DK0839806T3 - Substituerede tricykliske forbindelser - Google Patents

Substituerede tricykliske forbindelser

Info

Publication number
DK0839806T3
DK0839806T3 DK97308645T DK97308645T DK0839806T3 DK 0839806 T3 DK0839806 T3 DK 0839806T3 DK 97308645 T DK97308645 T DK 97308645T DK 97308645 T DK97308645 T DK 97308645T DK 0839806 T3 DK0839806 T3 DK 0839806T3
Authority
DK
Denmark
Prior art keywords
tricyclic compounds
substituted tricyclic
substituted
compounds
tricyclic
Prior art date
Application number
DK97308645T
Other languages
Danish (da)
English (en)
Inventor
John Michael Morin Jr
Robert Delane Dillard
Susan Elizabeth Draheim
Nicholas James Bach
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0839806T3 publication Critical patent/DK0839806T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Pyridine Compounds (AREA)
DK97308645T 1996-10-30 1997-10-29 Substituerede tricykliske forbindelser DK0839806T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2984996P 1996-10-30 1996-10-30

Publications (1)

Publication Number Publication Date
DK0839806T3 true DK0839806T3 (da) 2003-10-27

Family

ID=21851210

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97308645T DK0839806T3 (da) 1996-10-30 1997-10-29 Substituerede tricykliske forbindelser

Country Status (26)

Country Link
EP (1) EP0839806B1 (ja)
JP (1) JP2001503055A (ja)
KR (1) KR20000049210A (ja)
CN (1) CN1233176A (ja)
AR (1) AR010050A1 (ja)
AT (1) ATE244703T1 (ja)
AU (1) AU734096B2 (ja)
BR (1) BR9713261A (ja)
CA (1) CA2269203A1 (ja)
CO (1) CO4920250A1 (ja)
CZ (1) CZ136899A3 (ja)
DE (1) DE69723393T2 (ja)
DK (1) DK0839806T3 (ja)
EA (1) EA003992B1 (ja)
ES (1) ES2202560T3 (ja)
ID (1) ID18685A (ja)
IL (1) IL129481A0 (ja)
NO (1) NO314899B1 (ja)
NZ (1) NZ335246A (ja)
PE (1) PE10999A1 (ja)
PL (1) PL332896A1 (ja)
PT (1) PT839806E (ja)
TR (1) TR199900956T2 (ja)
TW (1) TW513428B (ja)
WO (1) WO1998018464A1 (ja)
YU (1) YU19299A (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011670A4 (en) * 1997-08-28 2004-10-27 Lilly Co Eli PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
CA2326522A1 (en) 1998-03-31 1999-10-14 Shionogi & Co., Ltd. Pyrrolo[1,2-a]pyrazine spla2 inhibitor
ID23219A (id) * 1998-04-17 2000-03-30 Lilly Co Eli Trisiklik tersubstitusi
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
CN1299348A (zh) 1998-05-01 2001-06-13 伊莱利利公司 用于治疗疾病的sPLA2抑制剂化合物
WO1999059999A1 (fr) 1998-05-21 1999-11-25 Shionogi & Co., Ltd. DERIVES DE LA PYRROLO[1,2-B] PYRIDAZINE, A EFFET INHIBITEUR SUR LE sPLA¿2?
WO2000021563A1 (fr) * 1998-10-14 2000-04-20 Shionogi & Co., Ltd. Moyens de traitement et de prevention contre les troubles ischemiques dus a la repercussion
CA2356162A1 (en) * 1998-12-22 2000-06-29 Eli Lilly And Company Substituted tricyclics
AU6015600A (en) 1999-07-19 2001-02-05 Shionogi & Co., Ltd. Tricyclic compounds having spla2-inhibitory activities
JP4636522B2 (ja) 1999-08-02 2011-02-23 塩野義製薬株式会社 sPLA2阻害作用を有する三環式化合物
JP4623483B2 (ja) 1999-08-23 2011-02-02 塩野義製薬株式会社 sPLA2阻害作用を有するピロロトリアジン誘導体
MY125942A (en) 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
AU1304801A (en) 1999-11-15 2001-05-30 Shionogi & Co., Ltd. Tricyclic azaindolizine derivatives having an SPLA2- inhibiting effect
KR20030016214A (ko) * 2000-01-06 2003-02-26 일라이 릴리 앤드 캄파니 염증성 및 호흡기 질환의 치료를 위한 복합 치료법
JPWO2002000621A1 (ja) 2000-06-29 2004-04-22 塩野義製薬株式会社 X型sPLA2阻害作用を有する化合物
WO2002000256A1 (en) 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedies for cirrhosis
EP1345898A2 (en) * 2000-12-18 2003-09-24 Eli Lilly And Company Teracyclic carbazole derivates and their use as spla2 inhibitors
TWI314457B (ja) * 2001-03-19 2009-09-11 Shionogi & Co
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
EP1852433B1 (en) 2004-10-29 2011-11-23 Zeria Pharmaceutical Co., Ltd. Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof
EP3307323B1 (en) 2015-06-15 2022-07-13 Raziel Therapeutics Ltd. Carbazole derivatives for the treatment of fibrotic diseases and related symptoms, and conditions thereof
CN112409493B (zh) * 2020-08-12 2022-09-30 浙江工业大学 一种重组融合酶及其在乙醛酸甲酯合成中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479391A (en) * 1966-10-03 1969-11-18 Squibb & Sons Inc Delta**3,14-17alpha-hydroxy-norprogesterone and esters
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO991831D0 (no) 1999-04-16
EP0839806A1 (en) 1998-05-06
BR9713261A (pt) 2000-03-28
ATE244703T1 (de) 2003-07-15
JP2001503055A (ja) 2001-03-06
NO314899B1 (no) 2003-06-10
AU5149498A (en) 1998-05-22
EA003992B1 (ru) 2003-12-25
PE10999A1 (es) 1999-02-10
DE69723393D1 (de) 2003-08-14
DE69723393T2 (de) 2004-06-09
YU19299A (sh) 2000-03-21
CN1233176A (zh) 1999-10-27
ES2202560T3 (es) 2004-04-01
CA2269203A1 (en) 1998-05-07
AR010050A1 (es) 2000-05-17
WO1998018464A1 (en) 1998-05-07
TW513428B (en) 2002-12-11
TR199900956T2 (xx) 1999-07-21
KR20000049210A (ko) 2000-07-25
NO991831L (no) 1999-06-21
NZ335246A (en) 2001-09-28
EP0839806B1 (en) 2003-07-09
AU734096B2 (en) 2001-06-07
EA199900305A1 (ru) 1999-12-29
PT839806E (pt) 2003-11-28
CZ136899A3 (cs) 1999-09-15
CO4920250A1 (es) 2000-05-29
ID18685A (id) 1998-04-30
PL332896A1 (en) 1999-10-25
IL129481A0 (en) 2000-02-29

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