DK1171417T3 - Fremgangsmåde til fremstilling af 3-aryloxy-3-arylpropylaminer og mellemprodukter deraf - Google Patents

Fremgangsmåde til fremstilling af 3-aryloxy-3-arylpropylaminer og mellemprodukter deraf

Info

Publication number
DK1171417T3
DK1171417T3 DK00917868T DK00917868T DK1171417T3 DK 1171417 T3 DK1171417 T3 DK 1171417T3 DK 00917868 T DK00917868 T DK 00917868T DK 00917868 T DK00917868 T DK 00917868T DK 1171417 T3 DK1171417 T3 DK 1171417T3
Authority
DK
Denmark
Prior art keywords
arylpropylamines
aryloxy
intermediates
preparation
methylpyrrolidinone
Prior art date
Application number
DK00917868T
Other languages
English (en)
Inventor
Douglas Patton Kjell
Kurt Thomas Lorenz
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1171417T3 publication Critical patent/DK1171417T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Pyrrole Compounds (AREA)
DK00917868T 1999-04-09 2000-03-22 Fremgangsmåde til fremstilling af 3-aryloxy-3-arylpropylaminer og mellemprodukter deraf DK1171417T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12848099P 1999-04-09 1999-04-09

Publications (1)

Publication Number Publication Date
DK1171417T3 true DK1171417T3 (da) 2006-02-20

Family

ID=22435565

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00917868T DK1171417T3 (da) 1999-04-09 2000-03-22 Fremgangsmåde til fremstilling af 3-aryloxy-3-arylpropylaminer og mellemprodukter deraf

Country Status (10)

Country Link
US (1) US6541668B1 (da)
EP (1) EP1171417B1 (da)
JP (1) JP2002541235A (da)
AT (1) ATE309196T1 (da)
AU (1) AU3877500A (da)
CA (1) CA2362185C (da)
DE (1) DE60023870T2 (da)
DK (1) DK1171417T3 (da)
ES (1) ES2249256T3 (da)
WO (1) WO2000061540A1 (da)

