DE69826695D1 - Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen - Google Patents
Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungenInfo
- Publication number
- DE69826695D1 DE69826695D1 DE69826695T DE69826695T DE69826695D1 DE 69826695 D1 DE69826695 D1 DE 69826695D1 DE 69826695 T DE69826695 T DE 69826695T DE 69826695 T DE69826695 T DE 69826695T DE 69826695 D1 DE69826695 D1 DE 69826695D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- inflammatory
- treatment
- immunomodulatory diseases
- urine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86302297A | 1997-05-23 | 1997-05-23 | |
US863022 | 1997-05-23 | ||
PCT/US1998/010375 WO1998052558A1 (en) | 1997-05-23 | 1998-05-21 | INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69826695D1 true DE69826695D1 (de) | 2004-11-04 |
DE69826695T2 DE69826695T2 (de) | 2006-02-02 |
Family
ID=25340046
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69826695T Expired - Lifetime DE69826695T2 (de) | 1997-05-23 | 1998-05-21 | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen |
DE1019040T Pending DE1019040T1 (de) | 1997-05-23 | 1998-05-21 | Hemmung von p38 kinase aktivität durch arylharnstoff |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1019040T Pending DE1019040T1 (de) | 1997-05-23 | 1998-05-21 | Hemmung von p38 kinase aktivität durch arylharnstoff |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1019040B1 (de) |
JP (1) | JP4344960B2 (de) |
AT (1) | ATE277612T1 (de) |
AU (1) | AU7585498A (de) |
CA (1) | CA2290520C (de) |
DE (2) | DE69826695T2 (de) |
ES (1) | ES2151467T3 (de) |
HK (1) | HK1026144A1 (de) |
PT (1) | PT1019040E (de) |
WO (1) | WO1998052558A1 (de) |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7585598A (en) * | 1997-05-23 | 1998-12-11 | Bayer Corporation | Raf kinase inhibitors |
PT986382E (pt) * | 1997-05-23 | 2008-07-10 | Onyx Pharma Inc | Inibidores de raf-quinase |
US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
AU1924699A (en) | 1997-12-19 | 1999-07-12 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses |
JP4403482B2 (ja) * | 1997-12-22 | 2010-01-27 | バイエル コーポレイション | 置換複素環尿素合成のための中間体およびその製造方法 |
JP3887769B2 (ja) * | 1997-12-22 | 2007-02-28 | バイエル コーポレイション | 対称および非対称ジフェニル尿素を用いるp38キナーゼの阻害 |
US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
SE9802209D0 (sv) | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
UY25842A1 (es) * | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
AU2004200566B2 (en) * | 1999-01-13 | 2006-08-17 | Bayer Pharmaceuticals Corporation | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
SI1140840T1 (sl) * | 1999-01-13 | 2006-06-30 | Bayer Pharmaceuticals Corp | Omega-karboksiarilno substituirane difenil secnine kot inhibitorji raf kinaze |
DK1140840T3 (da) * | 1999-01-13 | 2006-07-31 | Bayer Pharmaceuticals Corp | omega-carboxyaryl-substituerede diphenylurinstoffer som raf-kinase-inhibitorer |
EP1158985B1 (de) * | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | GAMMA CARBOXYARYLSUBSTITUIERTE DIPHENYLHARNSTOFFVERBINDUNGEN ALS p38 KINASEHEMMER |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
WO2000050425A1 (en) * | 1999-02-22 | 2000-08-31 | Boehringer Ingelheim Pharmaceuticals, Inc. | Polycyclo heterocyclic derivatives as antiinflammatory agents |
EP1159273A1 (de) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Verbindungen, verwendbar als reversible inhibitoren von cathepsin s |
DE60014603T2 (de) | 1999-03-12 | 2006-02-16 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Heterocyklischer harnstoff und verwandte verbindungen als entzündungshemmende mittel |
EP1163236B1 (de) * | 1999-03-12 | 2005-11-09 | Boehringer Ingelheim Pharmaceuticals Inc. | Aromatische heterozyklische verbindungen als antientzündungwirkstoffe |
EP1466906A1 (de) * | 1999-03-12 | 2004-10-13 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterozyklischer Harnstoff und verwandte Verbindungen als entzündungshemmende Mittel |
EP1690854A1 (de) * | 1999-03-12 | 2006-08-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterozyklischer Harnstoff und verwandte Verbindungen als entzündungshemmende Mittel |
WO2000061552A1 (fr) * | 1999-04-07 | 2000-10-19 | Santen Pharmaceutical Co., Ltd. | DERIVE D'UREE N-SUBSTITUE-N'-SUBSTITUE, ET SON UTILISATION COMME INHIBITEUR DE LA PRODUCTION DE TNF-$g(a) |
US6573409B1 (en) | 1999-07-02 | 2003-06-03 | The Nutrasweet Company | Process for the preparation of 3,3-dimethylbutanal |
IL147280A0 (en) | 1999-07-07 | 2002-08-14 | Astrazeneca Uk Ltd | Quinazoline derivatives |
WO2001004115A2 (en) | 1999-07-09 | 2001-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel process for synthesis of heteroaryl-substituted urea compounds |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6407238B1 (en) * | 1999-10-29 | 2002-06-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
JP4955171B2 (ja) * | 1999-11-16 | 2012-06-20 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症剤としての尿素誘導体 |
WO2001038312A1 (en) | 1999-11-23 | 2001-05-31 | Smithkline Beecham Corporation | 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS |
US6525046B1 (en) | 2000-01-18 | 2003-02-25 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as antiinflammatory agents |
US6608052B2 (en) | 2000-02-16 | 2003-08-19 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
US6822093B2 (en) | 2000-05-23 | 2004-11-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis of heteroarylamine intermediate compounds |
US6635767B2 (en) | 2000-05-23 | 2003-10-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis of heteroarylamine intermediate compounds |
US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
ATE413394T1 (de) | 2000-06-24 | 2008-11-15 | Astrazeneca Ab | Guanidin-derivate von chinazoin zur behandlung von autoimmunkrankheiten |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
DE60134679D1 (de) | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
JP2004517080A (ja) | 2000-11-29 | 2004-06-10 | グラクソ グループ リミテッド | Tie−2および/またはvegfr−2の阻害剤として有用なベンゾイミダゾール誘導体 |
US6949567B2 (en) | 2001-02-26 | 2005-09-27 | 4Sc Ag | Compounds for the treatment of protozoal diseases |
DE10109204A1 (de) * | 2001-02-26 | 2002-09-19 | 4Sc Ag | Verbindungen zur Behandlung von Protozoen-Erkrankungen |
JP2004530690A (ja) | 2001-05-16 | 2004-10-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症性薬剤として有用なジアリールウレア誘導体 |
EP1395561A1 (de) | 2001-05-25 | 2004-03-10 | Boehringer Ingelheim Pharmaceuticals Inc. | Carbamat und oxamid verbindungen als inhibitoren der cytokinproduktion |
KR100900304B1 (ko) | 2001-06-11 | 2009-06-02 | 바이로켐 파마 인코포레이티드 | 플라비 바이러스 감염용 항바이러스제로서의 티오펜 유도체 |
EP1709965A3 (de) | 2001-07-11 | 2006-12-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methode zur Behandlung von zytokinvermittelten Erkrankungen |
JP2004536845A (ja) * | 2001-07-11 | 2004-12-09 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | サイトカイン媒介疾患の治療方法 |
US6603000B2 (en) | 2001-07-11 | 2003-08-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis for heteroarylamine compounds |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
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WO1995013067A1 (en) * | 1993-11-08 | 1995-05-18 | Smithkline Beecham Corporation | Oxazoles for treating cytokine mediated diseases |
JP4437270B2 (ja) * | 1997-12-22 | 2010-03-24 | バイエル コーポレイション | 置換複素環式尿素を用いたrafキナーゼの阻害 |
JP4403482B2 (ja) * | 1997-12-22 | 2010-01-27 | バイエル コーポレイション | 置換複素環尿素合成のための中間体およびその製造方法 |
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1998
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- 1998-05-21 PT PT98923600T patent/PT1019040E/pt unknown
- 1998-05-21 CA CA002290520A patent/CA2290520C/en not_active Expired - Fee Related
- 1998-05-21 AU AU75854/98A patent/AU7585498A/en not_active Abandoned
- 1998-05-21 ES ES98923600T patent/ES2151467T3/es not_active Expired - Lifetime
- 1998-05-21 DE DE69826695T patent/DE69826695T2/de not_active Expired - Lifetime
- 1998-05-21 DE DE1019040T patent/DE1019040T1/de active Pending
- 1998-05-21 AT AT98923600T patent/ATE277612T1/de active
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- 1998-05-21 WO PCT/US1998/010375 patent/WO1998052558A1/en active IP Right Grant
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HK1026144A1 (en) | 2000-12-08 |
ATE277612T1 (de) | 2004-10-15 |
DE69826695T2 (de) | 2006-02-02 |
AU7585498A (en) | 1998-12-11 |
ES2151467T1 (es) | 2001-01-01 |
JP4344960B2 (ja) | 2009-10-14 |
CA2290520C (en) | 2009-01-27 |
DE1019040T1 (de) | 2001-02-08 |
EP1019040A4 (de) | 2000-10-04 |
PT1019040E (pt) | 2005-01-31 |
JP2001526687A (ja) | 2001-12-18 |
ES2151467T3 (es) | 2005-03-01 |
CA2290520A1 (en) | 1998-11-26 |
EP1019040B1 (de) | 2004-09-29 |
EP1019040A1 (de) | 2000-07-19 |
WO1998052558A1 (en) | 1998-11-26 |
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