DK1032575T3 - 2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor - Google Patents

2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor

Info

Publication number: DK1032575T3
Authority: DK; Denmark
Prior art keywords: cyclooxygenase; diaryl; cox; pyrazole; inhibitor
Prior art date: 1997-09-05

Application number

DK98947502T

Other languages

Danish (da)

English (en)

Inventor

Paul Beswick

Ian Campbell

Neil Mathews

Alan Naylor

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-05

Filing date

1998-09-03

Publication date

2003-10-20

1997-09-05 Priority claimed from GBGB9718792.6A external-priority patent/GB9718792D0/en

1997-12-23 Priority claimed from GBGB9727116.7A external-priority patent/GB9727116D0/en

1998-09-03 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2003-10-20 Application granted granted Critical

2003-10-20 Publication of DK1032575T3 publication Critical patent/DK1032575T3/da

Links

102000010907 Cyclooxygenase 2 Human genes 0.000 title 2
108010037462 Cyclooxygenase 2 Proteins 0.000 title 2
239000003112 inhibitor Substances 0.000 title 1
150000004892 pyridazines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Obesity (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)

DK98947502T 1997-09-05 1998-09-03 2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor DK1032575T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9718792.6A GB9718792D0 (en)	1997-09-05	1997-09-05	Chemical compounds
GBGB9727116.7A GB9727116D0 (en)	1997-12-23	1997-12-23	Chemical compounds
PCT/EP1998/005558 WO1999012930A1 (en)	1997-09-05	1998-09-03	2,3-diaryl-pyrazolo[1,5-b]pyridazines derivatives, their prepa ration and their use as cyclooxygenase 2 (cox-2) inhibitors

Publications (1)

Publication Number	Publication Date
DK1032575T3 true DK1032575T3 (da)	2003-10-20

Family

ID=26312181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK98947502T DK1032575T3 (da)	1997-09-05	1998-09-03	2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor

Country Status (28)

Country	Link
US (4)	US6451794B1 (sk)
EP (3)	EP1510519B1 (sk)
KR (1)	KR100382619B1 (sk)
CN (1)	CN1155600C (sk)
AP (1)	AP1354A (sk)
AT (3)	ATE281458T1 (sk)
AU (1)	AU744997B2 (sk)
BG (1)	BG64420B1 (sk)
BR (1)	BR9812046A (sk)
CA (1)	CA2303152A1 (sk)
DE (3)	DE69816651T2 (sk)
DK (1)	DK1032575T3 (sk)
EA (1)	EA002775B1 (sk)
EE (1)	EE04617B1 (sk)
ES (3)	ES2231757T3 (sk)
HR (1)	HRP20000122B1 (sk)
HU (1)	HUP0003644A3 (sk)
IL (1)	IL134688A (sk)
IS (1)	IS5389A (sk)
NO (1)	NO315559B1 (sk)
NZ (1)	NZ502985A (sk)
PL (1)	PL194557B1 (sk)
PT (1)	PT1032575E (sk)
SK (1)	SK283922B6 (sk)
TR (1)	TR200000595T2 (sk)
TW (1)	TW570922B (sk)
WO (1)	WO1999012930A1 (sk)
YU (1)	YU11900A (sk)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU11900A (sh) *	1997-09-05	2002-11-15	Glaxo Group Limited	Derivati 2,3-diaril-pirazolo (1,5-b) piridazina, njihovo dobijanje i njihova upotreba kao inhibitora ciklooksigenaze 2(cox-2)
ES2228127T3 (es)	1998-11-03	2005-04-01	Glaxo Group Limited	Derivados de pirazolopiridina como inhibidores selectivos de cox-2.
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6498166B1 (en)	1999-02-27	2002-12-24	Smithkline Beecham Corporation	Pyrazolopyridines
GB9929039D0 (en) *	1999-12-08	2000-02-02	Glaxo Group Ltd	Medicaments
GB9930358D0 (en) *	1999-12-22	2000-02-09	Glaxo Group Ltd	Process for the preparation of chemical compounds
IL150368A0 (en)	1999-12-23	2002-12-01	Nitromed Inc	Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
GB0002312D0 (en) *	2000-02-01	2000-03-22	Glaxo Group Ltd	Medicaments
CN100488500C (zh)	2000-07-20	2009-05-20	劳拉斯有限公司	Cox-2抑制剂预防免疫缺陷的用途
PE20020506A1 (es) *	2000-08-22	2002-07-09	Glaxo Group Ltd	Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0021494D0 (en) *	2000-09-01	2000-10-18	Glaxo Group Ltd	Chemical comkpounds
GB0025449D0 (en) *	2000-10-17	2000-11-29	Glaxo Group Ltd	Chemical compounds
ATE300541T1 (de)	2000-12-15	2005-08-15	Glaxo Group Ltd	Pyrazolopyridinderivate
WO2002048147A2 (en)	2000-12-15	2002-06-20	Glaxo Group Limited	Pyrazolopyridines
DE60201074T2 (de)	2001-03-08	2005-09-15	Smithkline Beecham Corp.	Pyrazolopyridinderivate
WO2002078700A1 (en)	2001-03-30	2002-10-10	Smithkline Beecham Corporation	Pyralopyridines, process for their preparation and use as therapteutic compounds
DE60212949T2 (de)	2001-04-10	2007-01-04	Smithkline Beecham Corp.	Antivirale pyrazolopyridin verbindungen
US6962914B2 (en)	2001-04-27	2005-11-08	Smithkline Beecham Corporation	Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds
US6756498B2 (en)	2001-04-27	2004-06-29	Smithkline Beecham Corporation	Process for the preparation of chemical compounds
GB0112810D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0112802D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
ATE337316T1 (de)	2001-06-21	2006-09-15	Smithkline Beecham Corp	Imidazo 1,2-aöpyridin-derivate zur prophylaxe und behandlung von herpes-infektionen
DE60211539T2 (de)	2001-10-05	2006-09-21	Smithkline Beecham Corp.	Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
GB0124936D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124933D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124934D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124939D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124931D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124941D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124938D0 (en)	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
GB0124932D0 (en) *	2001-10-17	2001-12-05	Glaxo Group Ltd	Chemical compounds
US7199120B2 (en)	2001-12-11	2007-04-03	Smithkline Beecham Corporation	Pyrazolo-pyridine derivatives as antiherpes agents
