DE69827664D1 - Thioharnstoffverbindungen, zusammensetzungen sowie verfahren zur behandlung oder verhütung von entzündlichen erkrankungen und atherosklerose - Google Patents
Thioharnstoffverbindungen, zusammensetzungen sowie verfahren zur behandlung oder verhütung von entzündlichen erkrankungen und atheroskleroseInfo
- Publication number
- DE69827664D1 DE69827664D1 DE69827664T DE69827664T DE69827664D1 DE 69827664 D1 DE69827664 D1 DE 69827664D1 DE 69827664 T DE69827664 T DE 69827664T DE 69827664 T DE69827664 T DE 69827664T DE 69827664 D1 DE69827664 D1 DE 69827664D1
- Authority
- DE
- Germany
- Prior art keywords
- thiosidary
- atherosclerosis
- compositions
- treating
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6860497P | 1997-12-23 | 1997-12-23 | |
US68604P | 1997-12-23 | ||
PCT/US1998/024688 WO1999032433A1 (en) | 1997-12-23 | 1998-11-20 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69827664D1 true DE69827664D1 (de) | 2004-12-23 |
DE69827664T2 DE69827664T2 (de) | 2005-12-08 |
Family
ID=22083601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69827664T Expired - Fee Related DE69827664T2 (de) | 1997-12-23 | 1998-11-20 | Thioharnstoffverbindungen, zusammensetzungen sowie verfahren zur behandlung oder verhütung von entzündlichen erkrankungen und atherosklerose |
Country Status (17)
Country | Link |
---|---|
US (2) | US6268387B1 (de) |
EP (1) | EP1042276B1 (de) |
JP (1) | JP2001526255A (de) |
KR (1) | KR20010033470A (de) |
AR (1) | AR024826A1 (de) |
AT (1) | ATE282591T1 (de) |
AU (1) | AU1529799A (de) |
BR (1) | BR9814327A (de) |
CA (1) | CA2300197A1 (de) |
CO (1) | CO4990966A1 (de) |
DE (1) | DE69827664T2 (de) |
ES (1) | ES2234169T3 (de) |
NZ (1) | NZ502963A (de) |
PE (1) | PE20000064A1 (de) |
UY (1) | UY25322A1 (de) |
WO (1) | WO1999032433A1 (de) |
ZA (1) | ZA9811805B (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6563802B2 (en) | 1998-06-22 | 2003-05-13 | Intel Corporation | Echo cancellation with dynamic latency adjustment |
US6214880B1 (en) | 1998-09-23 | 2001-04-10 | Tularik Inc. | Arylsulfonanilide ureas |
JP4794793B2 (ja) * | 1999-12-28 | 2011-10-19 | ファーマコペイア, インコーポレイテッド | N−ヘテロ環TNF−α発現阻害剤 |
WO2001096298A2 (en) * | 2000-06-14 | 2001-12-20 | Warner-Lambert Company | 1,2,4-trisubstituted benzenes as inhibitors of 15-lipoxygenase |
UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
BR0212189A (pt) | 2001-08-15 | 2004-07-13 | Du Pont | Composto, método para controle de pragas invertebradas e composição para controle de pragas invertebradas |
RU2315765C2 (ru) | 2002-01-22 | 2008-01-27 | Е.И.Дюпон Де Немур Энд Компани | Хиназолин(ди)оны, композиция для борьбы с насекомыми-вредителями, способ борьбы с насекомыми-вредителями, промежуточное соединение |
CN100410388C (zh) | 2002-02-08 | 2008-08-13 | 霍夫曼-拉罗奇有限公司 | 一种鉴定增加骨矿物质密度的化合物的方法 |
EP1507756B1 (de) | 2002-05-24 | 2015-07-22 | Millennium Pharmaceuticals, Inc. | Ccr9-inhibitoren und verfahren zu deren verwendung |
KR20040018295A (ko) * | 2002-08-22 | 2004-03-03 | 임철부 | 항암 활성을 갖는 티오우레이도 세라마이드 유도체 및 이화합물을 함유하는 약학적 조성물 |
US6812355B2 (en) | 2002-10-22 | 2004-11-02 | Sekhsaria Chemicals Limited | Process for the manufacture of citalopram hydrobromide from 5-bromophthalide |
FR2846326A1 (fr) * | 2002-10-29 | 2004-04-30 | Isochem Sa | Procede de purification des n-carboxyanhydrides |
US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
JP4611746B2 (ja) | 2002-11-18 | 2011-01-12 | ケモセントリックス, インコーポレイテッド | アリールスルホンアミド |
US7227035B2 (en) | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
WO2004046095A1 (en) * | 2002-11-19 | 2004-06-03 | Achillion Pharmaceuticals, Inc. | Substituted aryl thioureas and related compounds; inhibitors of viral replication |
KR100555655B1 (ko) * | 2002-11-20 | 2006-03-03 | 임철부 | 항암 활성을 갖는 우레이도 또는 티오우레이도 유도체 및이 화합물을 함유하는 약학조성물 |
CA2515544A1 (en) * | 2003-02-11 | 2004-08-26 | Kemia Inc. | Compounds for the treatment of viral infection |
TW200529812A (en) | 2003-12-26 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Benzamide derivatives |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
EP1775283A4 (de) * | 2004-07-14 | 2008-12-10 | Japan Tobacco Inc | 3-aminobenzamid-verbindung und hemmer der aktivität des vanilloid-rezeptors 1 (vr1) |
CN1984906A (zh) * | 2004-07-15 | 2007-06-20 | 日本烟草产业株式会社 | 稠合苯甲酰胺化合物和香草素受体1(vr1)活性抑制剂 |
KR100956703B1 (ko) * | 2005-06-06 | 2010-05-06 | 에프. 호프만-라 로슈 아게 | 간 카르니틴 팔미토일 전이효소(l-cpt1) 저해제로서유용한 설폰아마이드 유도체 |
CA2612976C (en) | 2005-06-21 | 2012-04-10 | Mitsui Chemicals, Inc. | Amide derivative and insecticide containing the same |
US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
US7464565B2 (en) | 2005-11-29 | 2008-12-16 | Maytag Corporation | Rapid temperature change device for a refrigerator |
US20070155746A1 (en) * | 2005-12-23 | 2007-07-05 | Kalypsys, Inc. | Novel substituted pyridinyloxy and pyrimidinyloxy amides useful as inhibitors of protein kinases |
US7906508B2 (en) * | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
US8466180B2 (en) | 2006-09-11 | 2013-06-18 | Syngenta Crop Protection Llc | Insecticidal compounds |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
GB0813403D0 (en) | 2008-07-22 | 2008-08-27 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
CN101367749B (zh) * | 2008-09-28 | 2013-04-24 | 中国医学科学院医药生物技术研究所 | 一组胺基苯酰衍生物及其制备方法和应用 |
MX349923B (es) | 2009-04-03 | 2017-08-21 | Hoffmann La Roche | Composiciones del ácido propano-1-sulfónico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil]-amida y el uso de las mismas. |
JP5890312B2 (ja) | 2009-10-09 | 2016-03-22 | ザフゲン,インコーポレイテッド | 肥満治療に用いられるスルホン化合物 |
ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
EP2590951B1 (de) | 2010-07-09 | 2015-01-07 | Pfizer Limited | Benzolsulfonamide als kaliumkanalhemmer |
AU2011281037B2 (en) | 2010-07-22 | 2014-11-27 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
AU2011295727B2 (en) * | 2010-09-03 | 2015-04-02 | Forma Tm, Llc. | Guanidine compounds and compositions for the inhibition of NAMPT |
CN103402989B (zh) | 2011-01-26 | 2016-04-06 | 扎夫根股份有限公司 | 四唑化合物及其制备和使用方法 |
PT2672967T (pt) | 2011-02-07 | 2018-12-07 | Plexxikon Inc | Compostos e métodos de modulação da quinase e suas indicações |
AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
EP2505198A1 (de) | 2011-04-01 | 2012-10-03 | Société Splicos | Verbindungen zur Verwendung als Therapiemittel mit Beeinträchtigung der p53-Expression und/oder -Aktivität |
BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
MX345535B (es) | 2011-05-06 | 2017-02-03 | Zafgen Inc | Compuestos tricíclicos parcialmente saturados y métodos para su fabricación y su uso. |
BR112014017673A8 (pt) | 2012-01-18 | 2017-07-11 | Zafgen Inc | Compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
JP2015509102A (ja) | 2012-01-18 | 2015-03-26 | ザフゲン,インコーポレイテッド | 三環式スルホン化合物並びにその作製および使用方法 |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
EA028367B1 (ru) | 2012-11-05 | 2017-11-30 | Зафджен, Инк. | Способы лечения заболеваний печени |
AU2013337288A1 (en) | 2012-11-05 | 2015-05-21 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
WO2014071363A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
GB201317609D0 (en) | 2013-10-04 | 2013-11-20 | Cancer Rec Tech Ltd | Inhibitor compounds |
JP6156846B2 (ja) * | 2014-03-04 | 2017-07-05 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
WO2015184405A1 (en) * | 2014-05-30 | 2015-12-03 | Medivation Technologies, Inc. | Aromatic compounds, compositions and uses thereof |
US9688637B2 (en) | 2014-08-21 | 2017-06-27 | Northwestern Universtiy | 3-amidobenzamides and uses thereof for increasing cellular levels of A3G and other A3 family members |
CA2969557A1 (en) * | 2014-12-02 | 2016-06-09 | Novira Therapeutics, Inc. | Sulfide alkyl and pyridyl reverse sulfonamide compounds for hbv treatment |
US9597332B2 (en) | 2014-12-02 | 2017-03-21 | Novira Therapeutics, Inc. | Sulfide alkyl compounds for HBV treatment |
US9765050B2 (en) | 2014-12-30 | 2017-09-19 | Novira Therapeutics, Inc. | Pyridyl reverse sulfonamides for HBV treatment |
GB201505658D0 (en) | 2015-04-01 | 2015-05-13 | Cancer Rec Tech Ltd | Inhibitor compounds |
EP3108883A1 (de) * | 2015-06-22 | 2016-12-28 | Fundació Institut de Recerca Biomèdica de Bellvitge | Therapeutische verwendungen von nicht-peptidischen hemmern des calcineurin-nfat-signalwegs |
GB201617103D0 (en) | 2016-10-07 | 2016-11-23 | Cancer Research Technology Limited | Compound |
CN109503518B (zh) * | 2018-11-15 | 2021-03-30 | 中国医学科学院医药生物技术研究所 | 一种取代的双芳香基酰胺化合物及其制备方法和应用 |
WO2021026257A1 (en) * | 2019-08-06 | 2021-02-11 | Empirico Inc. | Prodrugs of alox-15 inhibitors and methods of using the same |
JP2023508952A (ja) * | 2019-12-23 | 2023-03-06 | エスアールアイ インターナショナル | リポキシゲナーゼ阻害剤 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH373028A (de) * | 1960-08-29 | 1963-11-15 | Geigy Ag J R | Verfahren zur Herstellung neuer Aminobenzoesäurederivate |
DE3743517A1 (de) | 1987-12-22 | 1989-07-06 | Basf Ag | Verfahren zur herstellung von aromatischen hydroxycarbonsaeuren |
DE3816703A1 (de) | 1988-05-17 | 1989-11-30 | Hoechst Ag | Heterocyclisch substituierte phenoxysulfonylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als herbizide oder pflanzenwachstumsregulatoren |
US5041545A (en) | 1989-04-06 | 1991-08-20 | Atochem North America, Inc. | 2-hydroxybenzophenone hydrazides and derivatives thereof |
US5256686A (en) * | 1989-06-27 | 1993-10-26 | Ono Pharmaceutical Co., Ltd. | Phenylalkan(en)oic acid |
US5177246A (en) | 1989-10-02 | 1993-01-05 | Ciba-Geigy Corporation | Hydroxphenylcarboxylic acid esters as stabilizers |
WO1992009577A1 (en) | 1990-11-22 | 1992-06-11 | Janssen Pharmaceutica N.V. | Isonicotinic acid derivatives and related spiro compounds with herbicidal action |
US5049496A (en) | 1990-12-24 | 1991-09-17 | General Electric Company | Method for microbiologically hydroxylating biphenyl and terphenyl compounds |
US5382690A (en) | 1992-08-11 | 1995-01-17 | Mitsui Toatsu Chemicals, Incorporated | Method for preparing aromatic secondary amino compound |
DE4238994A1 (de) | 1992-11-19 | 1994-05-26 | Basf Ag | Aniline als Markierungsmittel für Mineralöle |
DE4331416A1 (de) | 1993-12-09 | 1995-06-14 | Bayer Ag | Verwendung von Phenylcarbonsäure-amiden als Kristallisationsinhibitoren |
-
1998
- 1998-11-20 AU AU15297/99A patent/AU1529799A/en not_active Abandoned
- 1998-11-20 DE DE69827664T patent/DE69827664T2/de not_active Expired - Fee Related
- 1998-11-20 KR KR1020007006971A patent/KR20010033470A/ko not_active Application Discontinuation
- 1998-11-20 ES ES98959510T patent/ES2234169T3/es not_active Expired - Lifetime
- 1998-11-20 BR BR9814327-1A patent/BR9814327A/pt not_active IP Right Cessation
- 1998-11-20 NZ NZ502963A patent/NZ502963A/en unknown
- 1998-11-20 JP JP2000525370A patent/JP2001526255A/ja not_active Withdrawn
- 1998-11-20 US US09/529,135 patent/US6268387B1/en not_active Expired - Fee Related
- 1998-11-20 WO PCT/US1998/024688 patent/WO1999032433A1/en active IP Right Grant
- 1998-11-20 EP EP98959510A patent/EP1042276B1/de not_active Expired - Lifetime
- 1998-11-20 AT AT98959510T patent/ATE282591T1/de not_active IP Right Cessation
- 1998-11-20 CA CA002300197A patent/CA2300197A1/en not_active Abandoned
- 1998-12-22 UY UY25322A patent/UY25322A1/es unknown
- 1998-12-22 CO CO98076093A patent/CO4990966A1/es unknown
- 1998-12-22 AR ARP980106614A patent/AR024826A1/es unknown
- 1998-12-22 ZA ZA9811805A patent/ZA9811805B/xx unknown
- 1998-12-22 PE PE1998001268A patent/PE20000064A1/es not_active Application Discontinuation
-
2001
- 2001-05-15 US US09/858,089 patent/US6528528B2/en not_active Expired - Fee Related
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CO4990966A1 (es) | 2000-12-26 |
BR9814327A (pt) | 2000-10-03 |
AR024826A1 (es) | 2002-10-30 |
DE69827664T2 (de) | 2005-12-08 |
EP1042276B1 (de) | 2004-11-17 |
US6528528B2 (en) | 2003-03-04 |
AU1529799A (en) | 1999-07-12 |
JP2001526255A (ja) | 2001-12-18 |
ATE282591T1 (de) | 2004-12-15 |
NZ502963A (en) | 2002-06-28 |
CA2300197A1 (en) | 1999-07-01 |
US20010031874A1 (en) | 2001-10-18 |
UY25322A1 (es) | 2004-07-30 |
WO1999032433A1 (en) | 1999-07-01 |
PE20000064A1 (es) | 2000-02-11 |
US6268387B1 (en) | 2001-07-31 |
KR20010033470A (ko) | 2001-04-25 |
ES2234169T3 (es) | 2005-06-16 |
EP1042276A1 (de) | 2000-10-11 |
ZA9811805B (en) | 1999-06-29 |
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