DK0770070T3 - Fremgangsmåde til fremstilling af 4-acetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta,10beta-trihydoxy-9-oxo-tax-11-en-13alfa - Google Patents

Fremgangsmåde til fremstilling af 4-acetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta,10beta-trihydoxy-9-oxo-tax-11-en-13alfa

Info

Publication number
DK0770070T3
DK0770070T3 DK95925022T DK95925022T DK0770070T3 DK 0770070 T3 DK0770070 T3 DK 0770070T3 DK 95925022 T DK95925022 T DK 95925022T DK 95925022 T DK95925022 T DK 95925022T DK 0770070 T3 DK0770070 T3 DK 0770070T3
Authority
DK
Denmark
Prior art keywords
beta
benzoyloxy
tax
acetoxy
oxo
Prior art date
Application number
DK95925022T
Other languages
English (en)
Inventor
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Jean-Rene Authelin
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0770070(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0770070T3 publication Critical patent/DK0770070T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK95925022T 1994-07-08 1995-07-07 Fremgangsmåde til fremstilling af 4-acetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta,10beta-trihydoxy-9-oxo-tax-11-en-13alfa DK0770070T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
PCT/FR1995/000910 WO1996001815A1 (fr) 1994-07-08 1995-07-07 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (1)

Publication Number Publication Date
DK0770070T3 true DK0770070T3 (da) 1999-03-01

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95925022T DK0770070T3 (da) 1994-07-08 1995-07-07 Fremgangsmåde til fremstilling af 4-acetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta,10beta-trihydoxy-9-oxo-tax-11-en-13alfa

Country Status (38)

Country Link
US (1) US6022985A (da)
EP (1) EP0770070B1 (da)
JP (1) JP3753155B2 (da)
KR (1) KR100391753B1 (da)
CN (1) CN1067996C (da)
AT (1) ATE171702T1 (da)
AU (1) AU706519B2 (da)
BR (1) BR9508789A (da)
CA (1) CA2193531C (da)
CO (1) CO4410189A1 (da)
CZ (1) CZ284695B6 (da)
DE (1) DE69505128T2 (da)
DK (1) DK0770070T3 (da)
DZ (1) DZ1905A1 (da)
ES (1) ES2121404T3 (da)
FI (1) FI119246B (da)
FR (1) FR2722191B1 (da)
GR (1) GR3027558T3 (da)
HU (1) HU220634B1 (da)
IL (1) IL114274A (da)
IN (1) IN183947B (da)
IS (1) IS2032B (da)
MA (1) MA23606A1 (da)
MX (1) MX9700173A (da)
MY (1) MY118481A (da)
NO (1) NO314500B1 (da)
NZ (1) NZ289455A (da)
PE (1) PE8697A1 (da)
PL (1) PL179876B1 (da)
RU (1) RU2126397C1 (da)
SI (1) SI0770070T1 (da)
SK (1) SK280520B6 (da)
TN (1) TNSN95071A1 (da)
TW (1) TW419473B (da)
UA (1) UA51624C2 (da)
UY (1) UY23991A1 (da)
WO (1) WO1996001815A1 (da)
ZA (1) ZA955646B (da)

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FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
EP1947094A3 (en) 2003-12-12 2009-02-18 Quiral Quimica Do Brasil Process for the preparation of taxane derivatives
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
PL3311805T3 (pl) 2005-08-31 2020-07-27 Abraxis Bioscience, Llc Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
NZ566705A (en) 2005-08-31 2011-06-30 Abraxis Bioscience Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
EP1819688A2 (en) * 2005-10-12 2007-08-22 Sicor, Inc. Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
WO2007084611A2 (en) * 2006-01-20 2007-07-26 Landmark Graphics Corporation Dynamic production system management
US20100160653A1 (en) * 2006-03-21 2010-06-24 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
JP2010506932A (ja) * 2006-10-20 2010-03-04 シノファーム シンガポール ピーティーイー，リミテッド 結晶性の無水ドセタキセルの製造方法
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
US20100197944A1 (en) * 2007-07-04 2010-08-05 Dr. Reddy's Laboratories Limited Docetaxel process and polymorphs
ES2389518T3 (es) * 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
ES2621613T3 (es) 2009-11-04 2017-07-04 Emcure Pharmaceuticals Limited Un proceso mejorado para la preparación de derivados de taxano
US10842770B2 (en) 2010-05-03 2020-11-24 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
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PT2753355T (pt) 2011-09-08 2019-02-01 Univ New York Vírus herpes simplex oncolítico e suas utilizações terapêuticas
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WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
WO2016205429A1 (en) 2015-06-15 2016-12-22 New York University Method of treatment using oncolytic viruses
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
BR9508789A (pt) 1997-10-21
FI970069A (fi) 1997-01-07
ZA955646B (en) 1996-02-21
MY118481A (en) 2004-11-30
DE69505128T2 (de) 1999-04-01
PL179876B1 (pl) 2000-11-30
WO1996001815A1 (fr) 1996-01-25
MX9700173A (es) 1997-04-30
NO970007D0 (no) 1997-01-02
FR2722191B1 (fr) 1996-08-23
PL318195A1 (en) 1997-05-26
HUT76833A (en) 1997-11-28
CN1067996C (zh) 2001-07-04
CA2193531A1 (fr) 1996-01-25
DE69505128D1 (de) 1998-11-05
SK697A3 (en) 1997-06-04
SK280520B6 (sk) 2000-03-13
KR970704721A (ko) 1997-09-06
CZ3597A3 (en) 1997-04-16
HU9700041D0 (en) 1997-02-28
IL114274A0 (en) 1995-10-31
IL114274A (en) 1999-04-11
TNSN95071A1 (fr) 1996-02-06
NO970007L (no) 1997-01-02
DZ1905A1 (fr) 2002-02-17
ATE171702T1 (de) 1998-10-15
JP3753155B2 (ja) 2006-03-08
FI119246B (fi) 2008-09-15
EP0770070B1 (fr) 1998-09-30
UY23991A1 (es) 1995-09-20
NZ289455A (en) 1997-12-19
AU706519B2 (en) 1999-06-17
GR3027558T3 (en) 1998-11-30
US6022985A (en) 2000-02-08
JPH10502627A (ja) 1998-03-10
ES2121404T3 (es) 1998-11-16
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
IS2032B (is) 2005-08-15
IN183947B (da) 2000-05-20
CA2193531C (fr) 2006-12-05
KR100391753B1 (ko) 2004-02-11
FR2722191A1 (fr) 1996-01-12
CO4410189A1 (es) 1997-01-09
CZ284695B6 (cs) 1999-02-17
UA51624C2 (uk) 2002-12-16
CN1151741A (zh) 1997-06-11
AU2930595A (en) 1996-02-09
HU220634B1 (hu) 2002-03-28
TW419473B (en) 2001-01-21
PE8697A1 (es) 1997-03-26
FI970069A0 (fi) 1997-01-07
RU2126397C1 (ru) 1999-02-20
IS4411A (is) 1997-01-07
SI0770070T1 (en) 1998-12-31
EP0770070A1 (fr) 1997-05-02

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