AR034792A1 - Derivados de 1-fenilsulfonil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de 1-fenilsulfonil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR034792A1 AR034792A1 ARP020102655A ARP020102655A AR034792A1 AR 034792 A1 AR034792 A1 AR 034792A1 AR P020102655 A ARP020102655 A AR P020102655A AR P020102655 A ARP020102655 A AR P020102655A AR 034792 A1 AR034792 A1 AR 034792A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- preparation
- alkyl
- halogen atom
- sulfonil
- Prior art date
Links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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Abstract
Compuestos de la fórmula (1) en la cual: n es 1 o 2; X representa un grupo -CH2-; -O-; NH-; -O-CH2-; -NH-CH2-; -NH-CH2CH2-; R1 representa un átomo de halógeno; un alquilo (C1-4); un alcoxi (C1-4); R2 representa un átomo de hidrógeno; un átomo de halógeno; un alquilo(C1-4); un alcoxi(C1-4); un radical trifluorometilo; R3 representa un átomo de halógeno; un alquilo (C1-3); un alcoxi (C1-5); un radical trifluorometilo, un radical trifluorometoxi; R4 representa un átomo de hidrógeno; un átomo de halógeno; un alquilo (C1-3); un alcoxi (C1-3); R5 representa un radical elegido entre el grupo de fórmulas (2) R6 representa un alcoxi (C1-4); R7 representa un alcoxi (C1-4); así como sus sales con ácidos minerales u orgánicos, sus solvatos y/o hidratos, que presentan una afinidad y una selectividad con los receptores V1b de la arginina-vasopresina y/o con los receptores de la oxitocina y además, para algunos compuestos una afinidad con los receptores V1a. Procedimiento de preparación, compuestos intermediarios de fórmula (4) útiles para su preparación, composiciones farmacéuticas que los contienen y su utilización para la preparación de medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0110359A FR2827604B1 (fr) | 2001-07-17 | 2001-07-17 | Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
AR034792A1 true AR034792A1 (es) | 2004-03-17 |
Family
ID=8866211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102655A AR034792A1 (es) | 2001-07-17 | 2002-07-16 | Derivados de 1-fenilsulfonil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeutica |
Country Status (32)
Country | Link |
---|---|
US (1) | US7119086B2 (es) |
EP (1) | EP1419150B1 (es) |
JP (1) | JP4262088B2 (es) |
KR (1) | KR20040017325A (es) |
CN (1) | CN1224623C (es) |
AR (1) | AR034792A1 (es) |
AT (1) | ATE294171T1 (es) |
AU (1) | AU2002340999B2 (es) |
BR (1) | BR0211284A (es) |
CA (1) | CA2450437A1 (es) |
CO (1) | CO5550440A2 (es) |
DE (1) | DE60203917T2 (es) |
DK (1) | DK1419150T3 (es) |
EA (1) | EA006019B1 (es) |
ES (1) | ES2240814T3 (es) |
FR (1) | FR2827604B1 (es) |
HK (1) | HK1061679A1 (es) |
HR (1) | HRP20040027A2 (es) |
HU (1) | HUP0401461A3 (es) |
IL (1) | IL159275A0 (es) |
IS (1) | IS2485B (es) |
MA (1) | MA27049A1 (es) |
ME (1) | MEP24508A (es) |
MX (1) | MXPA04000507A (es) |
NO (1) | NO20040219L (es) |
NZ (1) | NZ530144A (es) |
PL (1) | PL366829A1 (es) |
PT (1) | PT1419150E (es) |
RS (1) | RS204A (es) |
UA (1) | UA77181C2 (es) |
WO (1) | WO2003008407A2 (es) |
ZA (1) | ZA200309717B (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7754711B2 (en) * | 2003-07-30 | 2010-07-13 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
WO2005018531A2 (fr) * | 2003-08-26 | 2005-03-03 | 'chemical Diversity Research Institute', Ltd. | Compositions pharmaceutiques, composes azo-heterocycliques et procedes de fabrication et d'utilisation correspondants |
JP4618127B2 (ja) | 2003-08-28 | 2011-01-26 | 大正製薬株式会社 | 1,3−ジヒドロ−2h−インドール−2−オン誘導体 |
US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US20050070718A1 (en) * | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US7514466B2 (en) | 2004-04-27 | 2009-04-07 | Wyeth | Purification of progesterone receptor modulators |
DE102004033834A1 (de) * | 2004-07-13 | 2006-02-02 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate und diese enthaltende Arzneimittel |
JPWO2006070742A1 (ja) * | 2004-12-27 | 2008-08-07 | 国立大学法人京都大学 | 麻薬性鎮痛剤の耐性形成抑制剤 |
US8030499B2 (en) | 2005-01-28 | 2011-10-04 | Taisho Pharmaceutical Co., Ltd. | 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle |
DE102005014936A1 (de) * | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
MX2007011693A (es) | 2005-03-24 | 2008-03-11 | Abbott Gmbh & Co Kg | Derivados de oxindoles sustituidos, farmacos que contienen dichos derivados y uso de los mismos. |
US7576082B2 (en) | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
SG132540A1 (en) | 2005-11-25 | 2007-06-28 | Matsushita Electric Ind Co Ltd | Magnetic trap for ferrous contaminants in lubricant |
JP2009517444A (ja) | 2005-12-02 | 2009-04-30 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 置換オキシインドール誘導体、それを含む医薬およびそれの使用 |
JP5437070B2 (ja) * | 2006-08-26 | 2014-03-12 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 置換ベンゾイミダゾロン誘導体、それを含む薬剤およびそれの使用 |
DE102006040915A1 (de) * | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
US8486979B2 (en) * | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
CN101611028B (zh) * | 2006-12-30 | 2013-09-11 | 艾博特股份有限两合公司 | 取代的羟吲哚衍生物、以及它们用作加压素受体配体的用途 |
RU2461556C2 (ru) * | 2006-12-30 | 2012-09-20 | Эбботт Гмбх Унд Ко. Кг | Замещенные производные оксидола и их применение в качестве лигандов рецептора вазопрессина |
US8486931B2 (en) * | 2007-03-02 | 2013-07-16 | Abbott Gmbh & Co. Kg | Substituted oxindole compounds |
FR2920023B1 (fr) * | 2007-08-16 | 2013-02-08 | Sanofi Aventis | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique |
WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
MX2010006202A (es) | 2007-12-07 | 2011-03-04 | Abbott Gmbh & Co Kg | Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina. |
BRPI0820668A2 (pt) | 2007-12-07 | 2017-08-22 | Abbott Gmbh & Co Kg | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina |
JP5645217B2 (ja) * | 2007-12-07 | 2014-12-24 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 5,6−二置換オキシンドール誘導体およびバソプレッシン依存性疾患を治療するためのこれらの使用 |
WO2009071691A2 (de) * | 2007-12-07 | 2009-06-11 | Abbott Gmbh & Co. Kg | Oxindol-derivate und ihre verwendung als medikament |
NZ587015A (en) * | 2007-12-27 | 2012-06-29 | Abbott Gmbh & Co Kg | Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
FR2927625B1 (fr) | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
FR2930249B1 (fr) * | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
WO2010017827A1 (en) * | 2008-08-14 | 2010-02-18 | European Molecular Biology Laboratory | 6-substituted 1-sulfonyl-2, 3-dihydro-indole derivatives for the treatment of proliferative diseases |
PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
FR2941947B1 (fr) | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
FR2941946B1 (fr) | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
US9040568B2 (en) | 2009-05-29 | 2015-05-26 | Abbvie Inc. | Pharmaceutical compositions for the treatment of pain |
US20110059983A1 (en) * | 2009-06-10 | 2011-03-10 | Abbott Gmbh & Co. Kg | Use of substituted oxindole derivatives for the treatment and prophylaxis of pain |
PT2498801T (pt) | 2009-11-13 | 2018-05-02 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendin-4(1-39)-lys6-nh2 e metionina |
US10029011B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine |
US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
AU2011202239C1 (en) * | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
SG187904A1 (en) | 2010-08-30 | 2013-04-30 | Sanofi Aventis Deutschland | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
WO2012084854A1 (de) | 2010-12-21 | 2012-06-28 | Bayer Cropscience Ag | Verfahren zur herstellung von n-sulfonylsubstituierten oxindolen |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
KR101983982B1 (ko) | 2011-08-29 | 2019-05-30 | 사노피-아벤티스 도이칠란트 게엠베하 | 2형 당뇨병 환자의 혈당 조절에 사용하기 위한 약제학적 병용물 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
JP6457484B2 (ja) | 2013-04-03 | 2019-01-23 | サノフイSanofi | インスリンの長時間作用型製剤による糖尿病の治療 |
NZ733670A (en) | 2014-12-12 | 2021-12-24 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
EP3912625A1 (en) * | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
KR20230090589A (ko) * | 2021-12-15 | 2023-06-22 | 국립해양생물자원관 | 성게 유래 펩타이드 및 이의 용도 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2714378B1 (fr) * | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
GB2326639A (en) * | 1997-06-18 | 1998-12-30 | Merck & Co Inc | Piperazine Oxytocin Receptor Antagonists |
US20050070718A1 (en) * | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
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