DK0788480T3 - Krystallisering af levobupivacain og analoger deraf - Google Patents

Krystallisering af levobupivacain og analoger deraf

Info

Publication number
DK0788480T3
DK0788480T3 DK95934738T DK95934738T DK0788480T3 DK 0788480 T3 DK0788480 T3 DK 0788480T3 DK 95934738 T DK95934738 T DK 95934738T DK 95934738 T DK95934738 T DK 95934738T DK 0788480 T3 DK0788480 T3 DK 0788480T3
Authority
DK
Denmark
Prior art keywords
pct
levobupivacaine
analogues
crystallization
sec
Prior art date
Application number
DK95934738T
Other languages
Danish (da)
English (en)
Inventor
Marianne Langston
Benjamin Mark Skead
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421476A external-priority patent/GB9421476D0/en
Priority claimed from GBGB9504926.8A external-priority patent/GB9504926D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of DK0788480T3 publication Critical patent/DK0788480T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95934738T 1994-10-25 1995-10-23 Krystallisering af levobupivacain og analoger deraf DK0788480T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9421476A GB9421476D0 (en) 1994-10-25 1994-10-25 Process and salt
GBGB9504926.8A GB9504926D0 (en) 1995-03-10 1995-03-10 Crystallisation
PCT/GB1995/002513 WO1996012699A1 (en) 1994-10-25 1995-10-23 Crystallisation of levobupivacaine and analogues thereof

Publications (1)

Publication Number Publication Date
DK0788480T3 true DK0788480T3 (da) 2003-09-29

Family

ID=26305863

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95934738T DK0788480T3 (da) 1994-10-25 1995-10-23 Krystallisering af levobupivacain og analoger deraf

Country Status (16)

Country Link
US (1) US5994548A (es)
EP (1) EP0788480B1 (es)
JP (1) JP3911545B2 (es)
AT (1) ATE245629T1 (es)
AU (1) AU698637B2 (es)
CA (1) CA2200355C (es)
DE (1) DE69531356T2 (es)
DK (1) DK0788480T3 (es)
ES (1) ES2202375T3 (es)
FI (1) FI117438B (es)
HU (1) HU227420B1 (es)
MX (1) MX9703024A (es)
NO (1) NO309266B1 (es)
PL (1) PL183210B1 (es)
PT (1) PT788480E (es)
WO (1) WO1996012699A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
EP2959893A1 (en) 2002-12-13 2015-12-30 DURECT Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
US7094812B2 (en) * 2003-04-24 2006-08-22 Xerox Corporations Colorant compositions
US6790267B1 (en) * 2003-04-24 2004-09-14 Xerox Corporation Colorant compositions
PL1809329T3 (pl) 2004-09-17 2012-08-31 Durect Corp Kompozycja znieczulająca zawierająca saib o przedłużonym uwalnianiu do stosowania miejscowego
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
JP2009535327A (ja) * 2006-04-25 2009-10-01 ディシュマン・ファーマシューティカルズ・アンド・ケミカルズ・リミテッド ロピバカイン塩酸塩無水物およびその調製
US8337883B2 (en) 2006-11-03 2012-12-25 Durect Corporation Transdermal delivery systems
WO2009088414A2 (en) 2007-12-06 2009-07-16 Durect Corporation Oral pharmaceutical dosage forms
ES2383714T3 (es) * 2008-01-15 2012-06-25 Pharmathen S.A. Proceso para preparar un compuesto (S)-1-alquil-2',6'-pipecoloxilidídico
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
IL290150B2 (en) * 2016-12-26 2024-03-01 Cellix Bio Private Ltd Compounds and methods for treating chronic pain
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (es) * 1967-05-18 1971-12-27 Sterling Drug Inc
US4695576A (en) * 1984-07-09 1987-09-22 Astra Lake Medel Aktiebolag L-N-n-propylpipecolic acid-2,6-xylidide

Also Published As

Publication number Publication date
DE69531356D1 (de) 2003-08-28
NO971903L (no) 1997-04-24
FI971711A0 (fi) 1997-04-22
PL183210B1 (pl) 2002-06-28
DE69531356T2 (de) 2004-05-27
CA2200355A1 (en) 1996-05-02
HU227420B1 (en) 2011-05-30
AU698637B2 (en) 1998-11-05
MX9703024A (es) 1997-10-31
NO309266B1 (no) 2001-01-08
FI971711A (fi) 1997-04-22
PL319829A1 (en) 1997-09-01
JP3911545B2 (ja) 2007-05-09
ATE245629T1 (de) 2003-08-15
NO971903D0 (no) 1997-04-24
HUT77631A (hu) 1998-06-29
FI117438B (fi) 2006-10-13
EP0788480B1 (en) 2003-07-23
JPH10507464A (ja) 1998-07-21
PT788480E (pt) 2003-12-31
US5994548A (en) 1999-11-30
WO1996012699A1 (en) 1996-05-02
CA2200355C (en) 2007-03-06
AU3704895A (en) 1996-05-15
EP0788480A1 (en) 1997-08-13
ES2202375T3 (es) 2004-04-01

Similar Documents

Publication Publication Date Title
DK0788480T3 (da) Krystallisering af levobupivacain og analoger deraf
DK0584136T3 (da) Bestemmelse af peptidmotiver på MHC-molekyler
DE59308619D1 (de) Germicide wirkstoffkombinationen
DE69406522T2 (de) Verfahren zur Herstellung von alkalilöslichen Emulsionscopolymeren
DK0788481T3 (da) Fremgangsmåde til fremstilling af levobupivacain og analoger deraf
DE69109401D1 (de) Wässrige Zusammensetzungen zur Behandlung von porösen Substraten.
DK0822816T3 (da) Dermatologisk præparat til behandling af actiniske keratoser
DK0394787T3 (da) Midler indeholdende carbonamidgruppeholdige (meth)acrylsyreestere til anvendelse som klæbestofkomponenter til behandling af kollagenholdige materialer i medicinen, samt fremstillingen af disse midler
NO20013128D0 (no) Sementblanding og fremgangsmåte dertil
DK0476113T3 (da) Lægemiddel til behandling af hyperlipidæmi og/eller atherosklerose
DE59106800D1 (de) Verfahren zur Herstellung von Benzylketonen.
DE59204902D1 (de) Verfahren zur Herstellung von Diphenylaminen
DK0821588T3 (da) Levobupivacain og anvendelse heraf som et anæstetikum til gravide kvinder
DE59105224D1 (de) Verfahren zur Herstellung von N-substituierten Pyrrolidonen.
DK0586589T3 (da) Amylin- eller amylinanalogpræparat, som eventuelt indeholder insulin, til behandling af anoreksi og beslægtede tilstande
DK0620607T3 (da) Fremgangsmåde til elektrolytisk behandling af brugte batterier
DK0687256T3 (da) Hydroxymethylfurazancarboxylsyrederivater og deresanvendelse ved behandling af kardiovaskulære sygdomme
ES2116089T3 (es) Elemento de bastidor.
ES2162078T3 (es) Compuestos terapeuticos.
DE58902228D1 (de) Verfahren zur herstellung von 5-gliedrigen, stickstoffhaltigen heteroaromaten.
DE69103913D1 (de) Verfahren zur Herstellung von Dodekandicarbonsäure.
NO881414D0 (no) Fremgangsmaate for behandling av spillvann og annet urent vann.
ATE131936T1 (de) Vorrichtung zur befestigung von zwei oder mehreren seismischen energiequellen an relativ fixierte positionen
DE69333521D1 (de) Verfahren zur Kristallisierung von N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-prolin
ATE84780T1 (de) Neue di(meth)acrylate, verfahren zu deren herstellung und deren verwendung.