NO20055210L - Inhibitorproteiner av en protease og anvendelse derav - Google Patents
Inhibitorproteiner av en protease og anvendelse deravInfo
- Publication number
- NO20055210L NO20055210L NO20055210A NO20055210A NO20055210L NO 20055210 L NO20055210 L NO 20055210L NO 20055210 A NO20055210 A NO 20055210A NO 20055210 A NO20055210 A NO 20055210A NO 20055210 L NO20055210 L NO 20055210L
- Authority
- NO
- Norway
- Prior art keywords
- protease
- inhibitor protein
- sequence
- chimeric inhibitor
- purified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Den foreliggende oppfinnelsen vedrører et kimert hemmerprotein til en protease som omfatter en hemmende polypeptidlignende sekvens, og minst en polypeptidlignende sekvens til et substrat-enzyminteraksjonssete som er spesifikt for en protease. Andre temaer i oppfinnelsen er å tilveiebringe en renset og isolert DNA-sekvens som koder for det kimere hemmerproteinet til en protease, en ekspresjonsvektor som er karakterisert ved at den omfatter nevnte, rensede og isolerte DNA-sekvens, en eukaryot eller prokaryot vertscelle transformert med denne ekspresjonsvektor og en fremgangsmåte for å produsere et kimert hemmerprotein.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46034503P | 2003-04-04 | 2003-04-04 | |
PCT/IB2004/001040 WO2004087912A1 (en) | 2003-04-04 | 2004-04-05 | Inhibitor proteins of a protease and use thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20055210D0 NO20055210D0 (no) | 2005-11-04 |
NO20055210L true NO20055210L (no) | 2005-12-23 |
NO334459B1 NO334459B1 (no) | 2014-03-10 |
Family
ID=33131923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20055210A NO334459B1 (no) | 2003-04-04 | 2005-11-04 | Kallikrein inhibitor, DNA, vektor, vertcelle, farmasøytisk sammensetning, kit, anvendelse samt fremgangsmåte for fremstilling. |
Country Status (19)
Country | Link |
---|---|
US (1) | US8975370B2 (no) |
EP (1) | EP1616007B1 (no) |
JP (1) | JP4754478B2 (no) |
KR (1) | KR101296367B1 (no) |
CN (1) | CN1798838B (no) |
AU (1) | AU2004225718B2 (no) |
BR (1) | BRPI0409557B8 (no) |
CA (1) | CA2521410C (no) |
CY (1) | CY1114526T1 (no) |
DK (1) | DK1616007T3 (no) |
ES (1) | ES2431548T3 (no) |
IL (1) | IL171158A (no) |
MX (1) | MXPA05010574A (no) |
NO (1) | NO334459B1 (no) |
PL (1) | PL1616007T3 (no) |
PT (1) | PT1616007E (no) |
SG (1) | SG161106A1 (no) |
SI (1) | SI1616007T1 (no) |
WO (1) | WO2004087912A1 (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2902501B1 (en) | 2002-01-28 | 2020-04-15 | Life Technologies Corporation | Preparing crude biological extracts using protease, suitable for preparing cDNA |
WO2006090282A2 (en) * | 2005-02-28 | 2006-08-31 | Universite De Lausanne | Recombinant inhibitor proteins of an hk14 protease and use thereof |
US7964350B1 (en) | 2007-05-18 | 2011-06-21 | Applied Biosystems, Llc | Sample preparation for in situ nucleic acid analysis |
CN110522905A (zh) * | 2008-01-21 | 2019-12-03 | 德莫迪斯公司 | 丝氨酸蛋白酶抑制剂在治疗皮肤病中的用途 |
EP2955233A1 (en) | 2008-12-19 | 2015-12-16 | Life Technologies Corporation | Proteinase K inhibitors, methods and compositions therefor |
AU2010222537B2 (en) * | 2009-03-10 | 2016-06-30 | Med Discovery Sa | Use of serine protease inhibitors in the treatment of neutropenia |
SG195083A1 (en) * | 2011-05-26 | 2013-12-30 | Baxter Int | Solid phase-bound elastase-binding assay for the measurement of alpha1,-antitrypsin activity |
