DE69803979D1 - Verfahren zur herstellung von carboxamido-4-azasteroiden - Google Patents

Verfahren zur herstellung von carboxamido-4-azasteroiden

Info

Publication number
DE69803979D1
DE69803979D1 DE69803979T DE69803979T DE69803979D1 DE 69803979 D1 DE69803979 D1 DE 69803979D1 DE 69803979 T DE69803979 T DE 69803979T DE 69803979 T DE69803979 T DE 69803979T DE 69803979 D1 DE69803979 D1 DE 69803979D1
Authority
DE
Germany
Prior art keywords
pct
producing
azasteroids
carboxamido
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69803979T
Other languages
English (en)
Other versions
DE69803979T2 (de
Inventor
Achille Panzeri
Anello Matteo D
Antonio Longo
Marcella Nesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Publication of DE69803979D1 publication Critical patent/DE69803979D1/de
Application granted granted Critical
Publication of DE69803979T2 publication Critical patent/DE69803979T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69803979T 1997-12-31 1998-12-17 Verfahren zur herstellung von carboxamido-4-azasteroiden Expired - Fee Related DE69803979T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9727522.6A GB9727522D0 (en) 1997-12-31 1997-12-31 Process for preparing carboxamido-4-azasteroids
PCT/EP1998/008527 WO1999035161A1 (en) 1997-12-31 1998-12-17 Process for preparing carboxamido-4-azasteroids

Publications (2)

Publication Number Publication Date
DE69803979D1 true DE69803979D1 (de) 2002-04-04
DE69803979T2 DE69803979T2 (de) 2003-02-06

Family

ID=10824341

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69803979T Expired - Fee Related DE69803979T2 (de) 1997-12-31 1998-12-17 Verfahren zur herstellung von carboxamido-4-azasteroiden

Country Status (19)

Country Link
US (2) US6121449A (de)
EP (1) EP0970105B1 (de)
JP (1) JP2001515518A (de)
KR (1) KR20000075845A (de)
CN (1) CN1248263A (de)
AT (1) ATE213741T1 (de)
AU (1) AU753602B2 (de)
CA (1) CA2278487A1 (de)
DE (1) DE69803979T2 (de)
DK (1) DK0970105T3 (de)
ES (1) ES2173675T3 (de)
GB (1) GB9727522D0 (de)
HU (1) HUP0001444A3 (de)
NO (1) NO312195B1 (de)
PT (1) PT970105E (de)
RU (1) RU2198176C2 (de)
TW (1) TW442491B (de)
WO (1) WO1999035161A1 (de)
ZA (1) ZA9811950B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001844A (en) 1995-09-15 1999-12-14 Merck & Co., Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
JP2007522087A (ja) * 2003-06-30 2007-08-09 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
CN1816528A (zh) * 2003-06-30 2006-08-09 麦克公司 作为雄激素受体调节剂的17－乙酰氨基－4－氮杂甾类衍生物
WO2005005606A2 (en) 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
EP1641535A4 (de) * 2003-06-30 2008-05-14 Merck & Co Inc 17-acetamido-4-azasteroidderivate als androgenrezeptormodulatoren
AU2004272004B2 (en) * 2003-09-10 2009-01-22 Merck Sharp & Dohme Corp. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
GB9115676D0 (en) * 1991-07-19 1991-09-04 Erba Carlo Spa Process for the preparation of 17 beta substituted-4-aza-5 alpha-androstan-3-one derivatives
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones

Also Published As

Publication number Publication date
HUP0001444A3 (en) 2001-03-28
NO994199L (no) 1999-10-29
GB9727522D0 (en) 1998-02-25
ES2173675T3 (es) 2002-10-16
NO994199D0 (no) 1999-08-30
EP0970105B1 (de) 2002-02-27
JP2001515518A (ja) 2001-09-18
DE69803979T2 (de) 2003-02-06
HUP0001444A2 (hu) 2000-11-28
ZA9811950B (en) 1999-06-30
TW442491B (en) 2001-06-23
WO1999035161A1 (en) 1999-07-15
NO312195B1 (no) 2002-04-08
CA2278487A1 (en) 1999-07-15
US6121449A (en) 2000-09-19
AU753602B2 (en) 2002-10-24
PT970105E (pt) 2002-07-31
CN1248263A (zh) 2000-03-22
EP0970105A1 (de) 2000-01-12
RU2198176C2 (ru) 2003-02-10
KR20000075845A (ko) 2000-12-26
DK0970105T3 (da) 2002-05-27
AU2514699A (en) 1999-07-26
ATE213741T1 (de) 2002-03-15
US6284887B1 (en) 2001-09-04

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA ITALIA S.P.A., MAILAND/MILANO, IT

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee