GR3031846T3 - Novel cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum. - Google Patents

Novel cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum.

Info

Publication number: GR3031846T3
Authority: GR; Greece
Prior art keywords: cyclic depsipeptides; novel cytotoxic; trididemnum solidum; cytotoxic cyclic; tunicate
Prior art date: 1989-04-10

Application number

GR990402940T

Other languages

English (en)

Original Assignee

Univ Illinois

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-10

Filing date

1999-11-16

Publication date

2000-02-29

1999-11-16 Application filed by Univ Illinois filed Critical Univ Illinois

2000-02-29 Publication of GR3031846T3 publication Critical patent/GR3031846T3/el

Links

241000804473 Trididemnum solidum Species 0.000 title abstract 2
230000001472 cytotoxic effect Effects 0.000 title abstract 2
108010002156 Depsipeptides Proteins 0.000 title 1
231100000433 cytotoxic Toxicity 0.000 title 1
KYHUYMLIVQFXRI-XYUQHQMCSA-N (2s)-n-[(2r)-1-[[(3s,6s,8s,12s,13r,16s,17r,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino Chemical class CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)O KYHUYMLIVQFXRI-XYUQHQMCSA-N 0.000 abstract 1
GXKAOWYTJPGGBI-BHTIDRDUSA-N (4s)-4-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(3r)-3-hydroxydecanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-[(2s)-1-[(2s)-2-[[(2r)-1-[[(3s,6s,8s,12s,13s,16s,17s,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20- Chemical compound CCCCCCC[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)[C@@H](O)CC(=O)O[C@@H](C(C)C)C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@H]1C GXKAOWYTJPGGBI-BHTIDRDUSA-N 0.000 abstract 1
BUHGEDVBBOQECR-HGESRAKOSA-N (4s)-4-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(3r)-3-hydroxydecanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-5-[(2s)-1-[(2s)-2-[[(2r)-1-[[(3s,6s,8s,12s,13s,16s,17s,20s,23s)-13-[(2s)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trime Chemical compound CCCCCCC[C@@H](O)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)O[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N(C)[C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)[C@@H](O)CC(=O)O[C@@H](C(C)C)C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@H]1C BUHGEDVBBOQECR-HGESRAKOSA-N 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

GR990402940T 1989-04-10 1999-11-16 Novel cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum. GR3031846T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/335,903 US4948791A (en)	1989-04-10	1989-04-10	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum

Publications (1)

Publication Number	Publication Date
GR3031846T3 true GR3031846T3 (en)	2000-02-29

Family

ID=23313708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR990402940T GR3031846T3 (en)	1989-04-10	1999-11-16	Novel cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum.

Country Status (10)

Country	Link
US (1)	US4948791A (el)
EP (1)	EP0393883B1 (el)
JP (1)	JP3431920B2 (el)
AT (1)	ATE183751T1 (el)
AU (1)	AU640130B2 (el)
CA (1)	CA2012867C (el)
DE (1)	DE69033257T2 (el)
DK (1)	DK0393883T3 (el)
ES (1)	ES2140373T3 (el)
GR (1)	GR3031846T3 (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030148933A1 (en)	1990-10-01	2003-08-07	Pharma Mar S.A.	Derivatives of dehydrodidemnin B
DE4120327A1 (de) *	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
US5830996A (en) *	1996-09-27	1998-11-03	University Of Utah Research Foundation	Cyclic peptide antitumor agent from an ascidian
ATE321773T1 (de) *	1996-10-24	2006-04-15	Univ Illinois	Semisynthetisches verfahren zur herstellung von didemninanalogen
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
GB9803448D0 (en)	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
ES2243555T3 (es)	2000-10-12	2005-12-01	Pharma Mar, S.A.	Tratamiento de canceres mediante aplidina en conjuncion con carnitina o acetilcarnitina.
PL1603584T3 (pl)	2003-03-12	2009-02-27	Dana Farber Cancer Inst Inc	Aplidyna do leczenia szpiczaka mnogiego
CA2516572A1 (en)	2003-03-12	2004-09-23	Pharma Mar, S.A.	Improved antitumoral treatments
JP5393159B2 (ja)	2006-02-28	2014-01-22	ファルマ・マール・ソシエダード・アノニマ	改善された抗腫瘍治療
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2576022B1 (fr) *	1985-01-11	1987-09-11	Rhone Poulenc Sante	Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent

1989
- 1989-04-10 US US07/335,903 patent/US4948791A/en not_active Expired - Lifetime
1990
- 1990-03-22 CA CA002012867A patent/CA2012867C/en not_active Expired - Fee Related
- 1990-04-05 DK DK90303672T patent/DK0393883T3/da active
- 1990-04-05 ES ES90303672T patent/ES2140373T3/es not_active Expired - Lifetime
- 1990-04-05 AT AT90303672T patent/ATE183751T1/de not_active IP Right Cessation
- 1990-04-05 DE DE69033257T patent/DE69033257T2/de not_active Expired - Fee Related
- 1990-04-05 EP EP90303672A patent/EP0393883B1/en not_active Expired - Lifetime
- 1990-04-09 AU AU53053/90A patent/AU640130B2/en not_active Ceased
- 1990-04-10 JP JP09327490A patent/JP3431920B2/ja not_active Expired - Fee Related
1999
- 1999-11-16 GR GR990402940T patent/GR3031846T3/el unknown

Also Published As

Publication number	Publication date
CA2012867A1 (en)	1990-10-10
AU640130B2 (en)	1993-08-19
JPH03135999A (ja)	1991-06-10
EP0393883A1 (en)	1990-10-24
CA2012867C (en)	1999-09-21
AU5305390A (en)	1990-10-11
ES2140373T3 (es)	2000-03-01
DK0393883T3 (da)	2000-03-20
US4948791A (en)	1990-08-14
ATE183751T1 (de)	1999-09-15
DE69033257D1 (de)	1999-09-30
JP3431920B2 (ja)	2003-07-28
DE69033257T2 (de)	2000-04-13
EP0393883B1 (en)	1999-08-25

Publication	Publication Date	Title
GB8922026D0 (en)	1989-11-15	Novel anti-viral and cytotoxic agent
PH31059A (en)	1998-02-05	Pharmaceutical compositions comprising cyclosporins.
GB2195889B (en)	1990-08-01	Pharmaceutical antioxidant composition produced from plants.
IL88898A0 (en)	1989-08-15	1,2-bis(aminomethyl)-cyclo-butane-platinum complexes,their preparation and pharmaceutical compositions containing them
GR3031846T3 (en)	2000-02-29	Novel cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum.
GR3032366T3 (en)	2000-04-27	Pharmaceutical cyclosporin composition.
EP0353678A3 (en)	1991-03-20	FR-901154 and FR-901155 substances, a process for their production
IE930197L (en)	1987-12-11	Anti-Inflammatory Compositions
DE59001121D1 (en)	1993-05-06	Antacidatabletten.
NZ220379A (en)	1989-02-24	Immunosuppressant cyclodepsipeptides from streptomyces sp. s-16328
SG46249A1 (en)	1998-02-20	Novel phospholipid derivatives
TW221692B (el)	1994-03-11
GB2189490B (en)	1990-02-14	Physiologically-active tripeptide.
ES2023759A6 (es)	1992-02-01	Procedimiento para la preparacion de nuevos derivados del 1,4-benzodioxano.
IL82705A0 (en)	1987-11-30	Pharmaceutical compositions containing avarone,avarol or derivatives thereof for the control of adult t-cell leukemia/lymphoma
GR3003132T3 (en)	1993-02-17	Pharmaceutical compositions having healing activity
NZ236628A (en)	1992-09-25	Preparation of 2,2-dialkoxy cyclic orthoesters from lactones
YU12189A (en)	1991-04-30	Derivatives tetrahydropyridin
AU8766591A (en)	1992-05-26	Assay for cyclic 1,2-dithiol-3-ones
IE900683L (en)	1990-08-27	Peptide lactones.
UA15644A (uk)	1997-06-30	Клей для склеюваhhя робочих елемеhтів іhфрачервоhих систем