DK0974359T4 - Formuleringer med FSH og FSH-varianter, der indeholder benzylalkohol som konserveringsmiddel - Google Patents

Formuleringer med FSH og FSH-varianter, der indeholder benzylalkohol som konserveringsmiddel

Info

Publication number
DK0974359T4
DK0974359T4 DK99305664T DK99305664T DK0974359T4 DK 0974359 T4 DK0974359 T4 DK 0974359T4 DK 99305664 T DK99305664 T DK 99305664T DK 99305664 T DK99305664 T DK 99305664T DK 0974359 T4 DK0974359 T4 DK 0974359T4
Authority
DK
Denmark
Prior art keywords
fsh
preservative
formulations
benzyl alcohol
variants containing
Prior art date
Application number
DK99305664T
Other languages
Danish (da)
English (en)
Other versions
DK0974359T3 (da
Inventor
James Arthur Hoffmann
Jirong Lu
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27536687&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0974359(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Application granted granted Critical
Publication of DK0974359T3 publication Critical patent/DK0974359T3/da
Publication of DK0974359T4 publication Critical patent/DK0974359T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK99305664T 1998-07-23 1999-07-16 Formuleringer med FSH og FSH-varianter, der indeholder benzylalkohol som konserveringsmiddel DK0974359T4 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9390698P 1998-07-23 1998-07-23
US9461198P 1998-07-30 1998-07-30
US9476798P 1998-07-31 1998-07-31
US9871198P 1998-09-01 1998-09-01
US10069698P 1998-09-17 1998-09-17

Publications (2)

Publication Number Publication Date
DK0974359T3 DK0974359T3 (da) 2003-03-03
DK0974359T4 true DK0974359T4 (da) 2009-06-29

Family

ID=27536687

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99305664T DK0974359T4 (da) 1998-07-23 1999-07-16 Formuleringer med FSH og FSH-varianter, der indeholder benzylalkohol som konserveringsmiddel

Country Status (24)

Country Link
EP (2) EP0974359B2 (es)
JP (1) JP4719357B2 (es)
KR (1) KR20010083126A (es)
CN (1) CN1309567A (es)
AR (1) AR020618A1 (es)
AT (2) ATE228850T1 (es)
AU (1) AU776823B2 (es)
BR (1) BR9912243A (es)
CA (1) CA2335340C (es)
CO (1) CO5090905A1 (es)
DE (2) DE69928296T2 (es)
DK (1) DK0974359T4 (es)
ES (2) ES2183486T3 (es)
HK (1) HK1026615A1 (es)
ID (1) ID28747A (es)
IL (1) IL140984A0 (es)
MY (1) MY135913A (es)
NO (1) NO20010326L (es)
NZ (1) NZ508874A (es)
PE (1) PE20000939A1 (es)
PL (1) PL346127A1 (es)
PT (1) PT974359E (es)
SI (1) SI0974359T1 (es)
WO (1) WO2000004913A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
EP1169053A1 (en) 1999-04-13 2002-01-09 Inhale Therapeutic Systems, Inc. Pulmonary administration of dry powder formulations for treating infertility
TW201002201A (en) 2001-03-01 2010-01-16 Lonza Ag Preservative blends containing quaternary ammonium compounds
RS57872B1 (sr) * 2003-04-02 2018-12-31 Ares Trading Sa Tečne farmaceutske formulacije fsh i lh zajedno sa nejonskim surfaktantom
US7740884B2 (en) 2003-06-20 2010-06-22 Ares Trading S.A. Freeze-dried FSH/LH formulations
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
WO2008098169A2 (en) * 2007-02-08 2008-08-14 Aspenbio Pharma, Inc. Compositions and methods including expression and bioactivity of bovine follicle stimulating hormone
CN101720332B (zh) 2007-06-28 2014-08-13 拉蒂奥法姆有限责任公司 生产促卵泡激素的细胞克隆
DK2219607T3 (da) * 2007-11-01 2013-06-17 Merck Serono Sa Flydende LH-formuleringer
UA99337C2 (ru) * 2008-02-08 2012-08-10 Биодженерикс Аг Жидкая лекарственная форма фсг
CN102309745B (zh) * 2008-09-17 2013-05-08 上海天伟生物制药有限公司 一种***冻干针剂
ES2558768T3 (es) 2009-06-24 2016-02-08 Tecpharma Licensing Ag Dispositivo de administración con función de cebado
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
WO2011076281A1 (de) 2009-12-23 2011-06-30 Tecpharma Licensing Ag Entfernen einer nadelschutzkappe von einer nadel
EP2515973B1 (de) 2009-12-23 2018-02-21 Tecpharma Licensing AG Injektionsvorrichtung mit einer nadelschutzhülse
EP2534650B1 (en) 2010-02-11 2016-07-13 Finox Ag Injection training dummy
RU2553375C2 (ru) * 2010-02-12 2015-06-10 Интас Биофармасьютикалс Лимитед Жидкий состав фолликулостимулирующего гормона
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
KR20140018970A (ko) * 2011-04-22 2014-02-13 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 저수준 잔류용매를 함유한 당단백질 조성물 및 그 제조방법과 용도
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN105658201A (zh) * 2013-11-12 2016-06-08 卡迪拉保健有限公司 ***的制剂
BR112018003455A2 (pt) * 2015-09-17 2018-09-25 Glycotope Gmbh composição ou composição farmacêutica e uso da composição
GB201603280D0 (en) * 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB839300A (en) * 1957-09-05 1960-06-29 Organon Labor Ltd Adrenocorticotropic hormone preparations and process for making same
US4659696A (en) † 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
US5162306A (en) * 1987-01-23 1992-11-10 Donaldson Lloyd E Composition and method for producing superovulation in mammals
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
FR2623715B1 (fr) * 1987-11-26 1990-12-21 Lafon Labor Structures peptidiques, immunogenes les contenant et leurs applications au controle de la fertilite
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
EP0955062B1 (en) * 1992-07-31 2007-04-18 Genentech, Inc. Human growth hormone aqueous formulation
US5661125A (en) * 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
ATE178789T1 (de) † 1994-02-21 1999-04-15 Takeda Chemical Industries Ltd Polyester matrix für eine pharmazeutische zusammensetzung mit verzögerter freigabe
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
JP4057058B2 (ja) * 1995-11-07 2008-03-05 ジェネンテック インコーポレーテッド Ｎｇｆの安定化処方
GB2317010A (en) * 1996-09-04 1998-03-11 Eev Ltd Gas sensor detecting only non-reflected light
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US6287587B2 (en) † 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
MY120063A (en) * 1997-12-09 2005-08-30 Lilly Co Eli Stabilized teriparatide solutions
JP2000151148A (ja) * 1998-11-13 2000-05-30 Mitsumi Electric Co Ltd 携帯用電子機器のコード接続構造

Also Published As

Publication number Publication date
PE20000939A1 (es) 2000-09-20
EP0974359A2 (en) 2000-01-26
EP1188444B1 (en) 2005-11-09
AR020618A1 (es) 2002-05-22
DE69904262T2 (de) 2003-07-24
NO20010326D0 (no) 2001-01-19
WO2000004913A1 (en) 2000-02-03
JP2002521342A (ja) 2002-07-16
EP0974359B1 (en) 2002-12-04
SI0974359T1 (en) 2003-04-30
KR20010083126A (ko) 2001-08-31
CN1309567A (zh) 2001-08-22
IL140984A0 (en) 2002-02-10
ATE308990T1 (de) 2005-11-15
PT974359E (pt) 2003-02-28
NZ508874A (en) 2004-03-26
DE69928296D1 (de) 2005-12-15
ES2250290T3 (es) 2006-04-16
ID28747A (id) 2001-06-28
EP0974359A3 (en) 2001-02-07
ATE228850T1 (de) 2002-12-15
HK1026615A1 (en) 2000-12-22
ES2183486T3 (es) 2003-03-16
AU4998099A (en) 2000-02-14
EP0974359B2 (en) 2009-04-22
DE69904262D1 (de) 2003-01-16
DK0974359T3 (da) 2003-03-03
CA2335340C (en) 2013-03-05
CA2335340A1 (en) 2000-02-03
MY135913A (en) 2008-07-31
EP1188444A1 (en) 2002-03-20
DE69928296T2 (de) 2006-07-27
AU776823B2 (en) 2004-09-23
NO20010326L (no) 2001-03-20
JP4719357B2 (ja) 2011-07-06
CO5090905A1 (es) 2001-10-30
BR9912243A (pt) 2001-10-16
DE69904262T3 (de) 2009-08-13
PL346127A1 (en) 2002-01-28

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