DE60023870T2 - Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte - Google Patents
Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte Download PDFInfo
- Publication number
- DE60023870T2 DE60023870T2 DE60023870T DE60023870T DE60023870T2 DE 60023870 T2 DE60023870 T2 DE 60023870T2 DE 60023870 T DE60023870 T DE 60023870T DE 60023870 T DE60023870 T DE 60023870T DE 60023870 T2 DE60023870 T2 DE 60023870T2
- Authority
- DE
- Germany
- Prior art keywords
- aryloxy
- preparation
- arylpropylamine
- intermediate products
- arylpropylamines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12848099P | 1999-04-09 | 1999-04-09 | |
PCT/US2000/006423 WO2000061540A1 (en) | 1999-04-09 | 2000-03-22 | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60023870D1 DE60023870D1 (de) | 2005-12-15 |
DE60023870T2 true DE60023870T2 (de) | 2006-06-14 |
Family
ID=22435565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60023870T Expired - Lifetime DE60023870T2 (de) | 1999-04-09 | 2000-03-22 | Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte |
Country Status (10)
Country | Link |
---|---|
US (1) | US6541668B1 (de) |
EP (1) | EP1171417B1 (de) |
JP (1) | JP2002541235A (de) |
AT (1) | ATE309196T1 (de) |
AU (1) | AU3877500A (de) |
CA (1) | CA2362185C (de) |
DE (1) | DE60023870T2 (de) |
DK (1) | DK1171417T3 (de) |
ES (1) | ES2249256T3 (de) |
WO (1) | WO2000061540A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL157779A0 (en) | 2001-03-06 | 2004-03-28 | Lilly Co Eli | Inhibitor of monoamine uptake |
US20040249170A1 (en) * | 2002-01-24 | 2004-12-09 | Alfio Borghese | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine |
GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
EP1708717B1 (de) * | 2003-07-28 | 2011-10-05 | Leslie Joe Dunaway | Atomoxetin zur Behandlung von allergischer Rhinitis und Asthma |
US20050197503A1 (en) * | 2004-03-05 | 2005-09-08 | Boehringer Ingelheim International Gmbh | Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines |
EP1687254A2 (de) * | 2004-06-28 | 2006-08-09 | Teva Pharmaceutical Fine Chemicals S.R.L. | Verfahren zur optischen trennung und rückgewinnung von tomoxetin |
US7439399B2 (en) * | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
EP1768949A2 (de) * | 2004-07-22 | 2007-04-04 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphe von atomoxetien-hydrochlorid |
US7550605B2 (en) * | 2004-08-05 | 2009-06-23 | Sun Pharmaceutical Industries Ltd. | Process for preparation of an anitdepressant compound |
US20080004470A1 (en) * | 2004-09-27 | 2008-01-03 | Mathad Vijayavitthal T | Synthesis of Atomoxetine Hydrochloride |
US20060194869A1 (en) * | 2004-12-23 | 2006-08-31 | Santiago Ini | Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof |
EP1856087A1 (de) * | 2005-03-08 | 2007-11-21 | Teva Pharmaceutical Industries Limited | Kristallformen von (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamin-oxalat und deren herstellung |
CA2599478A1 (en) * | 2005-03-14 | 2006-09-21 | Teva Pharmaceutical Industries Ltd. | Process for the purification of duloxetine hydrochloride |
EP1889828A1 (de) * | 2005-04-05 | 2008-02-20 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stabiles Atomoxetinhydrochlorid, Herstellungsverfahren und analytische Steuerung seiner Stabilität |
