DE69928951D1 - 2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) - Google Patents

2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)

Info

Publication number
DE69928951D1
DE69928951D1 DE69928951T DE69928951T DE69928951D1 DE 69928951 D1 DE69928951 D1 DE 69928951D1 DE 69928951 T DE69928951 T DE 69928951T DE 69928951 T DE69928951 T DE 69928951T DE 69928951 D1 DE69928951 D1 DE 69928951D1
Authority
DE
Germany
Prior art keywords
optionally substituted
formula
zero
group
antipsychotic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69928951T
Other languages
English (en)
Inventor
N-Smithkline Beecham P Johnson
Geoffrey-Smithkline Beec Stemp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69928951D1 publication Critical patent/DE69928951D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69928951T 1998-10-08 1999-10-06 2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) Expired - Lifetime DE69928951D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9821978.5A GB9821978D0 (en) 1998-10-08 1998-10-08 Compounds
PCT/EP1999/007762 WO2000021950A1 (en) 1998-10-08 1999-10-06 2,3-dihydro-1h-isoindole derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)

Publications (1)

Publication Number Publication Date
DE69928951D1 true DE69928951D1 (de) 2006-01-19

Family

ID=10840234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69928951T Expired - Lifetime DE69928951D1 (de) 1998-10-08 1999-10-06 2,3-dihydro-1h-isoindol-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel)

Country Status (9)

Country Link
US (2) US6521638B1 (de)
EP (1) EP1119562B1 (de)
JP (1) JP2002527432A (de)
AT (1) ATE312830T1 (de)
AU (1) AU1038000A (de)
DE (1) DE69928951D1 (de)
GB (1) GB9821978D0 (de)
HK (1) HK1040393A1 (de)
WO (1) WO2000021950A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
EP1632483B1 (de) * 2001-02-16 2008-10-29 Aventis Pharmaceuticals Inc. Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
GB0117577D0 (en) 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
JP5701213B2 (ja) 2008-10-10 2015-04-15 インスティチュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー．エル．エー．チャイナ 新規なドーパミンｄ３受容体リガンド、その調製及び使用
EP3495363B1 (de) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Stickstoffhaltige kondensierte ringverbindungen mit antagonistischer dopamin-d3-rezeptor-wirkung
JPWO2019146739A1 (ja) * 2018-01-26 2021-01-07 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する縮環化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
IL126747A0 (en) * 1996-05-11 1999-08-17 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptors
WO1998006699A1 (en) 1996-08-14 1998-02-19 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives and their pharmaceutical use
PL336628A1 (en) 1997-05-03 2000-07-03 Smithkline Beecham Plc Derivatives of tetrahydroisoquinoline as modulators of d3 dopamine receptors

Also Published As

Publication number Publication date
EP1119562A1 (de) 2001-08-01
US20030158222A1 (en) 2003-08-21
US6521638B1 (en) 2003-02-18
JP2002527432A (ja) 2002-08-27
GB9821978D0 (en) 1998-12-02
HK1040393A1 (zh) 2002-06-07
EP1119562B1 (de) 2005-12-14
WO2000021950A1 (en) 2000-04-20
ATE312830T1 (de) 2005-12-15
AU1038000A (en) 2000-05-01

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