US7279473B2 (en)	2001-12-17	2007-10-09	Smithkline Beecham Corporation	Pyrazolopyridazine derivatives
KR100686537B1 (ko) *	2001-12-28	2007-02-27	씨제이 주식회사	사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체
KR100840907B1 (ko) *	2001-12-28	2008-06-24	씨제이제일제당 (주)	사이클로옥시게나제-2의 저해제로서 선택성이 뛰어난바이피리디닐 유도체
PT1474395E (pt) *	2002-02-12	2008-01-02	Smithkline Beecham Corp	Derivados de nicotinamida úteis como inibidores de p38
GB0206200D0 (en) *	2002-03-15	2002-05-01	Glaxo Group Ltd	Pharmaceutical compositions
GB0217757D0 (en)	2002-07-31	2002-09-11	Glaxo Group Ltd	Novel compounds
AU2003258630A1 (en) *	2002-08-19	2004-03-11	Glaxo Group Limited	Pyrimidine derivatives as selective cox-2 inhibitors
UY27939A1 (es)	2002-08-21	2004-03-31	Glaxo Group Ltd	Compuestos
GB0221443D0 (en)	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
US7153863B2 (en)	2002-10-03	2006-12-26	Smithkline Beecham Corporation	Therapeutic compounds based on pyrazolopyridline derivatives
US20040147581A1 (en) *	2002-11-18	2004-07-29	Pharmacia Corporation	Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
GB0227443D0 (en) *	2002-11-25	2002-12-31	Glaxo Group Ltd	Pyrimidine derivatives
ES2214129B1 (es) *	2003-02-13	2005-12-01	Almirall Prodesfarma, S.A.	3-fenilfuran-2-onas.
ES2214130B1 (es) *	2003-02-13	2005-12-01	Almirall Prodesfarma, S.A.	2-3'-bipiridinas.
ES2213485B1 (es) *	2003-02-13	2005-12-16	Almirall Prodesfarma, S.A.	Derivados de la 2-fenilpiran-4-ona.
US20040220155A1 (en) *	2003-03-28	2004-11-04	Pharmacia Corporation	Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith
GB0308201D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0308186D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
GB0308185D0 (en) *	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
ATE342722T1 (de)	2003-05-07	2006-11-15	Osteologix As	Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen
WO2005009342A2 (en) *	2003-07-16	2005-02-03	Pharmacia Corporation	Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
GB0318814D0 (en) *	2003-08-11	2003-09-10	Smithkline Beecham Corp	Novel compounds
GB0319037D0 (en) *	2003-08-13	2003-09-17	Glaxo Group Ltd	7-Azaindole Derivatives
US20050119262A1 (en) *	2003-08-21	2005-06-02	Pharmacia Corporation	Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
US20050113409A1 (en) *	2003-09-03	2005-05-26	Pharmacia Corporation	Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith
GB0402143D0 (en) *	2004-01-30	2004-03-03	Smithkline Beecham Corp	Novel compounds
US20080051416A1 (en) *	2004-10-05	2008-02-28	Smithkline Beecham Corporation	Novel Compounds
JP2008525439A (ja) *	2004-12-23	2008-07-17	ボイジャー・ファーマシューティカル・コーポレーション	アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはｎｍｄａレセプターアゴニスト
WO2006066968A1 (en)	2004-12-23	2006-06-29	Glaxo Group Limited	Pyridine compounds for the treatment of prostaglandin mediated diseases
US20060269579A1 (en) *	2005-05-25	2006-11-30	Musculoskeletal Research Llc	Compositions for treating osteoarthritis
US7767710B2 (en)	2005-05-25	2010-08-03	Calosyn Pharma, Inc.	Method for treating osteoarthritis
GB0512429D0 (en) *	2005-06-17	2005-07-27	Smithkline Beecham Corp	Novel compound
GB0704407D0 (en)	2007-03-07	2007-04-18	Glaxo Group Ltd	Compounds
US7943658B2 (en)	2007-07-23	2011-05-17	Bristol-Myers Squibb Company	Indole indane amide compounds useful as CB2 agonists and method
WO2009042854A1 (en) *	2007-09-26	2009-04-02	Musculoskeletal Research Llc	Ion-channel regulator compositions and methods of using same
UA103319C2 (en)	2008-05-06	2013-10-10	Глаксосмитклайн Ллк	Thiazole- and oxazole-benzene sulfonamide compounds
GB0813144D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
GB0813142D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
WO2011012622A1 (en)	2009-07-30	2011-02-03	Glaxo Group Limited	Benzoxazinone derivatives for the treatment of glytl mediated disorders
WO2011023753A1 (en)	2009-08-27	2011-03-03	Glaxo Group Limited	Benzoxazine derivatives as glycine transport inhibitors
GB201000685D0 (en)	2010-01-15	2010-03-03	Glaxo Group Ltd	Novel compounds
GB201007791D0 (en)	2010-05-10	2010-06-23	Glaxo Group Ltd	Novel compounds
GB201007789D0 (en)	2010-05-10	2010-06-23	Glaxo Group Ltd	Novel Compound
WO2012004604A1 (en)	2010-07-09	2012-01-12	Convergence Pharmaceuticals Limited	Tetrazole compounds as calcium channel blockers
JP6058556B2 (ja)	2011-01-19	2017-01-11	クオンベルゲンセプハルマセウトイカルスリミテッド	ＣａＶ２．２カルシウムチャンネルブロッカーとしてのピペラジン誘導体
GB201122113D0 (en)	2011-12-22	2012-02-01	Convergence Pharmaceuticals	Novel compounds
GB201417499D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417497D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417500D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
CA3209491A1 (en)	2021-03-15	2022-09-22	Saul Yedgar	Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease
CN115611901B (zh) *	2021-07-16	2024-04-30	华南理工大学	一种氮杂䓬类化合物或其药学上可接受的盐及其制备方法和应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5002941A (en)	1985-12-12	1991-03-26	Smithkline Beecham Corporation	Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
US4925849A (en)	1987-06-15	1990-05-15	Fujisawa Pharmaceutical Company, Ltd.	Pharmaceutically useful pyrazolopyridines
US5155114A (en)	1989-01-23	1992-10-13	Fujisawa Pharmaceutical Company, Ltd.	Method of treatment using pyrazolopyridine compound
GB8901423D0 (en)	1989-01-23	1989-03-15	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
AU6355190A (en)	1989-06-13	1991-01-17	Smithkline Beecham Corporation	Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
AU622330B2 (en)	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
IL95031A (en) *	1989-07-18	2007-03-08	Amgen Inc	A method of producing a recombinant human necrotic factor absorber
EP0533837A4 (en)	1990-06-12	1994-11-17	Smithkline Beecham Corp	Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases
GB9015764D0 (en)	1990-07-18	1990-09-05	Fujisawa Pharmaceutical Co	Pyrazolopyridine compound and processes for preparation thereof
FR2699077B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US5300478A (en)	1993-01-28	1994-04-05	Zeneca Limited	Substituted fused pyrazolo compounds
US5474995A (en) *	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
EP0739340A1 (en)	1994-01-10	1996-10-30	Merck Frosst Canada Inc.	Phenyl heterocycles as cox-2 inhibitors
US5521213A (en) *	1994-08-29	1996-05-28	Merck Frosst Canada, Inc.	Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5552422A (en)	1995-01-11	1996-09-03	Merck Frosst Canada, Inc.	Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
CA2216809A1 (en) *	1995-04-04	1996-10-10	Alan Naylor	Imidazo[1,2-a]pyridine derivatives
US5700816A (en)	1995-06-12	1997-12-23	Isakson; Peter C.	Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US6342510B1 (en)	1995-06-12	2002-01-29	G. D. Searle & Co.	Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
EP0833622B8 (en)	1995-06-12	2005-10-12	G.D. Searle & Co.	Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
GB9513508D0 (en) *	1995-07-03	1995-09-06	Fujisawa Pharmaceutical Co	Quinazoline derivatives
YU11900A (sh)	1997-09-05	2002-11-15	Glaxo Group Limited	Derivati 2,3-diaril-pirazolo (1,5-b) piridazina, njihovo dobijanje i njihova upotreba kao inhibitora ciklooksigenaze 2(cox-2)
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds

1998
- 1998-09-03 YU YU11900A patent/YU11900A/sh unknown
- 1998-09-03 HU HU0003644A patent/HUP0003644A3/hu unknown
- 1998-09-03 AT AT03077298T patent/ATE281458T1/de not_active IP Right Cessation
- 1998-09-03 AP APAP/P/2000/001753A patent/AP1354A/en active
- 1998-09-03 EP EP04025990A patent/EP1510519B1/en not_active Expired - Lifetime
- 1998-09-03 PT PT98947502T patent/PT1032575E/pt unknown
- 1998-09-03 AT AT98947502T patent/ATE245649T1/de not_active IP Right Cessation
- 1998-09-03 SK SK294-2000A patent/SK283922B6/sk unknown
- 1998-09-03 KR KR10-2000-7002322A patent/KR100382619B1/ko not_active IP Right Cessation
- 1998-09-03 ES ES03077298T patent/ES2231757T3/es not_active Expired - Lifetime
- 1998-09-03 NZ NZ502985A patent/NZ502985A/en unknown
- 1998-09-03 AU AU94395/98A patent/AU744997B2/en not_active Ceased
- 1998-09-03 WO PCT/EP1998/005558 patent/WO1999012930A1/en not_active Application Discontinuation
- 1998-09-03 DE DE69816651T patent/DE69816651T2/de not_active Expired - Lifetime
- 1998-09-03 DK DK98947502T patent/DK1032575T3/da active
- 1998-09-03 DE DE69827419T patent/DE69827419T2/de not_active Expired - Lifetime
- 1998-09-03 PL PL98339059A patent/PL194557B1/pl unknown
- 1998-09-03 ES ES04025990T patent/ES2256817T3/es not_active Expired - Lifetime
- 1998-09-03 TR TR2000/00595T patent/TR200000595T2/xx unknown
- 1998-09-03 AT AT04025990T patent/ATE317845T1/de not_active IP Right Cessation
- 1998-09-03 EA EA200000188A patent/EA002775B1/ru not_active IP Right Cessation
- 1998-09-03 IL IL13468898A patent/IL134688A/xx not_active IP Right Cessation
- 1998-09-03 EP EP98947502A patent/EP1032575B1/en not_active Expired - Lifetime
- 1998-09-03 CN CNB988108763A patent/CN1155600C/zh not_active Expired - Fee Related
- 1998-09-03 BR BR9812046-8A patent/BR9812046A/pt not_active Application Discontinuation
- 1998-09-03 CA CA002303152A patent/CA2303152A1/en not_active Abandoned
- 1998-09-03 ES ES98947502T patent/ES2203985T3/es not_active Expired - Lifetime
- 1998-09-03 EP EP03077298A patent/EP1369421B1/en not_active Expired - Lifetime
- 1998-09-03 DE DE69833464T patent/DE69833464T2/de not_active Expired - Lifetime
- 1998-09-03 US US09/508,029 patent/US6451794B1/en not_active Expired - Fee Related
- 1998-09-03 EE EEP200000113A patent/EE04617B1/xx not_active IP Right Cessation
1999
- 1999-02-19 TW TW088102423A patent/TW570922B/zh not_active IP Right Cessation
2000
- 2000-02-25 IS IS5389A patent/IS5389A/is unknown
- 2000-03-03 NO NO20001102A patent/NO315559B1/no unknown
- 2000-03-03 HR HR960321A patent/HRP20000122B1/xx not_active IP Right Cessation
- 2000-03-28 BG BG104279A patent/BG64420B1/bg unknown
2002
- 2002-08-05 US US10/212,514 patent/US6831097B2/en not_active Expired - Fee Related
- 2002-08-05 US US10/212,513 patent/US6861429B2/en not_active Expired - Fee Related
2004
- 2004-10-27 US US10/974,893 patent/US20050113377A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20050113377A1 (en)	2005-05-26
DE69833464D1 (de)	2006-04-20
US6861429B2 (en)	2005-03-01
HUP0003644A3 (en)	2002-11-28
CN1278263A (zh)	2000-12-27
ATE281458T1 (de)	2004-11-15
IL134688A0 (en)	2001-04-30
AU744997B2 (en)	2002-03-07
EP1369421A1 (en)	2003-12-10
EA002775B1 (ru)	2002-08-29
JP3167700B2 (sk)	2001-05-21
IL134688A (en)	2005-05-17
US20030040517A1 (en)	2003-02-27
EE200000113A (et)	2000-12-15
EP1510519B1 (en)	2006-02-15
BR9812046A (pt)	2000-09-26
AP2000001753A0 (en)	2000-03-31
ATE245649T1 (de)	2003-08-15
BG64420B1 (bg)	2005-01-31
KR20010023669A (ko)	2001-03-26
PT1032575E (pt)	2003-11-28
ES2256817T3 (es)	2006-07-16
HUP0003644A2 (hu)	2001-09-28
NO20001102L (no)	2000-05-03
CN1155600C (zh)	2004-06-30
DE69816651D1 (de)	2003-08-28
IS5389A (is)	2000-02-25
JP2001515901A (ja)	2001-09-25
EP1032575A1 (en)	2000-09-06
NO20001102D0 (no)	2000-03-03
CA2303152A1 (en)	1999-03-18
EA200000188A1 (ru)	2000-10-30
NO315559B1 (no)	2003-09-22
DE69827419D1 (de)	2004-12-09
DE69833464T2 (de)	2006-08-24
EP1032575B1 (en)	2003-07-23
DE69827419T2 (de)	2005-10-27
EE04617B1 (et)	2006-04-17
WO1999012930A1 (en)	1999-03-18
PL194557B1 (pl)	2007-06-29
BG104279A (en)	2000-12-29
SK283922B6 (sk)	2004-05-04
US20030008872A1 (en)	2003-01-09
DE69816651T2 (de)	2004-04-01
YU11900A (sh)	2002-11-15
EP1369421B1 (en)	2004-11-03
ES2203985T3 (es)	2004-04-16
TW570922B (en)	2004-01-11
ATE317845T1 (de)	2006-03-15
ES2231757T3 (es)	2005-05-16
SK2942000A3 (en)	2001-03-12
HRP20000122A2 (en)	2001-02-28
US6451794B1 (en)	2002-09-17
AP1354A (en)	2004-12-29
HRP20000122B1 (en)	2003-06-30
NZ502985A (en)	2002-04-26
TR200000595T2 (tr)	2000-12-21
AU9439598A (en)	1999-03-29
KR100382619B1 (ko)	2003-05-09
EP1510519A1 (en)	2005-03-02
US6831097B2 (en)	2004-12-14
PL339059A1 (en)	2000-12-04

Publication	Publication Date	Title
DK1032575T3 (da)	2003-10-20	2,3-diaryl-pyrazol(1,5-b)pyridazinderivater, deres fremstilling og anvendelse som cyclooxygenase 2 (COX-2) inhibitor
NO996491D0 (no)	1999-12-27	4-brom- eller 4-iod-fenylaminobenzhydroksamsyre-derivater og deres anvendelse som MEK-inhibitorer
NO20011956L (no)	2001-04-20	Substituerte fenylderivater, deres fremstilling og anvendelse
DK1015434T3 (da)	2002-08-05	Ny pyrimidin-4-on og pyrimidin-4-thion som fungicid
DK0906292T3 (da)	2003-10-27	Triazolylmercaptider og deres anvendelse som mikrobicider
NO986103D0 (no)	1998-12-23	Substituerte indazol-derivater og deres anvendelse som fosfodiesterase (PDE
NO20006029L (no)	2001-01-26	Pyrazolinderivater, deres fremstilling og anvendelse som legemidler
DK0958292T3 (da)	2007-05-07	4-3(3-heterocyclyl-1-benzoyl)pyrazoler og deres anvendelse som herbicider
NO993003D0 (no)	1999-06-18	Sulfonamid-derivater, fremgangsmÕte for deres fremstilling og deres anvendelse som medikamenter
NO954369L (no)	1996-05-03	Oksazolidindionderivater, deres fremstilling og anvendelse
NO20011503D0 (no)	2001-03-23	Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, deres fremstilling og anvendelse som anorektiske legemidler
NO985977D0 (no)	1998-12-18	Spiro-piperidinderivater og deres anvendelse som terapeutiske midler
DK1006110T3 (da)	2004-04-26	Derivater af acylpiperazinylpyrimidiner, fremstilling deraf og anvendelse som lægemidler
NO984761D0 (no)	1998-10-12	Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler
DK1019358T3 (da)	2003-09-01	3,3-diarylpropylaminer, deres anvendelse og fremstilling
DK1012137T3 (da)	2003-03-10	Aromatiske C-16-C-20-substituerede tetrahydro-prostaglandiner og deres anvendelse som prostaglandin FP-agonister
NO20005146D0 (no)	2000-10-13	Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter
DK1073672T3 (da)	2003-12-08	Antipicornavirale forbindelser, deres fremstilling og anvendelse
NO995513L (no)	2000-01-12	N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK-
NO20001934D0 (no)	2000-04-13	3-Substituerte tetrahydropyridopyrimidinon-derivater, deres fremstilling og anvendelse
NO972256D0 (no)	1997-05-16	O-Benzyloksimeterderivater og deres anvendelse som pesticider
NO20006479D0 (no)	2000-12-19	Tienopyridinforbindelser, deres fremstilling og anvendelse
NO20012802D0 (no)	2001-06-07	Benzofuranderivater, deres fremstilling og anvendelse
DK1010689T3 (da)	2003-02-10	Substituerede cycloheptener, deres fremstilling og anvendelse
NO992629D0 (no)	1999-06-01	Substituerte benzotiopyransalter og deres anvendelse som herbicider