JP2008501721A (ja) * | 2005-04-05 | 2008-01-24 | テバ ファーマシューティカル ファイン ケミカルズ ソチエタ レスポンサビリタ リミテ | 安定性アトモキセチン塩酸塩、その調製方法及びその安定性の分析的調節 |
US7485754B2 (en) * | 2005-07-08 | 2009-02-03 | Apotex Pharmachem Inc. | Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers |
CZ296345B6 (cs) * | 2005-07-21 | 2006-02-15 | Zentiva, A. S | Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu) |
US20080207923A1 (en) * | 2005-09-22 | 2008-08-28 | Santiago Ini | Pure DNT-maleate and methods of preparation thereof |
US7842717B2 (en) | 2005-09-22 | 2010-11-30 | Teva Pharmaceutical Industries Ltd. | DNT-maleate and methods of preparation thereof |
US7759500B2 (en) * | 2005-12-05 | 2010-07-20 | Teva Pharmaceutical Industries Ltd. | 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride |
US20090221668A1 (en) | 2005-12-12 | 2009-09-03 | Medichem, S.A. | Synthesis and preparations of duloxetine salts |
EP1798215A1 (de) * | 2005-12-14 | 2007-06-20 | SOLMAG S.p.A. | Polymorph von Atomoxetin-hydrochloride in kristalliner Form |
US7538232B2 (en) | 2006-01-19 | 2009-05-26 | Eli Lilly And Company | Process for the asymmetric synthesis of duloxetine |
MX2007011611A (es) * | 2006-01-23 | 2007-10-18 | Teva Pharma | Fumarato de dnt y metodos de preparacion de ellos. |
MX2007011727A (es) * | 2006-01-23 | 2007-11-15 | Teva Pharma | Dnt-succinato y metodos de preparacion de el. |
CA2640212A1 (en) * | 2006-02-13 | 2007-08-23 | Teva Pharmaceutical Industries Ltd. | A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate |
EP1888554A2 (de) * | 2006-02-21 | 2008-02-20 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamin, einem duloxetin-zwischenprodukt |
US20080146675A1 (en) * | 2006-04-05 | 2008-06-19 | Eugenio Castelli | Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
MX2008001079A (es) * | 2006-05-23 | 2008-03-19 | Teva Pharma | Polimorfos de hidrocloruro de duloxetina. |
EP1976846A2 (de) * | 2006-05-31 | 2008-10-08 | Teva Pharmaceutical Industries Ltd | Verfahren zur herstellung von duloxetin und vermittler davon |
CN100430370C (zh) * | 2006-11-03 | 2008-11-05 | 华东理工大学 | 一种丙胺衍生物及其在制备托莫西汀中的应用 |
US20080145318A1 (en) * | 2006-12-13 | 2008-06-19 | Midha Kamal K | Atomoxetine formulations and associated methods |
ATE552250T1 (de) | 2006-12-22 | 2012-04-15 | Synthon Bv | Verfahren zur herstellung von duloxetin und verwandten verbindungen |
WO2008107911A2 (en) * | 2007-03-05 | 2008-09-12 | Lupin Limited | Novel process for preparation of duloxetine hydrochloride |
WO2009019719A2 (en) * | 2007-08-09 | 2009-02-12 | Ind-Swift Laboratories Limited | Process for the preparation of 3-aryloxy-3-arylpropanamines |
EP2060559A1 (de) | 2007-11-19 | 2009-05-20 | Cadila Pharmaceuticals Limited | Herstellungsverfahren für enantiomerenreine 3-Hydroxy-3-Arylpropylamine und ihrer optischen Stereoisomere |
US20100267968A1 (en) * | 2007-12-26 | 2010-10-21 | Orchid Chemicals & Pharmaceuticals Limited | Method for the preparation of duloxetine hydrochloride |
AU2009206204B2 (en) * | 2008-01-25 | 2015-03-19 | Alphapharm Pty Ltd | Delayed release pharmaceutical composition of duloxetine |
WO2009141833A2 (en) * | 2008-04-17 | 2009-11-26 | Ind-Swift Laboratories Limited | An improved process for synthesizing highly pure atomoxetine |
WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
US8426178B2 (en) | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
EP2558455B1 (de) | 2010-04-13 | 2017-08-09 | KRKA, D.D., Novo Mesto | Synthese von duloxetin- und/oder pharmazeutisch akzeptablen salzen daraus |
CN102863344B (zh) * | 2012-07-20 | 2015-06-03 | 葫芦岛国帝药业有限责任公司 | 一种托莫西汀药物制备方法 |
CN106916074A (zh) * | 2017-02-14 | 2017-07-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
CN108929236A (zh) * | 2017-05-26 | 2018-12-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
CN110294680A (zh) * | 2018-03-22 | 2019-10-01 | 北京深蓝海生物医药科技有限公司 | 一种盐酸阿托莫西汀的制备方法 |
CN111302958B (zh) * | 2020-03-24 | 2023-05-02 | 合肥医工医药股份有限公司 | 一种光学纯的(r)-n-甲基-3-苯基-3-(邻-甲苯氧基)-丙胺盐酸盐制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI77018C (fi) | 1980-11-14 | 1989-01-10 | Lilly Co Eli | Analogifoerfarande foer framstaellning av antidepressivt aktiv (-)-enantiomer av n-metyl-n-/3-(2-metylfenoxi) -3-fenylpropyl/amin och dess farmaceutiskt godtagbara salt. |
JPS6023656A (ja) | 1983-07-20 | 1985-02-06 | Nissan Motor Co Ltd | 自動変速機の遊星歯車列 |
US4868344A (en) | 1988-03-30 | 1989-09-19 | Aldrich-Boranes, Inc. | Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein |
US5166437A (en) * | 1989-03-03 | 1992-11-24 | Orion-Yhtyma Oy | Process for the preparation of fluoxetine |
FI81083C (fi) * | 1989-03-03 | 1990-09-10 | Orion Yhtymae Oy | Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid. |
US5104899A (en) | 1990-08-13 | 1992-04-14 | Sepracor, Inc. | Methods and compositions for treating depression using optically pure fluoxetine |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
ES2120368B1 (es) * | 1996-06-14 | 1999-07-01 | Almirall Prodesfarma Sa | Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables. |
IT1283141B1 (it) * | 1996-07-11 | 1998-04-07 | Laporte Organics Francis S P A | Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi |
TW514634B (en) | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
-
2000
- 2000-03-22 EP EP00917868A patent/EP1171417B1/de not_active Expired - Lifetime
- 2000-03-22 AT AT00917868T patent/ATE309196T1/de not_active IP Right Cessation
- 2000-03-22 CA CA002362185A patent/CA2362185C/en not_active Expired - Fee Related
- 2000-03-22 AU AU38775/00A patent/AU3877500A/en not_active Abandoned
- 2000-03-22 ES ES00917868T patent/ES2249256T3/es not_active Expired - Lifetime
- 2000-03-22 US US09/936,468 patent/US6541668B1/en not_active Expired - Lifetime
- 2000-03-22 JP JP2000610817A patent/JP2002541235A/ja active Pending
- 2000-03-22 WO PCT/US2000/006423 patent/WO2000061540A1/en active IP Right Grant
- 2000-03-22 DK DK00917868T patent/DK1171417T3/da active
- 2000-03-22 DE DE60023870T patent/DE60023870T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2000061540A1 (en) | 2000-10-19 |
EP1171417B1 (de) | 2005-11-09 |
ES2249256T3 (es) | 2006-04-01 |
CA2362185C (en) | 2009-06-02 |
US6541668B1 (en) | 2003-04-01 |
DK1171417T3 (da) | 2006-02-20 |
AU3877500A (en) | 2000-11-14 |
DE60023870D1 (de) | 2005-12-15 |
EP1171417A1 (de) | 2002-01-16 |
JP2002541235A (ja) | 2002-12-03 |
CA2362185A1 (en) | 2000-10-19 |
ATE309196T1 (de) | 2005-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |