BR112013028666A2 - compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo - Google Patents

compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo

Info

Publication number
BR112013028666A2
BR112013028666A2 BR112013028666A BR112013028666A BR112013028666A2 BR 112013028666 A2 BR112013028666 A2 BR 112013028666A2 BR 112013028666 A BR112013028666 A BR 112013028666A BR 112013028666 A BR112013028666 A BR 112013028666A BR 112013028666 A2 BR112013028666 A2 BR 112013028666A2
Authority
BR
Brazil
Prior art keywords
methods
making
same
tricyclic
sulfonamide compounds
Prior art date
Application number
BR112013028666A
Other languages
English (en)
Inventor
Joan Dyke Hazel
Zahler Robert
Mary Cramp Susan
David Pallin Thomas
Original Assignee
Zafgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zafgen Inc filed Critical Zafgen Inc
Publication of BR112013028666A2 publication Critical patent/BR112013028666A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

composto de pirazolo sulfonamida tricíclicos e métodos para fazer e usar o mesmo a invenção proporciona compostos de sulfonamida tricíclicos e seu uso no tratamento de desordens médicas, tais como a obesidade. as composições farmacêuticas e os métodos de fazer vários compostos tricíclicos são proporcionados. os compostos são contemplados como tendo uma atividade contra metionil aminopeptidase 2.
BR112013028666A 2011-05-06 2012-05-07 compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo BR112013028666A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161483275P 2011-05-06 2011-05-06
PCT/US2012/036793 WO2012154679A1 (en) 2011-05-06 2012-05-07 Tricyclic pyrazole sulfonamide compounds and methods of making and using same

Publications (1)

Publication Number Publication Date
BR112013028666A2 true BR112013028666A2 (pt) 2017-08-08

Family

ID=46085253

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013028666A BR112013028666A2 (pt) 2011-05-06 2012-05-07 compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo

Country Status (10)

Country Link
US (2) US9242997B2 (pt)
EP (1) EP2705035B1 (pt)
JP (1) JP6035327B2 (pt)
KR (1) KR20140040739A (pt)
CN (1) CN103764652B (pt)
AU (1) AU2012253760B2 (pt)
BR (1) BR112013028666A2 (pt)
CA (1) CA2835209A1 (pt)
MX (1) MX343688B (pt)
WO (1) WO2012154679A1 (pt)

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US9242997B2 (en) 2016-01-26
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CN103764652B (zh) 2016-03-23
US20140080822A1 (en) 2014-03-20
JP2014513140A (ja) 2014-05-29
KR20140040739A (ko) 2014-04-03
MX2013012923A (es) 2014-02-27
JP6035327B2 (ja) 2016-11-30
AU2012253760B2 (en) 2016-02-04
EP2705035B1 (en) 2016-12-14
WO2012154679A1 (en) 2012-11-15
WO2012154679A8 (en) 2013-11-14
CA2835209A1 (en) 2012-11-15
CN103764652A (zh) 2014-04-30
US20160324865A1 (en) 2016-11-10
AU2012253760A1 (en) 2013-11-21

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