CN103044542B (zh) * | 2012-08-17 | 2015-08-19 | 常熟理工学院 | 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用 |
CN117169519B (zh) * | 2023-10-26 | 2024-01-30 | 艾康生物技术(杭州)有限公司 | 用于检测样本中tt3和/或tt4的解离剂和试剂盒 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
ATE226636T1 (de) * | 1989-03-06 | 2002-11-15 | Univ Texas | Serpin-resistenter t-pa; mutanten; gene |
US5612194A (en) * | 1989-06-23 | 1997-03-18 | Trustees Of The University Of Pennsylvania | Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors |
US5723316A (en) | 1989-06-23 | 1998-03-03 | Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin analogues having chymase inhibiting activity |
US5827662A (en) | 1989-06-23 | 1998-10-27 | The Trustees Of The University Of Pennsylvania | Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
ATE275583T1 (de) | 1994-01-11 | 2004-09-15 | Dyax Corp | KALLIKREINHEMMENDE ßKUNITZ-DOMÄNEß-PROTEINE UND DERIVATEN DAVON |
US6284873B1 (en) | 1999-03-12 | 2001-09-04 | Hybritech Incorporated | Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex |
-
2004
- 2004-04-05 WO PCT/IB2004/001040 patent/WO2004087912A1/en active Application Filing
- 2004-04-05 US US10/552,786 patent/US8975370B2/en active Active
- 2004-04-05 ES ES04725742T patent/ES2431548T3/es not_active Expired - Lifetime
- 2004-04-05 CA CA2521410A patent/CA2521410C/en not_active Expired - Lifetime
- 2004-04-05 PL PL04725742T patent/PL1616007T3/pl unknown
- 2004-04-05 JP JP2006506440A patent/JP4754478B2/ja not_active Expired - Lifetime
- 2004-04-05 BR BRPI0409557-0 patent/BRPI0409557B8/pt active IP Right Grant
- 2004-04-05 PT PT47257423T patent/PT1616007E/pt unknown
- 2004-04-05 CN CN2004800152687A patent/CN1798838B/zh not_active Expired - Lifetime
- 2004-04-05 SG SG200718462-5A patent/SG161106A1/en unknown
- 2004-04-05 MX MXPA05010574A patent/MXPA05010574A/es active IP Right Grant
- 2004-04-05 DK DK04725742.3T patent/DK1616007T3/da active
- 2004-04-05 AU AU2004225718A patent/AU2004225718B2/en not_active Expired
- 2004-04-05 KR KR1020057018938A patent/KR101296367B1/ko active IP Right Grant
- 2004-04-05 EP EP04725742.3A patent/EP1616007B1/en not_active Expired - Lifetime
- 2004-04-05 SI SI200432098T patent/SI1616007T1/sl unknown
-
2005
- 2005-09-28 IL IL171158A patent/IL171158A/en active IP Right Grant
- 2005-11-04 NO NO20055210A patent/NO334459B1/no unknown
-
2013
- 2013-10-23 CY CY20131100937T patent/CY1114526T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR101296367B1 (ko) | 2013-08-14 |
SG161106A1 (en) | 2010-05-27 |
WO2004087912A8 (en) | 2005-01-20 |
JP4754478B2 (ja) | 2011-08-24 |
EP1616007A1 (en) | 2006-01-18 |
EP1616007B1 (en) | 2013-07-24 |
MXPA05010574A (es) | 2006-03-09 |
BRPI0409557A (pt) | 2006-04-18 |
US8975370B2 (en) | 2015-03-10 |
PL1616007T3 (pl) | 2013-12-31 |
AU2004225718B2 (en) | 2009-11-05 |
DK1616007T3 (da) | 2013-10-28 |
ES2431548T3 (es) | 2013-11-26 |
SI1616007T1 (sl) | 2013-12-31 |
CY1114526T1 (el) | 2016-10-05 |
KR20060010740A (ko) | 2006-02-02 |
CN1798838B (zh) | 2012-01-04 |
US20060269536A1 (en) | 2006-11-30 |
CA2521410C (en) | 2014-06-03 |
PT1616007E (pt) | 2013-10-28 |
CN1798838A (zh) | 2006-07-05 |
NO334459B1 (no) | 2014-03-10 |
BRPI0409557B1 (pt) | 2019-07-23 |
NO20055210D0 (no) | 2005-11-04 |
IL171158A (en) | 2011-05-31 |
WO2004087912A1 (en) | 2004-10-14 |
CA2521410A1 (en) | 2004-10-14 |
JP2006523097A (ja) | 2006-10-12 |
AU2004225718A1 (en) | 2004-10-14 |
BRPI0409557B8 (pt) | 2021-05-25 |
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