ATE228850T1 - Benzylalkohol enthaltene fsh und fsh-varianten formulierungen - Google Patents

Benzylalkohol enthaltene fsh und fsh-varianten formulierungen

Info

Publication number
ATE228850T1
ATE228850T1 AT99305664T AT99305664T ATE228850T1 AT E228850 T1 ATE228850 T1 AT E228850T1 AT 99305664 T AT99305664 T AT 99305664T AT 99305664 T AT99305664 T AT 99305664T AT E228850 T1 ATE228850 T1 AT E228850T1
Authority
AT
Austria
Prior art keywords
fsh
benzyl alcohol
formulations containing
containing benzyl
variant formulations
Prior art date
Application number
AT99305664T
Other languages
English (en)
Inventor
James Arthur Hoffmann
Jirong Lu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27536687&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE228850(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE228850T1 publication Critical patent/ATE228850T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pregnancy & Childbirth (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99305664T 1998-07-23 1999-07-16 Benzylalkohol enthaltene fsh und fsh-varianten formulierungen ATE228850T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9390698P 1998-07-23 1998-07-23
US9461198P 1998-07-30 1998-07-30
US9476798P 1998-07-31 1998-07-31
US9871198P 1998-09-01 1998-09-01
US10069698P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
ATE228850T1 true ATE228850T1 (de) 2002-12-15

Family

ID=27536687

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99305664T ATE228850T1 (de) 1998-07-23 1999-07-16 Benzylalkohol enthaltene fsh und fsh-varianten formulierungen
AT01130213T ATE308990T1 (de) 1998-07-23 1999-07-16 Stabile fsh und fsh varianten enthaltende arzneimitteln

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01130213T ATE308990T1 (de) 1998-07-23 1999-07-16 Stabile fsh und fsh varianten enthaltende arzneimitteln

Country Status (24)

Country Link
EP (2) EP0974359B2 (de)
JP (1) JP4719357B2 (de)
KR (1) KR20010083126A (de)
CN (1) CN1309567A (de)
AR (1) AR020618A1 (de)
AT (2) ATE228850T1 (de)
AU (1) AU776823B2 (de)
BR (1) BR9912243A (de)
CA (1) CA2335340C (de)
CO (1) CO5090905A1 (de)
DE (2) DE69904262T3 (de)
DK (1) DK0974359T4 (de)
ES (2) ES2183486T3 (de)
HK (1) HK1026615A1 (de)
ID (1) ID28747A (de)
IL (1) IL140984A0 (de)
MY (1) MY135913A (de)
NO (1) NO20010326L (de)
NZ (1) NZ508874A (de)
PE (1) PE20000939A1 (de)
PL (1) PL346127A1 (de)
PT (1) PT974359E (de)
SI (1) SI0974359T1 (de)
WO (1) WO2000004913A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US20030166525A1 (en) 1998-07-23 2003-09-04 Hoffmann James Arthur FSH Formulation
AU779869B2 (en) 1999-04-13 2005-02-17 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
TW201002201A (en) 2001-03-01 2010-01-16 Lonza Ag Preservative blends containing quaternary ammonium compounds
AR043972A1 (es) * 2003-04-02 2005-08-17 Ares Trading Sa Formulaciones farmaceuticas de fsh y lh
EP1638595B1 (de) 2003-06-20 2013-03-20 Ares Trading S.A. Gefriergetrocknete fsh / lh formulierungen
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
US8518881B2 (en) 2007-02-08 2013-08-27 Aspenbio Pharma, Inc. Methods for inducing superovulation in ungulates
UA103598C2 (uk) 2007-06-28 2013-11-11 Биодженерикс Аг Клон клітин, що продукують fsh
JP5551601B2 (ja) * 2007-11-01 2014-07-16 メルク セローノ ソシエテ アノニム Ｌｈ液体調製物
WO2009098318A1 (en) * 2008-02-08 2009-08-13 Biogenerix Ag Liquid formulation of fsh
CN102309745B (zh) * 2008-09-17 2013-05-08 上海天伟生物制药有限公司 一种***冻干针剂
WO2010149214A1 (de) 2009-06-24 2010-12-29 Tecpharma Licensing Ag Verabreichungsgerät mit priming funktion
EP2325194A1 (de) 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
WO2011076280A1 (de) 2009-12-23 2011-06-30 Tecpharma Licensing Ag Injektionsvorrichtung mit einer nadelschutzhülse
WO2011076281A1 (de) 2009-12-23 2011-06-30 Tecpharma Licensing Ag Entfernen einer nadelschutzkappe von einer nadel
EP2534650B1 (de) 2010-02-11 2016-07-13 Finox Ag Attrappe für injektionsübungen
CN102821782B (zh) * 2010-02-12 2015-07-15 印塔斯生物制药有限公司 促卵泡激素的液体配制品
EP2417982A1 (de) 2010-07-30 2012-02-15 Ferring B.V. Stabilisierung von Gonadotropinen
WO2012142961A1 (zh) * 2011-04-22 2012-10-26 上海天伟生物制药有限公司 一种低溶剂残留的糖蛋白组合物及其制备方法和用途
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN105658201A (zh) * 2013-11-12 2016-06-08 卡迪拉保健有限公司 ***的制剂
MX2018002921A (es) * 2015-09-17 2018-12-10 Glycotope Gmbh Composicion de hormona foliculo-estimulante mamifera con estabilidad incrementada.
GB201603280D0 (en) * 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB839300A (en) * 1957-09-05 1960-06-29 Organon Labor Ltd Adrenocorticotropic hormone preparations and process for making same
US4659696A (en) † 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
US5162306A (en) * 1987-01-23 1992-11-10 Donaldson Lloyd E Composition and method for producing superovulation in mammals
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
FR2623715B1 (fr) * 1987-11-26 1990-12-21 Lafon Labor Structures peptidiques, immunogenes les contenant et leurs applications au controle de la fertilite
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
IT1250075B (it) * 1991-12-18 1995-03-30 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti gonadotropine.
AU686567C (en) * 1992-07-31 2002-08-08 Genentech Inc. Human growth hormone aqueous formulation
US5661125A (en) * 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
DE69508985T2 (de) † 1994-02-21 1999-08-19 Takeda Chemical Industries Ltd Polyester Matrix für eine pharmazeutische Zusammensetzung mit verzögerter Freigabe
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
AU721112B2 (en) * 1995-11-07 2000-06-22 Genentech Inc. Stabilizing formulation for NGF
GB2317010A (en) * 1996-09-04 1998-03-11 Eev Ltd Gas sensor detecting only non-reflected light
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US6287587B2 (en) † 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
ZA9811127B (en) * 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
JP2000151148A (ja) * 1998-11-13 2000-05-30 Mitsumi Electric Co Ltd 携帯用電子機器のコード接続構造

Also Published As

Publication number Publication date
DE69904262T3 (de) 2009-08-13
PE20000939A1 (es) 2000-09-20
BR9912243A (pt) 2001-10-16
HK1026615A1 (en) 2000-12-22
IL140984A0 (en) 2002-02-10
JP2002521342A (ja) 2002-07-16
CA2335340C (en) 2013-03-05
ATE308990T1 (de) 2005-11-15
ES2183486T3 (es) 2003-03-16
ES2250290T3 (es) 2006-04-16
ID28747A (id) 2001-06-28
EP0974359A2 (de) 2000-01-26
NO20010326L (no) 2001-03-20
MY135913A (en) 2008-07-31
DE69928296D1 (de) 2005-12-15
NO20010326D0 (no) 2001-01-19
CO5090905A1 (es) 2001-10-30
DE69904262D1 (de) 2003-01-16
EP1188444B1 (de) 2005-11-09
KR20010083126A (ko) 2001-08-31
CN1309567A (zh) 2001-08-22
EP0974359A3 (de) 2001-02-07
DE69928296T2 (de) 2006-07-27
WO2000004913A1 (en) 2000-02-03
CA2335340A1 (en) 2000-02-03
DK0974359T4 (da) 2009-06-29
EP0974359B1 (de) 2002-12-04
AU776823B2 (en) 2004-09-23
PL346127A1 (en) 2002-01-28
SI0974359T1 (en) 2003-04-30
DE69904262T2 (de) 2003-07-24
EP0974359B2 (de) 2009-04-22
NZ508874A (en) 2004-03-26
EP1188444A1 (de) 2002-03-20
DK0974359T3 (da) 2003-03-03
JP4719357B2 (ja) 2011-07-06
AU4998099A (en) 2000-02-14
PT974359E (pt) 2003-02-28
AR020618A1 (es) 2002-05-22

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