DK1155692T3 - Anvendelse af med albumin stabiliseret paclitaxel til fremstilling af et lægemiddel til behandling af faste tumorer, samt det således opnåede lægemiddel - Google Patents

Anvendelse af med albumin stabiliseret paclitaxel til fremstilling af et lægemiddel til behandling af faste tumorer, samt det således opnåede lægemiddel

Info

Publication number
DK1155692T3
DK1155692T3 DK01110509T DK01110509T DK1155692T3 DK 1155692 T3 DK1155692 T3 DK 1155692T3 DK 01110509 T DK01110509 T DK 01110509T DK 01110509 T DK01110509 T DK 01110509T DK 1155692 T3 DK1155692 T3 DK 1155692T3
Authority
DK
Denmark
Prior art keywords
drug
treatment
solid tumors
manufacture
well
Prior art date
Application number
DK01110509T
Other languages
English (en)
Inventor
Marco Falciani
Original Assignee
Acs Dobfar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11445079&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1155692(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa
Application granted granted Critical
Publication of DK1155692T3 publication Critical patent/DK1155692T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01110509T 2000-05-18 2001-04-27 Anvendelse af med albumin stabiliseret paclitaxel til fremstilling af et lægemiddel til behandling af faste tumorer, samt det således opnåede lægemiddel DK1155692T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001107A ITMI20001107A1 (it) 2000-05-18 2000-05-18 Metodo per il trattamento di tumori solici mediante microparticelle di albumina incorporanti paclitaxel

Publications (1)

Publication Number Publication Date
DK1155692T3 true DK1155692T3 (da) 2004-08-09

Family

ID=11445079

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01110509T DK1155692T3 (da) 2000-05-18 2001-04-27 Anvendelse af med albumin stabiliseret paclitaxel til fremstilling af et lægemiddel til behandling af faste tumorer, samt det således opnåede lægemiddel

Country Status (23)

