DE69808921D1 - 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOL-1-ACETAMID-DERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE ANWENDUNG - Google Patents

4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOL-1-ACETAMID-DERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE ANWENDUNG

Info

Publication number: DE69808921D1
Authority: DE; Germany
Prior art keywords: pyridazino; indol; dihydro; oxo; production
Prior art date: 1997-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69808921T

Other languages

English (en)

Other versions

DE69808921T2 (de

Inventor

Yannick Evanno

Laurent Dubois

Mireille Sevrin

Frank Marguet

Jacques Froissant

Regine Bartsch

Catherine Gille

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sanofi Synthelabo SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-30

Filing date

1998-07-28

Publication date

2002-11-28

1998-07-28 Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA

2002-11-28 Publication of DE69808921D1 publication Critical patent/DE69808921D1/de

2003-07-03 Application granted granted Critical

2003-07-03 Publication of DE69808921T2 publication Critical patent/DE69808921T2/de

2018-07-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse

DE69808921T 1997-07-30 1998-07-28 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOL-1-ACETAMID-DERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE ANWENDUNG Expired - Lifetime DE69808921T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9709692A FR2766823B1 (fr)	1997-07-30	1997-07-30	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
PCT/FR1998/001667 WO1999006406A1 (fr)	1997-07-30	1998-07-28	DERIVES DE 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b] INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number	Publication Date
DE69808921D1 true DE69808921D1 (de)	2002-11-28
DE69808921T2 DE69808921T2 (de)	2003-07-03

Family

ID=9509801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69808921T Expired - Lifetime DE69808921T2 (de)	1997-07-30	1998-07-28	4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOL-1-ACETAMID-DERIVATE, IHRE HERSTELLUNG UND THERAPEUTISCHE ANWENDUNG

Country Status (33)

Country	Link
US (1)	US6262045B1 (de)
EP (1)	EP1000063B1 (de)
JP (1)	JP4322421B2 (de)
KR (1)	KR100497782B1 (de)
CN (1)	CN1134440C (de)
AR (1)	AR013264A1 (de)
AT (1)	ATE226584T1 (de)
AU (1)	AU736600B2 (de)
BG (1)	BG64283B1 (de)
BR (1)	BR9811582B1 (de)
CA (1)	CA2298522C (de)
CO (1)	CO5210883A1 (de)
CZ (1)	CZ290011B6 (de)
DE (1)	DE69808921T2 (de)
DK (1)	DK1000063T3 (de)
EE (1)	EE04317B1 (de)
ES (1)	ES2186212T3 (de)
FR (1)	FR2766823B1 (de)
HK (1)	HK1028027A1 (de)
HU (1)	HU229430B1 (de)
IL (1)	IL133633A (de)
NO (1)	NO313963B1 (de)
NZ (1)	NZ502361A (de)
PL (1)	PL194245B1 (de)
PT (1)	PT1000063E (de)
RU (1)	RU2197490C2 (de)
SI (1)	SI1000063T1 (de)
SK (1)	SK283075B6 (de)
TR (1)	TR200000278T2 (de)
TW (1)	TW506971B (de)
UA (1)	UA57088C2 (de)
WO (1)	WO1999006406A1 (de)
ZA (1)	ZA986786B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2788696B1 (fr)	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) *	1999-01-26	2001-02-23	Synthelabo	Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
GB0000564D0 (en)	2000-01-11	2000-03-01	Merck Sharp & Dohme	Therapeutic agents
FR2811990A1 (fr) *	2000-07-24	2002-01-25	Sanofi Synthelabo	DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2811897A1 (fr) *	2000-07-24	2002-01-25	Sanofi Synthelabo	UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2833953B1 (fr) *	2001-12-21	2004-12-03	Sanofi Synthelabo	DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr)	2002-04-03	2004-05-28	Sanofi Synthelabo	Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
KR20080015077A (ko) *	2005-05-05	2008-02-18	사노피-아벤티스 유.에스. 엘엘씨	안정한 나노입자 제형
WO2007027525A1 (en) *	2005-08-29	2007-03-08	Sanofi-Aventis U.S. Llc	Novel crystalline form of a pyridazino [4 , 5-b] indole derivative
SI1926476T1 (sl) *	2005-08-29	2013-07-31	Sanofi-Aventis U.S. Llc	Amorfne trdne disperzije 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5- dihidro-4H-piridazino/4,5-b/indol-1-acetamida
WO2007038209A2 (en) *	2005-09-23	2007-04-05	Schering Corporation	Fused tetracyclic mglur1 antagonists as therapeutic agents
CN1946120B (zh) *	2006-10-20	2010-05-12	华为技术有限公司	实现话单关联的方法及***
MX2011001474A (es) *	2008-08-18	2011-03-25	Sanofi Aventis Llc	Proceso para preparar polimorfos.
EP2181717A1 (de)	2008-10-28	2010-05-05	Sanofi-Aventis	Verwendung von 7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indol-1-Acetamid als Biomarker für periphere Benzodiazepin-Rezeptorverteilung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4985560A (en) *	1990-01-12	1991-01-15	American Home Products Corporation	Pyridazino(4,5-b)indolizines
GB9411955D0 (en) *	1994-06-15	1994-08-03	Merck Sharp & Dohme	Therapeutic agents
US5756501A (en) *	1995-12-13	1998-05-26	American Home Products Corporation	Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr)	1996-10-08	1998-10-30	Synthelabo	Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

1997
- 1997-07-30 FR FR9709692A patent/FR2766823B1/fr not_active Expired - Fee Related
1998
- 1998-07-28 NZ NZ502361A patent/NZ502361A/en not_active IP Right Cessation
- 1998-07-28 CZ CZ2000320A patent/CZ290011B6/cs not_active IP Right Cessation
- 1998-07-28 DE DE69808921T patent/DE69808921T2/de not_active Expired - Lifetime
- 1998-07-28 PT PT98941468T patent/PT1000063E/pt unknown
- 1998-07-28 WO PCT/FR1998/001667 patent/WO1999006406A1/fr active IP Right Grant
- 1998-07-28 TR TR2000/00278T patent/TR200000278T2/xx unknown
- 1998-07-28 AT AT98941468T patent/ATE226584T1/de active
- 1998-07-28 EE EEP200000056A patent/EE04317B1/xx not_active IP Right Cessation
- 1998-07-28 US US09/463,634 patent/US6262045B1/en not_active Expired - Lifetime
- 1998-07-28 PL PL98338445A patent/PL194245B1/pl not_active IP Right Cessation
- 1998-07-28 CA CA002298522A patent/CA2298522C/en not_active Expired - Fee Related
- 1998-07-28 BR BRPI9811582-0A patent/BR9811582B1/pt not_active IP Right Cessation
- 1998-07-28 UA UA99127213A patent/UA57088C2/uk unknown
- 1998-07-28 SK SK129-2000A patent/SK283075B6/sk not_active IP Right Cessation
- 1998-07-28 EP EP98941468A patent/EP1000063B1/de not_active Expired - Lifetime
- 1998-07-28 HU HU0002650A patent/HU229430B1/hu not_active IP Right Cessation
- 1998-07-28 KR KR10-2000-7000935A patent/KR100497782B1/ko not_active IP Right Cessation
- 1998-07-28 ES ES98941468T patent/ES2186212T3/es not_active Expired - Lifetime
- 1998-07-28 IL IL13363398A patent/IL133633A/en active IP Right Grant
- 1998-07-28 RU RU2000102672/04A patent/RU2197490C2/ru not_active IP Right Cessation
- 1998-07-28 DK DK98941468T patent/DK1000063T3/da active
- 1998-07-28 AU AU89832/98A patent/AU736600B2/en not_active Ceased
- 1998-07-28 CN CNB988076071A patent/CN1134440C/zh not_active Expired - Fee Related
- 1998-07-28 SI SI9830309T patent/SI1000063T1/xx unknown
- 1998-07-28 JP JP2000505164A patent/JP4322421B2/ja not_active Expired - Fee Related
- 1998-07-29 CO CO98043191A patent/CO5210883A1/es active IP Right Grant
- 1998-07-29 TW TW087112458A patent/TW506971B/zh not_active IP Right Cessation
- 1998-07-29 AR ARP980103713A patent/AR013264A1/es active IP Right Grant
- 1998-07-29 ZA ZA986786A patent/ZA986786B/xx unknown
2000
- 2000-01-20 BG BG104096A patent/BG64283B1/bg unknown
- 2000-01-28 NO NO20000462A patent/NO313963B1/no not_active IP Right Cessation
- 2000-11-16 HK HK00107288A patent/HK1028027A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK283075B6 (sk)	2003-02-04
EP1000063A1 (de)	2000-05-17
NO313963B1 (no)	2003-01-06
PL194245B1 (pl)	2007-05-31
EE200000056A (et)	2000-10-16
RU2197490C2 (ru)	2003-01-27
JP2001512122A (ja)	2001-08-21
HUP0002650A3 (en)	2002-09-30
AU8983298A (en)	1999-02-22
CA2298522A1 (en)	1999-02-11
HU229430B1 (en)	2013-12-30
BG64283B1 (bg)	2004-08-31
KR20010022356A (ko)	2001-03-15
CN1265108A (zh)	2000-08-30
BR9811582A (pt)	2000-09-26
NZ502361A (en)	2001-06-29
AU736600B2 (en)	2001-08-02
FR2766823B1 (fr)	1999-10-08
NO20000462L (no)	2000-03-29
UA57088C2 (uk)	2003-06-16
DK1000063T3 (da)	2003-02-24
CN1134440C (zh)	2004-01-14
ES2186212T3 (es)	2003-05-01
ZA986786B (en)	1999-02-02
PL338445A1 (en)	2000-11-06
SK1292000A3 (en)	2000-08-14
PT1000063E (pt)	2003-03-31
BR9811582B1 (pt)	2010-10-19
EE04317B1 (et)	2004-06-15
IL133633A0 (en)	2001-04-30
SI1000063T1 (en)	2003-04-30
ATE226584T1 (de)	2002-11-15
AR013264A1 (es)	2000-12-13
NO20000462D0 (no)	2000-01-28
BG104096A (en)	2000-08-31
FR2766823A1 (fr)	1999-02-05
EP1000063B1 (de)	2002-10-23
TW506971B (en)	2002-10-21
TR200000278T2 (tr)	2000-08-21
CZ2000320A3 (cs)	2000-05-17
CZ290011B6 (cs)	2002-05-15
DE69808921T2 (de)	2003-07-03
HUP0002650A2 (hu)	2001-01-29
CA2298522C (en)	2008-07-15
KR100497782B1 (ko)	2005-06-27
HK1028027A1 (en)	2001-02-02
WO1999006406A1 (fr)	1999-02-11
JP4322421B2 (ja)	2009-09-02
CO5210883A1 (es)	2002-10-30
IL133633A (en)	2004-02-08
US6262045B1 (en)	2001-07-17

Legal Events

Date

Code

Title

Description

2003-11-20

8364

No opposition during term of opposition

2005-04-21

8327

Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

2013-02-05

R082

Change of representative

Ref document number: 1000063

Country of ref document: EP

Representative=s name: TER MEER STEINMEISTER & PARTNER GBR PATENTANWA, DE

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