ES2101420T3 - Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos. - Google Patents

Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.

Info

Publication number
ES2101420T3
ES2101420T3 ES94117017T ES94117017T ES2101420T3 ES 2101420 T3 ES2101420 T3 ES 2101420T3 ES 94117017 T ES94117017 T ES 94117017T ES 94117017 T ES94117017 T ES 94117017T ES 2101420 T3 ES2101420 T3 ES 2101420T3
Authority
ES
Spain
Prior art keywords
preparation
medicines
amides
esters
substituted hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94117017T
Other languages
English (en)
Inventor
Klaus Dr Weidmann
Karl-Heinz Dr Baringhaus
Georg Dr Tschank
Martin Dr Bickel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4337270A external-priority patent/DE4337270A1/de
Priority claimed from DE19944434288 external-priority patent/DE4434288A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2101420T3 publication Critical patent/ES2101420T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA I, UN PROCEDIMIENTO PARA SU ELABORACION ASI COMO SU UTILIZACION COMO MEDICAMENTO. EN PARTICULAR SE UTILIZAN LOS COMPUESTOS COMO PREPARADOS MEDICINALES DE ESTER DE INHIBIDORES DE PROLILHIDROXILASA PARA LA INHIBICION DE LA BIOSINTESIS DE COLAGENO, Y SU UTILIZACION COMO FIBROSUPRESIVA.
ES94117017T 1993-11-02 1994-10-27 Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos. Expired - Lifetime ES2101420T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4337270A DE4337270A1 (de) 1993-11-02 1993-11-02 Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19944434288 DE4434288A1 (de) 1994-09-26 1994-09-26 Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ES2101420T3 true ES2101420T3 (es) 1997-07-01

Family

ID=25930886

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94117017T Expired - Lifetime ES2101420T3 (es) 1993-11-02 1994-10-27 Esteres-amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.

Country Status (21)

Country Link
US (1) US5658933A (es)
EP (1) EP0650960B1 (es)
JP (1) JPH07224039A (es)
KR (1) KR950014069A (es)
CN (1) CN1084736C (es)
AT (1) ATE149485T1 (es)
AU (1) AU689135B2 (es)
CA (1) CA2134865A1 (es)
CZ (1) CZ287767B6 (es)
DE (1) DE59401923D1 (es)
DK (1) DK0650960T3 (es)
ES (1) ES2101420T3 (es)
GR (1) GR3023177T3 (es)
HK (1) HK1006712A1 (es)
IL (1) IL111455A0 (es)
NO (1) NO302028B1 (es)
NZ (1) NZ264822A (es)
PH (1) PH31264A (es)
PL (1) PL179687B1 (es)
RU (1) RU2145959C1 (es)
TW (1) TW330202B (es)

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JPH1067674A (ja) * 1996-06-19 1998-03-10 Advanced Sukin Res Kenkyusho:Kk 細胞外マトリツクスの異常蓄積抑制剤
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2353627C (en) * 1998-11-04 2010-10-26 Keiichi Imamura Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
FR2803592A1 (fr) * 2000-01-06 2001-07-13 Aventis Cropscience Sa Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant.
AU2001275014A1 (en) * 2000-05-30 2001-12-11 Neurogen Corporation Imidazoloisoquinolines
CN101664551B (zh) * 2001-12-06 2013-08-14 法布罗根股份有限公司 低氧诱导因子(HIF)α的稳定化
EP2324834B1 (en) 2001-12-06 2019-05-08 Fibrogen, Inc. Methods of Increasing Endogenous Erythropoietin (EPO)
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
DK1644336T3 (da) 2003-06-06 2011-05-09 Fibrogen Inc Nitrogenholdige heteroarylforbindelser og deres anvendelse til forøgelse af endogent erythropoietin
ATE513833T1 (de) 2005-03-02 2011-07-15 Fibrogen Inc Thienopyridinverbindungen und verfahren zu ihrer verwendung
WO2006133391A2 (en) * 2005-06-06 2006-12-14 Fibrogen, Inc. Improved treatment for anemia using a hif-alpha stabilising agent
US8530404B2 (en) 2005-06-15 2013-09-10 Fibrogen, Inc. Compounds and methods for treatment of cancer
EP2476669A1 (en) 2006-01-27 2012-07-18 Fibrogen, Inc. Cyanoisoquinoline compounds and methods of use thereof
WO2007098214A1 (en) * 2006-02-21 2007-08-30 Amgen Inc. Cinnoline derivatives as phosphodiesterase 10 inhibitors
CA2644850A1 (en) * 2006-03-08 2007-09-13 Amgen Inc. Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors
JP5111491B2 (ja) 2006-04-04 2013-01-09 フィブロジェン， インコーポレイテッド ピロロ−およびピラゾロ−ピリミジン化合物、およびそれらの使用方法
AU2013231191B2 (en) * 2006-06-23 2015-09-03 Glaxosmithkline Llc Prolyl hydroxylase inhibitors
TWI394747B (zh) * 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
LT3357911T (lt) 2006-06-26 2022-08-10 Akebia Therapeutics Inc. Prolilo hidroksilazės inhibitoriai ir naudojimo būdai
WO2008000408A1 (en) * 2006-06-28 2008-01-03 Sanofi-Aventis Cxcr2 antagonists
WO2008000410A1 (en) * 2006-06-30 2008-01-03 Sanofi-Aventis Cxcr2 inhibitors
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
US8962530B2 (en) 2007-06-27 2015-02-24 Regents Of The University Of Colorado Inflammatory bowel disease therapies
WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
ES2548250T3 (es) 2009-02-10 2015-10-15 Janssen Pharmaceutica, N.V. Quinazolinonas como inhibidores de prolilhidroxilasa
AU2010314976B2 (en) * 2009-11-06 2014-03-06 Aerpio Therapeutics Inc. Prolyl hydroxylase inhibitors
US8247436B2 (en) * 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
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CN113767089A (zh) * 2019-04-26 2021-12-07 株式会社钟化 伐度司他中间体的制造方法
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Also Published As

Publication number Publication date
KR950014069A (ko) 1995-06-15
CZ268294A3 (en) 1995-05-17
DK0650960T3 (da) 1997-09-01
HK1006712A1 (en) 1999-03-12
RU94040163A (ru) 1997-02-20
DE59401923D1 (de) 1997-04-10
CA2134865A1 (en) 1995-05-03
CN1107144A (zh) 1995-08-23
US5658933A (en) 1997-08-19
ATE149485T1 (de) 1997-03-15
NO944161D0 (no) 1994-11-01
GR3023177T3 (en) 1997-07-30
NO302028B1 (no) 1998-01-12
AU7756694A (en) 1995-05-18
RU2145959C1 (ru) 2000-02-27
CZ287767B6 (en) 2001-01-17
PL179687B1 (pl) 2000-10-31
CN1084736C (zh) 2002-05-15
NO944161L (no) 1995-05-03
IL111455A0 (en) 1994-12-29
AU689135B2 (en) 1998-03-26
NZ264822A (en) 1997-02-24
EP0650960A1 (de) 1995-05-03
PL305647A1 (en) 1995-05-15
TW330202B (en) 1998-04-21
JPH07224039A (ja) 1995-08-22
EP0650960B1 (de) 1997-03-05
PH31264A (en) 1998-06-18

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