DK0885212T3 - Quinoxalindioner - Google Patents

Quinoxalindioner

Info

Publication number
DK0885212T3
DK0885212T3 DK97908156T DK97908156T DK0885212T3 DK 0885212 T3 DK0885212 T3 DK 0885212T3 DK 97908156 T DK97908156 T DK 97908156T DK 97908156 T DK97908156 T DK 97908156T DK 0885212 T3 DK0885212 T3 DK 0885212T3
Authority
DK
Denmark
Prior art keywords
quinoxalinediones
Prior art date
Application number
DK97908156T
Other languages
Danish (da)
English (en)
Inventor
David John Bull
Christopher Lee Carr
Michael Jonathan Fray
Elisabeth Colette Loui Gautier
Charles Eric Mowbray
Alan Stobie
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Application granted granted Critical
Publication of DK0885212T3 publication Critical patent/DK0885212T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK97908156T 1996-03-09 1997-02-27 Quinoxalindioner DK0885212T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9605027.3A GB9605027D0 (en) 1996-03-09 1996-03-09 Quinoxalinediones
PCT/EP1997/000995 WO1997032873A1 (en) 1996-03-09 1997-02-27 Quinoxalinediones

Publications (1)

Publication Number Publication Date
DK0885212T3 true DK0885212T3 (da) 2002-03-25

Family

ID=10790134

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97908156T DK0885212T3 (da) 1996-03-09 1997-02-27 Quinoxalindioner

Country Status (42)

Country Link
US (1) US6376490B1 (ja)
EP (1) EP0885212B1 (ja)
JP (1) JP3110467B2 (ja)
KR (1) KR100288099B1 (ja)
CN (1) CN1103770C (ja)
AP (1) AP767A (ja)
AR (1) AR006119A1 (ja)
AT (1) ATE208773T1 (ja)
AU (1) AU717972B2 (ja)
BG (1) BG63340B1 (ja)
BR (1) BR9707851A (ja)
CA (1) CA2248366C (ja)
CO (1) CO4770976A1 (ja)
CZ (1) CZ292792B6 (ja)
DE (1) DE69708269T2 (ja)
DK (1) DK0885212T3 (ja)
DZ (1) DZ2188A1 (ja)
EA (1) EA001730B1 (ja)
ES (1) ES2163742T3 (ja)
GB (1) GB9605027D0 (ja)
HN (1) HN1998000034A (ja)
HR (1) HRP970132A2 (ja)
HU (1) HUP9900975A3 (ja)
ID (1) ID18112A (ja)
IL (1) IL125491A (ja)
IS (1) IS4811A (ja)
MA (1) MA26422A1 (ja)
NO (1) NO984058L (ja)
NZ (1) NZ331060A (ja)
OA (1) OA10850A (ja)
PE (2) PE43398A1 (ja)
PL (1) PL329032A1 (ja)
PT (1) PT885212E (ja)
SI (1) SI0885212T1 (ja)
SK (1) SK283467B6 (ja)
TN (1) TNSN97044A1 (ja)
TR (1) TR199801782T2 (ja)
TW (1) TW454004B (ja)
UY (1) UY24482A1 (ja)
WO (1) WO1997032873A1 (ja)
YU (2) YU39698A (ja)
ZA (1) ZA971987B (ja)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE282608T1 (de) * 1997-02-27 2004-12-15 Pfizer Chinoxalindionen
AP982A (en) 1997-02-27 2001-07-16 Pfizer Quinoxalinediones.
US6340758B1 (en) * 1997-05-16 2002-01-22 Warner-Lambert Company Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
DE10005150A1 (de) 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden
SK16242002A3 (sk) * 2000-05-19 2003-04-01 Merck Patent Gmbh Derivát triazolu a farmaceutický prostriedok, ktorý ho obsahuje
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2005006945A2 (en) * 2003-07-03 2005-01-27 The Salk Institute For Biological Studies Methods for treating neural disorders and compounds useful therefor
MY145368A (en) * 2004-01-13 2012-01-31 Nissan Chemical Ind Ltd Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
US7799894B2 (en) 2004-02-06 2010-09-21 Yamaguchi University Electrode for energy storage device and process for producing the same
JP2007223901A (ja) * 2004-03-24 2007-09-06 Takeda Chem Ind Ltd 複素環化合物およびその用途
US20060211739A1 (en) * 2005-02-08 2006-09-21 Arturo Perez-Medrano Use of selective P2X7 receptor antagonists
WO2007112347A1 (en) * 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
DK2091948T3 (da) 2006-11-30 2012-07-23 Probiodrug Ag Nye inhibitorer af glutaminylcyclase
CA2686816A1 (en) 2007-01-16 2008-07-24 The Johns Hopkins University Use of various glutamate receptor antagonists for delaying or preventing platelet activity or for treating or preventing a thrombotic disease or disorder
KR20090115951A (ko) 2007-03-01 2009-11-10 프로비오드룩 아게 글루타미닐 사이클라제 저해제의 신규 용도
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
WO2008143019A1 (en) 2007-05-17 2008-11-27 Semiconductor Energy Laboratory Co., Ltd. Triazole derivative, and light-emitting element, light-emitting device, and electronic device with the use of triazole derivative
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US9879004B2 (en) * 2013-02-07 2018-01-30 Merck Patent Gmbh Substituted acetylene derivatives and their use as positive allosteric modulators of mGluR4
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN111548320B (zh) * 2019-10-09 2023-03-24 贵州大学 一类1,3,4-噁二唑酰肼类化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0556393B1 (en) * 1990-11-06 2000-07-26 Yamanouchi Pharmaceutical Co. Ltd. Fused pyrazine derivative
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
GB9418443D0 (en) 1994-09-13 1994-11-02 Pfizer Ltd Therapeutic agents
DE4439492A1 (de) * 1994-10-25 1996-05-02 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
ATE282608T1 (de) * 1997-02-27 2004-12-15 Pfizer Chinoxalindionen

Also Published As

Publication number Publication date
SK121498A3 (en) 2000-10-09
TW454004B (en) 2001-09-11
EP0885212A1 (en) 1998-12-23
HUP9900975A3 (en) 2001-12-28
NO984058L (no) 1998-11-06
EA199800702A1 (ru) 1999-04-29
IS4811A (is) 1998-07-27
PT885212E (pt) 2002-02-28
AU717972B2 (en) 2000-04-06
WO1997032873A1 (en) 1997-09-12
CA2248366C (en) 2002-06-04
TNSN97044A1 (fr) 2005-03-15
NZ331060A (en) 2000-01-28
NO984058D0 (no) 1998-09-03
DE69708269T2 (de) 2002-07-25
PE43398A1 (es) 1998-08-29
UY24482A1 (es) 2000-09-29
AU2023197A (en) 1997-09-22
EA001730B1 (ru) 2001-08-27
OA10850A (en) 2001-08-16
CN1103770C (zh) 2003-03-26
HUP9900975A2 (hu) 1999-07-28
KR19990087614A (ko) 1999-12-27
YU41199A (sh) 2001-09-28
CO4770976A1 (es) 1999-04-30
CZ292792B6 (cs) 2003-12-17
SK283467B6 (sk) 2003-08-05
CN1213369A (zh) 1999-04-07
PE58199A1 (es) 1999-06-11
JP3110467B2 (ja) 2000-11-20
AP767A (en) 1999-09-29
GB9605027D0 (en) 1996-05-08
YU39698A (sh) 1999-03-04
AR006119A1 (es) 1999-08-11
KR100288099B1 (ko) 2001-05-02
BG63340B1 (bg) 2001-10-31
DZ2188A1 (fr) 2002-12-02
TR199801782T2 (xx) 1998-12-21
CZ286498A3 (cs) 1999-07-14
IL125491A (en) 2003-07-06
ZA971987B (en) 1998-09-07
CA2248366A1 (en) 1997-09-12
JPH11506123A (ja) 1999-06-02
ES2163742T3 (es) 2002-02-01
PL329032A1 (en) 1999-03-01
AP9700947A0 (en) 1997-04-30
BG102760A (en) 1999-09-30
SI0885212T1 (en) 2002-02-28
ID18112A (id) 1998-03-05
HN1998000034A (es) 1999-02-09
IL125491A0 (en) 1999-03-12
US6376490B1 (en) 2002-04-23
EP0885212B1 (en) 2001-11-14
HRP970132A2 (en) 1998-06-30
MA26422A1 (fr) 2004-12-20
DE69708269D1 (de) 2001-12-20
ATE208773T1 (de) 2001-11-15
BR9707851A (pt) 1999-07-27

Similar Documents

Publication Publication Date Title
DK0885212T3 (da) Quinoxalindioner
ID18010A (id) Oligosakarida termodifikasi
FI964549A (fi) Monisylinteripipetti
DK0923562T3 (da) Substituerede p-trifluormethylphenyluraciler
DE59707428D1 (de) Substituierte 1-methyl-3-benzyluracile
DE59711889D1 (de) Substituierte pyrazol-3-ylbenzazole
BR9708893A (pt) Ferniluracilas substituidas
KR970058619U (ko) 공동용 납골함
DE59708674D1 (de) Substituierte 3-phenylpyrazole
DE59712222D1 (de) Substituierte phenyluracile
FI962277A0 (fi) Loed- eller tennknoelstruktur foer oinkapslade mikrokretsar
FI965275A0 (fi) Aonglaoda i kartong- eller pappersmaskin
FI2674U1 (fi) Långnyppress i en pappers- eller kartongmaskin
FI964372A0 (fi) Flyttbar kontainerlaos i jaernvaegsvagn
FI965276A0 (fi) Aonglaoda i kartong- eller pappersmaskin
FI964603A0 (fi) Vaermefogningsstoedstomme i silikon-gummi foer en ankelsockas skaftdel
FI964904A0 (fi) Tryckknapp i hissen
FI964979A0 (fi) Stoedvagga foer bestrykningsstav i pappersbanebestrykningsanordning
FI960287A0 (fi) Anordning i avdammningsanlaeggning
FI960733A0 (fi) Anordning i en kontaktskena
FI964279A0 (fi) Foerfarande foer avlaegsna torsionspaenning i textilgarn
FI964007A0 (fi) Styrsystem foer ventiler i en foerbraenningsmotor
FI963961A0 (fi) Saekerhetsanordning i vaegtrafiken
FI963104A0 (fi) Basskontroll i en hemteateranordning
FI963563A0 (fi) Taetningsarrangemang i en fibersbanas torkningsanordning