DK0393883T3 - Nye cytotoksiske cykliske depsipeptider fra sækdyret Trididemnum solidum - Google Patents

Nye cytotoksiske cykliske depsipeptider fra sækdyret Trididemnum solidum

Info

Publication number: DK0393883T3
Authority: DK; Denmark
Prior art keywords: turtle; cyclic depsipeptides; novel cytotoxic; trididemnum solidum; cytotoxic cyclic
Prior art date: 1989-04-10

Application number

DK90303672T

Other languages

Danish (da)

English (en)

Inventor

Kenneth L Rinehart Jr

Ryuichi Sakai

Justin G Stroh

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-10

Filing date

1990-04-05

Publication date

2000-03-20

1990-04-05 Application filed by Univ Illinois filed Critical Univ Illinois

2000-03-20 Application granted granted Critical

2000-03-20 Publication of DK0393883T3 publication Critical patent/DK0393883T3/da

Links

241000804473 Trididemnum solidum Species 0.000 title abstract 2
230000001472 cytotoxic effect Effects 0.000 title abstract 2
108010002156 Depsipeptides Proteins 0.000 title 1
241000270666 Testudines Species 0.000 title 1
231100000433 cytotoxic Toxicity 0.000 title 1
KYHUYMLIVQFXRI-XYUQHQMCSA-N (2s)-n-[(2r)-1-[[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino Chemical class CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)O KYHUYMLIVQFXRI-XYUQHQMCSA-N 0.000 abstract 1
GXKAOWYTJPGGBI-BHTIDRDUSA-N (4s)-4-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(3r)-3-hydroxydecanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-[(2s)-1-[(2s)-2-[[(2r)-1-[[(3s,6s,8s,12s,13s,16s,17s,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20- Chemical compound CCCCCCC[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)[C@@H](O)CC(=O)O[C@@H](C(C)C)C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@H]1C GXKAOWYTJPGGBI-BHTIDRDUSA-N 0.000 abstract 1
BUHGEDVBBOQECR-HGESRAKOSA-N (4s)-4-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(3r)-3-hydroxydecanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-[(2s)-1-[(2s)-2-[[(2r)-1-[[(3s,6s,8s,12s,13s,16s,17s,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trime Chemical compound CCCCCCC[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)[C@@H](O)CC(=O)O[C@@H](C(C)C)C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@H]1C BUHGEDVBBOQECR-HGESRAKOSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK90303672T 1989-04-10 1990-04-05 Nye cytotoksiske cykliske depsipeptider fra sækdyret Trididemnum solidum DK0393883T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/335,903 US4948791A (en)	1989-04-10	1989-04-10	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum

Publications (1)

Publication Number	Publication Date
DK0393883T3 true DK0393883T3 (da)	2000-03-20

Family

ID=23313708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90303672T DK0393883T3 (da)	1989-04-10	1990-04-05	Nye cytotoksiske cykliske depsipeptider fra sækdyret Trididemnum solidum

Country Status (10)

Country	Link
US (1)	US4948791A (de)
EP (1)	EP0393883B1 (de)
JP (1)	JP3431920B2 (de)
AT (1)	ATE183751T1 (de)
AU (1)	AU640130B2 (de)
CA (1)	CA2012867C (de)
DE (1)	DE69033257T2 (de)
DK (1)	DK0393883T3 (de)
ES (1)	ES2140373T3 (de)
GR (1)	GR3031846T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
DE4120327A1 (de) *	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
US5830996A (en) *	1996-09-27	1998-11-03	University Of Utah Research Foundation	Cyclic peptide antitumor agent from an ascidian
ATE321773T1 (de) *	1996-10-24	2006-04-15	Univ Illinois	Semisynthetisches verfahren zur herstellung von didemninanalogen
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
ES2243555T3 (es)	2000-10-12	2005-12-01	Pharma Mar, S.A.	Tratamiento de canceres mediante aplidina en conjuncion con carnitina o acetilcarnitina.
PL1603584T3 (pl)	2003-03-12	2009-02-27	Dana Farber Cancer Inst Inc	Aplidyna do leczenia szpiczaka mnogiego
CA2516572A1 (en)	2003-03-12	2004-09-23	Pharma Mar, S.A.	Improved antitumoral treatments
JP5393159B2 (ja)	2006-02-28	2014-01-22	ファルマ・マール・ソシエダード・アノニマ	改善された抗腫瘍治療
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2576022B1 (fr) *	1985-01-11	1987-09-11	Rhone Poulenc Sante	Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent

1989
- 1989-04-10 US US07/335,903 patent/US4948791A/en not_active Expired - Lifetime
1990
- 1990-03-22 CA CA002012867A patent/CA2012867C/en not_active Expired - Fee Related
- 1990-04-05 DK DK90303672T patent/DK0393883T3/da active
- 1990-04-05 ES ES90303672T patent/ES2140373T3/es not_active Expired - Lifetime
- 1990-04-05 AT AT90303672T patent/ATE183751T1/de not_active IP Right Cessation
- 1990-04-05 DE DE69033257T patent/DE69033257T2/de not_active Expired - Fee Related
- 1990-04-05 EP EP90303672A patent/EP0393883B1/de not_active Expired - Lifetime
- 1990-04-09 AU AU53053/90A patent/AU640130B2/en not_active Ceased
- 1990-04-10 JP JP09327490A patent/JP3431920B2/ja not_active Expired - Fee Related
1999
- 1999-11-16 GR GR990402940T patent/GR3031846T3/el unknown

Also Published As

Publication number	Publication date
CA2012867A1 (en)	1990-10-10
GR3031846T3 (en)	2000-02-29
AU640130B2 (en)	1993-08-19
JPH03135999A (ja)	1991-06-10
EP0393883A1 (de)	1990-10-24
CA2012867C (en)	1999-09-21
AU5305390A (en)	1990-10-11
ES2140373T3 (es)	2000-03-01
US4948791A (en)	1990-08-14
ATE183751T1 (de)	1999-09-15
DE69033257D1 (de)	1999-09-30
JP3431920B2 (ja)	2003-07-28
DE69033257T2 (de)	2000-04-13
EP0393883B1 (de)	1999-08-25

Publication	Publication Date	Title
DE69024965T2 (de)	1996-08-22	Dehydrodidemnin b
DK0393883T3 (da)	2000-03-20	Nye cytotoksiske cykliske depsipeptider fra sækdyret Trididemnum solidum
IL89921A (en)	1993-08-18	1,3-dioxolane derivatives and pharmaceutical compositions containing the same
DE3778365D1 (de)	1992-05-21	Entzuendungshemmende mittel.
ES2097736T3 (es)	1997-04-16	Peptido ciclico con actividad antagonista de sustancia p y sustancia k.
DE58900290D1 (de)	1991-10-24	Ringkanalgeblaese.
FI891153A0 (fi)	1989-03-10	Nya 3,4,5-substituerade 4h-1,2,4-triazoler, deras framstaellning och anvaendning.
FI901199A0 (fi)	1990-03-09	Nya steroiddioler, dessa innehaollande farmaceutiska foereningar och foerfarande foer framstaellning av dem.
YU47393A (sh)	1997-08-22	Novi derivati fosfolipida
ES2126580T3 (es)	1999-04-01	Proteina condromodulina-ii.
DE3851054D1 (de)	1994-09-15	Antitumor 6-sulfenamid, 6-sulfinamid und 6-sulfonamid-purine, purin-nukleoside, purin-nukleotide und verwandte verbindungen.
IT8622051A1 (it)	1988-04-17	Composizioni farmaceutiche ad attivita' cicatrizzante
ATE80873T1 (de)	1992-10-15	Tetrahydropyridin-derivate.
IT8919498A0 (it)	1989-02-21	Derivati del 3,4 deidro piperidin 5 one ad attivita' erbicida.
ITMI910600A1 (it)	1992-09-08	6, 9-bis (amino sostituiti) benzo(g) ftalazin-5, 10-dioni come farmaci antitumorali.
IT8885566A0 (it)	1988-04-29	Alzata registrabile per sedie.