DE69505128T2 - Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3-phenylpropionylsäure ester von 4-acetoxy-2alfa-benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en-13alfa-yl - Google Patents

Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3-phenylpropionylsäure ester von 4-acetoxy-2alfa-benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en-13alfa-yl

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Publication number
DE69505128T2
DE69505128T2 DE69505128T DE69505128T DE69505128T2 DE 69505128 T2 DE69505128 T2 DE 69505128T2 DE 69505128 T DE69505128 T DE 69505128T DE 69505128 T DE69505128 T DE 69505128T DE 69505128 T2 DE69505128 T2 DE 69505128T2
Authority
DE
Germany
Prior art keywords
beta
benzoyloxy
tax
acetoxy
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69505128T
Other languages
English (en)
Other versions
DE69505128D1 (de
Inventor
Jean-Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69505128(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of DE69505128D1 publication Critical patent/DE69505128D1/de
Publication of DE69505128T2 publication Critical patent/DE69505128T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DE69505128T 1994-07-08 1995-07-07 Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3-phenylpropionylsäure ester von 4-acetoxy-2alfa-benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en-13alfa-yl Expired - Lifetime DE69505128T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
PCT/FR1995/000910 WO1996001815A1 (fr) 1994-07-08 1995-07-07 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (2)

Publication Number Publication Date
DE69505128D1 DE69505128D1 (de) 1998-11-05
DE69505128T2 true DE69505128T2 (de) 1999-04-01

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69505128T Expired - Lifetime DE69505128T2 (de) 1994-07-08 1995-07-07 Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3-phenylpropionylsäure ester von 4-acetoxy-2alfa-benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en-13alfa-yl

Country Status (38)

Country Link
US (1) US6022985A (de)
EP (1) EP0770070B1 (de)
JP (1) JP3753155B2 (de)
KR (1) KR100391753B1 (de)
CN (1) CN1067996C (de)
AT (1) ATE171702T1 (de)
AU (1) AU706519B2 (de)
BR (1) BR9508789A (de)
CA (1) CA2193531C (de)
CO (1) CO4410189A1 (de)
CZ (1) CZ284695B6 (de)
DE (1) DE69505128T2 (de)
DK (1) DK0770070T3 (de)
DZ (1) DZ1905A1 (de)
ES (1) ES2121404T3 (de)
FI (1) FI119246B (de)
FR (1) FR2722191B1 (de)
GR (1) GR3027558T3 (de)
HU (1) HU220634B1 (de)
IL (1) IL114274A (de)
IN (1) IN183947B (de)
IS (1) IS2032B (de)
MA (1) MA23606A1 (de)
MX (1) MX9700173A (de)
MY (1) MY118481A (de)
NO (1) NO314500B1 (de)
NZ (1) NZ289455A (de)
PE (1) PE8697A1 (de)
PL (1) PL179876B1 (de)
RU (1) RU2126397C1 (de)
SI (1) SI0770070T1 (de)
SK (1) SK280520B6 (de)
TN (1) TNSN95071A1 (de)
TW (1) TW419473B (de)
UA (1) UA51624C2 (de)
UY (1) UY23991A1 (de)
WO (1) WO1996001815A1 (de)
ZA (1) ZA955646B (de)

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SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
ES2325506T3 (es) 2003-12-12 2009-09-07 Quiral Quimica Do Brasil Procedimiento para la preparacion de principios activos farmaceuticos (api) anhidros e hidratados; composiciones farmaceuticas estables preparadas a partir de los mismos y usos de dichas composiciones.
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
BRPI0615265A8 (pt) * 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos
JP5368093B2 (ja) 2005-08-31 2013-12-18 アブラクシス バイオサイエンス， エルエルシー 増大した安定性を有する難水溶性薬剤の組成物および調製の方法
EP1819688A2 (de) * 2005-10-12 2007-08-22 Sicor, Inc. Kristalline formen von docetaxel und herstellungsverfahren dafür
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
US8195401B2 (en) * 2006-01-20 2012-06-05 Landmark Graphics Corporation Dynamic production system management
US20100160653A1 (en) * 2006-03-21 2010-06-24 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
CA2756603C (en) * 2006-10-20 2013-05-28 Scinopharm Singapore Pte, Ltd. Process for making crystalline docetaxel trihydrate
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
EP2173732A4 (de) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr Herstellungsverfahren für docetaxel und polymorphe
EP2080764B1 (de) 2008-01-18 2012-08-22 INDENA S.p.A. Feste Formen von Ortataxel
EP2080763A1 (de) * 2008-01-18 2009-07-22 INDENA S.p.A. Ortataxel in Kristallform I
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
EP2330100B1 (de) 2009-11-04 2017-01-11 Emcure Pharmaceuticals Limited Verbessertes Verfahren zur Herstellung von Taxanderivaten
BR112012028037A2 (pt) 2010-05-03 2016-08-02 Teikoku Pharma Usa Inc formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
ES2704632T3 (es) 2011-09-08 2019-03-19 Univ New York Virus de herpes simplex oncolítico y sus usos terapéuticos
WO2013096455A1 (en) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
DK2833905T3 (en) 2012-04-04 2018-07-30 Halozyme Inc Combination therapy with hyaluronidase and a tumor-targeted taxane
US10138479B2 (en) 2012-05-24 2018-11-27 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer
US20150285802A1 (en) 2012-07-18 2015-10-08 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2968406A4 (de) 2013-03-14 2016-10-26 Icahn School Med Mount Sinai Mit autologem tumorlysat beladener dendritischer zellimpfstoff zur behandlung von leberkrebs
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
WO2016205429A1 (en) 2015-06-15 2016-12-22 New York University Method of treatment using oncolytic viruses
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
CZ284695B6 (cs) 1999-02-17
FI119246B (fi) 2008-09-15
DK0770070T3 (da) 1999-03-01
NO970007L (no) 1997-01-02
IS2032B (is) 2005-08-15
KR100391753B1 (ko) 2004-02-11
KR970704721A (ko) 1997-09-06
ZA955646B (en) 1996-02-21
MY118481A (en) 2004-11-30
PL318195A1 (en) 1997-05-26
UY23991A1 (es) 1995-09-20
NZ289455A (en) 1997-12-19
PE8697A1 (es) 1997-03-26
WO1996001815A1 (fr) 1996-01-25
ATE171702T1 (de) 1998-10-15
SI0770070T1 (en) 1998-12-31
HUT76833A (en) 1997-11-28
IS4411A (is) 1997-01-07
RU2126397C1 (ru) 1999-02-20
NO970007D0 (no) 1997-01-02
IL114274A0 (en) 1995-10-31
CA2193531A1 (fr) 1996-01-25
US6022985A (en) 2000-02-08
MX9700173A (es) 1997-04-30
CN1067996C (zh) 2001-07-04
FR2722191B1 (fr) 1996-08-23
HU220634B1 (hu) 2002-03-28
IL114274A (en) 1999-04-11
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
CN1151741A (zh) 1997-06-11
FI970069A0 (fi) 1997-01-07
EP0770070B1 (de) 1998-09-30
HU9700041D0 (en) 1997-02-28
EP0770070A1 (de) 1997-05-02
ES2121404T3 (es) 1998-11-16
UA51624C2 (uk) 2002-12-16
DE69505128D1 (de) 1998-11-05
PL179876B1 (pl) 2000-11-30
FI970069A (fi) 1997-01-07
CZ3597A3 (en) 1997-04-16
IN183947B (de) 2000-05-20
CA2193531C (fr) 2006-12-05
AU706519B2 (en) 1999-06-17
GR3027558T3 (en) 1998-11-30
TW419473B (en) 2001-01-21
TNSN95071A1 (fr) 1996-02-06
JP3753155B2 (ja) 2006-03-08
CO4410189A1 (es) 1997-01-09
BR9508789A (pt) 1997-10-21
SK280520B6 (sk) 2000-03-13
JPH10502627A (ja) 1998-03-10
SK697A3 (en) 1997-06-04
FR2722191A1 (fr) 1996-01-12
AU2930595A (en) 1996-02-09
DZ1905A1 (fr) 2002-02-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC