ITMI20020681A1 - Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina - Google Patents

Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina

Info

Publication number
ITMI20020681A1
ITMI20020681A1 IT2002MI000681A ITMI20020681A ITMI20020681A1 IT MI20020681 A1 ITMI20020681 A1 IT MI20020681A1 IT 2002MI000681 A IT2002MI000681 A IT 2002MI000681A IT MI20020681 A ITMI20020681 A IT MI20020681A IT MI20020681 A1 ITMI20020681 A1 IT MI20020681A1
Authority
IT
Italy
Prior art keywords
albumina
paclitaxel
nanoparticles
procedure
production
Prior art date
Application number
IT2002MI000681A
Other languages
English (en)
Inventor
Maurizio Zenoni
Simone Maschio
Original Assignee
Acs Dobfar Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of ITMI20020681A0 publication Critical patent/ITMI20020681A0/it
Priority to IT2002MI000681A priority Critical patent/ITMI20020681A1/it
Application filed by Acs Dobfar Spa filed Critical Acs Dobfar Spa
Priority to EP03004629A priority patent/EP1348431A1/en
Priority to IL15476203A priority patent/IL154762A0/xx
Priority to AU2003200920A priority patent/AU2003200920A1/en
Priority to NZ524605A priority patent/NZ524605A/en
Priority to US10/383,639 priority patent/US20030185894A1/en
Priority to ZA200302040A priority patent/ZA200302040B/xx
Priority to JP2003070028A priority patent/JP4794115B2/ja
Priority to MXPA03002543A priority patent/MXPA03002543A/es
Priority to BR0300846-0A priority patent/BR0300846A/pt
Priority to KR10-2003-0019242A priority patent/KR20030078722A/ko
Priority to CA002423915A priority patent/CA2423915A1/en
Priority to NO20031448A priority patent/NO334407B1/no
Priority to RU2003108821/15A priority patent/RU2003108821A/ru
Priority to CNB031083617A priority patent/CN1259902C/zh
Priority to CNA2006100770064A priority patent/CN1911446A/zh
Publication of ITMI20020681A1 publication Critical patent/ITMI20020681A1/it
Priority to US11/334,004 priority patent/US20060121119A1/en
Priority to JP2011043799A priority patent/JP2011132253A/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
IT2002MI000681A 2002-03-29 2002-03-29 Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina ITMI20020681A1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT2002MI000681A ITMI20020681A1 (it) 2002-03-29 2002-03-29 Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina
EP03004629A EP1348431A1 (en) 2002-03-29 2003-03-03 Process for producing nanoparticles of paclitaxel and albumin
IL15476203A IL154762A0 (en) 2002-03-29 2003-03-05 Process for producing nanoparticles of paclitaxel and albumin
AU2003200920A AU2003200920A1 (en) 2002-03-29 2003-03-05 Process for producing nanoparticles of paclitaxel and albumin
NZ524605A NZ524605A (en) 2002-03-29 2003-03-07 Process for producing nanoparticles of paclitaxel and albumin
US10/383,639 US20030185894A1 (en) 2002-03-29 2003-03-10 Process for producing nanoparticles of paclitaxel and albumin
ZA200302040A ZA200302040B (en) 2002-03-29 2003-03-13 Process for producing nanoparticles of paclitaxel and albumin.
JP2003070028A JP4794115B2 (ja) 2002-03-29 2003-03-14 パクリタキセルおよびアルブミンのナノ粒子を作製する方法
MXPA03002543A MXPA03002543A (es) 2002-03-29 2003-03-24 Proceso para producir nanoparticulas de paclitaxel y albumina.
BR0300846-0A BR0300846A (pt) 2002-03-29 2003-03-26 Processo para produzir nanopartìculas de paclitaxel e albumina
KR10-2003-0019242A KR20030078722A (ko) 2002-03-29 2003-03-27 파클리탁셀 및 알부민의 나노입자의 제조방법
CA002423915A CA2423915A1 (en) 2002-03-29 2003-03-28 Process for producing nanoparticles of paclitaxel and albumin
NO20031448A NO334407B1 (no) 2002-03-29 2003-03-28 Fremgangsmåte for fremstilling av et sterilt, lyofilisert pulver bestående av nanopartikler av paclitaxel og humant serumalbumin
RU2003108821/15A RU2003108821A (ru) 2002-03-29 2003-03-28 Способ получения наночастиц паклитаксела и альбумина
CNB031083617A CN1259902C (zh) 2002-03-29 2003-03-28 制造紫杉醇和白蛋白的纳米颗粒的方法
CNA2006100770064A CN1911446A (zh) 2002-03-29 2003-03-28 制备紫杉醇和白蛋白的纳米颗粒的方法
US11/334,004 US20060121119A1 (en) 2002-03-29 2006-01-17 Process for producing nanoparticles of paclitaxel and albumin
JP2011043799A JP2011132253A (ja) 2002-03-29 2011-03-01 パクリタキセルおよびアルブミンのナノ粒子を作製する方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI000681A ITMI20020681A1 (it) 2002-03-29 2002-03-29 Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina

Publications (2)

Publication Number Publication Date
ITMI20020681A0 ITMI20020681A0 (it) 2002-03-29
ITMI20020681A1 true ITMI20020681A1 (it) 2003-09-29

Family

ID=11449619

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI000681A ITMI20020681A1 (it) 2002-03-29 2002-03-29 Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina

Country Status (15)

Country Link
US (2) US20030185894A1 (it)
EP (1) EP1348431A1 (it)
JP (2) JP4794115B2 (it)
KR (1) KR20030078722A (it)
CN (2) CN1259902C (it)
AU (1) AU2003200920A1 (it)
BR (1) BR0300846A (it)
CA (1) CA2423915A1 (it)
IL (1) IL154762A0 (it)
IT (1) ITMI20020681A1 (it)
MX (1) MXPA03002543A (it)
NO (1) NO334407B1 (it)
NZ (1) NZ524605A (it)
RU (1) RU2003108821A (it)
ZA (1) ZA200302040B (it)

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US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
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KR20130028727A (ko) 2010-03-29 2013-03-19 아브락시스 바이오사이언스, 엘엘씨 치료제의 약물 전달 및 유효성 향상 방법
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Also Published As

Publication number Publication date
NZ524605A (en) 2004-03-26
KR20030078722A (ko) 2003-10-08
JP2003300878A (ja) 2003-10-21
NO20031448L (no) 2003-09-30
NO20031448D0 (no) 2003-03-28
US20060121119A1 (en) 2006-06-08
AU2003200920A1 (en) 2003-10-16
CA2423915A1 (en) 2003-09-29
NO334407B1 (no) 2014-02-24
ZA200302040B (en) 2003-09-17
US20030185894A1 (en) 2003-10-02
MXPA03002543A (es) 2005-08-26
JP2011132253A (ja) 2011-07-07
IL154762A0 (en) 2003-10-31
CN1911446A (zh) 2007-02-14
BR0300846A (pt) 2004-08-17
CN1448128A (zh) 2003-10-15
EP1348431A1 (en) 2003-10-01
RU2003108821A (ru) 2004-11-10
JP4794115B2 (ja) 2011-10-19
ITMI20020681A0 (it) 2002-03-29
CN1259902C (zh) 2006-06-21

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