Country Link
US (1) US6652884B2 (da)
EP (1) EP1155692B1 (da)
JP (1) JP2001354559A (da)
KR (2) KR20010105248A (da)
CN (1) CN1198609C (da)
AT (1) ATE267594T1 (da)
AU (1) AU781517B2 (da)
BR (1) BR0102040A (da)
CA (1) CA2345482A1 (da)
DE (1) DE60103453T2 (da)
DK (1) DK1155692T3 (da)
ES (1) ES2221874T3 (da)
HK (1) HK1040368A1 (da)
HU (1) HU229909B1 (da)
IL (1) IL142674A0 (da)
IT (1) ITMI20001107A1 (da)
MX (1) MXPA01004980A (da)
NO (1) NO330511B1 (da)
NZ (1) NZ511201A (da)
PT (1) PT1155692E (da)
RU (1) RU2270003C2 (da)
TR (1) TR200101353A3 (da)
ZA (1) ZA200103755B (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
HUP9701554D0 (en) * 1997-09-18 1997-11-28 Human Oltoanyagtermeloe Gyogys Pharmaceutical composition containing plazma proteins
ITMI20020680A1 (it) * 2002-03-29 2003-09-29 Acs Dobfar Spa Composizione antitumorale migliorata a base di paclitaxel e metodo per il suo ottenimento
ITMI20020681A1 (it) * 2002-03-29 2003-09-29 Acs Dobfar Spa Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina
LT1585548T (lt) 2002-12-09 2018-09-25 Abraxis Bioscience, Llc Farmakologinių agentų kompozicijos ir įvedimo būdai
CN1925874B (zh) * 2002-12-09 2014-12-17 阿布拉西斯生物科学有限责任公司 组合物和传递药剂的方法
US7670627B2 (en) * 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
US20040224019A1 (en) * 2004-03-03 2004-11-11 Adi Shefer Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs
AU2006249235B2 (en) 2004-05-14 2010-11-11 Abraxis Bioscience, Llc Sparc and methods of use thereof
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
US20070166388A1 (en) * 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
PT2301531T (pt) 2005-02-18 2018-07-30 Abraxis Bioscience Llc Combinações e modos de administração de agentes terapêuticos e terapia de combinação
TWI429452B (zh) 2005-08-31 2014-03-11 Abraxis Bioscience Llc 包含弱水溶性藥劑及抗微生物劑之組合物
EP1928435B8 (en) 2005-08-31 2019-03-20 Abraxis BioScience, LLC Compositions of poorly water soluble drugs with increased stability and methods for preparation thereof
JP2009512682A (ja) * 2005-10-21 2009-03-26 パナセア バイオテック リミテッド 少なくとも１種の抗癌性薬物および少なくとも１種のポリマーを含む医薬組成物
US20080280987A1 (en) * 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
PT2117520T (pt) * 2006-12-14 2018-12-04 Abraxis Bioscience Llc Terapia do cancro da mama com base no estado do receptor do hormona com nanoparticulas compreendendo taxane
KR20090118999A (ko) 2007-03-07 2009-11-18 아브락시스 바이오사이언스, 엘엘씨 항암제로서 라파마이신 및 알부민을 포함하는 나노입자
EP2146707A2 (en) * 2007-05-03 2010-01-27 Abraxis BioScience, LLC Methods and compositions for treating pulmonary hypertension
JP5579057B2 (ja) 2007-06-01 2014-08-27 アブラクシス バイオサイエンス， エルエルシー 再発性癌の処置のための方法および組成物
AU2009234127B2 (en) * 2008-04-10 2015-04-30 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
KR101090505B1 (ko) * 2008-12-30 2011-12-06 최은아 난담반을 포함하는 암 예방 및 치료용 조성물
RU2559570C2 (ru) 2009-04-15 2015-08-10 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Композиции без приона на основе наночастиц и способы их получения
EP2552438B1 (en) 2010-03-26 2016-05-11 Abraxis BioScience, LLC Methods of treatment of hepatocellular carcinoma
SG10201906075VA (en) 2010-03-29 2019-08-27 Abraxis Bioscience Llc Methods of treating cancer
KR20130028727A (ko) 2010-03-29 2013-03-19 아브락시스 바이오사이언스, 엘엘씨 치료제의 약물 전달 및 유효성 향상 방법
KR20190130050A (ko) 2010-06-04 2019-11-20 아브락시스 바이오사이언스, 엘엘씨 췌장암의 치료 방법
MX354216B (es) 2011-04-28 2018-02-19 Mercator Medsystems Inc Suministro intravascular de composiciones de nanoparticulas y sus usos.
PT2790675T (pt) 2011-12-14 2019-09-23 Abraxis Bioscience Llc Utilização de excipientes poliméricos para a liofilização ou a congelação de partículas
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
EP2968254B1 (en) 2013-03-12 2020-04-22 Abraxis BioScience, LLC Methods of treating lung cancer
MX2015011783A (es) * 2013-03-13 2015-12-01 Abraxis Bioscience Llc Metodos para tratar tumores solidos pediatricos.
JP6309610B2 (ja) 2013-03-14 2018-04-11 アブラクシス バイオサイエンス， エルエルシー 膀胱がんを処置する方法
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
HUE057175T2 (hu) 2015-06-29 2022-04-28 Abraxis Bioscience Llc Sirolimuszt és albumint tartalmazó nanorészecskék hámsejtes daganatok kezelésében történõ alkalmazásra
EP3505183B1 (en) * 2016-08-26 2022-03-30 Tetsuji Okuno Microvascular blood flow decreasing agent and use thereof
TWI660728B (zh) 2018-02-09 2019-06-01 國立交通大學 胺基喹唑啉衍生物及其醫藥組合物與用途
SG11202009145PA (en) 2018-03-20 2020-10-29 Abraxis Bioscience Llc Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin
CN115003284A (zh) 2019-10-28 2022-09-02 阿布拉科斯生物科学有限公司 白蛋白和雷帕霉素的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
ATE264671T1 (de) 1993-02-22 2004-05-15 American Bioscience Inc Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
MX337149B (es) * 1997-06-27 2016-02-15 Abraxis Bioscience Llc Nuevas formulaciones de agentes farmacologicos, metodos para su preparacion y metodos para el uso de los mismos.
IL141155A0 (en) 1998-07-30 2002-02-10 Human Rt Pharmaceutically acceptable composition comprising an aqueous solution of paclitaxel and albumin

Also Published As

Publication number Publication date
AU781517B2 (en) 2005-05-26
ITMI20001107A0 (it) 2000-05-18
CN1324613A (zh) 2001-12-05
TR200101353A2 (tr) 2001-12-21
ATE267594T1 (de) 2004-06-15
NO20012409D0 (no) 2001-05-16
DE60103453T2 (de) 2005-06-23
EP1155692A1 (en) 2001-11-21
ZA200103755B (en) 2001-11-15
HK1040368A1 (en) 2002-06-07
ITMI20001107A1 (it) 2001-11-18
MXPA01004980A (es) 2002-08-06
BR0102040A (pt) 2002-03-19
HUP0102039A2 (hu) 2002-05-29
JP2001354559A (ja) 2001-12-25
KR20080091747A (ko) 2008-10-14
PT1155692E (pt) 2004-09-30
ES2221874T3 (es) 2005-01-16
RU2270003C2 (ru) 2006-02-20
HUP0102039A3 (en) 2002-12-28
TR200101353A3 (tr) 2001-12-21
AU3876501A (en) 2001-11-22
CA2345482A1 (en) 2001-11-18
EP1155692B1 (en) 2004-05-26
NO330511B1 (no) 2011-05-09
DE60103453D1 (de) 2004-07-01
US20010046961A1 (en) 2001-11-29
US6652884B2 (en) 2003-11-25
KR20010105248A (ko) 2001-11-28
HU229909B1 (en) 2014-12-29
NZ511201A (en) 2002-11-26
CN1198609C (zh) 2005-04-27
IL142674A0 (en) 2002-03-10
NO20012409L (no) 2001-11-19
HU0102039D0 (en) 2001-07-30

Similar Documents

Publication Publication Date Title
DK1155692T3 (da) Anvendelse af med albumin stabiliseret paclitaxel til fremstilling af et lægemiddel til behandling af faste tumorer, samt det således opnåede lægemiddel
DK1292594T3 (da) Quinazolinderivater til behandling af tumorer
CY2014008I2 (el) Παραγωγα κιναζολινης, φαρμακα που περιεχουν τις ενωσεις αυτες, χρηση αυτων και μεθοδους για την παραγωγη τους
DE60202677D1 (de) Implantierbare medizinische vorrichtung mit kontrollierter freigabe von gasförmigen mitteln
CY1113312T1 (el) Κυκλικοι αναστολεις κινασης τυροσινης πρωτεϊνων
DK1239829T3 (da) Indretninger til indgivelse af medikamenter med antiprogestinegenskaber
DK1066269T3 (da) Trisubstituerede 1,3,5-triazinderivater til behandling af HIV-infektioner
NO20034931L (no) Substituerte 2-pyridin-cykloheksan-1,4-diaminderivater
DK1439829T3 (da) Lægemiddel indeholdende 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol med forsinket frigivelse af det aktive stof
NO20031018D0 (no) Oksymorfonpreparater med kontrollert frigivelse
DK1443955T3 (da) PDGF-BB til behandling af Parkinsons sygdom
DK1265889T3 (da) Lægemidler imod virussygdomme
DE69925133D1 (de) Pyrrolobenzodiazepine
DK1259512T3 (da) Pteridinforbindelser til behandling af psoreasis
DK1242060T3 (da) Behandling af metastatisk sygdom
HRP20080447T3 (en) 7-(2-(4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyrid-1-yl)ethyl) isoquinoline besylate salt, preparation and therapeutic use thereof
DK0979079T3 (da) Anvendelse af tetrahydropyridinderivater til fremstilling af lægemidler til behandling af sygdomme, der medförer en demyelinisering
DK1214061T3 (da) Anvendelse af docetaxel til behandling af hepatocellulært carcinom
DE60112960D1 (de) Kondensierte pyridoindolderivate
NO20014752D0 (no) Taksanpreparater med forbedret opplöselighet
EE05241B1 (et) Distamtsiini a-halogenoakrlolderivaadi kasutamine
NO20033341D0 (no) Metoder for administrering av epothilone-analoger for behandling av kreft
EE200200605A (et) Asendatud akrüloüüldistamütsiini derivaadi kasutamine ravimi valmistamiseks, mis on ette nähtud glutatiooni kõrge tasemega seotud kasvajate raviks
DK1615668T3 (da) Et lægemiddel til to-trins perioperativ behandling af faste tumorer med radioimmunoterapi
IS6984A (is) Notkun á pýridóindólon afleiðum til framleiðslu lyfja gegn krabbameini