370247T1 (de) * | 1998-08-14 | 2007-09-15 | Chromagenics Bv | Dns sequenz, verfahren für dessen nachweis und herstellung und ihre benutzung |
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WO2003106674A2 (en) * | 2002-06-14 | 2003-12-24 | Chromagenics B.V. | Means and methods for regulating gene expression |
CA2489475C (en) | 2002-06-14 | 2011-03-29 | Chromagenics B.V. | A method for simultaneous production of multiple proteins; vectors and cells for use therein |
EP1554389A2 (de) | 2002-09-20 | 2005-07-20 | Novo Nordisk A/S | Verfahren zur herstellung von rekombinanten proteinen |
ATE524559T1 (de) * | 2002-12-18 | 2011-09-15 | Chromagenics Bv | Methode zur verbesserung der proteinproduktion |
DE60312039T2 (de) | 2002-12-20 | 2007-11-08 | Chromagenics B.V. | Mittel und methoden zur produktion eines proteins durch chromatin-öffner, die chromatin zugänglicher für transkriptionsfaktoren machen können |
EP1660686B1 (de) * | 2003-09-05 | 2012-05-09 | Genencor International, Inc. | Hpv cd8+ t-zell-epitope |
CN1863913B (zh) | 2003-10-24 | 2011-01-12 | 思兰克斯有限公司 | 通过mar序列的多次转染过程在哺乳动物细胞中实现高效基因转移和表达 |
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US8039230B2 (en) * | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20060195935A1 (en) * | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
ES2384391T3 (es) * | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
EA010863B1 (ru) | 2004-11-08 | 2008-12-30 | Хромагеникс Б.В. | Отбор клеток-хозяев, экспрессирующих белок на высоких уровнях |
JP5225107B2 (ja) | 2006-02-21 | 2013-07-03 | クロマジェニックス ベー ヴェー | 高レベルでタンパク質を発現する宿主細胞の選択 |
US7968700B2 (en) * | 2006-03-20 | 2011-06-28 | Chromagenics B.V. | Expression augmenting DNA fragments, use thereof, and methods for finding thereof |
-
2003
- 2003-12-19 DE DE60312039T patent/DE60312039T2/de not_active Expired - Lifetime
- 2003-12-19 DK DK03782989T patent/DK1572994T3/da active
- 2003-12-19 AT AT03782989T patent/ATE354645T1/de not_active IP Right Cessation
- 2003-12-19 WO PCT/NL2003/000909 patent/WO2004056986A2/en active IP Right Grant
- 2003-12-19 EP EP03782989A patent/EP1572994B1/de not_active Expired - Lifetime
- 2003-12-19 AU AU2003290453A patent/AU2003290453A1/en not_active Abandoned
-
2005
- 2005-06-20 US US11/156,910 patent/US8263393B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2003290453A8 (en) | 2004-07-14 |
AU2003290453A1 (en) | 2004-07-14 |
EP1572994B1 (de) | 2007-02-21 |
WO2004056986A3 (en) | 2004-08-19 |
DE60312039D1 (de) | 2007-04-05 |
WO2004056986A2 (en) | 2004-07-08 |
US20060003416A1 (en) | 2006-01-05 |
US8263393B2 (en) | 2012-09-11 |
DK1572994T3 (da) | 2007-05-29 |
EP1572994A2 (de) | 2005-09-14 |
DE60312039T2 (de) | 2007-11-08 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |