DK0650960T3 - Substituerede heterocykliske carboxylsyreamid-estere, deres fremstilling og deres anvendelse som lægemidler. - Google Patents
Substituerede heterocykliske carboxylsyreamid-estere, deres fremstilling og deres anvendelse som lægemidler.Info
- Publication number
- DK0650960T3 DK0650960T3 DK94117017.7T DK94117017T DK0650960T3 DK 0650960 T3 DK0650960 T3 DK 0650960T3 DK 94117017 T DK94117017 T DK 94117017T DK 0650960 T3 DK0650960 T3 DK 0650960T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- drugs
- carboxylic acid
- acid amide
- substituted heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337270A DE4337270A1 (de) | 1993-11-02 | 1993-11-02 | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19944434288 DE4434288A1 (de) | 1994-09-26 | 1994-09-26 | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0650960T3 true DK0650960T3 (da) | 1997-09-01 |
Family
ID=25930886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94117017.7T DK0650960T3 (da) | 1993-11-02 | 1994-10-27 | Substituerede heterocykliske carboxylsyreamid-estere, deres fremstilling og deres anvendelse som lægemidler. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5658933A (da) |
| EP (1) | EP0650960B1 (da) |
| JP (1) | JPH07224039A (da) |
| KR (1) | KR950014069A (da) |
| CN (1) | CN1084736C (da) |
| AT (1) | ATE149485T1 (da) |
| AU (1) | AU689135B2 (da) |
| CA (1) | CA2134865A1 (da) |
| CZ (1) | CZ287767B6 (da) |
| DE (1) | DE59401923D1 (da) |
| DK (1) | DK0650960T3 (da) |
| ES (1) | ES2101420T3 (da) |
| GR (1) | GR3023177T3 (da) |
| HK (1) | HK1006712A1 (da) |
| IL (1) | IL111455A0 (da) |
| NO (1) | NO302028B1 (da) |
| NZ (1) | NZ264822A (da) |
| PH (1) | PH31264A (da) |
| PL (1) | PL179687B1 (da) |
| RU (1) | RU2145959C1 (da) |
| TW (1) | TW330202B (da) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046219A (en) * | 1995-01-20 | 2000-04-04 | Cornell Research Foundation, Inc. | Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation |
| IL135495A (en) * | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
| KR20000065090A (ko) * | 1996-04-30 | 2000-11-06 | 훽스트 악티엔게젤샤프트 | 3-알콕시피리딘-2-카복실산아미드에스테르,이의제조방법및약제로서의이의용도 |
| JPH1067674A (ja) * | 1996-06-19 | 1998-03-10 | Advanced Sukin Res Kenkyusho:Kk | 細胞外マトリツクスの異常蓄積抑制剤 |
| DE19746287A1 (de) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| EP1134214A4 (en) * | 1998-11-04 | 2004-12-15 | Meiji Seika Kaisha | PICOLINAMIDE DERIVATIVES AND PESTICIDES CONTAINING THESE DERIVATIVES AS ACTIVE INGREDIENT |
| FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
| US6528649B2 (en) | 2000-05-30 | 2003-03-04 | Neurogen Corporation | Imidazoloisoquinolines |
| CN101664553B (zh) * | 2001-12-06 | 2013-08-21 | 法布罗根股份有限公司 | 低氧诱导因子(HIF)α的稳定化 |
| WO2003049686A2 (en) | 2001-12-06 | 2003-06-19 | Fibrogen, Inc. | Stabilization of hypoxia inducible factor (hif) alpha |
| EP2295060B1 (en) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Treatment or prevention of ischemic or hypoxic conditions |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| KR100932169B1 (ko) * | 2003-06-06 | 2009-12-16 | 피브로겐, 인크. | 질소-함유 헤테로아릴 화합물 및 내인성 적혈구생성소의증가에서의 그들의 사용 |
| US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| US8703795B2 (en) * | 2005-03-02 | 2014-04-22 | Fibrogen, Inc. | Thienopyridine compounds, and methods of use thereof |
