DK1280531T3 - Formulering bestående af phentolaminmesylat og anvendelse heraf - Google Patents

Formulering bestående af phentolaminmesylat og anvendelse heraf

Info

Publication number
DK1280531T3
DK1280531T3 DK01933419T DK01933419T DK1280531T3 DK 1280531 T3 DK1280531 T3 DK 1280531T3 DK 01933419 T DK01933419 T DK 01933419T DK 01933419 T DK01933419 T DK 01933419T DK 1280531 T3 DK1280531 T3 DK 1280531T3
Authority
DK
Denmark
Prior art keywords
adrenergic receptor
alpha adrenergic
phentolamine mesylate
anesthesia
local
Prior art date
Application number
DK01933419T
Other languages
English (en)
Inventor
Eckard Weber
Howard I Katz
Original Assignee
Novalar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novalar Pharmaceuticals Inc filed Critical Novalar Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1280531T3 publication Critical patent/DK1280531T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
DK01933419T 2000-05-12 2001-05-11 Formulering bestående af phentolaminmesylat og anvendelse heraf DK1280531T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20380000P 2000-05-12 2000-05-12
US23585500P 2000-09-27 2000-09-27
PCT/US2001/040711 WO2001085171A1 (en) 2000-05-12 2001-05-11 Local anesthetic methods and kits

Publications (1)

Publication Number Publication Date
DK1280531T3 true DK1280531T3 (da) 2007-05-29

Family

ID=26898913

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01933419T DK1280531T3 (da) 2000-05-12 2001-05-11 Formulering bestående af phentolaminmesylat og anvendelse heraf

Country Status (14)

Country Link
US (8) US6432401B2 (da)
EP (2) EP1762236B1 (da)
JP (2) JP2003532678A (da)
AT (1) ATE352300T1 (da)
AU (3) AU2001259848B2 (da)
CA (1) CA2408417C (da)
CY (1) CY1107617T1 (da)
DE (1) DE60126265T2 (da)
DK (1) DK1280531T3 (da)
ES (1) ES2281418T3 (da)
NZ (1) NZ522930A (da)
PT (1) PT1280531E (da)
WO (1) WO2001085171A1 (da)
ZA (1) ZA200209811B (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085171A1 (en) 2000-05-12 2001-11-15 Novalar Pharmaceuticals, Inc. Local anesthetic methods and kits
CN100391460C (zh) * 2002-06-20 2008-06-04 诺瓦乐医药公司 α-肾上腺素能受体拮抗剂的稳定配方及其用途
US7229630B2 (en) * 2002-06-20 2007-06-12 Novalar Pharmaceuticals, Inc. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
JP4787977B2 (ja) * 2002-06-20 2011-10-05 セプトドン ホールディング エスエーエス αアドレナリン受容体アンタゴニストの安定化製剤およびその利用
US20030236306A1 (en) * 2002-06-20 2003-12-25 Chen Andrew X. Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof
WO2008109124A1 (en) * 2007-03-06 2008-09-12 Novalar Pharmaceuticals, Inc. Use of nitroglycerin to reverse local anesthesia
US20090143436A1 (en) * 2007-11-06 2009-06-04 Weg Stuart L Anesthetic composition, formulation and method of use
WO2009066972A1 (es) * 2007-11-20 2009-05-28 Innovamédica S.A.P.I. De C.V. Jeringa electrónica con sistema de seguridad para inyección espinal
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8170659B2 (en) * 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8989858B2 (en) 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8195287B2 (en) * 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US20090149799A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for chemical modulation of neural activity
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US8523569B2 (en) * 2007-12-28 2013-09-03 Khashayar Kevin Neshat Controlled release local anesthetic for post dental surgery and method of use
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
NZ588638A (en) 2008-04-14 2012-09-28 Halozyme Inc Screening method for identifying a subject for treatment with a modified hyaluronidase polypeptides
US20110262407A1 (en) * 2008-11-11 2011-10-27 Targacept, Inc. Treatment with alpha7 selective ligands
SE533552C2 (sv) * 2008-12-30 2010-10-26 Igeloesa Transplantation Science Ab Förfarande och lösning för behandling av en potentiell organdonator
US20110229451A2 (en) * 2009-03-06 2011-09-22 Halozyme, Inc. Temperature sensitive mutants of matrix metalloproteases and uses thereof
CA2761283A1 (en) * 2009-05-29 2010-12-02 Galderma Research & Development Combination of adrenergic receptor agonist .alpha.-1 or .alpha.-2, preferably brimonidine with fillers, preferablyhyaluronic acid
WO2011001676A1 (ja) 2009-07-02 2011-01-06 国立大学法人山口大学 表面麻酔剤
FR2951450B1 (fr) 2009-10-20 2011-12-09 Commissariat Energie Atomique Peptides a proprietes d'antagoniste selectif des recepteurs adrenergiques alpha 2 et leurs applications
SE534862C2 (sv) 2010-05-14 2012-01-24 Vivoline Medical Ab Användning av en medicinsk vätska för behandling av ett uttaget organ
US8997136B2 (en) 2010-07-22 2015-03-31 Time Warner Cable Enterprises Llc Apparatus and methods for packetized content delivery over a bandwidth-efficient network
RU2537184C2 (ru) * 2010-08-06 2014-12-27 Галдерма Ресерч Энд Девелопмент Комбинация соединений для лечения или предотвращения кожных заболеваний
US20130310422A1 (en) 2010-09-01 2013-11-21 The General Hospital Corporation Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine
US9602414B2 (en) 2011-02-09 2017-03-21 Time Warner Cable Enterprises Llc Apparatus and methods for controlled bandwidth reclamation
BR112013022949A2 (pt) * 2011-03-07 2016-12-06 3M Innovative Properties Co dispositivo e métodos de microagulha
WO2014107745A1 (en) 2013-01-07 2014-07-10 Halozyme, Inc. Metal sensitive mutants of matrix metalloproteases and uses thereof
DK2950648T3 (da) 2013-02-01 2019-12-02 Ocuphire Pharma Inc Vandige oftalmiske opløsninger af phentolamin og medicinske anvendelser deraf
US9089560B2 (en) 2013-02-01 2015-07-28 Ocularis Pharma, Llc Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
CA2914608A1 (en) * 2013-03-14 2014-09-25 Jsn I, Llc Taste masking of anesthetics and analgesics
EP3035903B1 (en) 2013-08-20 2018-08-22 Anutra Medical, Inc. Syringe fill system and method
EP3086785A4 (en) * 2014-01-01 2017-08-30 Real Time Imaging Technologies, LLC Improved local anesthetic solution for dental and/or contrast media use
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
EP3244800A1 (en) 2015-01-12 2017-11-22 Real Time Imaging Technologies, LLC Low-dose x-ray imaging system
CA3051467C (en) 2017-01-30 2022-11-29 Nevakar, Inc Norepinephrine compositions and methods therefor
WO2019226599A1 (en) * 2018-05-22 2019-11-28 Alkalidx, Inc. Diagnostics and treatments of anesthetic insensitive subjects
WO2020023084A1 (en) * 2018-07-26 2020-01-30 Applied Biology, Inc. Taar receptor agonists for the treatment of alopecia
KR20210096096A (ko) 2018-10-26 2021-08-04 오큐파이어 파마, 인크. 노안, 산동, 및 기타 안구 장애의 치료를 위한 방법 및 조성물
CN110193011B (zh) * 2019-06-19 2022-02-11 四川美大康华康药业有限公司 一种甲磺酸酚妥拉明注射液及其制备方法
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919425A (en) * 1971-04-09 1975-11-11 Miles Lab Method of producing vasodilation using certain 3-substituted-quinazoline derivatives
IL53452A (en) * 1976-11-30 1980-12-31 Pierpaoli W Combination of drugs for the selective control of immune reactions
US4197301A (en) * 1978-10-16 1980-04-08 Allergan Pharmaceuticals, Inc. Topical ophthalmic use of Prazosin
US4508715A (en) * 1981-07-01 1985-04-02 University Of Georgia Research Foundation, Inc. Antagonism of central nervous system drugs by the administration of 4-aminopyridine alone or in combination with other drugs
SU1082432A1 (ru) * 1981-07-02 1984-03-30 Горьковский государственный медицинский институт им.С.М.Кирова Способ лечени сосудистых заболеваний мозга
DE3270634D1 (en) * 1981-11-12 1986-05-22 John Joseph Jacklich A dental syringe
US4659714A (en) 1984-03-27 1987-04-21 Dentsply, Ltd. Anesthetic methods for mammals
DK193287A (da) 1986-04-16 1987-10-17 Alcan Int Ltd Sammensat membran
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
US4938970A (en) 1987-02-06 1990-07-03 Hustead Robert E Painless electrolyte solutions
US5149320A (en) * 1988-04-11 1992-09-22 Dhaliwal Avtar S Composite anesthetic article and method of use
US5261903A (en) * 1988-04-11 1993-11-16 M.D. Inc. Composite anesthetic article and method of use
JP2824863B2 (ja) * 1989-07-12 1998-11-18 エーザイ株式会社 α▲下1▼―ブロッカー点眼剤
US5236904A (en) * 1989-09-18 1993-08-17 Senetek, Plc Erection-inducing methods and compositions
US5447912A (en) * 1989-09-18 1995-09-05 Senetek, Plc Erection-inducing methods and compositions
ATE113839T1 (de) * 1990-05-31 1994-11-15 Pfizer Arzneimittel gegen impotenz.
US5192527A (en) * 1991-07-01 1993-03-09 Abrahmsohn Glenn M Method of reversing local anesthesia and reagent system therefor
US6291528B1 (en) * 1991-07-03 2001-09-18 Nathan Earl Scott Prostaglandin E1/F2 in combination with prostaglandin F2α for enhancing female sexual arousal
US5370613A (en) * 1993-02-11 1994-12-06 Helmy; Ali M. Catheter apparatus for delivering drugs to the penis
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
JPH07258068A (ja) * 1994-03-18 1995-10-09 Kao Corp 浴用剤組成物
US5731339A (en) * 1995-04-28 1998-03-24 Zonagen, Inc. Methods and formulations for modulating the human sexual response
AU742787B2 (en) * 1997-07-09 2002-01-10 Androsolutions, Inc. Improved methods and compositions for treating male erectile dysfunction
AU1827299A (en) * 1997-12-18 1999-07-05 Nathan Earl Scott Prostaglandin e2/f2alpha combination for treating impotence and enhancing sexual arousal
EP1059940B1 (en) 1998-02-27 2010-01-20 Synchroneuron, LLC topical compositions comprising an alpha 1-adrenergic blocker FOR TREATING PAINFUL CONDITIONS OF THE ANAL REGION
JPH11282142A (ja) * 1998-03-30 1999-10-15 Fuji Photo Film Co Ltd 感光材料処理装置の処理部密閉構造
US6001845A (en) * 1998-06-19 1999-12-14 Schering Corporation Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction
US6482426B1 (en) * 1998-09-17 2002-11-19 Zonagen, Inc. Compositions for the treatment of male erectile dysfunction
US6416323B1 (en) * 2000-05-11 2002-07-09 Safety Syringes, Inc. Aspirating dental syringe with needle shield
WO2001085171A1 (en) * 2000-05-12 2001-11-15 Novalar Pharmaceuticals, Inc. Local anesthetic methods and kits

Also Published As

Publication number Publication date
JP2006225400A (ja) 2006-08-31
US20020183396A1 (en) 2002-12-05
ZA200209811B (en) 2003-12-03
US20090076023A1 (en) 2009-03-19
US6872390B2 (en) 2005-03-29
DE60126265T2 (de) 2007-10-31
EP1280531A1 (en) 2003-02-05
NZ522930A (en) 2004-10-29
ES2281418T3 (es) 2007-10-01
EP1762236A2 (en) 2007-03-14
AU5984801A (en) 2001-11-20
US20020183356A1 (en) 2002-12-05
ATE352300T1 (de) 2007-02-15
CY1107617T1 (el) 2013-03-13
EP1762236B1 (en) 2015-07-15
AU2001259848B2 (en) 2005-10-13
DE60126265D1 (de) 2007-03-15
WO2001085171A1 (en) 2001-11-15
AU2005211689B2 (en) 2008-02-21
US20050165097A1 (en) 2005-07-28
US6432401B2 (en) 2002-08-13
EP1280531A4 (en) 2005-05-11
US20050165098A1 (en) 2005-07-28
JP2003532678A (ja) 2003-11-05
EP1280531B1 (en) 2007-01-24
US6764678B2 (en) 2004-07-20
CA2408417C (en) 2009-09-15
EP1762236A3 (en) 2007-10-31
US20040198816A1 (en) 2004-10-07
PT1280531E (pt) 2007-02-28
CA2408417A1 (en) 2001-11-15
US20010056125A1 (en) 2001-12-27
US20040063747A1 (en) 2004-04-01
US7261889B2 (en) 2007-08-28
AU2005211689A1 (en) 2005-10-13

Similar Documents

Publication Publication Date Title
DK1280531T3 (da) Formulering bestående af phentolaminmesylat og anvendelse heraf
NO20024309D0 (no) Intradermal penetreringsmidler for topikal lokal anestetisk administrering
ATE431738T1 (de) Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
UY27760A1 (es) Nuevos derivados de pirrolidinio.
RS50814B (sr) Tartaratne soli 5,8,14-triazatetraciklo(10.3.1.02,11.04,9)- heksadeka-2(11),3,5,7,9-pentaena
CY1108885T1 (el) Συνδυασμοι περιλαμβανοντες αντιμουσκαρινους παραγοντες και κορτικοστεροειδη
DK1187635T3 (da) Anæstetisk formulering der omfatter en NMDA-antagonist og en alfa-2 adrenerg agonist
ATE331726T1 (de) Adenine-derivate
MXPA03007140A (es) Derivados de carbolina.
BRPI0412695A (pt) derivados de quinolina e quinazolina dotados de afinidade para receptores do tipo 5ht1
DK1199069T3 (da) Anvendelse af en estrogenagonist/-antagonist til forbedring eller bibeholdelse af urogenital sundhed
DE60302157D1 (de) Opioidrezeptorantagonisten
ATE346067T1 (de) Carbolinderivate
DE60121461D1 (de) Kondensierte pyridoindolderivate
CY1105721T1 (el) Δερματικοι αναισθητικοι παραγοντες
ATE416157T1 (de) Inhibitoren von integrin alpha-v-beta-6
ATE300543T1 (de) Kondensierte pyrazindionderivate als pde5 inhibitore
BR0314844A (pt) Novo composto
UY28007A1 (es) Tratamiento terapeutico
BR0314843A (pt) Novo composto
DE60112960D1 (de) Kondensierte pyridoindolderivate
ATE333457T1 (de) Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60301261D1 (de) Pharmazeutische zusammensetzungen enthaltend 17alpha-furanylester von 17beta-carbothioat androstanderivaten und einen muskarinrezeptorantagonist
DE60122559D1 (de) Indolderivate als pde5-inhibitoren
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE