DK0970046T3 - N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorer - Google Patents
N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorerInfo
- Publication number
- DK0970046T3 DK0970046T3 DK98910022T DK98910022T DK0970046T3 DK 0970046 T3 DK0970046 T3 DK 0970046T3 DK 98910022 T DK98910022 T DK 98910022T DK 98910022 T DK98910022 T DK 98910022T DK 0970046 T3 DK0970046 T3 DK 0970046T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- heteroarylsulfanyl
- sulfinyl
- sulfonyl
- aryl
- Prior art date
Links
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
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- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
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- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
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Applications Claiming Priority (2)
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US80672897A | 1997-02-27 | 1997-02-27 | |
PCT/US1998/003291 WO1998038163A1 (en) | 1997-02-27 | 1998-02-17 | N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
Publications (1)
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DK0970046T3 true DK0970046T3 (da) | 2004-04-13 |
Family
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Family Applications (2)
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DK98910022T DK0970046T3 (da) | 1997-02-27 | 1998-02-17 | N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorer |
DK98906468T DK0973512T3 (da) | 1997-02-27 | 1998-02-17 | N-hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl-, aryl- eller heteroarylamider som matrixmetalloproteinaseinhibitorer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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DK98906468T DK0973512T3 (da) | 1997-02-27 | 1998-02-17 | N-hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl-, aryl- eller heteroarylamider som matrixmetalloproteinaseinhibitorer |
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EP (2) | EP0970046B1 (no) |
JP (2) | JP2001519777A (no) |
KR (2) | KR20000075808A (no) |
CN (2) | CN1210263C (no) |
AR (1) | AR011451A1 (no) |
AT (2) | ATE256107T1 (no) |
AU (2) | AU748998B2 (no) |
BG (2) | BG103757A (no) |
BR (2) | BR9807802A (no) |
CA (2) | CA2282656A1 (no) |
CY (1) | CY2477B1 (no) |
DE (2) | DE69823019T2 (no) |
DK (2) | DK0970046T3 (no) |
EA (2) | EA001742B1 (no) |
EE (2) | EE04150B1 (no) |
ES (2) | ES2217540T3 (no) |
GE (2) | GEP20022627B (no) |
HK (1) | HK1024875A1 (no) |
HU (2) | HUP0002092A3 (no) |
IL (2) | IL131258A0 (no) |
NO (2) | NO314302B1 (no) |
NZ (2) | NZ337298A (no) |
PL (2) | PL335401A1 (no) |
PT (2) | PT973512E (no) |
SK (2) | SK115899A3 (no) |
TR (2) | TR199902095T2 (no) |
TW (1) | TW568900B (no) |
UA (1) | UA58543C2 (no) |
WO (2) | WO1998038163A1 (no) |
YU (2) | YU40999A (no) |
ZA (2) | ZA981625B (no) |
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PL342548A1 (en) * | 1998-02-19 | 2001-06-18 | American Cyanamid Co | N-hydroxy-2-(alkyl-, aryl- or heteroarylsulphanyl-, sulphinyl- or sulphonyl)-3-substituted alkyl-, aryl- or heteroarylamides as inhibitors of matrix metaloproteinases |
ES2213985T3 (es) * | 1998-11-05 | 2004-09-01 | Pfizer Products Inc. | Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico. |
US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
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US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
AR035312A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Compuestos de acido hidroxamico que contienen alquinilo como inhibidores de metaloproteinasa de matriz/tace, composicion farmaceutica que los comprenden y el uso de los mismos para la manufactura de un medicamento |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
EP1157021A1 (en) | 1999-02-08 | 2001-11-28 | G.D. SEARLE & CO. | Sulfamato hydroxamic acid metalloprotease inhibitor |
SE9901572D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
US6511993B1 (en) | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
AU2001233034A1 (en) * | 2000-01-27 | 2001-08-07 | American Cyanamid Company | Method for preparing alpha-sulfonyl hydroxamic acid derivatives |
US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
JP2004530691A (ja) | 2001-05-11 | 2004-10-07 | ファルマシア・コーポレーション | 芳香族スルホンヒドロキサメートおよびプロテアーゼ阻害剤としてのそれらの使用 |
US6683078B2 (en) | 2001-07-19 | 2004-01-27 | Pharmacia Corporation | Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors |
CN100525763C (zh) | 2002-03-05 | 2009-08-12 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
JP2005537228A (ja) | 2002-04-25 | 2005-12-08 | ファルマシア・コーポレーション | ピペリジニル−及びピペラジニル−スルホニルメチルヒドロキサム酸並びにプロテアーゼ阻害剤としてのその使用 |
BR0312036A (pt) * | 2002-06-25 | 2005-04-05 | Pharmacia Corp | ácido arilsulfonilhidroxâmico e derivados de amida bem como composição farmacêutica contendo os mesmos e uso dos mesmos |
TW200418825A (en) | 2002-12-16 | 2004-10-01 | Hoffmann La Roche | Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives |
US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
CA2632030A1 (en) | 2005-12-15 | 2007-06-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
EP2081905B1 (en) | 2006-07-28 | 2012-09-12 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
US7928123B2 (en) | 2006-09-25 | 2011-04-19 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
CA2665629A1 (en) | 2006-10-05 | 2008-04-17 | Janssen Pharmaceutica N.V. | Heterocyclic derived metalloprotease inhibitors |
WO2009008905A1 (en) * | 2007-02-01 | 2009-01-15 | Panthera Biopharma, Llc. | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
WO2009061652A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
WO2010005782A1 (en) | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
BRPI0919172A2 (pt) | 2008-09-25 | 2015-12-15 | Boehringer Ingelheim Int | compostos os quais modulam seletivamente o receptor de cb2 |
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WO2010147791A1 (en) | 2009-06-16 | 2010-12-23 | Boehringer Ingelheim International Gmbh | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
EP2480544A1 (en) | 2009-09-22 | 2012-08-01 | Boehringer Ingelheim International GmbH | Compounds which selectively modulate the cb2 receptor |
JP5805646B2 (ja) | 2009-09-30 | 2015-11-04 | ブイティーブイ・セラピューティクス・エルエルシー | アルツハイマー病の治療のための置換イミダゾール誘導体 |
JP5671545B2 (ja) * | 2009-10-13 | 2015-02-18 | ファイザー・インク | 抗菌薬として有用なc結合ヒドロキサム酸誘導体 |
JP2013517271A (ja) | 2010-01-15 | 2013-05-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節する化合物 |
WO2011109324A1 (en) | 2010-03-05 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the cb2 receptor |
US8846936B2 (en) | 2010-07-22 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the CB2 receptor |
KR101836547B1 (ko) * | 2010-09-17 | 2018-04-19 | 고쿠리츠다이가쿠호우진 도쿄다이가쿠 | 혈소판의 기능을 유지하기 위한 조성물 |
WO2014012964A1 (en) * | 2012-07-18 | 2014-01-23 | Proyecto De Biomedicina Cima, S.L. | New antifibrinolytic compounds |
EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
MX2016014989A (es) | 2014-05-16 | 2017-03-31 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de quinazolina-4 (3h)-ona. |
CN107188837B (zh) * | 2017-06-06 | 2019-05-28 | 温州大学 | 一种α-酰基高烯丙基硫醚类化合物的合成方法 |
US20210393632A1 (en) | 2018-10-04 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr inhibitors for treating keratodermas |
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GB1574822A (en) * | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
FR2528041A1 (fr) * | 1982-06-04 | 1983-12-09 | Lafon Labor | Acides halogenobenzhydrylsulfinylacetohydroxamiques, procede de preparation et utilisation en therapeutique |
FR2561646B1 (fr) * | 1984-03-23 | 1987-10-09 | Lafon Labor | Derives d'acide (a-(alkylaminomethyl)-benzyl)-thioacetique, procede de preparation et utilisation en therapeutique |
IL92915A0 (en) * | 1989-01-05 | 1990-09-17 | Ciba Geigy Ag | Certain pyrrolylphenyl-substituted hydroxamic acid derivatives |
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US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
FR2708201B1 (fr) * | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
DE69624477T2 (de) * | 1995-05-10 | 2003-06-26 | Darwin Discovery Ltd | Peptide, die metallproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung |
US5665777A (en) * | 1995-11-14 | 1997-09-09 | Abbott Laboratories | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
JP4358908B2 (ja) * | 1996-01-02 | 2009-11-04 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換(アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル)ヒドロキサム酸化合物 |
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1998
- 1998-02-17 CA CA002282656A patent/CA2282656A1/en not_active Abandoned
- 1998-02-17 CN CNB988043335A patent/CN1210263C/zh not_active Expired - Fee Related
- 1998-02-17 EA EA199900769A patent/EA001742B1/ru not_active IP Right Cessation
- 1998-02-17 NZ NZ337298A patent/NZ337298A/xx unknown
- 1998-02-17 UA UA99095311A patent/UA58543C2/uk unknown
- 1998-02-17 PL PL98335401A patent/PL335401A1/xx unknown
- 1998-02-17 IL IL13125898A patent/IL131258A0/xx not_active IP Right Cessation
- 1998-02-17 CN CN98804329A patent/CN1252790A/zh active Pending
- 1998-02-17 WO PCT/US1998/003291 patent/WO1998038163A1/en not_active Application Discontinuation
- 1998-02-17 AU AU64368/98A patent/AU748998B2/en not_active Ceased
- 1998-02-17 YU YU40999A patent/YU40999A/sh unknown
- 1998-02-17 GE GEAP19985007A patent/GEP20022627B/en unknown
- 1998-02-17 DE DE69823019T patent/DE69823019T2/de not_active Expired - Fee Related
- 1998-02-17 TR TR1999/02095T patent/TR199902095T2/xx unknown
- 1998-02-17 SK SK1158-99A patent/SK115899A3/sk unknown
- 1998-02-17 GE GEAP19985008A patent/GEP20022626B/en unknown
- 1998-02-17 PL PL98335286A patent/PL335286A1/xx unknown
- 1998-02-17 YU YU41099A patent/YU41099A/sh unknown
- 1998-02-17 EP EP98910022A patent/EP0970046B1/en not_active Expired - Lifetime
- 1998-02-17 DK DK98910022T patent/DK0970046T3/da active
- 1998-02-17 TR TR1999/01901T patent/TR199901901T2/xx unknown
- 1998-02-17 AU AU61686/98A patent/AU726204B2/en not_active Ceased
- 1998-02-17 DE DE69820424T patent/DE69820424T2/de not_active Expired - Fee Related
- 1998-02-17 PT PT98906468T patent/PT973512E/pt unknown
- 1998-02-17 KR KR1019997007881A patent/KR20000075808A/ko not_active Application Discontinuation
- 1998-02-17 WO PCT/US1998/002987 patent/WO1998037877A1/en not_active Application Discontinuation
- 1998-02-17 KR KR1019997007882A patent/KR20000075809A/ko not_active Application Discontinuation
- 1998-02-17 CA CA002282655A patent/CA2282655A1/en not_active Abandoned
- 1998-02-17 AT AT98910022T patent/ATE256107T1/de not_active IP Right Cessation
- 1998-02-17 EA EA199900768A patent/EA003836B1/ru not_active IP Right Cessation
- 1998-02-17 ES ES98906468T patent/ES2217540T3/es not_active Expired - Lifetime
- 1998-02-17 HU HU0002092A patent/HUP0002092A3/hu unknown
- 1998-02-17 JP JP53770698A patent/JP2001519777A/ja not_active Withdrawn
- 1998-02-17 PT PT98910022T patent/PT970046E/pt unknown
- 1998-02-17 NZ NZ337336A patent/NZ337336A/en unknown
- 1998-02-17 EE EEP199900369A patent/EE04150B1/xx not_active IP Right Cessation
- 1998-02-17 BR BR9807802A patent/BR9807802A/pt not_active IP Right Cessation
- 1998-02-17 AT AT98906468T patent/ATE263554T1/de not_active IP Right Cessation
- 1998-02-17 EP EP98906468A patent/EP0973512B1/en not_active Expired - Lifetime
- 1998-02-17 HU HU0001463A patent/HUP0001463A3/hu unknown
- 1998-02-17 SK SK1157-99A patent/SK115799A3/sk unknown
- 1998-02-17 ES ES98910022T patent/ES2212274T3/es not_active Expired - Lifetime
- 1998-02-17 DK DK98906468T patent/DK0973512T3/da active
- 1998-02-17 BR BR9807803-8A patent/BR9807803A/pt not_active IP Right Cessation
- 1998-02-17 IL IL13125798A patent/IL131257A0/xx unknown
- 1998-02-17 EE EEP199900371A patent/EE04295B1/xx not_active IP Right Cessation
- 1998-02-17 JP JP53772498A patent/JP2001513771A/ja not_active Withdrawn
- 1998-02-26 ZA ZA9801625A patent/ZA981625B/xx unknown
- 1998-02-26 ZA ZA9801628A patent/ZA981628B/xx unknown
- 1998-02-27 AR ARP980100909A patent/AR011451A1/es not_active Application Discontinuation
- 1998-03-17 TW TW087102853A patent/TW568900B/zh active
-
1999
- 1999-08-26 NO NO19994125A patent/NO314302B1/no unknown
- 1999-08-26 NO NO19994124A patent/NO314258B1/no not_active IP Right Cessation
- 1999-09-24 BG BG103757A patent/BG103757A/bg unknown
- 1999-09-27 BG BG103760A patent/BG103760A/bg unknown
-
2000
- 2000-07-07 HK HK00104181A patent/HK1024875A1/xx not_active IP Right Cessation
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2004
- 2004-09-08 CY CY0400069A patent/CY2477B1/xx unknown
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