| CN101394843A (zh) * | 2005-06-06 | 2009-03-25 | 菲布罗根公司 | 使用HIFα稳定剂的改进的贫血治疗 |
| US8530404B2 (en) | 2005-06-15 | 2013-09-10 | Fibrogen, Inc. | Compounds and methods for treatment of cancer |
| JP5161793B2 (ja) | 2006-01-27 | 2013-03-13 | フィブロジェン， インコーポレイテッド | 低酸素症誘導因子（ｈｉｆ）を安定化するシアノイソキノリン化合物 |
| EP1991540A1 (en) * | 2006-02-21 | 2008-11-19 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| MX2008011257A (es) * | 2006-03-08 | 2008-09-25 | Amgen Inc | Derivados de quinolina e isoquinolina como inhibidores de fosfodiesterasa 10. |
| CA2647596C (en) | 2006-04-04 | 2012-06-12 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as hif modulators |
| AU2013231191B2 (en) * | 2006-06-23 | 2015-09-03 | Glaxosmithkline Llc | Prolyl hydroxylase inhibitors |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| ES2922078T3 (es) * | 2006-06-26 | 2022-09-07 | Akebia Therapeutics Inc | Inhibidores de prolil hidroxilasa y métodos de uso |
| EP2041072B1 (en) * | 2006-06-28 | 2013-09-11 | Sanofi | Cxcr2 antagonists |
| EP2041073B1 (en) * | 2006-06-30 | 2016-07-27 | Sanofi | Cxcr2 inhibitors |
| CL2008000066A1 (es) | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
| WO2009002533A1 (en) | 2007-06-27 | 2008-12-31 | The Brigham And Women's Hospital, Inc. | Inflammatory bowel disease therapies |
| CN102272117B (zh) | 2008-11-14 | 2015-06-17 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
| RU2528412C2 (ru) * | 2009-02-10 | 2014-09-20 | Янссен Фармацевтика Нв | Хиназолиноны как ингибиторы пролилгидроксилазы |
| WO2011057115A1 (en) * | 2009-11-06 | 2011-05-12 | Akebia Therapeutics Inc. | Prolyl hydroxylase inhibitors |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| EP2670750B1 (en) | 2011-02-02 | 2016-09-14 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor |
| NO2686520T3 (da) * | 2011-06-06 | 2018-03-17 | ||
| US8865748B2 (en) | 2011-06-06 | 2014-10-21 | Akebia Therapeutics Inc. | Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
| AU2012328763A1 (en) | 2011-10-25 | 2014-05-01 | Janssen Pharmaceutica Nv | Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo(d)imidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
| EP2834220B1 (en) * | 2012-03-09 | 2016-11-09 | Fibrogen, Inc. | 4-hydroxy-isoquinoline compounds as hif hydroxylase inhibitors |
| CN103435546B (zh) | 2012-07-16 | 2016-08-10 | 菲布罗根有限公司 | 制备异喹啉化合物的方法 |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| KR102318720B1 (ko) | 2012-07-16 | 2021-10-28 | 피브로겐, 인크. | 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형 |
| MX360048B (es) | 2013-01-24 | 2018-10-19 | Fibrogen Inc | Formas cristalinas de acido { [1-ciano-5-(4-clorofenoxi)-4-hidroxi -isoquinolin-3-carbonil]-amino}-acetico. |
| RU2019134558A (ru) | 2013-06-13 | 2020-02-20 | Экебиа Терапьютикс, Инк. | Композиции и способы лечения анемии |
| KR102381295B1 (ko) | 2013-11-15 | 2022-03-31 | 아케비아 테라퓨틱스 인코포레이티드 | ｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도 |
| NZ732591A (en) * | 2014-12-30 | 2018-12-21 | Dow Agrosciences Llc | Picolinamides and related compounds with fungicidal activity |
