DE602006021628D1 - Verbesserte synthese und zubereitungen von duloxetinsalzen - Google Patents

Verbesserte synthese und zubereitungen von duloxetinsalzen

Info

Publication number
DE602006021628D1
DE602006021628D1 DE602006021628T DE602006021628T DE602006021628D1 DE 602006021628 D1 DE602006021628 D1 DE 602006021628D1 DE 602006021628 T DE602006021628 T DE 602006021628T DE 602006021628 T DE602006021628 T DE 602006021628T DE 602006021628 D1 DE602006021628 D1 DE 602006021628D1
Authority
DE
Germany
Prior art keywords
duloxetin
preparations
salts
improved synthesis
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006021628T
Other languages
English (en)
Inventor
Stephen Winter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38437735&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602006021628(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medichem SA filed Critical Medichem SA
Publication of DE602006021628D1 publication Critical patent/DE602006021628D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602006021628T 2005-12-12 2006-12-12 Verbesserte synthese und zubereitungen von duloxetinsalzen Active DE602006021628D1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US74909505P 2005-12-12 2005-12-12
US74909705P 2005-12-12 2005-12-12
US74909605P 2005-12-12 2005-12-12
US81585606P 2006-06-23 2006-06-23
US81583506P 2006-06-23 2006-06-23
US81585406P 2006-06-23 2006-06-23
PCT/IB2006/004250 WO2007119114A2 (en) 2005-12-12 2006-12-12 Improved synthesis and preparations of duloxetine salts

Publications (1)

Publication Number Publication Date
DE602006021628D1 true DE602006021628D1 (de) 2011-06-09

Family

ID=38437735

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006021628T Active DE602006021628D1 (de) 2005-12-12 2006-12-12 Verbesserte synthese und zubereitungen von duloxetinsalzen

Country Status (9)

Country Link
US (4) US20090093645A1 (de)
EP (3) EP1971592B1 (de)
AR (1) AR058321A1 (de)
AT (1) ATE507215T1 (de)
CA (3) CA2634009A1 (de)
DE (1) DE602006021628D1 (de)
IL (3) IL192115A0 (de)
PL (1) PL1971592T3 (de)
WO (3) WO2007119114A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399871B2 (en) 2005-03-08 2008-07-15 Teva Pharmaceutical Industries Ltd. Crystal forms of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof
WO2006099459A1 (en) 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Process for the preparation of optically active (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
US7842717B2 (en) 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
WO2007067581A1 (en) 2005-12-05 2007-06-14 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphthol) thiophene, an impurity of duloxetine hydrochloride
DE602006021628D1 (de) 2005-12-12 2011-06-09 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
EP1888554A2 (de) 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamin, einem duloxetin-zwischenprodukt
HU228458B1 (en) 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
EP2016066A4 (de) * 2006-05-10 2010-11-24 Reddys Lab Ltd Dr Verfahren zur herstellung von duloxetin
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
EP2107057A1 (de) 2008-04-04 2009-10-07 Ranbaxy Laboratories Limited Verfahren zur Herstellung von reinem Duloxetin
WO2011092065A1 (en) * 2010-01-29 2011-08-04 Nicox S.A. Nitric oxide releasing compounds for the treatment of neurophatic pain
CN103896910B (zh) * 2012-12-27 2016-02-03 成都国弘医药有限公司 一种度洛西汀的合成方法
CN103524480B (zh) * 2013-10-21 2016-04-20 山东鲁药制药有限公司 一种盐酸度洛西汀的制备方法
CN104478849A (zh) * 2014-02-14 2015-04-01 广东东阳光药业有限公司 制备去甲肾上腺素再摄取双重抑制剂的方法
JP2016172704A (ja) * 2015-03-17 2016-09-29 株式会社トクヤマ デュロキセチン塩酸塩の製造方法、及び新規な結晶構造のデュロキセチン塩酸塩
CN107382958B (zh) * 2017-07-05 2021-11-09 浙江华海药业股份有限公司 一种度洛西汀中间体的结晶方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956388A (en) 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
HU9202128D0 (en) 1992-06-26 1992-10-28 Richter Gedeon Vegyeszet Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
ES2249256T3 (es) 1999-04-09 2006-04-01 Eli Lilly And Company Procedimientos de preparacion de 3-ariloxi-3-arilpropilamidas y sus intermedios.
US20040053948A1 (en) * 2002-05-10 2004-03-18 Cytokinetics, Inc. Compounds, compositions and methods
CA2494518A1 (en) * 2002-08-06 2004-02-12 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of gatifloxacin
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
GB0410470D0 (en) * 2004-05-11 2004-06-16 Cipla Ltd Pharmaceutical compound and polymorphs thereof
US7550605B2 (en) 2004-08-05 2009-06-23 Sun Pharmaceutical Industries Ltd. Process for preparation of an anitdepressant compound
CZ297560B6 (cs) 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
JP2007523213A (ja) 2004-12-23 2007-08-16 テバ ファーマシューティカル インダストリーズ リミティド 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法
WO2006099459A1 (en) 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Process for the preparation of optically active (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
US7842717B2 (en) 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
DE602006021628D1 (de) 2005-12-12 2011-06-09 Medichem Sa Verbesserte synthese und zubereitungen von duloxetinsalzen
CZ299270B6 (cs) * 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu

Also Published As

Publication number Publication date
CA2634009A1 (en) 2007-10-25
CA2634007A1 (en) 2007-08-30
WO2007096707A3 (en) 2008-01-24
AR058321A1 (es) 2008-01-30
PL1971592T3 (pl) 2011-09-30
US20090093645A1 (en) 2009-04-09
EP1971591A2 (de) 2008-09-24
IL192116A0 (en) 2009-08-03
IL192114A0 (en) 2009-08-03
WO2007119114A2 (en) 2007-10-25
US8158808B2 (en) 2012-04-17
WO2007096707A2 (en) 2007-08-30
EP1971592B1 (de) 2011-04-27
ATE507215T1 (de) 2011-05-15
CA2634008A1 (en) 2007-10-25
US20090182156A1 (en) 2009-07-16
WO2007119114A3 (en) 2008-01-24
WO2007119116A3 (en) 2008-01-31
US20100286412A1 (en) 2010-11-11
WO2007119116A2 (en) 2007-10-25
EP1971592A2 (de) 2008-09-24
IL192115A0 (en) 2009-08-03
US20090221668A1 (en) 2009-09-03
EP1971593A2 (de) 2008-09-24

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