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ATE526954T1 (de) * 2003-07-28 2011-10-15 Leslie Joe Dunaway Atomoxetin zur behandlung von allergischer rhinitis und asthma
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
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US7439399B2 (en) * 2004-06-28 2008-10-21 Teva Pharmaceutical Fine Chemicals Processes for the preparation of atomoxetine hydrochloride
CA2568629A1 (en) * 2004-07-22 2006-02-23 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of atomoxetine hydrochloride
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US20080004470A1 (en) * 2004-09-27 2008-01-03 Mathad Vijayavitthal T Synthesis of Atomoxetine Hydrochloride
JP2007523213A (ja) * 2004-12-23 2007-08-16 テバ ファーマシューティカル インダストリーズ リミティド 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法
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US7534900B2 (en) * 2005-03-14 2009-05-19 Teva Pharmaceutical Industries Ltd Process for the purification of duloxetine hydrochloride
EP1751085A1 (en) * 2005-04-05 2007-02-14 Teva Pharmaceutical Fine Chemicals S.R.L. Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
EP1889828A1 (en) * 2005-04-05 2008-02-20 Teva Pharmaceutical Fine Chemicals S.R.L. Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US7485754B2 (en) * 2005-07-08 2009-02-03 Apotex Pharmachem Inc. Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
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US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
EP1838692A2 (en) * 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleate and methods of preparation thereof
WO2007067581A1 (en) 2005-12-05 2007-06-14 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphthol) thiophene, an impurity of duloxetine hydrochloride
DE602006021628D1 (de) 2005-12-12 2011-06-09 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
EP1798215A1 (en) * 2005-12-14 2007-06-20 SOLMAG S.p.A. Polymorph of atomoxetine hydrochloride in crystalline form
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
WO2007086948A1 (en) * 2006-01-23 2007-08-02 Teva Pharmaceutical Industries Ltd. Dnt-fumarate and methods of preparation thereof
MX2007011727A (es) * 2006-01-23 2007-11-15 Teva Pharma Dnt-succinato y metodos de preparacion de el.
BRPI0707724A2 (pt) * 2006-02-13 2011-05-10 Teva Pharma um novo processo para preparaÇço de (s)-(+)-n, n-dimetil-3-(1-naftaleniloxi)-3-(2-tienil)propanamina), um intermediÁrio de duloxetina
EP1888554A2 (en) * 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate
US20080146675A1 (en) * 2006-04-05 2008-06-19 Eugenio Castelli Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US20080027128A1 (en) * 2006-05-23 2008-01-31 Santiago Ini Duloxetine HCL polymorphs
WO2007143065A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Process for preparing duloxetine and intermediates thereof
CN100430370C (zh) * 2006-11-03 2008-11-05 华东理工大学 一种丙胺衍生物及其在制备托莫西汀中的应用
US20080145318A1 (en) * 2006-12-13 2008-06-19 Midha Kamal K Atomoxetine formulations and associated methods
CN101657438A (zh) 2006-12-22 2010-02-24 斯索恩有限公司 制备度洛西汀和相关化合物的方法
EP2132192B1 (en) * 2007-03-05 2013-04-24 Lupin Limited Novel process for preparation of duloxetine hydrochloride
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
EP2060559A1 (en) 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers
US20100267968A1 (en) * 2007-12-26 2010-10-21 Orchid Chemicals & Pharmaceuticals Limited Method for the preparation of duloxetine hydrochloride
WO2009092129A1 (en) * 2008-01-25 2009-07-30 Alpharma Pty Ltd Delayed release pharmaceutical composition of duloxetine
WO2009141833A2 (en) * 2008-04-17 2009-11-26 Ind-Swift Laboratories Limited An improved process for synthesizing highly pure atomoxetine
US8426178B2 (en) 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2558455B1 (en) 2010-04-13 2017-08-09 KRKA, D.D., Novo Mesto Synthesis of duloxetine and/or pharmaceutically acceptable salts thereof
CN102863344B (zh) * 2012-07-20 2015-06-03 葫芦岛国帝药业有限责任公司 一种托莫西汀药物制备方法
CN106916074A (zh) * 2017-02-14 2017-07-04 万特制药(海南)有限公司 盐酸托莫西汀的制备
CN108929236A (zh) * 2017-05-26 2018-12-04 万特制药(海南)有限公司 盐酸托莫西汀的制备
CN110294680A (zh) * 2018-03-22 2019-10-01 北京深蓝海生物医药科技有限公司 一种盐酸阿托莫西汀的制备方法
CN111302958B (zh) * 2020-03-24 2023-05-02 合肥医工医药股份有限公司 一种光学纯的（r）-n-甲基-3-苯基-3-（邻-甲苯氧基）-丙胺盐酸盐制备方法

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JPS6023656A (ja) 1983-07-20 1985-02-06 Nissan Motor Co Ltd 自動変速機の遊星歯車列
US4868344A (en) 1988-03-30 1989-09-19 Aldrich-Boranes, Inc. Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
US5166437A (en) 1989-03-03 1992-11-24 Orion-Yhtyma Oy Process for the preparation of fluoxetine
FI81083C (fi) * 1989-03-03 1990-09-10 Orion Yhtymae Oy Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.
US5104899A (en) 1990-08-13 1992-04-14 Sepracor, Inc. Methods and compositions for treating depression using optically pure fluoxetine
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
ES2120368B1 (es) * 1996-06-14 1999-07-01 Almirall Prodesfarma Sa Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.
IT1283141B1 (it) * 1996-07-11 1998-04-07 Laporte Organics Francis S P A Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi
TW514634B (en) 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds

Also Published As

Publication number Publication date
DE60023870T2 (de) 2006-06-14
EP1171417B1 (en) 2005-11-09
EP1171417A1 (en) 2002-01-16
ES2249256T3 (es) 2006-04-01
WO2000061540A1 (en) 2000-10-19
CA2362185C (en) 2009-06-02
US6541668B1 (en) 2003-04-01
DE60023870D1 (de) 2005-12-15
AU3877500A (en) 2000-11-14
JP2002541235A (ja) 2002-12-03
CA2362185A1 (en) 2000-10-19
ATE309196T1 (de) 2005-11-15

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