| TW201632504A (zh) | 2015-01-23 | 2016-09-16 | 阿克比治療有限公司 | ２－（５－（３－氟苯基）－３－羥吡啶醯胺基）乙酸之固體形式、其組合物及其用途 |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| BR112017021097B1 (pt) | 2015-04-01 | 2024-01-02 | Akebia Therapeutics, Inc | Formulação de dosagem oral e seu uso |
| KR20210006967A (ko) | 2018-05-09 | 2021-01-19 | 아케비아 테라퓨틱스 인코포레이티드 | 2-[[5-(3-클로로페닐)-3-하이드록시피리딘-2-카르보닐]아미노]아세트산을 제조하는 방법 |
| WO2020217733A1 (ja) * | 2019-04-26 | 2020-10-29 | 株式会社カネカ | Ｖａｄａｄｕｓｔａｔ中間体の製造方法 |
| CN110305143B (zh) * | 2019-07-19 | 2021-03-09 | 济南新科医药科技有限公司 | 一种呋喃[2，3-c]并吡啶衍生物及其制备方法和用途 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| EP0541042A1 (de) * | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | Pyridin-2,4- und 2,5-dicarbonsäureamide und deren Derivate, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
-
1994
- 1994-10-27 ES ES94117017T patent/ES2101420T3/es not_active Expired - Lifetime
- 1994-10-27 DE DE59401923T patent/DE59401923D1/de not_active Expired - Fee Related
- 1994-10-27 AT AT94117017T patent/ATE149485T1/de not_active IP Right Cessation
- 1994-10-27 EP EP94117017A patent/EP0650960B1/de not_active Expired - Lifetime
- 1994-10-27 DK DK94117017.7T patent/DK0650960T3/da active
- 1994-10-28 PL PL94305647A patent/PL179687B1/pl unknown
- 1994-10-28 PH PH49264A patent/PH31264A/en unknown
- 1994-10-30 IL IL11145594A patent/IL111455A0/xx unknown
- 1994-10-31 NZ NZ264822A patent/NZ264822A/en unknown
- 1994-10-31 US US08/332,824 patent/US5658933A/en not_active Expired - Lifetime
- 1994-10-31 AU AU77566/94A patent/AU689135B2/en not_active Ceased
- 1994-11-01 NO NO944161A patent/NO302028B1/no not_active IP Right Cessation
- 1994-11-01 CZ CZ19942682A patent/CZ287767B6/cs not_active IP Right Cessation
- 1994-11-01 RU RU94040163A patent/RU2145959C1/ru active
- 1994-11-01 CA CA002134865A patent/CA2134865A1/en not_active Abandoned
- 1994-11-02 KR KR1019940028870A patent/KR950014069A/ko not_active Application Discontinuation
- 1994-11-02 JP JP6292031A patent/JPH07224039A/ja not_active Abandoned
- 1994-11-02 CN CN94117622A patent/CN1084736C/zh not_active Expired - Fee Related
- 1994-12-05 TW TW083111258A patent/TW330202B/zh active
-
1997
- 1997-04-18 GR GR970400836T patent/GR3023177T3/el unknown
-
1998
- 1998-06-22 HK HK98105874A patent/HK1006712A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ268294A3 (en) | 1995-05-17 |
| PL179687B1 (pl) | 2000-10-31 |
| CA2134865A1 (en) | 1995-05-03 |
| AU689135B2 (en) | 1998-03-26 |
| DE59401923D1 (de) | 1997-04-10 |
| ATE149485T1 (de) | 1997-03-15 |
| NO944161L (no) | 1995-05-03 |
| CN1107144A (zh) | 1995-08-23 |
| ES2101420T3 (es) | 1997-07-01 |
| TW330202B (en) | 1998-04-21 |
| AU7756694A (en) | 1995-05-18 |
| GR3023177T3 (en) | 1997-07-30 |
| CZ287767B6 (en) | 2001-01-17 |
| JPH07224039A (ja) | 1995-08-22 |
| RU2145959C1 (ru) | 2000-02-27 |
| NZ264822A (en) | 1997-02-24 |
| HK1006712A1 (en) | 1999-03-12 |
| CN1084736C (zh) | 2002-05-15 |
| EP0650960B1 (de) | 1997-03-05 |
| IL111455A0 (en) | 1994-12-29 |
| PL305647A1 (en) | 1995-05-15 |
| RU94040163A (ru) | 1997-02-20 |
| NO302028B1 (no) | 1998-01-12 |
| KR950014069A (ko) | 1995-06-15 |
| NO944161D0 (no) | 1994-11-01 |
| PH31264A (en) | 1998-06-18 |
| US5658933A (en) | 1997-08-19 |
| EP0650960A1 (de) | 1995-05-03 |
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